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VENTRICULAR PREMATURE BEATS IN DIAGNOSIS OF CARDIAC INFARCTION
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MAURICE S. TARSHIS
17 YEGIAN, D., AND BUDD, V.: "Mutation of Streptomycin-Dependent Mycobacterium Ranae Selected from Sulfathiazole-Resistant Variant," t. Bact., 61: 167, 1951. 18 MARSHAK, A.: "Differences in Response of Virulent Strain of Tubercle Bacillus and Its Avirulent Variant to Metabolites and Their Genetic Significance," l- Bact., 61: 1, 1951. 19 SCHAEFER, W. B.: "The Effect of Isoniazid on Growing and Resting Tubercle Bacilli," Am. Rev. Tuberc., 69: 125, 1954. 20 KOCH-WESER, D., BARCLAY, W. R., AND EBERT, R. H.: "The Influence of Isoniazid and Streptomycin on Acid-Fastness, Tetrazolium Reduction, Growth, and Survival of Tubercle Bacilli," Am. Rev. Tuberc., 71: 556, 1955. 21 BARCLAY, W. R., AND RUSSE, H.: "The In Vitro Action of Cycloserine on M. Tuberculosis," Am. Rev. Tuberc., 72: 236, 1955. 22 DUNBAR, J. M.: "L'apparition de Formes Non Acido-Resistantes de Mycobacterium Tuberculosis en Presence D'isoniazide, de Cycloserine et du Thioamide de L'acide a-Ethyl Iso-Nicotique," Ann. Inst. Pasteur (Par.), 92 :451, 1957. 23 TARSHIS, M. S.: "Preliminary Observations on the Development of Atypical (Chromogenic)
24 25
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Diseases of the Chest
Variants of the H37Rv Strain of M. Tuberculosis Under the Influence of Streptomycin and Isoniazid In Vitro," Am. Rev. Tuberc., 78:921, 1958. TARSHIS, M. S.: "Unclassified Mycobacteria from Human Sources," A mer. Rev. Resp. Dis., 81: 426, 1960. XALABARDER, C.: "Descubrimientos y Nociones Recientes Modificaciones Morfologicas del Bacilo de Koch bajo la Accion de los Antibioticos," Symposium Ciba, 3: 19, 1955. DI MARCO, A., GHIONE, M., AND ZAVAGLIO, V. : "Ceppi Micobatterici Resistenti ad Isoniazide," G. Microbiol., 1: 266, 1956. LUCCHESI, M., ZUBIANI, M., MAURO, B., AND MAGGINI, P.: "Osservazioni al Microscopio Elettronico sull Azione della Kanamicina," Ann. 1st. Forlanini, 19: 86, 1959. MAURICE S. TARSHIS, PH.D.* Alexandria, Louisiana
*Director, Tuberculosis Research, Medical Research Laboratory, Veterans Administration Hospital.
VENTRICULAR PREMATURE BEATS IN DIAGNOSIS OF CARDIAC INFARCTION Experimental and cllnical studies on the significance of ventricular premature beats in the diagnosis of myocardial infarction are reported. The unipolar patterns of VPB that are diagnostic of myocardial Infarction are of the QR type (Qr, Qs, and Qrs complexes). The post mortem studies revealed that the Interventricular septum was always Involved. The conclusion is reached that any ectopic beat with aberrant conduction, Irrespective of its site of origin (right or left ventricle, ventricular or supraventricular), is diagnostic of myocardial infarction when the ectopic beat presents a QR type of morphology In leads reflecting the potential variations of the ventricles. A comparison of the diagnostic value of ectopic beats and sinus beats with
normal conduction can be summarized according to the three main possibilities, thus: 1. The Infarction may be diagnosed from sinus beats as well as from ectopic beats;
2. The Infarction may be diagnosed from sinus beats and from ectopic beats, but the latter are of greater value in defining its loeallzatlon and extent; or
3. The Infarction may be diagnosed only by the patterns of the ectopic beats and not by those of the sinus beats. BISTENI, A., MEDRANO, G. A. AND SODl-PALLARES, D.: "Ventricular Premature Beats in the Diagnosis of Myocardial Infarction," Brit. Heart J., 23:'21, 1961.
HIGH BODY SODIUM Measurements of total body water and total exchangeable sodium were made by Carroll and Farber In patients with heart disease rendered free of edema following congestive heart failure. The total exchangeable sodium In most of the patients was higher than would have been predicted on the basis of their body weight and total body water. Serial measurements showed that some patients gradually
lose theIr excess sodium over a perIod of months without a loss of body water; others maintain an elevated ratio of body sodIum to body weight and body sodium to body water for periods of at least several months. CADOLL, H. J. AND FARBER, S. J.: "The Persistence of High Body Sodium in Previously Edematous Patients with Heart Disease," Circulation, 24:626, 1961.
