- Email: [email protected]
Very low birth weight (VLBW) premature infants
Growth Hormone & IGF Research 14 (2004) S129 www.elsevier.com/locate/ghir
Workshop 4
Very low birth weight (VLBW) premature infants For decades, the primary sequelae of prematurity have been considered to be neurological and visual handicaps. However, in this workshop, data were presented suggesting that there may also be long-term growth and endocrine sequelae for these children. Prepubertal children born very prematurely (<32 weeks gestation) have abnormalities in the insulin–glucose axis and in the growth hormone (GH)–insulin-like growth
factor I (IGF-I)-binding protein axis, manifest as insulin resistance and low IGF-I and IGFBP-3 levels. Low IGF-I levels in the neonatal period prevent vascular endothelial growth factor signaling and are associated with retinopathy of prematurity and blindness. Very premature children do not achieve their genetic height potential and demonstrate acceleration in height velocity with GH therapy. A. Hokken-Koelega Associate Professor of Pediatric Endocrinology Department of Pediatrics Erasmus University Medical Center Rotterdam Sophia Children’s Hospital P.O. Box 2060, 3000 CB Rotterdam The Netherlands Tel.: +31-10-4636744 Fax: +31-10-4636811 E-mail address: [email protected] W. Cutfield Professor Department of Pediatrics Faculty of Medicine and Health Sciences Liggins Institute University of Auckland Private Bag 92019, Auckland New Zealand Tel.: +64-9-3737-599 Fax: +64-9-373-8763 E-mail address: w.cutfi[email protected]
1096-6374/$ - see front matter Ó 2004 Published by Elsevier Ltd. doi:10.1016/j.ghir.2004.03.027
Workshop 4
Very low birth weight (VLBW) premature infants For decades, the primary sequelae of prematurity have been considered to be neurological and visual handicaps. However, in this workshop, data were presented suggesting that there may also be long-term growth and endocrine sequelae for these children. Prepubertal children born very prematurely (<32 weeks gestation) have abnormalities in the insulin–glucose axis and in the growth hormone (GH)–insulin-like growth
factor I (IGF-I)-binding protein axis, manifest as insulin resistance and low IGF-I and IGFBP-3 levels. Low IGF-I levels in the neonatal period prevent vascular endothelial growth factor signaling and are associated with retinopathy of prematurity and blindness. Very premature children do not achieve their genetic height potential and demonstrate acceleration in height velocity with GH therapy. A. Hokken-Koelega Associate Professor of Pediatric Endocrinology Department of Pediatrics Erasmus University Medical Center Rotterdam Sophia Children’s Hospital P.O. Box 2060, 3000 CB Rotterdam The Netherlands Tel.: +31-10-4636744 Fax: +31-10-4636811 E-mail address: [email protected] W. Cutfield Professor Department of Pediatrics Faculty of Medicine and Health Sciences Liggins Institute University of Auckland Private Bag 92019, Auckland New Zealand Tel.: +64-9-3737-599 Fax: +64-9-373-8763 E-mail address: w.cutfi[email protected]
1096-6374/$ - see front matter Ó 2004 Published by Elsevier Ltd. doi:10.1016/j.ghir.2004.03.027