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VITAMIN-C. DEFICIENCY IN " IRRESPONSIVE " PERNICIOUS ANÆMIA
278
" XBD=986 XBD=1267XHG=942 XBD=167 XBD=285 XBD=427 XBD=548 XBD=637 XBD=920 XHG=73 XHG=189 XHG=307 XHG=447 XHG=570 XHG=659 XHG=1004 YBD=222 YBD=215 YBD=223 YBD=216 YBD=222 YHG=194>may YHG=186>arise YHG=187>either YHG=186>from YHG=186>the YHG=186>employment YHG=185>of YHG=185>preparations " XBD=1268 XBD=116 XHG=812 XBD=205 XBD=390 XBD=453 XBD=571 XBD=791 XBD=856 XBD=938 XBD=1123 XBD=1186 XHG=871 XHG=74 XHG=132 XHG=224 XHG=410 XHG=470 XHG=589 XHG=957 XHG=1143 XHG=1201 YBD=253 YBD=261 YBD=260 YBD=252 YBD=253 YBD=260 YBD=252 YBD=253 YHG=223>of YHG=224>low YHG=225>potency YHG=233>or YHG=224>from YHG=225>ignorance YHG=224>of YHG=223>the YHG=224>potency YHG=224>of YHG=224>the " XBD=1269 XBD=321 XHG=880 XBD=471 XBD=847 XBD=992 XBD=1057 XHG=73 XHG=352 XHG=518 XHG=1023 XHG=1090 YBD=298 YBD=296 YBD=292 YBD=291 YBD=291 YBD=292 YHG=261>preparation YHG=263>used; YHG=262>from.whatever YHG=270>cause YHG=262>it YHG=262>arises, it " XBD=1269 XBD=299 XHG=759 XBD=345 XBD=481 XBD=546 XBD=739 XBD=946 XBD=1205 XHG=74 XHG=321 XHG=362 XHG=502 XHG=562 XHG=967 XHG=1227 YBD=331 YBD=330 YBD=331 YBD=335 YBD=330 YBD=331 YHG=301>constitutes YHG=311>a YHG=301>waste YHG=301>of YHG=301>valuable YHG=301>material, YHG=301>undesirable YHG=301>at
" XBD=961 XBD=152 XHG=785 XBD=260 XBD=347 XBD=449 XBD=645 XBD=767 XHG=74 YBD=377 XHG=167 XHG=275 XHG=363 XHG=465 XHG=661 YBD=370YHG=348>any YBD=377 YBD=369 YHG=340>time YHG=340>but YHG=349>now YHG=340>specially YHG=339>to YHG=339>avoided. be REFERENCES
Isaacs, R., Bethell, F. H., Riddle, M. C. and Friedman, A. (1938) J. Amer. med. Ass. 111, 2291. Kracke, R. R. and Garver, H. E. (1937) Diseases of the Blood and Atlas of hæmatology, London, p. 236. Minot, G. R., Cohn, E. J., Murphy, W. P. and Lawson, H. A. (1928) Amer. J. med. Sci. 175, 599. Murphy, W. P. (1933) Arch. intern. Med. 52, 829. Riddle, M. C. (1930) Ibid, 46, 417 ; (1940) Amer. J. med. Sci. 200, 145.
Schiødt, E. (1939) Acta med. scand. 98, 449. USP (1938) J. Amer. med. Ass. 110, 812. J. F. and Israëls, M. C. G. Wilkinson, XHG=2485 XBD=1433 XBD=1520 XBD=1583 XBD=1814 XBD=2059 XBD=2238 XBD=2323 XBD=2386 XBD=2468 XBD=2519 XHG=1334 XHG=1447 XHG=1533 XHG=1595 XHG=1831 XHG=2076 XHG=2253 XHG=2341 XHG=2404 YBD=792 YBD=793 YBD=785 YBD=783 YBD=784 YHG=757>there YHG=765>was YHG=762>no YHG=756>appreciable YHG=756>reticulocyte YHG=765>response YHG=755>and YHG=764>no YHG=756>rise YHG=756>in (1942) Lancet, i, 240.
" " " " " " "
XBD=2520 XHG=2438 XBD=1395 XBD=1476 XBD=1585 XBD=1676 XBD=1784 XBD=1843 XBD=1918 XBD=2010 XBD=2109 XBD=2368 XBD=2424 XHG=1333 YBD=823 XHG=1413 XHG=1494 XHG=1632 XHG=1694 XHG=1802 XHG=1856 XHG=1936 XHG=2027 XHG=2127 XHG=2386 YBD=824 YHG=795>liver YBD=832 YBD=822 YHG=796>red YHG=796>cells. YHG=796>In YHG=796>spite YHG=796>of YHG=796>the YHG=796>fact YHG=796>that YHG=795>preparations YHG=795>of XBD=1426 XHG=2364 XBD=1519 XBD=1731 XBD=1830 XBD=1923 XBD=2067 XBD=2215 XBD=2350 XBD=2517 XHG=1334 XHG=1447 XHG=1539 XHG=1751 XHG=1850 XHG=1936 XHG=2081 XHG=2229 YBD=871 YBD=862 YBD=863 YBD=870 YBD=867 YHG=835>fromIN YHG=834>this YHG=834>particular YHG=835>firm YHG=835>had YHG=835>always YHG=834>proved YHG=834>highly YHG=834>efficient, VITAMIN-C. DEFICIENCY XBD=1407 XHG=2499 XBD=1571 XBD=1763 XBD=1818 XBD=1872 XHG=1335 YBD=901 XHG=1422 XHG=1588 XHG=1779 XHG=1834 YBD=902 YHG=882>a YHG=874>this YHG=874>aroused YHG=873>suspicion YHG=882>as YHG=877>to XBD=2122 XBD=2178 XBD=2267 XBD=2402 XBD=2483 XBD=2519 XHG=1968 XHG=2139 XHG=2196 XHG=2284 XHG=2436 YBD=910 YBD=900 YHG=876>potency YHG=873>of YHG=873>this YHG=873>batch. YHG=873>As " IRRESPONSIVE " PERNICIOUS XBD=1409 XBD=1494 XBD=1658 XBD=1753 XBD=1880 XBD=1965 XBD=2160 XBD=2310 XBD=2375 XBD=2416 XBD=2520 XHG=1336 YBD=940 XHG=1433 XHG=1519 XHG=1681 XHG=1778 XHG=1904 XHG=1990 XHG=2184 XHG=2336 XHG=2395 XHG=2439 YBD=949 YBD=941 YBD=947 YBD=939 YHG=915>test ANÆMIA YHG=913>patient YHG=922>was YHG=913>given YHG=913>the YHG=912>standard YHG=912>dosage YHG=912>of YHG=921>a YHG=912>liver
the
XBD=2519 S.XHG=2484 XBD=1475 XBD=1536 XBD=1679 XBD=1861 XBD=1957 XBD=2048 XBD=2140 XBD=2221 XBD=2345 XBD=2466 XHG=1337 XHG=1496 XHG=1551 XHG=1697 XHG=1908 XHG=1978 XHG=2068 XHG=2160 XHG=2240 XHG=2364 YBD=989 YHG=954>to YBD=980 YHG=954>extract YHG=952>of YHG=951>known YHG=954>potency. YHG=953>To YHG=952>this YHG=952>also YHG=951>the YHG=951>blood YHG=950>failed C. DYKEYBD=979 B. L. DELLA VIDA XBD=1441 XHG=2333 XBD=1485 XBD=1732 XBD=1926 XBD=2046 XBD=2171 XBD=2232 XBD=2311 XBD=2520 XHG=1336 YBD=1018 XHG=1463 XHG=1507 XHG=1753 XHG=1973 XHG=2068 XHG=2194 XHG=2250 YBD=1027 YHG=990>exhibition YBD=1028 YBD=1019 YHG=991>make YHG=1000>a YHG=991>satisfactory YHG=1000>response. YHG=991>The YHG=991>effect YHG=991>of YHG=991>the
MD BRATISLAVA ELIZABETHYBD=1059 DELIKAT,YHG=1030>2. " XBD=2520 XBD=1378 XHG=2492 XBD=1540 XBD=1580 XBD=1630 XBD=1804 XBD=1856 XBD=1932 XBD=2032 XBD=2183 XBD=2225 XBD=2359 XBD=2408 XBD=2476 XHG=1339 XHG=1388 XHG=1554 XHG=1593 XHG=1644 XHG=1818 XHG=1871 XHG=1946 XHG=2045 XHG=2196 XHG=2240 XHG=2372 XHG=2422 YBD=1058 YBD=1066 YHG=1031>of YHG=1030>vitamin YHG=1030>C YHG=1030>addition YHG=1034>to YHG=1031>the YHG=1031>liver YHG=1032>extract YHG=1030>is YHG=1031>shown YHG=1030>in YHG=1030>fig.
" XBD=1725 XBD=1772 XBD=1371 XBD=1528 XBD=1650 XBD=1705 XHG=1337 XHG=1400 XHG=1557 XHG=1681 XHG=1713 XHG=1735 YBD=1098 YBD=1097 YHG=1069>A YHG=1069>month YHG=1070>after YHG=1070>d YHG=1070>i YHG=1078>s XBD=315 XHG=593 XBD=572 XBD=706 XBD=897 XBD=1222 XHG=726 XHG=138 XHG=335 XHG=920YBD=1100 YBD=1096 YBD=1101 YBD=1097 YBD=1096 YHG=1077>ASSISTANT YHG=1077>PATHOLOGIST, YHG=1078>ROYAL YHG=1078>HOSPITAL, YHG=1076>WOLVERHAMPTON
" XBD=1464 XBD=1590 XHG=1339 XHG=1499 XHG=1621 YBD=1136 YBD=1145 YHG=1108>charge YHG=1109>from YHG=1108>hospital " XBD=1774 XBD=257 XHG=881 XBD=339 XBD=472 XBD=576 XBD=636 XBD=714 XBD=865 XBD=925 XBD=1003 XBD=1171 XBD=1277 XHG=135 XHG=274 XHG=356 XHG=487 XHG=593 XHG=648 XHG=729 XHG=937YBD=1148 XHG=1019 XHG=1186 YBD=1156 YBD=1149 YBD=1147 YBD=1155 YHG=1118>SINCE YHG=1119>the YHG=1119>latter YHG=1119>part YHG=1119>of YHG=1120>the YHG=1119>winter YHG=1118>of YHG=1118>the YHG=1119>present YHG=1126>year " XBD=1774 XBD=1416 XBD=1559 XHG=1338 XHG=1453 XHG=1591 YBD=1175 YBD=1176 YBD=1184 YHG=1147>the YHG=1148>blood YHG=1148>picture " XBD=139 XHG=663 XBD=263 XBD=386 XBD=520 XBD=639 XBD=729 XBD=1089 XBD=1212 XBD=1280 XHG=82 XHG=164 XHG=288 XHG=409 XHG=544 XHG=754 XHG=1110 XHG=1238 YBD=1188 YBD=1189 YBD=1188 YBD=1195 YBD=1187 YBD=1186 YHG=1167>we YHG=1158>have YHG=1158>been YHG=1159>faced YHG=1159>with YHG=1159>the YHG=1157>phenomenon’of YHG=1166>cases YHG=1156>of " XBD=1472 XBD=1568 XBD=1690 XBD=1775 XHG=1341 XHG=1496 XHG=1587 XHG=1713 YBD=1215 YBD=1223 YBD=1214 YHG=1187>shows: YHG=1187>Hb. YHG=1186>73%; YHG=1187>red wholly |>" XBD=293 XBD=673 XBD=483 XHG=82 XHG=512 XHG=323 YBD=1235 YBD=1235 YBD=1228 YHG=1197>pernicious YHG=1198>proving YHG=1200>anaemia " XBD=919 XBD=1154 XBD=1275 XHG=877 XHG=954 XHG=1188 YBD=1226 YBD=1233 YBD=1226 YHG=1206>or YHG=1196>relatively YHG=1197>irre-
cells3,840,000;
" XBD=1775 XHG=1731 YBD=1254 YHG=1226>CI " XBD=261 XHG=460 XBD=327 XBD=443 XBD=679 XBD=890 XBD=1202 XBD=1277 XHG=729 XHG=84 XHG=285 XHG=348 XHG=906 XHG=1217 YBD=1274 YBD=1267 YBD=1266 YBD=1265 YBD=1265 YHG=1237>sponsive YHG=1238>to YHG=1238>liver YHG=1237>treatment. YHG=1236>Various YHG=1235>considerations YHG=1235>led " XBD=1429 XHG=1341 YBD=1294 YHG=1266>0-95.
