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Viscosimetric study of fluorocarbon emulsions and of their mixtures with blood
259
VISCOSIMETRIC STUDY OF FLUOROCARBON EMULSIONS AND OF THEIR MIXTURES WITH BLOOD Hayat Hamai, Catherine Lacombe, Jean-Claude Lelitvre Unit6 de BiorhCologie, Associke au CNRS, UniversitC de Paris VI, CHU PitiC Salpitriere, 91 Bd de I’Hbpital, 75013 Paris (France) and Maurice Le Blanc* Laboratoire de Chimie Molkulaire, 06034 Nice (France)
In order
to appreciate
of fluorocarbon
emulsions
med on the emulsions
the hemorheologic
on blood circulation,
in stationary
the viscoelasticity
and unstationary
0.03 and
aggregation,
30 s-1)
injections were perfor-
with human blood.
Couette
of the various
viscosimeter
with coaxial
media
cylinders
modes. and its evolution
were
disaggregability
when in the presence
of intravenous measurements
and the thixotropy
by using a servo-controlled
The blood structure ween
consequences viscosimetric
alone, and on their mixtures
The rheofluidification, may be evaluated
Unite Associke au CNRS, Universite de Nice, Part Valrose,
in relation
characterized
from
and deformability
to the applied
these
of the
rheological red
cells
shear
rate
properties. could
(betThus,
be determined
of the emulsions.
This study may be summarized - The F-66E emulsion
exhibits
as follows:
a newtonian
rheological
behavior.
Its viscosity
is about
3 CP at 25% (%1.&P for human plasma). - The rheofluidification to the oncotic
properties
agent entering
- The F-66E emulsion/blood - No significant examination
differences
several
In conclusion, significant
mixtures
perturbation
structure
in the emulsions
are due
of the emulsion.
closely resemble
with blood alone
of the aggregated
sions, even after
of the red cell suspensions
into the formulation
blood in their rheological
could be detected
of red cells diluted
from
behavior.
the microscopic
in the fluorocarbon
emul-
hours.
contact
with
fluorocarbon
in the normal rheological
emulsions behavior
does not introduce
of blood.
any
VISCOSIMETRIC STUDY OF FLUOROCARBON EMULSIONS AND OF THEIR MIXTURES WITH BLOOD Hayat Hamai, Catherine Lacombe, Jean-Claude Lelitvre Unit6 de BiorhCologie, Associke au CNRS, UniversitC de Paris VI, CHU PitiC Salpitriere, 91 Bd de I’Hbpital, 75013 Paris (France) and Maurice Le Blanc* Laboratoire de Chimie Molkulaire, 06034 Nice (France)
In order
to appreciate
of fluorocarbon
emulsions
med on the emulsions
the hemorheologic
on blood circulation,
in stationary
the viscoelasticity
and unstationary
0.03 and
aggregation,
30 s-1)
injections were perfor-
with human blood.
Couette
of the various
viscosimeter
with coaxial
media
cylinders
modes. and its evolution
were
disaggregability
when in the presence
of intravenous measurements
and the thixotropy
by using a servo-controlled
The blood structure ween
consequences viscosimetric
alone, and on their mixtures
The rheofluidification, may be evaluated
Unite Associke au CNRS, Universite de Nice, Part Valrose,
in relation
characterized
from
and deformability
to the applied
these
of the
rheological red
cells
shear
rate
properties. could
(betThus,
be determined
of the emulsions.
This study may be summarized - The F-66E emulsion
exhibits
as follows:
a newtonian
rheological
behavior.
Its viscosity
is about
3 CP at 25% (%1.&P for human plasma). - The rheofluidification to the oncotic
properties
agent entering
- The F-66E emulsion/blood - No significant examination
differences
several
In conclusion, significant
mixtures
perturbation
structure
in the emulsions
are due
of the emulsion.
closely resemble
with blood alone
of the aggregated
sions, even after
of the red cell suspensions
into the formulation
blood in their rheological
could be detected
of red cells diluted
from
behavior.
the microscopic
in the fluorocarbon
emul-
hours.
contact
with
fluorocarbon
in the normal rheological
emulsions behavior
does not introduce
of blood.
any