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Very low-energy plasma skin resurfacing treatments improve photodamage
P2913
P2915
The Brazilian experience in the treatment of mild to moderate acne using blue light from a new device Valeria Campos, MD, Clinica Valeria Campos, Jundiai, KS, Brazil; Christiane Ferreira, MD, Clinica Valeria Campos, Jundiai, MA, Brazil
Patients’ assessment of age-related appearance after botulinum toxin type A treatment of upper facial rhytids: Results across six clinical studies Alastair Carruthers, MD, University of British Columbia, Division of Dermatology, Vancouver, BC, Canada; Jean Carruthers, MD, University of British Columbia, Department of Ophthalmology, Vancouver, BC, Canada; Sue Ellen Cox, MD, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Steven Fagien, MD, Private practice, Boca Raton, FL, United States Purpose: To assess the effect of botulinum toxin type A (BoNTA) treatment for facial rhytids in the glabellar, crow’s feet, and multiple upper face areas (glabellar, crow’s feet, and forehead combined) on patients’ age-related appearance. Methods: Data from 6 clinical studies of BoNTA treatment of facial rhytids were analyzed: 3 studies of glabellar rhytids treatment, 1 study of crow’s feet treatment, and 2 studies of multiple upper facial rhytids treatment (glabellar, crow’s feet, forehead rhytids). Patients in each of the clinical studies reported how old they thought they looked over the last 7 days using the self-perception of age (SPA), a single-item scale for which patients indicate whether they feel they look their current age, younger than their current age, or older than their current age. If younger or older than their current age, the number of years younger or older is reported. The SPA was analyzed as the proportion of patients reporting looking younger and the mean years younger at 4 weeks post-BoNTA treatment using pooled data across studies by treatment dose and area e20 U BoNTA for glabellar rhytids, 12 U/side BoNTA for crow’s feet, or 64 U BoNTA for multiple upper facial rhytids. For comparison, SPA results for patients receiving placebo for any treatment area were pooled. Results: Data from 295 patients treated with BoNTA or placebo from 6 clinical studies were analyzed. At week 4 post-BoNTA treatment, 40.5% of patients receiving 20 U for glabellar rhytids, 44.8% of patients receiving 12 U bilateral treatment for crow’s feet, and 62.5% of patients receiving 64 U for multiple upper facial rhytids reported looking younger relative to their current age. These BoNTA-treated patients reported they looked on average from 5 years younger. In comparison, 21.8% of patients receiving placebo reported they looked younger at week 4 post-treatment. Conclusions: BoNTA treatment for glabellar rhytids, crow’s feet, and multiple upper facial rhytids results in improvements in patients’ perception of their age-related appearance, with as many as 63% of patients reporting they look an average of 5 years younger than their current age 4 weeks following BoNTA treatment.
Background: Acne occurs in people of all ethnicity and races. Although the physiopathology and treatment options are similar in all skin phototypes, darkerskinned patients have higher incidence rates of 2 sequelae of acne that are postinflammatory hyper-pigmentation and keloidal scarring. Objective: The present study was designed to assess the efficacy and safety of this photo-therapy in Brazil where the majority of the population is darker-skinned. Methods: Twenty subjects, Fitzpatrick skin types III-V, with mild to moderate facial acne was recruited for the study. Subjects were treated over twelve sessions, two per week, using 405 nm blue light (20 minutes/session, 18 J/cm2 and 10 mw/cm2) from a light emitting diode (LED) based therapy system Multiwaves (Industra, Sa˜o Carlos, SP, Brazil). Results: Blinded observers of standardized photographs taken 2 weeks after the last treatment scored percent improvement as follows:\25% (poor), 26-50% (good), 5175% (very good), [75% (excellent). Moreover, 70% of all patients showed very good or excellent improvement and 1 patient (5%) did not respond to the treatment. In 20% of the patients, mostly dark-skinned, we observed hyper-pigmentation similar to a recent light exposure tan, which faded spontaneously after a couple of days. Commercial support: None identified.
100% sponsored by Allergan.