" XBD=1281 XBD=126 XHG=964 XBD=215 XBD=354 XBD=462 XBD=562 XBD=709 XBD=778 XBD=875 XBD=954 XBD=990 XBD=1217 XHG=84 XHG=149 XHG=238 XHG=373 XHG=484 XHG=584 XHG=730 XHG=802 XHG=899 XHG=1012 XHG=1240 YBD=1306 YBD=1307 YBD=1306 YBD=1312 YBD=1313 YBD=1305 YBD=1312 YBD=1304 YHG=1277>to YHG=1277>the YHG=1276>belief YHG=1276>that YHG=1276>this YHG=1276>might YHG=1276>be YHG=1275>due YHG=1275>to, YHG=1283>a YHG=1275>deficiency YHG=1274>of " XBD=250 XBD=312 XBD=412 XBD=581 XBD=647 XBD=773 XBD=902 XBD=992 XBD=1127 XBD=1193 XHG=85 XHG=273 XHG=364 XHG=436 XHG=604 XHG=666 XHG=796 XHG=1015 XHG=1151 XHG=1213 YBD=1346 YBD=1345 YBD=1344 YBD=1344 YHG=1316>vitamin YHG=1315>C. YHG=1317>In YHG=1316>certain YHG=1315>of YHG=1315>these YHG=1323>cases YHG=1314>the YHG=1314>effect YHG=1315>of YHG=1314>the " XBD=1279 XBD=1480XHG=925 XBD=1687 XBD=1844 XHG=1387 XHG=1508 XHG=1713 YBD=1341 YBD=1347 YBD=1349 YHG=1313>CASE YHG=1313>3.-Male, YHG=1302>age
XBD=299 XBD=362 XBD=546 XBD=652 XBD=714 XBD=802 XBD=961 XBD=1051 XBD=1168 XBD=1281 XHG=86 XHG=319 XHG=379 XHG=567 XHG=672 XHG=732 XHG=982 XHG=1072 XHG=1187 YBD=1385 YBD=1385 YBD=1384 YBD=1391 YBD=1383 YBD=1383 YHG=1355>exhibition YHG=1355>of YHG=1354>ascorbic YHG=1354>acid YHG=1354>in YHG=1354>full YHG=1354>dosage YHG=1354>has YHG=1353>been YHG=1353>such " XBD=1706 XBD=1844XHG=824 XBD=1396 XBD=1536 XHG=1344 XHG=1442 XHG=1565 XHG=1739 YBD=1381 YBD=1392 YHG=1353>69. YHG=1352>First YHG=1353>treated YHG=1355>at " XBD=1279 XBD=127 XBD=191 XBD=371 XBD=471 XBD=602 XBD=732 XBD=944 XBD=1072 XBD=1158 XHG=754 XHG=86 XHG=150 XHG=214 XHG=393 XHG=493 XHG=966 XHG=1096 XHG=1179 YBD=1425 YBD=1424 YBD=1423 YBD=1431 YBD=1423 YBD=1423 YHG=1404>as YHG=1395>to YHG=1394>confirm YHG=1394>this YHG=1394>view. YHG=1393>The YHG=1393>following YHG=1393>three YHG=1403>are YHG=1393>illusXBD=1403XHG=654 XBD=1540 XBD=1723 XBD=1831 XHG=1342 XHG=1424 XHG=1559 XHG=1740 YBD=1420 YBD=1428 YBD=1429 YBD=1432 YHG=1392>the YHG=1392>Royal YHG=1392>Hospital YHG=1392>in
I
" XBD=353 XBD=225 XHG=84 YBD=1464 YBD=1463 YHG=1434>trative YHG=1443>cases. XBD=1436XHG=240 XBD=1560 XBD=1844 XHG=1343 XHG=1467 XHG=1607 YBD=1468 YBD=1460 YBD=1463 YHG=1432>May, YHG=1432>1937. YHG=1432>Mainten-
estab-
" XBD=840 XHG=545 YBD=1493 YHG=1469>CASE-RECORDS
" XBD=1587 XBD=1429 XHG=1460 XHG=1344 YBD=1508 YBD=1500 YHG=1472>dosage YHG=1481>ance " " " " " " " " " " " " "
’
I.-Female, XBD=1657XHG=837 XBD=225 XBD=581 XBD=666 XBD=808 XBD=977 XBD=1045 XBD=1136 XBD=1282 XBD=1456 XBD=1509 XBD=1545 XHG=131 XHG=518 XHG=613 XHG=713 XHG=1008 XHG=1076 XHG=1167 XHG=1344 XHG=1470 XHG=1525 XHG=1559 YBD=1548 YBD=1539 YBD=1540 YBD=1548 YBD=1539 YHG=1511>CASE YHG=1520>age YHG=1513>57. YHG=1511>First YHG=1511>treated YHG=1514>at YHG=1512>the YHG=1511>Royal YHG=1511>lished YHG=1513>at YHG=1512>4 YHG=1520>c.cm. XBD=1441XHG=678 XBD=1593 XBD=1688 XBD=1835 XBD=252 XBD=314 XBD=504 XBD=632 XBD=923 XBD=1162 XBD=1235 XBD=1282 XHG=84 XHG=277 XHG=342 XHG=537 XHG=949YBD=1588 XHG=1188 XHG=1260 XHG=1345 XHG=1468 XHG=1637 XHG=1719 YBD=1579 YBD=1586 YBD=1580 YBD=1579 YBD=1588 YBD=1579 YBD=1578 YBD=1594 YHG=1551>Hospital YHG=1551>in YHG=1548>October, YHG=1552>1937. YHG=1545>Maintenance YHG=1551>established YHG=1561>on YHG=1560>a YHG=1551>eight YHG=1551>weeks. YHG=1550>At YHG=1551>the XBD=1533 XBD=1595 XBD=1696 XBD=1780 XHG=1345 XHG=1554 XHG=1615 XHG=1719 YBD=1627 YBD=1618 YHG=1591>beginning YHG=1590>of YHG=1590>1941 YHG=1590>the XBD=170 XHG=852 XBD=233 XBD=272 XBD=394 XBD=459 XBD=500 XBD=609 XBD=770 XBD=833 XBD=980 XBD=1155 XBD=1283 XHG=87 XHG=192 XHG=253 XHG=297 XHG=419 XHG=478 XHG=523 XHG=631 XHG=793 XHG=1002 XHG=1177 YBD=1620 YBD=1620 YBD=1619 YBD=1628 YHG=1591>dose YHG=1591>2 YHG=1600>c.cm. YHG=1600>a YHG=1591>liver YHG=1593>extract YHG=1591>of YHG=1591>known YHG=1593>potency YHG=1600>every XBD=225 XHG=752 XBD=315 XBD=535 XBD=653 XBD=734 XBD=891 XBD=1018 XBD=1117 XBD=1195 XBD=1284 XHG=86 XHG=271 XHG=333 XHG=558 XHG=672 XHG=907 XHG=1034 XHG=1135 XHG=1212 YBD=1659 YBD=1664 YBD=1659 YBD=1667 YBD=1659 YHG=1630>month. YHG=1631>In YHG=1630>December, YHG=1631>1941, YHG=1630>the YHG=1630>patient YHG=1632>noted YHG=1630>that YHG=1631>she YHG=1639>was XBD=1486 XBD=1606 XBD=1781 XHG=1345 XHG=1500 XHG=1625 YBD=1659 YBD=1658 YBD=1667 YHG=1630>red-cell YHG=1632>count YHG=1630>dropped XBD=1456 XBD=1640 XBD=1781 XHG=1345 XHG=1465 XHG=1646 YBD=1698 YBD=1703 YBD=1706 YHG=1670>below YHG=1664>4,000,000 YHG=1669>though XBD=152 XHG=842 XBD=209 XBD=328 XBD=401 XBD=492 XBD=598 XBD=680 XBD=824 XBD=914 XBD=1061 XBD=1118 XBD=1284 XHG=86 XHG=171 XHG=229 XHG=362 XHG=420 XHG=511 XHG=617 XHG=700 XHG=932 XHG=1081 XHG=1139 YBD=1699 YBD=1703 YBD=1699 YBD=1698 YBD=1698 YBD=1707 YHG=1673>not YHG=1679>so YHG=1670>well YHG=1673>at YHG=1670>this YHG=1670>time YHG=1670>her YHG=1670>doctor YHG=1679>was YHG=1670>unable YHG=1673>to ; YHG=1679>procure XBD=225 XHG=641 XBD=394 XBD=450 XBD=523 XBD=627 XBD=867 XBD=1096 XBD=1198 XBD=1310 XBD=1408 XBD=1576 XBD=1706 XBD=1781 XHG=88 XHG=242 XHG=410 XHG=462 XHG=540 XHG=882 XHG=1111 XHG=1214 XHG=1346 XHG=1437 XHG=1603 XHG=1734 YBD=1738 YBD=1747 YBD=1738 YBD=1746 YBD=1738 YBD=1738 YBD=1747 YBD=1737 YHG=1710>further YHG=1709>supplies YHG=1711>of YHG=1710>the YHG=1709>liver YHG=1710>preparation YHG=1710>theretofore YHG=1710>used YHG=1710>and YHG=1709>the YHG=1710>patient YHG=1710>made YHG=1718>no XBD=247 XHG=867 XBD=310 XBD=485 XBD=634 XBD=725 XBD=841 XBD=907 XBD=1063 XBD=1286 XHG=89 XHG=271 XHG=336 XHG=509 XHG=681 XHG=750 XHG=928 XHG=1089 YBD=1786 YBD=1781 YBD=1777 YBD=1786 YBD=1778 YBD=1786 YBD=1778 YHG=1749>changed YHG=1752>to YHG=1749>another YHG=1749>brand. YHG=1749>In YHG=1749>spite YHG=1749>of YHG=1750>greatly YHG=1749>intensified XBD=1541 XBD=1601 XBD=1742 XBD=1898 XBD=2047 XBD=2166 XBD=2248 XBD=2329 XBD=2427 XBD=2528 XHG=1349 XHG=1560 XHG=1616 