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Viruses with Recombinant Surface Proteins
Patent reports Transposable Cloning Vector Nigel J. Grinter Imperial Chemical Industries, P LC, London, U K US 4,590,162; May 20, 1986 A pair of plasmids for effecting the insertion of foreign DNA into the genome of a Gram-negative bacterium. One is a carrier plasmid carrying transposon Tn7 which lacks the transposition gene but which includes the foreign DNA insert. The other plasmid is a helper plasmid which carries elements of DNA from transposon Tn7 including the transposition gene.
Broad Host Range DNA Cloning System for Gram-Negative Bacteria Donald R. Helinski and Gary S. Ditta
The Regents of the University of California, Berkeley, CA, USA US 4,590,163; May 20, 1986 A plasmid having an RK2 replication system, capable of replicating in a range of Gram-negative bacteria, transmissible with the aid of a helper plasmid.
Viruses with Recombinant Surface Proteins
Hoffman-La Roche Inc., Nutley, N J, USA US 4,591,559; May 27, 1986
Thromboxane Synthase Inhibitors as Antiobesity Agents James G. Hamilton, Ann C. Sullivan, Lawrence D. Tobias and Joseph Triscari
Hoffman-La Roche Inc., Nutley, N J, USA US 4,591,594; May 27, 1986
Process for Producing Daunomycin Hameo Umizawa, Tomio Takeuchi, Kageaki Kouno, Tomoyuki Ishikura, Akihiro Yoshimoto, Yukio Takatsuki and Hiroyasu Tobe
Sanraku Incorporated, Tokyo, Japan US 4,592,999; June 3, 1986 The use of a mutant strain of Streptomyces, S. coeruleorubidus 3T-373, for the production of daunomycin.
Applications Process for Production of p-Glycosyl Stevioside Derivatives Hideji Nishihashi, Tado Matsubayashi, Tadashi Katabami and Ken-ichi Matsuda
Associates, Inc., San
Dainippon Ink and Chemicals, Inc., and Dic Fine Chemicals, Inc., Tokyo, Japan
US 4,593,002; Jun 3, 1986 The insertion of nucleotide sequences into viral genomes at such a position that the sequence is expressed within a modified capsid protein at a site exposed on the surface of the virus.
US 4,590,160; May 20, 1986 A sweetener containing a fl-l,3-glycosyl stevioside may be produced by subjecting an aqueous solution or suspension of stevioside and a fl-l,3-glycosyl sugar to the action of fl-l,4glycosyl transferring enzyme or to the action of a microorganism producing such an enzyme.
Renato Dulbecco
Salk Institute Biotechnology/lndustrial Diego, CA, USA
Isolation and Localization of DNA Segments James F. Gusella, David Housman, Cheryl Keys, Aviva Varsanyi-Breiner, Theodore T. Puck, Carol Jones and Fa-Ten Kao
Massachusetts Institute of Technology, Cambridge, MA, USA US 4,594,318; Jun 10, 1986 The use of fragments of human DNA cloned in lambda phage as probes to isolate repetitive fragments of human chromosomal DNA by hybridization.
Composition of Improved Absorption of 2A Cations and Gold Comprising Yeast or Lactobacillus Georges S Grimberg
Paris, France US 4,591,504; May 27, 1986 Yeast or lactobacilli admixed with gold or metallic cations are able to enhance the absorption of the metals by a mammal when administered orally.
Hybrid DNA Conferring Osmotic Tolerance
Recombinant DNA Screening System Including Fixed Array Replicator and Support
Laszlo N. Csonka and Raymond C. Valentine
Roy J. Britten and Eric H. Davidson
The Regents of the University of California, Berkeley, CA, USA US 4,594,323; Jun 10, 1986 A DNA sequence which codes for at least two enzymes in the biosynthetic pathway from 2-ketoglutarate to L-proline inserted into a pBR322 plasmid at the EcoRI cleavage site. When inserted into a compatible host the construct confers osmotic tolerance.
Pharmaceuticals Intermediates for 6-(Aminoacyloxymethyl) Penicillanic Acid 1,l-Dioxides Wayne E. Barth
Pfizer Inc., New York, NY, USA US 4,591,459; May 27, 1986
Human Leucocyte Pepsin-like Enzyme as a Therapeutic Agent for Treating Allergic Disorders and Immune Complex Diseases Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki and Ei Mochida
Mochida Pharmaceutical Co., Ltd, Tokyo, Japan US 4,591,504; May 27, 1986 A pepsin-like enzyme, molecular weight 35 000 to 41000, isolated from human leucocytes which is useful for the treatment of allergies and immune complex diseases.
Antibiotic X-14934A and a Method for Its Preparation Chao-Min Liu and John Westley
California Institute of Technology, Pasadena, CA, USA US 4,591,567; May 27, 1986 A device for the replication of recombinant DNA libraries. Essentially the device consists of a culture container capable of carrying at least 50 000 bacterial colonies or phage plaques together with a corresponding array of 50000 points for the inoculation and transfer of colonies or plaques. Alignment between the transfer array and the cultures is maintained by a supporting framework which controls the movement of the transfer array.
Process for Coupling Biological Substances by Covalent Bonds Stratis Avrameas and Th&~se M. F. Ternynck
Establissement Declarb d'Utilitb Publique Dit : lnstitut Pasteur, Paris France US 4,592,998; Jun 3, 1986 A process for the use of benzoquinone as a crosslinking agent. One of the two substances to be crosslinked is activated with benzoquinone, then the activated substance is separated from excess benzoquinone before being bound to the second substance.
Method of Producing Guanosine Yasuhiro Sumino, Koji Sonoi, and Muneharu Doi
Takeda Chemical Industries, Ltd., Osaka, Japan US 4,593,000; Jun 3, 1986 Guanosine is produced in culture by an adenine-requiring, guanosine-producing microorganism grown under adeninelimited culture conditions.