MAURICE S. TARSHIS
17 YEGIAN, D., AND BUDD, V.: "Mutation of Streptomycin-Dependent Mycobacterium Ranae Selected from Sulfathiazole-Resistant Variant," t. Bact., 61: 167, 1951. 18 MARSHAK, A.: "Differences in Response of Virulent Strain of Tubercle Bacillus and Its Avirulent Variant to Metabolites and Their Genetic Significance," l- Bact., 61: 1, 1951. 19 SCHAEFER, W. B.: "The Effect of Isoniazid on Growing and Resting Tubercle Bacilli," Am. Rev. Tuberc., 69: 125, 1954. 20 KOCH-WESER, D., BARCLAY, W. R., AND EBERT, R. H.: "The Influence of Isoniazid and Streptomycin on Acid-Fastness, Tetrazolium Reduction, Growth, and Survival of Tubercle Bacilli," Am. Rev. Tuberc., 71: 556, 1955. 21 BARCLAY, W. R., AND RUSSE, H.: "The In Vitro Action of Cycloserine on M. Tuberculosis," Am. Rev. Tuberc., 72: 236, 1955. 22 DUNBAR, J. M.: "L'apparition de Formes Non Acido-Resistantes de Mycobacterium Tuberculosis en Presence D'isoniazide, de Cycloserine et du Thioamide de L'acide a-Ethyl Iso-Nicotique," Ann. Inst. Pasteur (Par.), 92 :451, 1957. 23 TARSHIS, M. S.: "Preliminary Observations on the Development of Atypical (Chromogenic)
24 25
26 27
Diseases of the Chest
Variants of the H37Rv Strain of M. Tuberculosis Under the Influence of Streptomycin and Isoniazid In Vitro," Am. Rev. Tuberc., 78:921, 1958. TARSHIS, M. S.: "Unclassified Mycobacteria from Human Sources," A mer. Rev. Resp. Dis., 81: 426, 1960. XALABARDER, C.: "Descubrimientos y Nociones Recientes Modificaciones Morfologicas del Bacilo de Koch bajo la Accion de los Antibioticos," Symposium Ciba, 3: 19, 1955. DI MARCO, A., GHIONE, M., AND ZAVAGLIO, V. : "Ceppi Micobatterici Resistenti ad Isoniazide," G. Microbiol., 1: 266, 1956. LUCCHESI, M., ZUBIANI, M., MAURO, B., AND MAGGINI, P.: "Osservazioni al Microscopio Elettronico sull Azione della Kanamicina," Ann. 1st. Forlanini, 19: 86, 1959. MAURICE S. TARSHIS, PH.D.* Alexandria, Louisiana
*Director, Tuberculosis Research, Medical Research Laboratory, Veterans Administration Hospital.
VENTRICULAR PREMATURE BEATS IN DIAGNOSIS OF CARDIAC INFARCTION Experimental and cllnical studies on the significance of ventricular premature beats in the diagnosis of myocardial infarction are reported. The unipolar patterns of VPB that are diagnostic of myocardial Infarction are of the QR type (Qr, Qs, and Qrs complexes). The post mortem studies revealed that the Interventricular septum was always Involved. The conclusion is reached that any ectopic beat with aberrant conduction, Irrespective of its site of origin (right or left ventricle, ventricular or supraventricular), is diagnostic of myocardial infarction when the ectopic beat presents a QR type of morphology In leads reflecting the potential variations of the ventricles. A comparison of the diagnostic value of ectopic beats and sinus beats with
normal conduction can be summarized according to the three main possibilities, thus: 1. The Infarction may be diagnosed from sinus beats as well as from ectopic beats;
2. The Infarction may be diagnosed from sinus beats and from ectopic beats, but the latter are of greater value in defining its loeallzatlon and extent; or
3. The Infarction may be diagnosed only by the patterns of the ectopic beats and not by those of the sinus beats. BISTENI, A., MEDRANO, G. A. AND SODl-PALLARES, D.: "Ventricular Premature Beats in the Diagnosis of Myocardial Infarction," Brit. Heart J., 23:'21, 1961.
HIGH BODY SODIUM Measurements of total body water and total exchangeable sodium were made by Carroll and Farber In patients with heart disease rendered free of edema following congestive heart failure. The total exchangeable sodium In most of the patients was higher than would have been predicted on the basis of their body weight and total body water. Serial measurements showed that some patients gradually
lose theIr excess sodium over a perIod of months without a loss of body water; others maintain an elevated ratio of body sodIum to body weight and body sodium to body water for periods of at least several months. CADOLL, H. J. AND FARBER, S. J.: "The Persistence of High Body Sodium in Previously Edematous Patients with Heart Disease," Circulation, 24:626, 1961.