XHG=1854 XHG=1917 XHG=2073 XHG=2187 XHG=2267 XHG=2349 XHG=2446 YBD=1787 YBD=1777 YBD=1785 YBD=1781 YBD=1780 YBD=1774 YBD=1775 YHG=1741>complaint YHG=1749>of YHG=1749>feeling YHG=1748>In YHG=1747>March, YHG=1747>1942, YHG=1746>the YHG=1746>red YHG=1747>cells YHG=1755>were XBD=218 XHG=698 XBD=296 XBD=481 XBD=680 XBD=932 XBD=1100 XBD=1188 XBD=1287 XBD=1573 XBD=1663 XBD=1741 XBD=1927 XBD=2082 XBD=2279 XBD=2367 XBD=2530 XHG=89 XHG=235 XHG=314 XHG=500 XHG=949 XHG=1117 XHG=1205 XHG=1423 XHG=1592 XHG=1680 XHG=1758 XHG=1944 XHG=2100 XHG=2296 XHG=2384 YBD=1826 YBD=1825 YBD=1817 YBD=1825 YBD=1817 YBD=1826 YBD=1824 YBD=1815 YBD=1814 YBD=1823 YHG=1789>dosage YHG=1789>the YHG=1788>patient’s YHG=1788>condition YHG=1789>deteriorated YHG=1789>steadily YHG=1790>and YHG=1789>trial YHG=1789>millions YHG=1789>and YHG=1789>the YHG=1786>patient’s YHG=1787>general YHG=1786>condition YHG=1795>was YHG=1795>progresXBD=1461 XBD=1738 XBD=1856 XBD=1973 XBD=2073 XBD=2131 XBD=2229 XBD=2382 XBD=2458 XBD=2532 XHG=1351 XHG=1478 XHG=1784 XHG=1872 XHG=1991 XHG=2091 XHG=2143 XHG=2244 XHG=2399 XHG=2473 YBD=1865 YBD=1855 YBD=1854 YHG=1828>sively YHG=1828>deteriorating. YHG=1827>The YHG=1827>usual YHG=1827>dose YHG=1826>of YHG=1826>liver YHG=1828>extract YHG=1826>did YHG=1828>not XBD=162 XHG=890 XBD=284 XBD=343 XBD=420 XBD=589 XBD=844 XBD=963 XBD=1234 XBD=1289 XHG=89 XHG=179 XHG=304 XHG=357 XHG=439 XHG=606 XHG=984 XHG=1251 YBD=1857 YBD=1856 YBD=1864 YBD=1866 YBD=1857 YBD=1857 YBD=1857 YHG=1837>was YHG=1829>made YHG=1828>of YHG=1831>yet YHG=1828>another YHG=1828>preparation. YHG=1828>The YHG=1829>deterioration YHG=1829>in XBD=1433 XBD=1511 XBD=1588 XBD=1644 XBD=1716 XBD=1872 XBD=2007 XBD=2110 XBD=2314 XBD=2367 XBD=2443 XBD=2531 XHG=1352 XHG=1449 XHG=1527 XHG=1604 XHG=1655 XHG=1732 XHG=1888 XHG=2055 XHG=2125 XHG=2329 XHG=2384 XHG=2458 YBD=1904 YBD=1897 YBD=1896 YBD=1895 YBD=1893 YBD=1894 YHG=1871>stop YHG=1868>the YHG=1868>fall YHG=1869>of YHG=1867>the YHG=1867>red-cell YHG=1869>count. YHG=1866>On YHG=1865>admission YHG=1868>to YHG=1865>the YHG=1866>hosXBD=230 XHG=837 XBD=433 XBD=691 XBD=816 XBD=946 XBD=1043 XBD=1221 XBD=1289 XHG=91 XHG=252 XHG=456 XHG=702 XHG=968 XHG=1067 XHG=1243 YBD=1904 YBD=1897 YBD=1896 YBD=1897 YBD=1905 YHG=1868>general YHG=1867>condition YHG=1867>continued.. YHG=1868>When YHG=1868>taken YHG=1868>into YHG=1868>hospital YHG=1878>on XBD=175 XHG=723 XBD=330 XBD=404 XBD=523 XBD=698 XBD=920 XBD=1008 XBD=1100 XBD=1290 XHG=91 XHG=187 XHG=343 XHG=416 XHG=535 XHG=945 XHG=1019 XHG=1115 YBD=1944 YBD=1942 YBD=1936 YBD=1944 YBD=1936 YBD=1936 YBD=1942 YHG=1908>May YHG=1907>3, YHG=1907>the YHG=1908>blood YHG=1907>showed YHG=1907>Hb. YHG=1909>red YHG=1908>cells YHG=1909>1,230,000 1942, 32% XBD=1442 XBD=1510 XBD=1615 XBD=1690 XBD=1811 XBD=1896 XBD=2024 XBD=2180 XBD=2296 XBD=2402 XHG=1352 XHG=1464 XHG=1531 XHG=1637 XHG=1717 XHG=1834 XHG=1918 XHG=2045 XHG=2202 XHG=2331 YBD=1945 YBD=1935 YBD=1944 YBD=1940 YBD=1943 YBD=1934 YHG=1908>pital YHG=1917>on YHG=1908>May YHG=1908>20, YHG=1907>1942, YHG=1907>the YHG=1906>blood YHG=1906>picture YHG=1914>was YHG=1905>Hb. ::; XBD=1415 XBD=1510 XBD=1725 XBD=1800 XBD=1906 XHG=1353 XHG=1430 XHG=1529 XHG=1756 XHG=1820 1-3 ; YBD=1974 YBD=1976 YBD=1981 YBD=1975 YHG=1947>red YHG=1947>cells YHG=1948>1,190,000 YHG=1947>CI YHG=1947>1.51. ; XBD=768 XBD=934 XHG=521 YBD=1984 YBD=1983 YHG=1947>reticulocytes YHG=1947>2/1,000. XBD=156 XHG=787 XBD=315 XBD=392 XHG=92 XHG=174 XHG=347 YBD=1984 YBD=1981 YBD=1975 YHG=1956>per YHG=1955>c.mm.; YHG=1947>CI
’
every
’::t:
ill; 2’5
36%; of’known
" XBD=2368 XBD=2536XHG=861 XBD=1448 XBD=1582 XBD=1632 XBD=1703 XBD=1753 XBD=1852 XBD=2004 XHG=1399 XHG=1463 XHG=1596 XHG=1646 XHG=1723 XHG=1765 XHG=1866 XHG=2216 XHG=2383 YBD=2015 YBD=2023 YBD=2020 YBD=2014 YBD=2022 YBD=2021 YHG=1987>As YHG=1987>shown YHG=1987>in YHG=1987>fig. YHG=1987>3, YHG=1987>liver YHG=1988>extract YHG=1987>potency YHG=1984>together XBD=285 XBD=339 XBD=412 XBD=497 XBD=584 XBD=845 XBD=900 XBD=1000 XBD=1102 XBD=1188 XBD=1292 XHG=138 XHG=299 XHG=351 XHG=428 XHG=513 XHG=601 XHG=912YBD=2015 XHG=1014 XHG=1116 XHG=1203 YBD=2024 YBD=2015 YBD=2016 YHG=1985>Neither YHG=1986>of YHG=1987>the YHG=1987>last YHG=1989>two YHG=1987>preparations YHG=1987>of YHG=1987>liver YHG=1987>used YHG=1987>had YHG=1987>been " XBD=2535 XBD=1442 XBD=1609 XBD=1651 XBD=1805 XBD=1976 XBD=2053 XBD=2175 XBD=2325 XBD=2380 XHG=1354 XHG=1458 XHG=1625 XHG=1666 XHG=1820 XHG=1991 XHG=2068 XHG=2191 XHG=2341 XHG=2396 YBD=2063 YBD=2054 YBD=2061 YBD=2053 YHG=2026>with YHG=2026>vitamin YHG=2026>C YHG=2027>rapidly YHG=2026>restored YHG=2025>the YHG=2024>blood YHG=2025>picture YHG=2027>to YHG=2025>normal. XBD=210 XHG=738 XBD=263 XBD=349 XBD=591 XBD=679 XBD=723 XBD=810 XBD=980 XBD=1077 XBD=1154 XBD=1293 XHG=825 XHG=92 XHG=225 XHG=278 XHG=366 XHG=607 XHG=693 XHG=996 XHG=1093 XHG=1170 YBD=2054 YBD=2054 YBD=2055 YBD=2063 YBD=2055 YBD=2055 YHG=2025>tested YHG=2026>in YHG=2026>this YHG=2026>department YHG=2027>and YHG=2027>it YHG=2036>was YHG=2027>thought YHG=2027>that YHG=2027>the YHG=2027>failure XBD=1442 XBD=1575 XBD=1688 XBD=1897 XBD=1978 XBD=2105 XBD=2232 XBD=2304 XBD=2409 XHG=1355 XHG=1462 XHG=1596 XHG=1707 XHG=1917 XHG=1998 XHG=2126 XHG=2252 XHG=2338 XHG=2434 YBD=2094 YBD=2092 YBD=2093 YBD=2101 YHG=2065>Five YHG=2066>weeks YHG=2066>after YHG=2065>admission YHG=2065>the YHG=2064>blood YHG=2066>count YHG=2065>is YHG=2064>Hb. YHG=2064>82% :; " XBD=2535 XBD=132 XHG=796 XBD=300 XBD=430 XBD=537 XBD=641 XBD=725 XBD=780 XBD=889 XBD=1049 XBD=1292 XHG=93 XHG=149 XHG=315 XHG=445 XHG=552 XHG=658 XHG=741 XHG=903 XHG=1066 YBD=2093 YBD=2101 YBD=2102 YBD=2095 YBD=2094 YBD=2095 YBD=2103 YHG=2067>to YHG=2066>respond YHG=2065>might YHG=2066>have YHG=2066>been YHG=2067>due YHG=2068>to YHG=2066>their YHG=2067>relative YHG=2067>impotency ; 0-78.
