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Vaccines: Recent trends and progress
Journal of Immunological Methods, 153 (1~)92) 267
267
© 1992 Elsevier Science Publishers B.V. All rights reserved (X)22-1759/92/$05.(~)
JIM 06438
Book review
Gregoriadis, G., Allison, A.C. and Poste, G. (Eds,), Vaccines: Recent Trends and Progress, VII! + 154 pp. Plenum Press, New York, 1991. USD59.50, ISBN 0-306-44044-X This book contains papers presented at the 2nd N A T O Advanced Study Institute held 24 June-5 July 1990 at Cape $ounion Beach, Greece. The preceding conference on the same subject and with largely the same participants took place 2 years earlier at the same site (see review in this journal, Vol. 135 (1990) p. 293). The scope of this volume is similar, with presentations of an equally high scientific level. Vaccines of different kind including recombinant and synthetic peptide preparations are evaluated and various adjuvants examined with regard to their safety and efficacy in aiding weak immunogens. The properties of bone marrow-derived dendritic cells as potent antigen-presenting cells are discussed both in the context of normal immune response initiation and of immunosuppression in HIV-infected individuals. Two papers deal with the adjuvant for-
mulation "SAF'" developed at Syntex Research in Palo Alto, CA, which consists of a pre-made emulsion of threonyl-muramyl dipcptide in a vehicle that binds antigen to microsphercs which are then presented to the immune system. According to the authors SAF was shown to enhance both humoral and cell-mediated immunity to a variety of antigens in a number of species. The antigen is not denatured during vaccine preparation, the emulsion is stable and so far has proved non-toxic. Animal studies described by a Wyeth-Ayerst Research group from Philadelphia, PA show satisfactory results of influenza vaccination using SAF. Also worthy of note is a report on the clinical trials of a subunit Epstein-Barr virus vaccine and a review of recent advances in the development of spermatozoa- and gonadotrophin-based birth control vaccines. A list of contributors and a subject index close the volume. F. BOREK
267
© 1992 Elsevier Science Publishers B.V. All rights reserved (X)22-1759/92/$05.(~)
JIM 06438
Book review
Gregoriadis, G., Allison, A.C. and Poste, G. (Eds,), Vaccines: Recent Trends and Progress, VII! + 154 pp. Plenum Press, New York, 1991. USD59.50, ISBN 0-306-44044-X This book contains papers presented at the 2nd N A T O Advanced Study Institute held 24 June-5 July 1990 at Cape $ounion Beach, Greece. The preceding conference on the same subject and with largely the same participants took place 2 years earlier at the same site (see review in this journal, Vol. 135 (1990) p. 293). The scope of this volume is similar, with presentations of an equally high scientific level. Vaccines of different kind including recombinant and synthetic peptide preparations are evaluated and various adjuvants examined with regard to their safety and efficacy in aiding weak immunogens. The properties of bone marrow-derived dendritic cells as potent antigen-presenting cells are discussed both in the context of normal immune response initiation and of immunosuppression in HIV-infected individuals. Two papers deal with the adjuvant for-
mulation "SAF'" developed at Syntex Research in Palo Alto, CA, which consists of a pre-made emulsion of threonyl-muramyl dipcptide in a vehicle that binds antigen to microsphercs which are then presented to the immune system. According to the authors SAF was shown to enhance both humoral and cell-mediated immunity to a variety of antigens in a number of species. The antigen is not denatured during vaccine preparation, the emulsion is stable and so far has proved non-toxic. Animal studies described by a Wyeth-Ayerst Research group from Philadelphia, PA show satisfactory results of influenza vaccination using SAF. Also worthy of note is a report on the clinical trials of a subunit Epstein-Barr virus vaccine and a review of recent advances in the development of spermatozoa- and gonadotrophin-based birth control vaccines. A list of contributors and a subject index close the volume. F. BOREK