Use of intrathecal narcotics in adolescents with relapsed CNS lymphoma

duration and side-effects of morphine and bupivscaino and bupivacaine alone injected into the ceudal space foe relief of postoperative pain was compared in sixty children aged between 1-8 years. In 30 petionta (Group f) 1 a5 mg/kg) alone and in anstbcr 30 b\?@vacaine (0.23, with mixed II) morphino (30 mcg/kg) pl4tlentfi (Group bupivacaine (0.25%, 1.5 mg/kg) WBBgiven caudally at the end The mean duration of analgesia wa5 I1 hour8 of surgery. (range lo-16 hours) in bupivacaine yroup and 22 houro (raRg@ 14-26 hrs) in morphinemixed with bupivacaine. Laeidonce of and nausea and vomiting bva8 urinary retention, pruritis found to be slightly higher with caudal morphirnr? but delayed respiratory depression wafi r..at observed in any, tie conclude that caudal mokphinc cambifml with bupivM.aiflQ pKW%dW longer duration of post-operative %nal$~oaia fil etzll.d?xm without significant Bide effects.

The efficacy,

M.K. Arora, 8. Rajeshwari, and

. Kaul

AUIndiaInstitutet$MediculSciences, NewDelhi,India