" XBD=1806 XBD=1418 XBD=1515 XBD=1731 XHG=1357 XHG=1435 XHG=1533 XHG=1762 YBD=2139 YBD=2133 YHG=2106>red YHG=2105>cells YHG=2106>5,280,000 YHG=2104>CI ; XBD=157 XHG=844 XBD=309 XBD=393 XBD=579 XBD=731 XBD=831 XBD=865 XBD=1105 XBD=1158 XBD=1294 XHG=94 XHG=170 XHG=321 XHG=406 XHG=591 XHG=743 XHG=878 XHG=1118 XHG=1166 YBD=2133 YBD=2142 YBD=2134 YBD=2142 YBD=2134 YBD=2135 YHG=2105>the YHG=2105>patient YHG=2115>was YHG=2106>therefore YHG=2107>treated YHG=2106>with YHG=2115>a YHG=2106>preparation YHG=2107>of YHG=2106>known
" " " " " " " " " " " " " " "
XBD=1294XHG=764 XBD=249 XBD=307 XBD=457 XBD=533 XBD=742 XBD=846 XBD=1080 XBD=1140 XHG=94 XHG=269 XHG=329 XHG=479 XHG=555 XHG=867 XHG=1103 XHG=1165 YBD=2182 YBD=2173 YBD=2182 YBD=2174 YBD=2174 YBD=2174 YHG=2147>potency YHG=2145>in YHG=2145>dosage YHG=2145>far YHG=2146>exceeding YHG=2146>that YHG=2146>established YHG=2155>as YHG=2145>&dquo; stanXBD=220 XBD=297 XBD=388 XBD=632 XBD=768 XBD=881 XBD=1016 XBD=1146 XBD=1295 XHG=96 XHG=242 XHG=316 XHG=408 XHG=656 XHG=790 XHG=906 XHG=1064 XHG=1168 YBD=2212 YBD=2221 YBD=2213 YBD=2220 YBD=2213 YBD=2222 YHG=2183>dard YHG=2184>for YHG=2184>this YHG=2185>department YHG=2185>(Della YHG=2185>Vida YHG=2185>1942). YHG=2185>This YHG=2185>dosage &dquo; XBD=1460 XBD=1539 XBD=1646 XBD=1749 XBD=1867 XBD=2048 XBD=2157 XBD=2291 XBD=2539 XHG=1406 XHG=1472 XHG=1552 XHG=1660 XHG=1761 XHG=1880 XHG=2061 XHG=2170 XHG=2304 YBD=2241 YBD=2234 YHG=2205>At YHG=2204>the YHG=2204>time YHG=2204>that YHG=2204>these YHG=2204>patients YHG=2213>were YHG=2204>under YHG=2204>observation XBD=276 XBD=370 XBD=400 XBD=514 XBD=594 XBD=878 XBD=1114 XBD=1294 XHG=97 XHG=287 XHG=378 XHG=408 XHG=523 XHG=601 XHG=885 XHG=1120 YBD=2260 YBD=2252 YBD=2253 YBD=2261 YBD=2260 YBD=2261 YHG=2224>produced YHG=2225>only YHG=2233>a YHG=2224>slight YHG=2225>and YHG=2225>unsatisfactory YHG=2225>reticulocyte YHG=2233>response. XBD=1633 XBD=1786 XBD=1853 XBD=1938 XBD=2116 XBD=2300 XBD=2480 XBD=2543 XHG=1566 XHG=1658 XHG=1809 XHG=1872 XHG=1963 XHG=2138 XHG=2324 XHG=2503 YBD=2274 YBD=2281 YBD=2273 YHG=2244>spring YHG=2244>of YHG=2244>the YHG=2244>present YHG=2253>year-a YHG=2243>number YHG=2243>of Redoxon ’ XBD=257 XBD=299 XBD=351 XBD=428 XBD=535 XBD=612 XBD=990 XBD=1077 XBD=1178 XBD=1297 XHG=97 XHG=274 XHG=314 XHG=366 XHG=444 XHG=551 XHG=843 XHG=1006 XHG=1092 XHG=1194 YBD=2291 YBD=2293 YBD=2292 YBD=2300 YBD=2292 YBD=2301 YHG=2263>Vitamin YHG=2264>C YHG=2264>in YHG=2264>the YHG=2264>form YHG=2264>of YHG=2264>(Roche) YHG=2273>was YHG=2264>then YHG=2265>given ’ XBD=1532 XBD=1669 XBD=1917 XBD=2115 XBD=2352 XBD=2431 XBD=2539 XHG=1359 XHG=1569 XHG=1706 XHG=1955 XHG=2153 XHG=2389 XHG=2466 YBD=2321 YBD=2313 YBD=2320 YBD=2314 YHG=2283>sufferers YHG=2284>from YHG=2283>pernicious YHG=2284>anaemia YHG=2283>attending YHG=2284>at YHG=2282>this XBD=134 XBD=259 XBD=322 XBD=406 XBD=499 XBD=631 XBD=777 XBD=1045 XBD=1108 XBD=1187 XBD=1297 XHG=95 XHG=159 XHG=282 XHG=343 XHG=428 XHG=525 XHG=678 XHG=800 XHG=1069 XHG=1126 XHG=1211 YBD=2331 YBD=2331 YBD=2332 YBD=2341 YBD=2333 YBD=2333 YBD=2332 YHG=2302>in YHG=2303>doses YHG=2304>of YHG=2304>300 YHG=2313>mg. YHG=2305>daily. YHG=2304>With YHG=2304>continuation YHG=2304>of YHG=2304>the YHG=2305>liver XBD=1604 XBD=1717 XBD=1857 XBD=1917 XBD=2033 XBD=2097 XBD=2212 XBD=2340 XBD=2536 XHG=1360 XHG=1621 XHG=1736 XHG=1875 XHG=1935 XHG=2054 XHG=2113 XHG=2230 XHG=2358 YBD=2361 YBD=2352 YBD=2360 YBD=2353 YHG=2324>department YHG=2332>were YHG=2323>found YHG=2323>in YHG=2323>spite YHG=2323>of YHG=2323>their YHG=2324>usual YHG=2323>maintene XBD=1191 XBD=1297 XHG=1020 YBD=2380 YHG=2343>dosage XBD=1454 XHG=1236 XBD=1613 XBD=1678 XBD=1788 XBD=1849 XBD=1918 XBD=2106 XBD=2151 XBD=2401 XBD=2485 XBD=2541 XHG=1361 YBD=2372 XHG=1475 XHG=1634 XHG=1693 XHG=1807 XHG=1870 XHG=1938 XHG=2127 XHG=2169 XHG=2420 XHG=2503 YBD=2399 YHG=2344>the YBD=2400 YBD=2393 YBD=2392 YHG=2372>ance YHG=2363>dosage YHG=2363>of YHG=2362>liver YHG=2363>to YHG=2362>be YHG=2362>showing YHG=2372>a YHG=2362>progressive YHG=2362>fall YHG=2363>in XBD=1123 XBD=1296 XHG=1016 XHG=1149 YBD=2412 YBD=2411 YHG=2383>blood YHG=2383>condiXBD=1426 XBD=1597 XBD=1740 XBD=1900 XBD=1940 XBD=2122 XBD=2269 XBD=2328 XBD=2498 XBD=2538 XHG=1361 XHG=1443 XHG=1612 XHG=1789 XHG=1916 XHG=1954 XHG=2140 XHG=2285 XHG=2340 XHG=2514 YBD=2439 YBD=2433 YBD=2432 YHG=2403>the YHG=2402>red-cell YHG=2403>count. YHG=2402>After YHG=2412>a YHG=2403>month’s YHG=2412>course YHG=2402>of YHG=2402>vitamin YHG=2402>C XBD=1093 XBD=1297 XHG=1017 YBD=2452 YHG=2423>tion XBD=1431 XHG=1114 XBD=1527 XBD=1652 XBD=1720 XBD=1844 XBD=2031 XBD=2213 XBD=2307 XBD=2486 XBD=2540 XHG=1364 YBD=2460 XHG=1451 XHG=1547 XHG=1670 XHG=1738 XHG=1862 XHG=2048 XHG=2230 XHG=2324 XHG=2503 YBD=2480 YHG=2423>improved YBD=2473 YBD=2472 YHG=2443>100 YHG=2452>mg. YHG=2442>daily YHG=2442>all YHG=2442>these YHG=2443>patients YHG=2443>without YHG=2451>any YHG=2442>increase YHG=2442>in
" " " " " " " "
XBD=2541 XBD=1460 XBD=1745 XBD=1856 XBD=1922 XBD=2033 XBD=2203 XBD=2375 XBD=2420 XBD=1075 XBD=1145 XBD=1298 XBD=1528 XBD=1600 XBD=1675 XBD=1746 XBD=1967 XBD=2062 XBD=2178 XBD=2273 XBD=2424 XBD=2541 XBD=1156 XBD=1199 XBD=1298 XBD=1653 XBD=1951 XBD=2012 XBD=2098 XBD=2269 XBD=2429 XBD=1120 XBD=1248 XBD=1299 XBD=1445 XBD=1582 XBD=1645 XBD=1727 XBD=1959 XBD=2363 XBD=2542 XBD=1300
" XBD=2068 XHG=1834 YBD=2187 YHG=2164>DISCUSSION
I
-
-
-
-
-
-during
.,_ _
" XBD=1298 XBD=1057 XHG=1262 XBD=1220 XHG=1019 YBD=2491 XHG=1100 YBD=2492 YHG=2464>in YHG=2473>as YHG=2464>shown
" " " " " " " " " "
XBD=2542 XBD=1563 XBD=1651 XBD=1917 XBD=2081 XBD=2169 XBD=2358 XBD=1123 XBD=1300 XBD=1444 XBD=1547 XBD=1698 XBD=1779 XBD=1923 XBD=1982 XBD=2085 XBD=2180 XBD=2236 XBD=2276 XBD=2403 XBD=2543 XBD=1112 XBD=1300 XBD=1452 XBD=1510 XBD=1613 XBD=1653 XBD=1890 XBD=1946 XBD=2064 XBD=2229 XBD=2266 XBD=2541 XBD=1097 XBD=1297 XBD=1404 XBD=1490 XBD=1625 XBD=1817 XBD=1951 XBD=2064 XBD=2151 XBD=2271 XBD=2335 XBD=2417 XBD=2543 XBD=1213 XBD=1301 XBD=1506 XBD=1564 XBD=1764 XBD=1102 XBD=1300
XHG=2440 XHG=1361 XHG=1480 XHG=1768 XHG=1879 XHG=1938 XHG=2055 XHG=2224 XHG=2396 YBD=2514 YBD=2513 YBD=2512 YBD=2520 YHG=2483>their YHG=2481>maintenance YHG=2482>dose YHG=2482>of YHG=2482>liver YHG=2483>extract YHG=2483>showed YHG=2492>a YHG=2481>rapid XHG=1018 XHG=1117 XHG=1207 YBD=2540 YBD=2531 YBD=2530 YHG=2504>fig. YHG=2505>1. YHG=2503>The XHG=1361 XHG=1555 XHG=1622 XHG=1703 XHG=1777 XHG=1996 XHG=2092 XHG=2206 XHG=2302 XHG=2452 YBD=2557 YBD=2559 YBD=2551 YBD=2552 YHG=2522>increase YHG=2522>of YHG=2531>up YHG=2522>to YHG=2522>1,000,000 YHG=2521>red YHG=2522>cells YHG=2531>per YHG=2531>c.mm. YHG=2522>with XHG=979 XHG=1170 XHG=1220 YBD=2581 YBD=2571 YBD=2570 YHG=2543>patient YHG=2542>is YHG=2551>now XHG=1362YBD=2618 XHG=1673 XHG=1971 XHG=2032 XHG=2120 XHG=2290 YBD=2591YHG=2583>well YBD=2599 YBD=2592 YHG=2561>corresponding YHG=2561>improvement YHG=2561>in YHG=2561>the YHG=2562>general YHG=2562>health. XHG=979 XHG=1155 XHG=1277 YBD=2610 YBD=2609 YHG=2582>and YHG=2590>a XHG=1409 XHG=1465 XHG=1602 XHG=1661 YBD=2630YHG=2622>bloodYHG=2601>A YHG=2601>study YHG=2601>the XHG=1916 XHG=1975 XHG=2382 YBD=2631 YBD=2638 YBD=2639 YHG=2601>of YHG=2601>pernicious-anaemia YHG=2601>patients t XHG=979 YBD=2651 count
records
XHG=2381 XHG=1363 XHG=1585 XHG=1674 XHG=1937 XHG=2104 XHG=2191 YBD=2677 YBD=2670 YHG=2640>attending YHG=2640>the YHG=2640>department YHG=2641>reveals YHG=2641>the YHG=2641>hitherto XHG=1019 YBD=2671 XHG=1153 YBD=2691 YHG=2640>unnoted YBD=2690 YHG=2662>four YHG=2661>weeks XHG=1362 YBD=2710 XHG=1459 XHG=1562 XHG=1712 XHG=1795 XHG=1938 XHG=1996 XHG=2103 XHG=2195 XHG=2253 XHG=2291 XHG=2418 YBD=2716 YBD=2717 YBD=2709 YBD=2711 YHG=2680>fact YHG=2680>that YHG=2679>during YHG=2680>the YHG=2680>spring YHG=2680>of YHG=2680>1941 YHG=2680>and YHG=2681>to YHG=2690>a YHG=2681>lesser XHG=1020 XHG=1173 YBD=2730 YHG=2681>extent YBD=2729 YHG=2702>after YHG=2701>admisXHG=1363 XHG=1466 XHG=1523 XHG=1629 XHG=1666 XHG=1904 XHG=1957 XHG=2077 XHG=2243 XHG=2281 YBD=2756 YBD=2749 YBD=2750 YHG=2719>that YHG=2719>of YHG=2719>1940 YHG=2719>proportion YHG=2720>of YHG=2720>them YHG=2720>showed YHG=2729>a YHG=2720>deterioration XHG=979 YBD=2771 XHG=1134 YBD=2770YHG=2730>sion YHG=2740>showed : XHG=1363 XHG=1423 XHG=1510 XHG=1645 XHG=1852 XHG=1972 XHG=2084 XHG=2171 XHG=2293 XHG=2351 XHG=2436 YBD=2788 YBD=2796 YBD=2797 YBD=2789 YBD=2790 YHG=2759>in YHG=2759>the YHG=2754>picture YHG=2760>after YHG=2759>July YHG=2760>state YHG=2760>of YHG=2760>the YHG=2759>blood XHG=979 XHG=1240 YBD=2818 YBD=2808 YHG=2775>’ YHG=2779>red Hb.80%;; XHG=1364 XHG=1523 XHG=1581 YBD=2828 YBD=2836 YHG=2798>tended YHG=2799>to YHG=2799>improve. XHG=979 YBD=2863 XHG=1112 YBD=2854YHG=2821>cells YHG=2820>4,170,000.
