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Veterinary cryotherapy of malignant melanoma
ABSTRACTS,
15TH
Cryosurgery has been used extensively by a large number of gynecologists in Japan and has been proved to have a definite role in the treatment of bening diseases. However, for potentially malignant diseases, its effectiveness has not been proved yet. 111 the past 5 years, we have used it on young patients with preinvasive cervical neoplasias such as dysplasia and carcinoma ill situ. We have treated 50 such patients so far and found that these precancerous conditions can be easily and safely cured by cryosurgery if it is combined with colposcopic examination. In a case of a malignant melanoma of the vagina, we achieved a complete cure after repeated cryosurgery. However, cryosurgery alone is generally not effective for invasive carcinomas, so we combined it with chemotherapy and/or radiation therapy, During combined treatment some patients demonstrated increased immunological reactions in skin tests and in examinations of immunogIobulins and lymphocytes. These findings suggested that cryosurgedy might be effective for treatment of malignant diseases especially when it combined with other therapeutic methods.
97.
Cryosurgery on Skin Cancer. H. MIZUTANI (Department of Dermatology, Yoyogi-Hospital, 5-31-1, Sendagaya, Shibuya-Ku, Tokyo, Japan. S. IKEDA (Department of Dermatology, Saitama Medical School, Saitama, Japan) AND K. MIURA (Second Department of Surgery, Tokyo University School of Medicine, Tokyo, Japan).
Cryotherapy has been applied mainly to benign conditions such as common warts rather than to skin cancer in this country, because the latter is not common in Japanese. The present series included five cases of solar keratosis, five of Bowen’s disease, two of xeroderma pigmentosum, two af oral florid papillomatosis, four of basa1 cell carcinoma, five of squamous cell carcinoma, nine of metastatic skin cancer, one of leiomyosarcoma, and two of malignant meIanoma treated over the past 5 years. Evaluation of cryosurgery for these diseases are as follows: (1) Cryospray is used successfully in any carcinoma in situ as well as in superficial basa1 cell carcinoma. (2) Carbon Dioxide remains most effective method of treatment in xeroderma pigmentosum, stage II. (3) Two cases of oral florid papillomatosis treated by the contact ,rnethod with copper disk, showed excellent complete remission for the past 2 years. (4) Two patients with malignant melanoma were classified as stage I. Both of them were treated successfuIly by the contact method without rtcurrence for 2 to 3 years.
ANNUAL 98.
MEETING
713
VderinaTy Clyotherap~ of Malignant Melamm. FL K. FARRELL (United States Department of Agriculture, Science and Education Administration, Washington State University, Pullman, Washington 99164).
In an attempt to establish a model of lethal malignant melanoma, a boar from a farm with occasional incidences of malignant melanoma was purchased and bread to his own daughter which had been treated by cryotherapy after the occurrence of malignant melanoma in the skin and lymph node. We have been rewarded by the appearance of malignant melanoma in the resnlting offspring. All cryotherapy-treated pigs (one male and three femaIes ) have remained clinicalIy tumor free to the present time. One gelded male was slaughtered and was tumor free. Two nntreated pigs died within 4 months of the first observable Iesion. Horses have been cryogenically treated on a routine basis for malignant melanoma. Some of these tumors have been internal (dorsal to the rectum) and s0me have metastasized to regional lymph nodes. Definite signs of regression an d cures have been seen after freezing tumors at intervals of 2 to 4 weeks. Of eight horses treated onIy one has died of malignant melanoma. The evidence supports a supposition that life has been prolonged by repeated cryotherapy, and two animals have been free of tumor on autopsy. The l.ongest .survival time after starting cryogenic treatment is 3 years and this animal continues under observation, SESSION SURGERY 99.
9.
HYPOTHERMIA-OPEN-HEART UNDER DEEP HYPOTHERMIA
Experimental Studies on Lung Surfuctant in Deep Hypothermia Induced by Surface Coding and Warming. M. NAGHI,* M. HIROSE,* K. MUHASE,* AND K. INADA * (First Department of Surgery, Gifu University School of Medicine, Gifu, Japan).
