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Value of Fusion of MRI and CT in Brachytherapy
Abstracts / Brachytherapy 16 (2017) S14eS118 status, clinical benefits, objective curative effects were analyzed to assess the effectiveness of interstitial I-125 seed implantation. Results: No patient died in the perioperative period. Median survival time of the whole group was 15.0 months, whereas from Stage I to IV was 25.5, 20.1, 15.3 and 7.1 months, respectively. Compared with the date of coordination group of the committee on pancreatic cancer Chinese Anti-cancer Association, the median survival time was significantly longer. For the severe abdominal and/or back pain patients, 91.8% (101/110) experienced completed or partial pain relief, and showed satisfactory palliative effect. Conclusions: Patients with pancreatic carcinoma can benefit from I-125 seed implantation in terms of survival time, pain relief and quality of life.
PO68 Delineation of Target Volume of Iodine125 Brachytherapy in the Treatment of High-Grade Gliomas Xiufeng Chu, Ph.D.1, Yang Gao, Ph.D.2, Xiaokun Hu, M.D.3 1The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; 2 Beihang University, Beijing, China; 3Interventional Center, The Affiliated Hospital of Qingdao University, Qingdao, China. Purpose: To study how enlarging target area of iodine -125 brachytherapy influences the therapeutic effects and complications in the treatment of highgrade gliomas. Materials and Methods: A retrospective analysis was performed in 120 patients with high-grade gliomas from 14 Chinese hospitals. They were classified into two groups: Enlarging group with its planning target volume (PTV) 0.3-1cm bigger than the gross tumor volume (GTV), and control group with its PTV equivalent to GTV. The therapeutic effects and complications were observed. Results: In the premise of similar operative methods, prescription dose, treatment history, age, gender and other variables, Enlarging group had a significantly prolonged overall survival time (OS) and progression-free survival time ( PFS) in comparison of control group, as well as a higher degree of complication. Conclusions: In the treatment high-grade gliomas with iodine -125 brachytherapy, it is reasonable to expand the target area and cover extra 0.3-1cm around GTV, which can significantly improve curative effects in company with controllable complications.
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catheters and lesion. Experimental results prove that the fusion algorithm is robust and reliable in clinical practice.
PO71 Iodine-125 Seed Implantation and Percutaneous Stenting in the Treatment of Pancreatic Cancer with Obstructive Jaundice Wujie Wang, MD, Yongzheng Wang, MD, Zheng Li, MD, Yuliang Li, MD. The Second Hospital of Shandong University, Jinan, China. Purpose: The aim of this study was to retrospectively evaluate the efficacy of iodine-125 seed implantation on survival of patients with malignant obstructive jaundice(locally advanced pancreatic carcinoma) treated with metallic stent. Materials and Methods: In the retrospective study, 26 patients with locally advanced pancreatic carcinoma presented with obstructive jaundice were treated with stents insertion. 12 of the 26 patients underwent CT-guided Iodine-125 Seed Implantation 7 days after the procedure and the other 14 patients were treated only with best supportive care. The actuarial D90 of the implanted iodine-125 seeds ranged from 110 Gy to 130 Gy (median,120Gy). The activity ranged from(0.5-0.6mci) (median,0.55 mCi). The follow-up period ranged from 3 to 20 months (median, 8.5 months). We did not find any statistically significant differences in ECOG score and tumor stage between these two groups of patients. Survival was analyzed using Kaplan-Meier method and log-rank test. Results: The median overall survival time of the 26 patients was 6.78 (95% CI 3.13-10.43) months. In the group of patients treated with iodine-125 seeds implantation and with stent insertion, the median survival time was 11.96 (95% CI 7.34-16.58)months. In the group of patients treated only with stent implantation the median survival was 5.82 (95% CI 5.51-6.13) months. The overall survivals in the iodine-125 seed combined group were higher than the only best supportive care group(p50.011). Conclusions: This study shows combined with Iodine-125 seed implantation could extend the survival in the patients with pancreatic cancer and obstructive jaundice.