" XBD=2543 XBD=1515 XHG=2500 XBD=1609 XBD=1718 XBD=1789 XBD=1883 XBD=2060 XBD=2313 XBD=2474 XHG=1414 YBD=2868 XHG=1542 XHG=1638 XHG=1746 XHG=1814 XHG=1912 XHG=2088 XHG=2341 YBD=2867 YHG=2839>be YBD=2875 YBD=2877 YBD=2869 YHG=2838>That YHG=2838>the YHG=2838>diet YHG=2838>of YHG=2847>our YHG=2839>general YHG=2838>population YHG=2838>should i " XBD=1186 XHG=1069 YBD=2904 YHG=2875>CASE " XBD=1302 XBD=1543 XHG=1218 XBD=1604 XBD=1789 XBD=1837 XBD=1996 XBD=2151 XBD=2291 XBD=2402 XBD=2540 XHG=1367 YBD=2902 XHG=1563 XHG=1624 XHG=1810 XHG=1860 XHG=2015 XHG=2170 XHG=2324 XHG=2423 YBD=2915 YHG=2874>2.YBD=2907 YBD=2908 YHG=2877>deficient YHG=2877>in YHG=2877>vitamin YHG=2878>C YHG=2877>during YHG=2878>winter YHG=2871>under YHG=2887>war YHG=2878>condi-
" """ " " " " " " " " " " " " "
XBD=1174 XBD=1303 XHG=1023 YBD=2947 XHG=1223 XHG=1284 YBD=2948 YHG=2918>been YBD=2949 YBD=2940 YHG=2915>Female, ; YHG=2922>age YHG=2922>e XBD=2545 XHG=2456 XBD=1468 XBD=1564 XBD=1627 XBD=1696 XBD=1924 XBD=2049 XBD=2162 XBD=2349 XBD=2436 XHG=1366 XHG=1487 XHG=1585 XHG=1648 XHG=1716 XHG=1960 XHG=2068 XHG=2182 XHG=2368 YBD=2955 YBD=2954 YHG=2917>tions YHG=2926>was YHG=2918>to YHG=2917>be YHG=2917>expected YHG=2917>that YHG=2917>such YHG=2917>actually YHG=2918>has XBD=1079 XBD=1304 XHG=1026 YBD=2987 XHG=1112 YBD=2982 YHG=2956>and YHG=2955>67. YHG=2953>OnadmisXBD=1433 XBD=1543 XBD=1636 XBD=1758 XBD=2145 XBD=2301 XBD=2450 XBD=2544 XHG=1366 XHG=1459 XHG=1567 XHG=1661 XHG=2091 XHG=2169 XHG=2330 XHG=2474 YBD=2986 YBD=2994 YBD=2993 YHG=2957>the YHG=2966>case YHG=2957>has YHG=2957>been YHG=2956>by YHG=2956>Harris YHG=2957>(1942) I-Blood XBD=161 XBD=446 XBD=486 XBD=647 XBD=725 XBD=841 XBD=880 XBD=988 XHG=109 XHG=319 XHG=455 XHG=499 XHG=659 XHG=737 XHG=852 XHG=890 YBD=3002 YBD=3000 YBD=2995 YBD=2997 YBD=2998 YBD=2999 YHG=2973>Fig. YHG=2979>response YHG=2977>to YHG=2974>parenteral YHG=2973>liver YHG=2980>extract YHG=2975>of YHG=2975>known XBD=1183 XBD=1304 XHG=1137 XHG=1226 XHG=1285 YBD=3022 YBD=3021 YHG=2996>to YHG=2993>the YHG=3002>e sion XBD=442 XHG=746 XBD=536 XBD=602 XBD=729 XBD=778 XHG=328 XHG=460 XHG=553 XHG=620 YBD=3032 YBD=3031 YBD=3026 YBD=3027 YHG=3008>potency YHG=3003>(PLE) YHG=3003>and YHG=3005>vitamin YHG=3004>C. XBD=1522 XBD=1607 XBD=1798 XBD=1946 XBD=2076 XBD=2175 XBD=2322 XBD=2384 XBD=2546 XHG=1366 XHG=1531 XHG=1617 XHG=1812 XHG=1998 XHG=2087 XHG=2185 XHG=2331 XHG=2392 YBD=3026 YBD=3033 YBD=3034 YBD=3027 YHG=2996>Francis YHG=2997>and YHG=2996>Wormall YHG=2996>(1942). YHG=2996>The YHG=2996>part YHG=2996>played YHG=2996>by YHG=2997>vitamin XBD=1304 XHG=2377 XHG=1027 YBD=3066 YBD=3070 YHG=3037>observaYHG=3033>Royal H o s XBD=1450 XBD=1720 XBD=1765 XBD=1860 XBD=2099 XBD=2229 XBD=2364 XBD=2540 XHG=1408 XHG=1461 XHG=1732 XHG=1777 XHG=1872 XHG=2151 XHG=2242 YBD=3074 YBD=3073 YHG=3036>in YHG=3036>haemopoiesis YHG=3036>is YHG=3036>well YHG=3036>recognised. YHG=3036>The YHG=3036>above XBD=198 XHG=848 XBD=344 XBD=528 XBD=630 XBD=806 XBD=986 XBD=1072 XBD=1305 XHG=108 XHG=238 XHG=388 XHG=569 XHG=672 XHG=1031 XHG=1108 YBD=3100 YBD=3099 YBD=3108 YBD=3109 YBD=3100 YBD=3109 YHG=3072>pital YHG=3072>blood YHG=3072>showed YHG=3072>the YHG=3072>typical YHG=3074>picture YHG=3073>of YHG=3072>pernicious XBD=1470 XBD=1600 XBD=1666 XBD=1948 XBD=2061 XBD=2125 XBD=2358 XBD=2546 XHG=1367 XHG=1494 XHG=1624 XHG=1692 XHG=1973 XHG=2084 XHG=2147 XHG=2382 YBD=3106 YBD=3105 YBD=3112 YBD=3110 YHG=3075>tions YHG=3085>serve YHG=3076>to YHG=3075>demonstrate YHG=3076>that YHG=3076>in YHG=3075>pernicious YHG=3076>anaemia, XBD=280 XBD=380 XBD=507 XBD=596 XBD=690 XBD=905 XBD=978 XBD=1094 XBD=1180 XBD=1303 XHG=109 XHG=308 XHG=397 XHG=534 XHG=610 XHG=707 XHG=997 XHG=1122 XHG=1194 YBD=3140 YBD=3148 YBD=3145 YBD=3139 YBD=3145 YBD=3140 YBD=3148 YHG=3111>ansemia YHG=3112>Hb. YHG=3110>49% YHG=3111>red YHG=3111>cells YHG=3112>1,650,000 YHG=3112>CI YHG=3112>1-48 YHG=3111>CV YHG=3111>24% ; ; : ; XBD=1465XHG=933 XBD=1585 XBD=1737 XBD=1903 XBD=1975 XBD=2065 XBD=2332 XBD=2544 XHG=1368 XHG=1490 XHG=1613 XHG=1766 XHG=1931 XHG=1999 XHG=2093 XHG=2360 YBD=3153 YBD=3145 YBD=3152 YHG=3124>even YHG=3115>with YHG=3115>ample YHG=3114>dosage YHG=3115>of YHG=3114>the YHG=3114>antianaemic YHG=3115>principle, 8-5 u; YHG=3150>reticulocytes MD XBD=205 XBD=292 XBD=408 XBD=930 XBD=1017 XBD=1134 XBD=1304 XHG=108 XHG=231 XHG=310 XHG=945 XHG=1043 XHG=1160 YBD=3178 YBD=3190 YBD=3186 YBD=3179 YBD=3178 YBD=3187 YHG=3150>MCV YHG=3151>145 YHG=3151>c.jM; YHG=3151>less YHG=3151>than YHG=3150>1/1000 ; XBD=1628XHG=686 XBD=1785 XBD=1848 XBD=2042 XBD=2100 XBD=2263 XBD=2318 XBD=2399 XBD=2494 XBD=2548 XHG=1368 XHG=1645 XHG=1801 XHG=1864 XHG=2058 XHG=2117 XHG=2278 XHG=2334 XHG=2414 XHG=2509 YBD=3192 YBD=3185 YBD=3184 YHG=3154>hsemopoiesis YHG=3155>cannot YHG=3154>be YHG=3154>returned YHG=3155>to YHG=3154>normal YHG=3154>in YHG=3155>the YHG=3155>face YHG=3153>of XBD=216 XHG=761 XBD=330 XBD=450 XBD=726 XBD=870 XBD=1162 XBD=1304 XHG=108 XHG=250 XHG=364 XHG=485 XHG=916YBD=3228 XHG=1195 YBD=3218 YBD=3219 YBD=3226 YBD=3227 YBD=3227 YHG=3190>white YHG=3179>cells YHG=3191>5400 YHG=3189>(polymorphs YHG=3189>62% YHG=3190>lymphocytes YHG=3190>34% ; ; XBD=1393 XBD=1629 XBD=1703 XBD=1893 XBD=1963 XBD=2093 XBD=2376 XBD=2449 XBD=2569 XHG=1369 XHG=1424 XHG=1660 XHG=1729 XHG=1924 XHG=2014 XHG=2123 XHG=2406 XHG=2473 YBD=3225 YBD=3223 YBD=3231 YBD=3224 YBD=3233 YHG=3204>a YHG=3194>deficiency YHG=3195>of YHG=3194>vitamin YHG=3194>C. YHG=3194>The YHG=3194>implications YHG=3194>of YHG=3194>this XBD=419 XHG=868 XBD=663 XBD=804 XBD=855 XBD=930 XBD=1035 XBD=1086 XBD=1158 XBD=1306 XHG=109 XHG=446 XHG=712 XHG=816 XHG=942YBD=3257 XHG=1048 XHG=1098 XHG=1170 YBD=3265 YBD=3256 YBD=3266 YBD=3256 YBD=3257 YHG=3230>monocytes YHG=3228>eosins2%). YHG=3228>Shift YHG=3231>to YHG=3229>the YHG=3229>right YHG=3229>in YHG=3229>the YHG=3229>Arneth 2% ; XBD=1613 XBD=1725 XBD=1783 XBD=1866 XBD=2093 XBD=2154 XBD=2379 XBD=2550 XHG=1370 XHG=1629 XHG=1742 XHG=1800 XHG=1884 XHG=2111 XHG=2168 XHG=2398 YBD=3264 YBD=3270 YBD=3263 YHG=3233>observation YHG=3234>both YHG=3234>in YHG=3234>the YHG=3233>treatment YHG=3233>of YHG=3234>pernicious YHG=3234>anaemia basophilic XBD=1307 XHG=1140 YBD=3305 YHG=3268>stippling XBD=259 XHG=829 XBD=519 XBD=805 XBD=901 XHG=109 XHG=279 XHG=543 YBD=3301 YBD=3305 YBD=3304 YBD=3295 YHG=3270>count YHG=3268>anisocytosis, YHG=3267>poikilocytosis YHG=3268>and ; XBD=1447 XBD=1512 XBD=1599 XBD=1764 XBD=1828 XBD=1941 XBD=2226 XBD=2306 XBD=2549 XHG=1370 XHG=1470 XHG=1533 XHG=1620 XHG=1784 XHG=1847 XHG=1962 XHG=2246 XHG=2320 YBD=3302 YBD=3310 YHG=3273>and YHG=3273>in YHG=3273>the YHG=3273>testing YHG=3273>of YHG=3273>liver YHG=3272>preparations YHG=3272>for YHG=3273>therapeutic XBD=153 XBD=236 XBD=317 XBD=426 XBD=552 XBD=640 XBD=778 XBD=976 XBD=1137 XBD=1306 XHG=112 XHG=174 XHG=254 XHG=335 XHG=473 XHG=573 XHG=662 XHG=1010 XHG=1156 YBD=3336 YBD=3343 YBD=3335 YBD=3344 YHG=3307>of YHG=3307>the YHG=3307>red YHG=3308>cells. YHG=3307>Van YHG=3307>den YHG=3307>Bergh YHG=3306>reaction YHG=3307>faintly YHG=3308>positive : XBD=1435XHG=795 XBD=1519 