Studies of lung surfactant, based on anslysis of lung ph0spholipids, were performed on dogs in deep hypothermia by surface cooling with ether anesthesia. The following results were obtained: ( 1) Dipalmityl lecithin in the lung tissue was not decreased during hypothermia around 2O”C, although it decreased about 30% immediately after rewarming at 37°C. It recovered nearly to the precwling level 2 hr after rewarming. (2) The palmitic acid, especially at the @-position, in lecithin was slightly decreased in the crude surfactant at the lowest body temperature by cooling. It decreased more significantly immediately after
15TH
Cryosurgery has been used extensively by a large number of gynecologists in Japan and has been proved to have a definite role in the treatment of bening diseases. However, for potentially malignant diseases, its effectiveness has not been proved yet. 111 the past 5 years, we have used it on young patients with preinvasive cervical neoplasias such as dysplasia and carcinoma ill situ. We have treated 50 such patients so far and found that these precancerous conditions can be easily and safely cured by cryosurgery if it is combined with colposcopic examination. In a case of a malignant melanoma of the vagina, we achieved a complete cure after repeated cryosurgery. However, cryosurgery alone is generally not effective for invasive carcinomas, so we combined it with chemotherapy and/or radiation therapy, During combined treatment some patients demonstrated increased immunological reactions in skin tests and in examinations of immunogIobulins and lymphocytes. These findings suggested that cryosurgedy might be effective for treatment of malignant diseases especially when it combined with other therapeutic methods.
97.
Cryosurgery on Skin Cancer. H. MIZUTANI (Department of Dermatology, Yoyogi-Hospital, 5-31-1, Sendagaya, Shibuya-Ku, Tokyo, Japan. S. IKEDA (Department of Dermatology, Saitama Medical School, Saitama, Japan) AND K. MIURA (Second Department of Surgery, Tokyo University School of Medicine, Tokyo, Japan).
Cryotherapy has been applied mainly to benign conditions such as common warts rather than to skin cancer in this country, because the latter is not common in Japanese. The present series included five cases of solar keratosis, five of Bowen’s disease, two of xeroderma pigmentosum, two af oral florid papillomatosis, four of basa1 cell carcinoma, five of squamous cell carcinoma, nine of metastatic skin cancer, one of leiomyosarcoma, and two of malignant meIanoma treated over the past 5 years. Evaluation of cryosurgery for these diseases are as follows: (1) Cryospray is used successfully in any carcinoma in situ as well as in superficial basa1 cell carcinoma. (2) Carbon Dioxide remains most effective method of treatment in xeroderma pigmentosum, stage II. (3) Two cases of oral florid papillomatosis treated by the contact ,rnethod with copper disk, showed excellent complete remission for the past 2 years. (4) Two patients with malignant melanoma were classified as stage I. Both of them were treated successfuIly by the contact method without rtcurrence for 2 to 3 years.
ANNUAL 98.
MEETING
713
VderinaTy Clyotherap~ of Malignant Melamm. FL K. FARRELL (United States Department of Agriculture, Science and Education Administration, Washington State University, Pullman, Washington 99164).
In an attempt to establish a model of lethal malignant melanoma, a boar from a farm with occasional incidences of malignant melanoma was purchased and bread to his own daughter which had been treated by cryotherapy after the occurrence of malignant melanoma in the skin and lymph node. We have been rewarded by the appearance of malignant melanoma in the resnlting offspring. All cryotherapy-treated pigs (one male and three femaIes ) have remained clinicalIy tumor free to the present time. One gelded male was slaughtered and was tumor free. Two nntreated pigs died within 4 months of the first observable Iesion. Horses have been cryogenically treated on a routine basis for malignant melanoma. Some of these tumors have been internal (dorsal to the rectum) and s0me have metastasized to regional lymph nodes. Definite signs of regression an d cures have been seen after freezing tumors at intervals of 2 to 4 weeks. Of eight horses treated onIy one has died of malignant melanoma. The evidence supports a supposition that life has been prolonged by repeated cryotherapy, and two animals have been free of tumor on autopsy. The l.ongest .survival time after starting cryogenic treatment is 3 years and this animal continues under observation, SESSION SURGERY 99.
9.
HYPOTHERMIA-OPEN-HEART UNDER DEEP HYPOTHERMIA
Experimental Studies on Lung Surfuctant in Deep Hypothermia Induced by Surface Coding and Warming. M. NAGHI,* M. HIROSE,* K. MUHASE,* AND K. INADA * (First Department of Surgery, Gifu University School of Medicine, Gifu, Japan).
Studies of lung surfactant, based on anslysis of lung ph0spholipids, were performed on dogs in deep hypothermia by surface cooling with ether anesthesia. The following results were obtained: ( 1) Dipalmityl lecithin in the lung tissue was not decreased during hypothermia around 2O”C, although it decreased about 30% immediately after rewarming at 37°C. It recovered nearly to the precwling level 2 hr after rewarming. (2) The palmitic acid, especially at the @-position, in lecithin was slightly decreased in the crude surfactant at the lowest body temperature by cooling. It decreased more significantly immediately after