P2916 Very low-energy plasma skin resurfacing treatments photodamage Eric Bernstein, MD, Laser Surgery Centers, Philadelphia, PA,
P2914 Comparison of hyaluronic acid fillers for nasolabial fold correction Kevin Smith, MD, Private practice, Niagara Falls, ON, Canada Several hyaluronic acid (HA) fillers have been approved by the U.S. Food and Drug Administration and such fillers have become the gold standard among dermal fillers. Nevertheless, there are few studies directly comparing individual HA fillers even though they may differ from each other in several ways. A double-blind, randomized, pilot study was performed in order to directly compare HA fillers. Subjects were required to have bilateral nasolabial folds that were approximately symmetrical and rated as both moderate or both severe on a validated nasolabial fold photographic scale (where 0 = none, 1 = mild, 2 = moderate, 3 = severe, and 4 = extreme). One HA filler was injected into one nasolabial fold and another HA filler was injected into the other nasolabial fold—with the aim of achieving full correction but without overcorrecting. Both injections were intradermal and touch-up treatments were not allowed. Standardized stereotactic photography was used to document the appearance of the nasolabial folds during the study. Results from up to 30 subjects will be presented. Supported by Allergan Medical Aesthetics.
AB200
J AM ACAD DERMATOL
improve
Purpose: Chronic sun-exposure results in 5 main changes to exposed skin: telangiectasia, hyperpigmentation, rhytides, enlarged pores, and sagging skin. Various laser and non-laser modalities have been used to improve sun-damaged skin. Plasma skin regeneration (PSR) is a new technology which has been shown to improve cutaneous photodamage. We investigate the effect of very low energy (0.5 J) PSR treatment to determine if the photodamage improvement seen at higher energies (1.0-1.5 J) will also be seen at 0.5 J, with less recovery time. Methods and Materials: Twelve subjects with cutaneous photodamage were treated with the PSR using 0.5 J per pulse, over the entire face 3 times at 3-week intervals. Subjects rated improvement and digital images were taken and evaluated using the Canfield Visio CR photographic system 1 and 3 months following the final treatment. Results: There was no down time associated with any treatment. Preliminary evaluation of data demonstrated a minimum of 25% reduction in physician wrinkle score at 1 month (with increased improvement at 3 months), improvement in textural irregularity and a 40 - 80% patient rated overall improvement. Conclusions: Very low-energy PSR treatments improve facial photodamage with no down time. The greatest improvement was noted in skin texture, rhytides, and pigmentary alterations. Further study of the mechanisms behind this improvement may better direct treatment protocols in the future. Supported by Research Study.
FEBRUARY 2007
P2915
The Brazilian experience in the treatment of mild to moderate acne using blue light from a new device Valeria Campos, MD, Clinica Valeria Campos, Jundiai, KS, Brazil; Christiane Ferreira, MD, Clinica Valeria Campos, Jundiai, MA, Brazil
Patients’ assessment of age-related appearance after botulinum toxin type A treatment of upper facial rhytids: Results across six clinical studies Alastair Carruthers, MD, University of British Columbia, Division of Dermatology, Vancouver, BC, Canada; Jean Carruthers, MD, University of British Columbia, Department of Ophthalmology, Vancouver, BC, Canada; Sue Ellen Cox, MD, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Steven Fagien, MD, Private practice, Boca Raton, FL, United States Purpose: To assess the effect of botulinum toxin type A (BoNTA) treatment for facial rhytids in the glabellar, crow’s feet, and multiple upper face areas (glabellar, crow’s feet, and forehead combined) on patients’ age-related appearance. Methods: Data from 6 clinical studies of BoNTA treatment of facial rhytids were analyzed: 3 studies of glabellar rhytids treatment, 1 study of crow’s feet treatment, and 2 studies of multiple upper facial rhytids treatment (glabellar, crow’s feet, forehead rhytids). Patients in each of the clinical studies reported how old they thought they looked over the last 7 days using the self-perception of age (SPA), a single-item scale for which patients indicate whether they feel they look their current age, younger than their current age, or older than their current age. If younger or older than their current age, the number of years younger or older is reported. The SPA was analyzed as the proportion of patients reporting looking younger and the mean years younger at 4 weeks post-BoNTA treatment using pooled data across studies by treatment dose and area e20 U BoNTA for glabellar rhytids, 12 U/side BoNTA for crow’s feet, or 64 U BoNTA for multiple upper facial rhytids. For comparison, SPA results for patients receiving placebo for any treatment area were pooled. Results: Data from 295 patients treated with BoNTA or placebo from 6 clinical studies were analyzed. At week 4 post-BoNTA treatment, 40.5% of patients receiving 20 U for glabellar rhytids, 44.8% of patients receiving 12 U bilateral treatment for crow’s feet, and 62.5% of patients receiving 64 U for multiple upper facial rhytids reported looking younger relative to their current age. These BoNTA-treated patients reported they looked on average from 5 years younger. In comparison, 21.8% of patients receiving placebo reported they looked younger at week 4 post-treatment. Conclusions: BoNTA treatment for glabellar rhytids, crow’s feet, and multiple upper facial rhytids results in improvements in patients’ perception of their age-related appearance, with as many as 63% of patients reporting they look an average of 5 years younger than their current age 4 weeks following BoNTA treatment.