XBD=1582 XBD=1757 XBD=2022 XHG=1373 XHG=1455 XHG=1539 XHG=1595 XHG=1774 YBD=3342 YBD=3343 YBD=3350 YHG=3320>use YHG=3321>are YHG=3312>of YHG=3312>obvious YHG=3312>importance. XBD=272 XHG=834 XBD=519 XBD=738 XBD=816 XBD=906 XBD=1020 XHG=111 XHG=318 XHG=536 XHG=770 XHG=924YBD=3373 YBD=3375 YBD=3374YHG=3345>free YHG=3346>indirect. YHG=3347>Fractional YHG=3346>test-meal YHG=3355>no YHG=3346>HC1. : XBD=240 XHG=797 XBD=394 XBD=448 XBD=647 XBD=686 XBD=779 XBD=837 XBD=1044 XBD=1209 XBD=1307 XHG=157 XHG=257 XHG=411 XHG=467 XHG=663 XHG=702 XHG=849YBD=3413 XHG=1061 XHG=1226 YBD=3415 YBD=3414 YBD=3422 YBD=3421 YBD=3414 YHG=3385>This YHG=3387>seemed YHG=3395>so YHG=3386>definitely YHG=3394>a YHG=3394>case YHG=3385>of YHG=3385>pernicious YHG=3386>anaemia YHG=3386>that XBD=142 XHG=975 XBD=230 XBD=399 XBD=471 XBD=652 XBD=731 XBD=902 XBD=960 XBD=998 XBD=1123 XBD=1182 XBD=1308 XHG=108 XHG=159 XHG=249 XHG=416 XHG=488 XHG=669 XHG=749 XHG=922 XHG=1015 XHG=1142 XHG=1195 YBD=3455 YBD=3454 YBD=3453 YBD=3461 YBD=3452 YBD=3451 YBD=3453 YBD=3452 YBD=3462 YHG=3426>it YHG=3434>was YHG=3426>selected YHG=3425>for YHG=3425>assaying YHG=3425>the YHG=3427>potency YHG=3424>of YHG=3433>a YHG=3424>batch YHG=3425>of YHG=3426>newly !VIr’I.,l
" XBD=1310 XBD=282 XHG=823 XBD=391 XBD=549 XBD=633 XBD=714 XBD=801 XBD=867 XBD=1120 XBD=1217 XHG=111 XHG=304 XHG=410 XHG=568 XHG=653 XHG=735 XHG=889YBD=3491 XHG=1167 XHG=1239 YBD=3502 YBD=3493 YBD=3492 YBD=3500 YBD=3501 YBD=3492 YBD=3492YHG=3473>on YBD=3493 YHG=3466>prepared YHG=3465>liver YHG=3467>extract YHG=3466>not YHG=3467>yet YHG=3467>put YHG=3462>the’market. YHG=3465>To YHG=3465>this
demonstrated -
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: I
REFERENCES
Della Vida, B. L. (1942) Lancet, ii, 275. Francis, G. E. C. and Wormall, A. (1942) Ibid, i, 647. Harris, L. J. (1942) Ibid, i, 642.
" XBD=986 XBD=1267XHG=942 XBD=167 XBD=285 XBD=427 XBD=548 XBD=637 XBD=920 XHG=73 XHG=189 XHG=307 XHG=447 XHG=570 XHG=659 XHG=1004 YBD=222 YBD=215 YBD=223 YBD=216 YBD=222 YHG=194>may YHG=186>arise YHG=187>either YHG=186>from YHG=186>the YHG=186>employment YHG=185>of YHG=185>preparations " XBD=1268 XBD=116 XHG=812 XBD=205 XBD=390 XBD=453 XBD=571 XBD=791 XBD=856 XBD=938 XBD=1123 XBD=1186 XHG=871 XHG=74 XHG=132 XHG=224 XHG=410 XHG=470 XHG=589 XHG=957 XHG=1143 XHG=1201 YBD=253 YBD=261 YBD=260 YBD=252 YBD=253 YBD=260 YBD=252 YBD=253 YHG=223>of YHG=224>low YHG=225>potency YHG=233>or YHG=224>from YHG=225>ignorance YHG=224>of YHG=223>the YHG=224>potency YHG=224>of YHG=224>the " XBD=1269 XBD=321 XHG=880 XBD=471 XBD=847 XBD=992 XBD=1057 XHG=73 XHG=352 XHG=518 XHG=1023 XHG=1090 YBD=298 YBD=296 YBD=292 YBD=291 YBD=291 YBD=292 YHG=261>preparation YHG=263>used; YHG=262>from.whatever YHG=270>cause YHG=262>it YHG=262>arises, it " XBD=1269 XBD=299 XHG=759 XBD=345 XBD=481 XBD=546 XBD=739 XBD=946 XBD=1205 XHG=74 XHG=321 XHG=362 XHG=502 XHG=562 XHG=967 XHG=1227 YBD=331 YBD=330 YBD=331 YBD=335 YBD=330 YBD=331 YHG=301>constitutes YHG=311>a YHG=301>waste YHG=301>of YHG=301>valuable YHG=301>material, YHG=301>undesirable YHG=301>at
" XBD=961 XBD=152 XHG=785 XBD=260 XBD=347 XBD=449 XBD=645 XBD=767 XHG=74 YBD=377 XHG=167 XHG=275 XHG=363 XHG=465 XHG=661 YBD=370YHG=348>any YBD=377 YBD=369 YHG=340>time YHG=340>but YHG=349>now YHG=340>specially YHG=339>to YHG=339>avoided. be REFERENCES
Isaacs, R., Bethell, F. H., Riddle, M. C. and Friedman, A. (1938) J. Amer. med. Ass. 111, 2291. Kracke, R. R. and Garver, H. E. (1937) Diseases of the Blood and Atlas of hæmatology, London, p. 236. Minot, G. R., Cohn, E. J., Murphy, W. P. and Lawson, H. A. (1928) Amer. J. med. Sci. 175, 599. Murphy, W. P. (1933) Arch. intern. Med. 52, 829. Riddle, M. C. (1930) Ibid, 46, 417 ; (1940) Amer. J. med. Sci. 200, 145.
Schiødt, E. (1939) Acta med. scand. 98, 449. USP (1938) J. Amer. med. Ass. 110, 812. J. F. and Israëls, M. C. G. Wilkinson, XHG=2485 XBD=1433 XBD=1520 XBD=1583 XBD=1814 XBD=2059 XBD=2238 XBD=2323 XBD=2386 XBD=2468 XBD=2519 XHG=1334 XHG=1447 XHG=1533 XHG=1595 XHG=1831 XHG=2076 XHG=2253 XHG=2341 XHG=2404 YBD=792 YBD=793 YBD=785 YBD=783 YBD=784 YHG=757>there YHG=765>was YHG=762>no YHG=756>appreciable YHG=756>reticulocyte YHG=765>response YHG=755>and YHG=764>no YHG=756>rise YHG=756>in (1942) Lancet, i, 240.
" " " " " " "
XBD=2520 XHG=2438 XBD=1395 XBD=1476 XBD=1585 XBD=1676 XBD=1784 XBD=1843 XBD=1918 XBD=2010 XBD=2109 XBD=2368 XBD=2424 XHG=1333 YBD=823 XHG=1413 XHG=1494 XHG=1632 XHG=1694 XHG=1802 XHG=1856 XHG=1936 XHG=2027 XHG=2127 XHG=2386 YBD=824 YHG=795>liver YBD=832 YBD=822 YHG=796>red YHG=796>cells. YHG=796>In YHG=796>spite YHG=796>of YHG=796>the YHG=796>fact YHG=796>that YHG=795>preparations YHG=795>of XBD=1426 XHG=2364 XBD=1519 XBD=1731 XBD=1830 XBD=1923 XBD=2067 XBD=2215 XBD=2350 XBD=2517 XHG=1334 XHG=1447 XHG=1539 XHG=1751 XHG=1850 XHG=1936 XHG=2081 XHG=2229 YBD=871 YBD=862 YBD=863 YBD=870 YBD=867 YHG=835>fromIN YHG=834>this YHG=834>particular YHG=835>firm YHG=835>had YHG=835>always YHG=834>proved YHG=834>highly YHG=834>efficient, VITAMIN-C. DEFICIENCY XBD=1407 XHG=2499 XBD=1571 XBD=1763 XBD=1818 XBD=1872 XHG=1335 YBD=901 XHG=1422 XHG=1588 XHG=1779 XHG=1834 YBD=902 YHG=882>a YHG=874>this YHG=874>aroused YHG=873>suspicion YHG=882>as YHG=877>to XBD=2122 XBD=2178 XBD=2267 XBD=2402 XBD=2483 XBD=2519 XHG=1968 XHG=2139 XHG=2196 XHG=2284 XHG=2436 YBD=910 YBD=900 YHG=876>potency YHG=873>of YHG=873>this YHG=873>batch. YHG=873>As " IRRESPONSIVE " PERNICIOUS XBD=1409 XBD=1494 XBD=1658 XBD=1753 XBD=1880 XBD=1965 XBD=2160 XBD=2310 XBD=2375 XBD=2416 XBD=2520 XHG=1336 YBD=940 XHG=1433 XHG=1519 XHG=1681 XHG=1778 XHG=1904 XHG=1990 XHG=2184 XHG=2336 XHG=2395 XHG=2439 YBD=949 YBD=941 YBD=947 YBD=939 YHG=915>test ANÆMIA YHG=913>patient YHG=922>was YHG=913>given YHG=913>the YHG=912>standard YHG=912>dosage YHG=912>of YHG=921>a YHG=912>liver
the
XBD=2519 S.XHG=2484 XBD=1475 XBD=1536 XBD=1679 XBD=1861 XBD=1957 XBD=2048 XBD=2140 XBD=2221 XBD=2345 XBD=2466 XHG=1337 XHG=1496 XHG=1551 XHG=1697 XHG=1908 XHG=1978 XHG=2068 XHG=2160 XHG=2240 XHG=2364 YBD=989 YHG=954>to YBD=980 YHG=954>extract YHG=952>of YHG=951>known YHG=954>potency. YHG=953>To YHG=952>this YHG=952>also YHG=951>the YHG=951>blood YHG=950>failed C. DYKEYBD=979 B. L. DELLA VIDA XBD=1441 XHG=2333 XBD=1485 XBD=1732 XBD=1926 XBD=2046 XBD=2171 XBD=2232 XBD=2311 XBD=2520 XHG=1336 YBD=1018 XHG=1463 XHG=1507 XHG=1753 XHG=1973 XHG=2068 XHG=2194 XHG=2250 YBD=1027 YHG=990>exhibition YBD=1028 YBD=1019 YHG=991>make YHG=1000>a YHG=991>satisfactory YHG=1000>response. YHG=991>The YHG=991>effect YHG=991>of YHG=991>the
MD BRATISLAVA ELIZABETHYBD=1059 DELIKAT,YHG=1030>2. " XBD=2520 XBD=1378 XHG=2492 XBD=1540 XBD=1580 XBD=1630 XBD=1804 XBD=1856 XBD=1932 XBD=2032 XBD=2183 XBD=2225 XBD=2359 XBD=2408 XBD=2476 XHG=1339 XHG=1388 XHG=1554 XHG=1593 XHG=1644 XHG=1818 XHG=1871 XHG=1946 XHG=2045 XHG=2196 XHG=2240 XHG=2372 XHG=2422 YBD=1058 YBD=1066 YHG=1031>of YHG=1030>vitamin YHG=1030>C YHG=1030>addition YHG=1034>to YHG=1031>the YHG=1031>liver YHG=1032>extract YHG=1030>is YHG=1031>shown YHG=1030>in YHG=1030>fig.