Enzyme Microb. Technol., 1987, vol. 9, February 123
Broad Host Range DNA Cloning System for Gram-Negative Bacteria Donald R. Helinski and Gary S. Ditta
The Regents of the University of California, Berkeley, CA, USA US 4,590,163; May 20, 1986 A plasmid having an RK2 replication system, capable of replicating in a range of Gram-negative bacteria, transmissible with the aid of a helper plasmid.
Viruses with Recombinant Surface Proteins
Hoffman-La Roche Inc., Nutley, N J, USA US 4,591,559; May 27, 1986
Thromboxane Synthase Inhibitors as Antiobesity Agents James G. Hamilton, Ann C. Sullivan, Lawrence D. Tobias and Joseph Triscari
Hoffman-La Roche Inc., Nutley, N J, USA US 4,591,594; May 27, 1986
Process for Producing Daunomycin Hameo Umizawa, Tomio Takeuchi, Kageaki Kouno, Tomoyuki Ishikura, Akihiro Yoshimoto, Yukio Takatsuki and Hiroyasu Tobe
Sanraku Incorporated, Tokyo, Japan US 4,592,999; June 3, 1986 The use of a mutant strain of Streptomyces, S. coeruleorubidus 3T-373, for the production of daunomycin.
Applications Process for Production of p-Glycosyl Stevioside Derivatives Hideji Nishihashi, Tado Matsubayashi, Tadashi Katabami and Ken-ichi Matsuda
Associates, Inc., San
Dainippon Ink and Chemicals, Inc., and Dic Fine Chemicals, Inc., Tokyo, Japan
US 4,593,002; Jun 3, 1986 The insertion of nucleotide sequences into viral genomes at such a position that the sequence is expressed within a modified capsid protein at a site exposed on the surface of the virus.
US 4,590,160; May 20, 1986 A sweetener containing a fl-l,3-glycosyl stevioside may be produced by subjecting an aqueous solution or suspension of stevioside and a fl-l,3-glycosyl sugar to the action of fl-l,4glycosyl transferring enzyme or to the action of a microorganism producing such an enzyme.
Renato Dulbecco
Salk Institute Biotechnology/lndustrial Diego, CA, USA
Isolation and Localization of DNA Segments James F. Gusella, David Housman, Cheryl Keys, Aviva Varsanyi-Breiner, Theodore T. Puck, Carol Jones and Fa-Ten Kao
Massachusetts Institute of Technology, Cambridge, MA, USA US 4,594,318; Jun 10, 1986 The use of fragments of human DNA cloned in lambda phage as probes to isolate repetitive fragments of human chromosomal DNA by hybridization.
Composition of Improved Absorption of 2A Cations and Gold Comprising Yeast or Lactobacillus Georges S Grimberg
Paris, France US 4,591,504; May 27, 1986 Yeast or lactobacilli admixed with gold or metallic cations are able to enhance the absorption of the metals by a mammal when administered orally.
Hybrid DNA Conferring Osmotic Tolerance
Recombinant DNA Screening System Including Fixed Array Replicator and Support
Laszlo N. Csonka and Raymond C. Valentine
Roy J. Britten and Eric H. Davidson
The Regents of the University of California, Berkeley, CA, USA US 4,594,323; Jun 10, 1986 A DNA sequence which codes for at least two enzymes in the biosynthetic pathway from 2-ketoglutarate to L-proline inserted into a pBR322 plasmid at the EcoRI cleavage site. When inserted into a compatible host the construct confers osmotic tolerance.
Pharmaceuticals Intermediates for 6-(Aminoacyloxymethyl) Penicillanic Acid 1,l-Dioxides Wayne E. Barth
Pfizer Inc., New York, NY, USA US 4,591,459; May 27, 1986
Human Leucocyte Pepsin-like Enzyme as a Therapeutic Agent for Treating Allergic Disorders and Immune Complex Diseases Haruo Ohnishi, Hiroshi Kosuzume, Yasuo Suzuki and Ei Mochida
Mochida Pharmaceutical Co., Ltd, Tokyo, Japan US 4,591,504; May 27, 1986 A pepsin-like enzyme, molecular weight 35 000 to 41000, isolated from human leucocytes which is useful for the treatment of allergies and immune complex diseases.
Antibiotic X-14934A and a Method for Its Preparation Chao-Min Liu and John Westley
California Institute of Technology, Pasadena, CA, USA US 4,591,567; May 27, 1986 A device for the replication of recombinant DNA libraries. Essentially the device consists of a culture container capable of carrying at least 50 000 bacterial colonies or phage plaques together with a corresponding array of 50000 points for the inoculation and transfer of colonies or plaques. Alignment between the transfer array and the cultures is maintained by a supporting framework which controls the movement of the transfer array.
Process for Coupling Biological Substances by Covalent Bonds Stratis Avrameas and Th&~se M. F. Ternynck
Establissement Declarb d'Utilitb Publique Dit : lnstitut Pasteur, Paris France US 4,592,998; Jun 3, 1986 A process for the use of benzoquinone as a crosslinking agent. One of the two substances to be crosslinked is activated with benzoquinone, then the activated substance is separated from excess benzoquinone before being bound to the second substance.
Method of Producing Guanosine Yasuhiro Sumino, Koji Sonoi, and Muneharu Doi
Takeda Chemical Industries, Ltd., Osaka, Japan US 4,593,000; Jun 3, 1986 Guanosine is produced in culture by an adenine-requiring, guanosine-producing microorganism grown under adeninelimited culture conditions.
Enzyme Microb. Technol., 1987, vol. 9, February 123