PO70 Value of Fusion of MRI and CT in Brachytherapy Yang Gao, Ph.D.1 Guo Nan, Ph.D.1, Xiaokun Hu, M.D.2. 1 School of Instrumentation Science & Opto-electronics Engineering, Beihang University, Beijing, China; 2Interventional Center, The Affiliated Hospital of Qingdao University, Qingdao, China. Purpose: To develop a fast, accurate and robust method of fusing intraoperative computed tomography (CT) with pre-operative magnetic resonance imaging (MRI) and evaluate the impact of using the fused data on 125Iodine (I125) seeds implanted brachytherapy for Intracranial tumors. Materials and Methods: A retrospective review of records was performed on a cohort of 10 consecutive patients who underwent I125 seeds implanted brachytherapy for recurrent, metastases and other brain tumors entities with fusing CT and MRI volumetric image which we recently developed and implemented an automated fusion algorithm. Adjusted analysis was performed to compare the accuracy of location of catheters, planning target volume(PTV) and the conformity index (COIN) with or without this method. Results: The accuracy of per catheter insertion was 91.2% after image fusion and 83.2% without this method. There was a significant difference between PTV with CT images and PTV with CT-MRI fused data (69.0429.83 cm3 vs. 60.1229.10 cm3), and for the conformity index (0.76 vs. 0.89, p!0.05). Conclusions: The proposed MRI and CT image fusion method enable a quantitative assessment of images under evaluation, and improve the efficacy of the seeds implanted. The additional information obtained from the fused images can be well utilized for more precise location of
PO72 Effectiveness and Safety of Sublobar Resection Combined with 125I Implation on Early Lung Cancer a Systematic Review Lili Wang, Graduate Student1, Bin Huo, Graduate Student2, Haitao Wang, Doctor2, Shude Chai, Doctor2, Lei Wang, Graduate Student2, Hao Wang, Graduate Student2, Dingkun Hou, Graduate Student2, Xiaodong Huo,
PO68 Delineation of Target Volume of Iodine125 Brachytherapy in the Treatment of High-Grade Gliomas Xiufeng Chu, Ph.D.1, Yang Gao, Ph.D.2, Xiaokun Hu, M.D.3 1The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; 2 Beihang University, Beijing, China; 3Interventional Center, The Affiliated Hospital of Qingdao University, Qingdao, China. Purpose: To study how enlarging target area of iodine -125 brachytherapy influences the therapeutic effects and complications in the treatment of highgrade gliomas. Materials and Methods: A retrospective analysis was performed in 120 patients with high-grade gliomas from 14 Chinese hospitals. They were classified into two groups: Enlarging group with its planning target volume (PTV) 0.3-1cm bigger than the gross tumor volume (GTV), and control group with its PTV equivalent to GTV. The therapeutic effects and complications were observed. Results: In the premise of similar operative methods, prescription dose, treatment history, age, gender and other variables, Enlarging group had a significantly prolonged overall survival time (OS) and progression-free survival time ( PFS) in comparison of control group, as well as a higher degree of complication. Conclusions: In the treatment high-grade gliomas with iodine -125 brachytherapy, it is reasonable to expand the target area and cover extra 0.3-1cm around GTV, which can significantly improve curative effects in company with controllable complications.
S91
catheters and lesion. Experimental results prove that the fusion algorithm is robust and reliable in clinical practice.
PO71 Iodine-125 Seed Implantation and Percutaneous Stenting in the Treatment of Pancreatic Cancer with Obstructive Jaundice Wujie Wang, MD, Yongzheng Wang, MD, Zheng Li, MD, Yuliang Li, MD. The Second Hospital of Shandong University, Jinan, China. Purpose: The aim of this study was to retrospectively evaluate the efficacy of iodine-125 seed implantation on survival of patients with malignant obstructive jaundice(locally advanced pancreatic carcinoma) treated with metallic stent. Materials and Methods: In the retrospective study, 26 patients with locally advanced pancreatic carcinoma presented with obstructive jaundice were treated with stents insertion. 12 of the 26 patients underwent CT-guided Iodine-125 Seed Implantation 7 days after the procedure and the other 14 patients were treated only with best supportive care. The actuarial D90 of the implanted iodine-125 seeds ranged from 110 Gy to 130 Gy (median,120Gy). The activity ranged from(0.5-0.6mci) (median,0.55 mCi). The follow-up period ranged from 3 to 20 months (median, 8.5 months). We did not find any statistically significant differences in ECOG score and tumor stage between these two groups of patients. Survival was analyzed using Kaplan-Meier method and log-rank test. Results: The median overall survival time of the 26 patients was 6.78 (95% CI 3.13-10.43) months. In the group of patients treated with iodine-125 seeds implantation and with stent insertion, the median survival time was 11.96 (95% CI 7.34-16.58)months. In the group of patients treated only with stent implantation the median survival was 5.82 (95% CI 5.51-6.13) months. The overall survivals in the iodine-125 seed combined group were higher than the only best supportive care group(p50.011). Conclusions: This study shows combined with Iodine-125 seed implantation could extend the survival in the patients with pancreatic cancer and obstructive jaundice.
PO70 Value of Fusion of MRI and CT in Brachytherapy Yang Gao, Ph.D.1 Guo Nan, Ph.D.1, Xiaokun Hu, M.D.2. 1 School of Instrumentation Science & Opto-electronics Engineering, Beihang University, Beijing, China; 2Interventional Center, The Affiliated Hospital of Qingdao University, Qingdao, China. Purpose: To develop a fast, accurate and robust method of fusing intraoperative computed tomography (CT) with pre-operative magnetic resonance imaging (MRI) and evaluate the impact of using the fused data on 125Iodine (I125) seeds implanted brachytherapy for Intracranial tumors. Materials and Methods: A retrospective review of records was performed on a cohort of 10 consecutive patients who underwent I125 seeds implanted brachytherapy for recurrent, metastases and other brain tumors entities with fusing CT and MRI volumetric image which we recently developed and implemented an automated fusion algorithm. Adjusted analysis was performed to compare the accuracy of location of catheters, planning target volume(PTV) and the conformity index (COIN) with or without this method. Results: The accuracy of per catheter insertion was 91.2% after image fusion and 83.2% without this method. There was a significant difference between PTV with CT images and PTV with CT-MRI fused data (69.0429.83 cm3 vs. 60.1229.10 cm3), and for the conformity index (0.76 vs. 0.89, p!0.05). Conclusions: The proposed MRI and CT image fusion method enable a quantitative assessment of images under evaluation, and improve the efficacy of the seeds implanted. The additional information obtained from the fused images can be well utilized for more precise location of
PO72 Effectiveness and Safety of Sublobar Resection Combined with 125I Implation on Early Lung Cancer a Systematic Review Lili Wang, Graduate Student1, Bin Huo, Graduate Student2, Haitao Wang, Doctor2, Shude Chai, Doctor2, Lei Wang, Graduate Student2, Hao Wang, Graduate Student2, Dingkun Hou, Graduate Student2, Xiaodong Huo,