" XBD=1725 XBD=1772 XBD=1371 XBD=1528 XBD=1650 XBD=1705 XHG=1337 XHG=1400 XHG=1557 XHG=1681 XHG=1713 XHG=1735 YBD=1098 YBD=1097 YHG=1069>A YHG=1069>month YHG=1070>after YHG=1070>d YHG=1070>i YHG=1078>s XBD=315 XHG=593 XBD=572 XBD=706 XBD=897 XBD=1222 XHG=726 XHG=138 XHG=335 XHG=920YBD=1100 YBD=1096 YBD=1101 YBD=1097 YBD=1096 YHG=1077>ASSISTANT YHG=1077>PATHOLOGIST, YHG=1078>ROYAL YHG=1078>HOSPITAL, YHG=1076>WOLVERHAMPTON
" XBD=1464 XBD=1590 XHG=1339 XHG=1499 XHG=1621 YBD=1136 YBD=1145 YHG=1108>charge YHG=1109>from YHG=1108>hospital " XBD=1774 XBD=257 XHG=881 XBD=339 XBD=472 XBD=576 XBD=636 XBD=714 XBD=865 XBD=925 XBD=1003 XBD=1171 XBD=1277 XHG=135 XHG=274 XHG=356 XHG=487 XHG=593 XHG=648 XHG=729 XHG=937YBD=1148 XHG=1019 XHG=1186 YBD=1156 YBD=1149 YBD=1147 YBD=1155 YHG=1118>SINCE YHG=1119>the YHG=1119>latter YHG=1119>part YHG=1119>of YHG=1120>the YHG=1119>winter YHG=1118>of YHG=1118>the YHG=1119>present YHG=1126>year " XBD=1774 XBD=1416 XBD=1559 XHG=1338 XHG=1453 XHG=1591 YBD=1175 YBD=1176 YBD=1184 YHG=1147>the YHG=1148>blood YHG=1148>picture " XBD=139 XHG=663 XBD=263 XBD=386 XBD=520 XBD=639 XBD=729 XBD=1089 XBD=1212 XBD=1280 XHG=82 XHG=164 XHG=288 XHG=409 XHG=544 XHG=754 XHG=1110 XHG=1238 YBD=1188 YBD=1189 YBD=1188 YBD=1195 YBD=1187 YBD=1186 YHG=1167>we YHG=1158>have YHG=1158>been YHG=1159>faced YHG=1159>with YHG=1159>the YHG=1157>phenomenon’of YHG=1166>cases YHG=1156>of " XBD=1472 XBD=1568 XBD=1690 XBD=1775 XHG=1341 XHG=1496 XHG=1587 XHG=1713 YBD=1215 YBD=1223 YBD=1214 YHG=1187>shows: YHG=1187>Hb. YHG=1186>73%; YHG=1187>red wholly |>" XBD=293 XBD=673 XBD=483 XHG=82 XHG=512 XHG=323 YBD=1235 YBD=1235 YBD=1228 YHG=1197>pernicious YHG=1198>proving YHG=1200>anaemia " XBD=919 XBD=1154 XBD=1275 XHG=877 XHG=954 XHG=1188 YBD=1226 YBD=1233 YBD=1226 YHG=1206>or YHG=1196>relatively YHG=1197>irre-
cells3,840,000;
" XBD=1775 XHG=1731 YBD=1254 YHG=1226>CI " XBD=261 XHG=460 XBD=327 XBD=443 XBD=679 XBD=890 XBD=1202 XBD=1277 XHG=729 XHG=84 XHG=285 XHG=348 XHG=906 XHG=1217 YBD=1274 YBD=1267 YBD=1266 YBD=1265 YBD=1265 YHG=1237>sponsive YHG=1238>to YHG=1238>liver YHG=1237>treatment. YHG=1236>Various YHG=1235>considerations YHG=1235>led " XBD=1429 XHG=1341 YBD=1294 YHG=1266>0-95.
" XBD=1281 XBD=126 XHG=964 XBD=215 XBD=354 XBD=462 XBD=562 XBD=709 XBD=778 XBD=875 XBD=954 XBD=990 XBD=1217 XHG=84 XHG=149 XHG=238 XHG=373 XHG=484 XHG=584 XHG=730 XHG=802 XHG=899 XHG=1012 XHG=1240 YBD=1306 YBD=1307 YBD=1306 YBD=1312 YBD=1313 YBD=1305 YBD=1312 YBD=1304 YHG=1277>to YHG=1277>the YHG=1276>belief YHG=1276>that YHG=1276>this YHG=1276>might YHG=1276>be YHG=1275>due YHG=1275>to, YHG=1283>a YHG=1275>deficiency YHG=1274>of " XBD=250 XBD=312 XBD=412 XBD=581 XBD=647 XBD=773 XBD=902 XBD=992 XBD=1127 XBD=1193 XHG=85 XHG=273 XHG=364 XHG=436 XHG=604 XHG=666 XHG=796 XHG=1015 XHG=1151 XHG=1213 YBD=1346 YBD=1345 YBD=1344 YBD=1344 YHG=1316>vitamin YHG=1315>C. YHG=1317>In YHG=1316>certain YHG=1315>of YHG=1315>these YHG=1323>cases YHG=1314>the YHG=1314>effect YHG=1315>of YHG=1314>the " XBD=1279 XBD=1480XHG=925 XBD=1687 XBD=1844 XHG=1387 XHG=1508 XHG=1713 YBD=1341 YBD=1347 YBD=1349 YHG=1313>CASE YHG=1313>3.-Male, YHG=1302>age
XBD=299 XBD=362 XBD=546 XBD=652 XBD=714 XBD=802 XBD=961 XBD=1051 XBD=1168 XBD=1281 XHG=86 XHG=319 XHG=379 XHG=567 XHG=672 XHG=732 XHG=982 XHG=1072 XHG=1187 YBD=1385 YBD=1385 YBD=1384 YBD=1391 YBD=1383 YBD=1383 YHG=1355>exhibition YHG=1355>of YHG=1354>ascorbic YHG=1354>acid YHG=1354>in YHG=1354>full YHG=1354>dosage YHG=1354>has YHG=1353>been YHG=1353>such " XBD=1706 XBD=1844XHG=824 XBD=1396 XBD=1536 XHG=1344 XHG=1442 XHG=1565 XHG=1739 YBD=1381 YBD=1392 YHG=1353>69. YHG=1352>First YHG=1353>treated YHG=1355>at " XBD=1279 XBD=127 XBD=191 XBD=371 XBD=471 XBD=602 XBD=732 XBD=944 XBD=1072 XBD=1158 XHG=754 XHG=86 XHG=150 XHG=214 XHG=393 XHG=493 XHG=966 XHG=1096 XHG=1179 YBD=1425 YBD=1424 YBD=1423 YBD=1431 YBD=1423 YBD=1423 YHG=1404>as YHG=1395>to YHG=1394>confirm YHG=1394>this YHG=1394>view. YHG=1393>The YHG=1393>following YHG=1393>three YHG=1403>are YHG=1393>illusXBD=1403XHG=654 XBD=1540 XBD=1723 XBD=1831 XHG=1342 XHG=1424 XHG=1559 XHG=1740 YBD=1420 YBD=1428 YBD=1429 YBD=1432 YHG=1392>the YHG=1392>Royal YHG=1392>Hospital YHG=1392>in
I
" XBD=353 XBD=225 XHG=84 YBD=1464 YBD=1463 YHG=1434>trative YHG=1443>cases. XBD=1436XHG=240 XBD=1560 XBD=1844 XHG=1343 XHG=1467 XHG=1607 YBD=1468 YBD=1460 YBD=1463 YHG=1432>May, YHG=1432>1937. YHG=1432>Mainten-
estab-
" XBD=840 XHG=545 YBD=1493 YHG=1469>CASE-RECORDS
" XBD=1587 XBD=1429 XHG=1460 XHG=1344 YBD=1508 YBD=1500 YHG=1472>dosage YHG=1481>ance " " " " " " " " " " " " "
’
I.-Female, XBD=1657XHG=837 XBD=225 XBD=581 XBD=666 XBD=808 XBD=977 XBD=1045 XBD=1136 XBD=1282 XBD=1456 XBD=1509 XBD=1545 XHG=131 XHG=518 XHG=613 XHG=713 XHG=1008 XHG=1076 XHG=1167 XHG=1344 XHG=1470 XHG=1525 XHG=1559 YBD=1548 YBD=1539 YBD=1540 YBD=1548 YBD=1539 YHG=1511>CASE YHG=1520>age YHG=1513>57. YHG=1511>First YHG=1511>treated YHG=1514>at YHG=1512>the YHG=1511>Royal YHG=1511>lished YHG=1513>at YHG=1512>4 YHG=1520>c.cm. XBD=1441XHG=678 XBD=1593 XBD=1688 XBD=1835 XBD=252 XBD=314 XBD=504 XBD=632 XBD=923 XBD=1162 XBD=1235 XBD=1282 XHG=84 XHG=277 XHG=342 XHG=537 XHG=949YBD=1588 XHG=1188 XHG=1260 XHG=1345 XHG=1468 XHG=1637 XHG=1719 YBD=1579 YBD=1586 YBD=1580 YBD=1579 YBD=1588 YBD=1579 YBD=1578 YBD=1594 YHG=1551>Hospital YHG=1551>in YHG=1548>October, YHG=1552>1937. YHG=1545>Maintenance YHG=1551>established YHG=1561>on YHG=1560>a YHG=1551>eight YHG=1551>weeks. YHG=1550>At YHG=1551>the XBD=1533 XBD=1595 XBD=1696 XBD=1780 XHG=1345 XHG=1554 XHG=1615 XHG=1719 YBD=1627 YBD=1618 YHG=1591>beginning YHG=1590>of YHG=1590>1941 YHG=1590>the XBD=170 XHG=852 XBD=233 XBD=272 XBD=394 XBD=459 XBD=500 XBD=609 XBD=770 XBD=833 XBD=980 XBD=1155 XBD=1283 XHG=87 XHG=192 XHG=253 XHG=297 XHG=419 XHG=478 XHG=523 XHG=631 XHG=793 XHG=1002 XHG=1177 YBD=1620 YBD=1620 YBD=1619 YBD=1628 YHG=1591>dose YHG=1591>2 YHG=1600>c.cm. YHG=1600>a YHG=1591>liver YHG=1593>extract YHG=1591>of YHG=1591>known YHG=1593>potency YHG=1600>every XBD=225 XHG=752 XBD=315 XBD=535 XBD=653 XBD=734 XBD=891 XBD=1018 XBD=1117 XBD=1195 XBD=1284 XHG=86 XHG=271 XHG=333 XHG=558 XHG=672 