Background: Acne occurs in people of all ethnicity and races. Although the physiopathology and treatment options are similar in all skin phototypes, darkerskinned patients have higher incidence rates of 2 sequelae of acne that are postinflammatory hyper-pigmentation and keloidal scarring. Objective: The present study was designed to assess the efficacy and safety of this photo-therapy in Brazil where the majority of the population is darker-skinned. Methods: Twenty subjects, Fitzpatrick skin types III-V, with mild to moderate facial acne was recruited for the study. Subjects were treated over twelve sessions, two per week, using 405 nm blue light (20 minutes/session, 18 J/cm2 and 10 mw/cm2) from a light emitting diode (LED) based therapy system Multiwaves (Industra, Sa˜o Carlos, SP, Brazil). Results: Blinded observers of standardized photographs taken 2 weeks after the last treatment scored percent improvement as follows:\25% (poor), 26-50% (good), 5175% (very good), [75% (excellent). Moreover, 70% of all patients showed very good or excellent improvement and 1 patient (5%) did not respond to the treatment. In 20% of the patients, mostly dark-skinned, we observed hyper-pigmentation similar to a recent light exposure tan, which faded spontaneously after a couple of days. Commercial support: None identified.
100% sponsored by Allergan.
P2916 Very low-energy plasma skin resurfacing treatments photodamage Eric Bernstein, MD, Laser Surgery Centers, Philadelphia, PA,
P2914 Comparison of hyaluronic acid fillers for nasolabial fold correction Kevin Smith, MD, Private practice, Niagara Falls, ON, Canada Several hyaluronic acid (HA) fillers have been approved by the U.S. Food and Drug Administration and such fillers have become the gold standard among dermal fillers. Nevertheless, there are few studies directly comparing individual HA fillers even though they may differ from each other in several ways. A double-blind, randomized, pilot study was performed in order to directly compare HA fillers. Subjects were required to have bilateral nasolabial folds that were approximately symmetrical and rated as both moderate or both severe on a validated nasolabial fold photographic scale (where 0 = none, 1 = mild, 2 = moderate, 3 = severe, and 4 = extreme). One HA filler was injected into one nasolabial fold and another HA filler was injected into the other nasolabial fold—with the aim of achieving full correction but without overcorrecting. Both injections were intradermal and touch-up treatments were not allowed. Standardized stereotactic photography was used to document the appearance of the nasolabial folds during the study. Results from up to 30 subjects will be presented. Supported by Allergan Medical Aesthetics.
AB200
J AM ACAD DERMATOL
improve
Purpose: Chronic sun-exposure results in 5 main changes to exposed skin: telangiectasia, hyperpigmentation, rhytides, enlarged pores, and sagging skin. Various laser and non-laser modalities have been used to improve sun-damaged skin. Plasma skin regeneration (PSR) is a new technology which has been shown to improve cutaneous photodamage. We investigate the effect of very low energy (0.5 J) PSR treatment to determine if the photodamage improvement seen at higher energies (1.0-1.5 J) will also be seen at 0.5 J, with less recovery time. Methods and Materials: Twelve subjects with cutaneous photodamage were treated with the PSR using 0.5 J per pulse, over the entire face 3 times at 3-week intervals. Subjects rated improvement and digital images were taken and evaluated using the Canfield Visio CR photographic system 1 and 3 months following the final treatment. Results: There was no down time associated with any treatment. Preliminary evaluation of data demonstrated a minimum of 25% reduction in physician wrinkle score at 1 month (with increased improvement at 3 months), improvement in textural irregularity and a 40 - 80% patient rated overall improvement. Conclusions: Very low-energy PSR treatments improve facial photodamage with no down time. The greatest improvement was noted in skin texture, rhytides, and pigmentary alterations. Further study of the mechanisms behind this improvement may better direct treatment protocols in the future. Supported by Research Study.
FEBRUARY 2007