XHG=907 XHG=1034 XHG=1135 XHG=1212 YBD=1659 YBD=1664 YBD=1659 YBD=1667 YBD=1659 YHG=1630>month. YHG=1631>In YHG=1630>December, YHG=1631>1941, YHG=1630>the YHG=1630>patient YHG=1632>noted YHG=1630>that YHG=1631>she YHG=1639>was XBD=1486 XBD=1606 XBD=1781 XHG=1345 XHG=1500 XHG=1625 YBD=1659 YBD=1658 YBD=1667 YHG=1630>red-cell YHG=1632>count YHG=1630>dropped XBD=1456 XBD=1640 XBD=1781 XHG=1345 XHG=1465 XHG=1646 YBD=1698 YBD=1703 YBD=1706 YHG=1670>below YHG=1664>4,000,000 YHG=1669>though XBD=152 XHG=842 XBD=209 XBD=328 XBD=401 XBD=492 XBD=598 XBD=680 XBD=824 XBD=914 XBD=1061 XBD=1118 XBD=1284 XHG=86 XHG=171 XHG=229 XHG=362 XHG=420 XHG=511 XHG=617 XHG=700 XHG=932 XHG=1081 XHG=1139 YBD=1699 YBD=1703 YBD=1699 YBD=1698 YBD=1698 YBD=1707 YHG=1673>not YHG=1679>so YHG=1670>well YHG=1673>at YHG=1670>this YHG=1670>time YHG=1670>her YHG=1670>doctor YHG=1679>was YHG=1670>unable YHG=1673>to ; YHG=1679>procure XBD=225 XHG=641 XBD=394 XBD=450 XBD=523 XBD=627 XBD=867 XBD=1096 XBD=1198 XBD=1310 XBD=1408 XBD=1576 XBD=1706 XBD=1781 XHG=88 XHG=242 XHG=410 XHG=462 XHG=540 XHG=882 XHG=1111 XHG=1214 XHG=1346 XHG=1437 XHG=1603 XHG=1734 YBD=1738 YBD=1747 YBD=1738 YBD=1746 YBD=1738 YBD=1738 YBD=1747 YBD=1737 YHG=1710>further YHG=1709>supplies YHG=1711>of YHG=1710>the YHG=1709>liver YHG=1710>preparation YHG=1710>theretofore YHG=1710>used YHG=1710>and YHG=1709>the YHG=1710>patient YHG=1710>made YHG=1718>no XBD=247 XHG=867 XBD=310 XBD=485 XBD=634 XBD=725 XBD=841 XBD=907 XBD=1063 XBD=1286 XHG=89 XHG=271 XHG=336 XHG=509 XHG=681 XHG=750 XHG=928 XHG=1089 YBD=1786 YBD=1781 YBD=1777 YBD=1786 YBD=1778 YBD=1786 YBD=1778 YHG=1749>changed YHG=1752>to YHG=1749>another YHG=1749>brand. YHG=1749>In YHG=1749>spite YHG=1749>of YHG=1750>greatly YHG=1749>intensified XBD=1541 XBD=1601 XBD=1742 XBD=1898 XBD=2047 XBD=2166 XBD=2248 XBD=2329 XBD=2427 XBD=2528 XHG=1349 XHG=1560 XHG=1616 XHG=1854 XHG=1917 XHG=2073 XHG=2187 XHG=2267 XHG=2349 XHG=2446 YBD=1787 YBD=1777 YBD=1785 YBD=1781 YBD=1780 YBD=1774 YBD=1775 YHG=1741>complaint YHG=1749>of YHG=1749>feeling YHG=1748>In YHG=1747>March, YHG=1747>1942, YHG=1746>the YHG=1746>red YHG=1747>cells YHG=1755>were XBD=218 XHG=698 XBD=296 XBD=481 XBD=680 XBD=932 XBD=1100 XBD=1188 XBD=1287 XBD=1573 XBD=1663 XBD=1741 XBD=1927 XBD=2082 XBD=2279 XBD=2367 XBD=2530 XHG=89 XHG=235 XHG=314 XHG=500 XHG=949 XHG=1117 XHG=1205 XHG=1423 XHG=1592 XHG=1680 XHG=1758 XHG=1944 XHG=2100 XHG=2296 XHG=2384 YBD=1826 YBD=1825 YBD=1817 YBD=1825 YBD=1817 YBD=1826 YBD=1824 YBD=1815 YBD=1814 YBD=1823 YHG=1789>dosage YHG=1789>the YHG=1788>patient’s YHG=1788>condition YHG=1789>deteriorated YHG=1789>steadily YHG=1790>and YHG=1789>trial YHG=1789>millions YHG=1789>and YHG=1789>the YHG=1786>patient’s YHG=1787>general YHG=1786>condition YHG=1795>was YHG=1795>progresXBD=1461 XBD=1738 XBD=1856 XBD=1973 XBD=2073 XBD=2131 XBD=2229 XBD=2382 XBD=2458 XBD=2532 XHG=1351 XHG=1478 XHG=1784 XHG=1872 XHG=1991 XHG=2091 XHG=2143 XHG=2244 XHG=2399 XHG=2473 YBD=1865 YBD=1855 YBD=1854 YHG=1828>sively YHG=1828>deteriorating. YHG=1827>The YHG=1827>usual YHG=1827>dose YHG=1826>of YHG=1826>liver YHG=1828>extract YHG=1826>did YHG=1828>not XBD=162 XHG=890 XBD=284 XBD=343 XBD=420 XBD=589 XBD=844 XBD=963 XBD=1234 XBD=1289 XHG=89 XHG=179 XHG=304 XHG=357 XHG=439 XHG=606 XHG=984 XHG=1251 YBD=1857 YBD=1856 YBD=1864 YBD=1866 YBD=1857 YBD=1857 YBD=1857 YHG=1837>was YHG=1829>made YHG=1828>of YHG=1831>yet YHG=1828>another YHG=1828>preparation. YHG=1828>The YHG=1829>deterioration YHG=1829>in XBD=1433 XBD=1511 XBD=1588 XBD=1644 XBD=1716 XBD=1872 XBD=2007 XBD=2110 XBD=2314 XBD=2367 XBD=2443 XBD=2531 XHG=1352 XHG=1449 XHG=1527 XHG=1604 XHG=1655 XHG=1732 XHG=1888 XHG=2055 XHG=2125 XHG=2329 XHG=2384 XHG=2458 YBD=1904 YBD=1897 YBD=1896 YBD=1895 YBD=1893 YBD=1894 YHG=1871>stop YHG=1868>the YHG=1868>fall YHG=1869>of YHG=1867>the YHG=1867>red-cell YHG=1869>count. YHG=1866>On YHG=1865>admission YHG=1868>to YHG=1865>the YHG=1866>hosXBD=230 XHG=837 XBD=433 XBD=691 XBD=816 XBD=946 XBD=1043 XBD=1221 XBD=1289 XHG=91 XHG=252 XHG=456 XHG=702 XHG=968 XHG=1067 XHG=1243 YBD=1904 YBD=1897 YBD=1896 YBD=1897 YBD=1905 YHG=1868>general YHG=1867>condition YHG=1867>continued.. YHG=1868>When YHG=1868>taken YHG=1868>into YHG=1868>hospital YHG=1878>on XBD=175 XHG=723 XBD=330 XBD=404 XBD=523 XBD=698 XBD=920 XBD=1008 XBD=1100 XBD=1290 XHG=91 XHG=187 XHG=343 XHG=416 XHG=535 XHG=945 XHG=1019 XHG=1115 YBD=1944 YBD=1942 YBD=1936 YBD=1944 YBD=1936 YBD=1936 YBD=1942 YHG=1908>May YHG=1907>3, YHG=1907>the YHG=1908>blood YHG=1907>showed YHG=1907>Hb. YHG=1909>red YHG=1908>cells YHG=1909>1,230,000 1942, 32% XBD=1442 XBD=1510 XBD=1615 XBD=1690 XBD=1811 XBD=1896 XBD=2024 XBD=2180 XBD=2296 XBD=2402 XHG=1352 XHG=1464 XHG=1531 XHG=1637 XHG=1717 XHG=1834 XHG=1918 XHG=2045 XHG=2202 XHG=2331 YBD=1945 YBD=1935 YBD=1944 YBD=1940 YBD=1943 YBD=1934 YHG=1908>pital YHG=1917>on YHG=1908>May YHG=1908>20, YHG=1907>1942, YHG=1907>the YHG=1906>blood YHG=1906>picture YHG=1914>was YHG=1905>Hb. ::; XBD=1415 XBD=1510 XBD=1725 XBD=1800 XBD=1906 XHG=1353 XHG=1430 XHG=1529 XHG=1756 XHG=1820 1-3 ; YBD=1974 YBD=1976 YBD=1981 YBD=1975 YHG=1947>red YHG=1947>cells YHG=1948>1,190,000 YHG=1947>CI YHG=1947>1.51. ; XBD=768 XBD=934 XHG=521 YBD=1984 YBD=1983 YHG=1947>reticulocytes YHG=1947>2/1,000. XBD=156 XHG=787 XBD=315 XBD=392 XHG=92 XHG=174 XHG=347 YBD=1984 YBD=1981 YBD=1975 YHG=1956>per YHG=1955>c.mm.; YHG=1947>CI
’
every
’::t:
ill; 2’5
36%; of’known
" XBD=2368 XBD=2536XHG=861 XBD=1448 XBD=1582 XBD=1632 XBD=1703 XBD=1753 XBD=1852 XBD=2004 XHG=1399 XHG=1463 XHG=1596 XHG=1646 XHG=1723 XHG=1765 XHG=1866 XHG=2216 XHG=2383 YBD=2015 YBD=2023 YBD=2020 YBD=2014 YBD=2022 YBD=2021 YHG=1987>As YHG=1987>shown YHG=1987>in YHG=1987>fig. YHG=1987>3, YHG=1987>liver YHG=1988>extract YHG=1987>potency YHG=1984>together XBD=285 XBD=339 XBD=412 XBD=497 XBD=584 XBD=845 XBD=900 XBD=1000 XBD=1102 XBD=1188 XBD=1292 XHG=138 XHG=299 XHG=351 XHG=428 XHG=513 XHG=601 XHG=912YBD=2015 XHG=1014 XHG=1116 XHG=1203 YBD=2024 YBD=2015 YBD=2016 YHG=1985>Neither YHG=1986>of YHG=1987>the YHG=1987>last YHG=1989>two YHG=1987>preparations YHG=1987>of YHG=1987>liver YHG=1987>used YHG=1987>had YHG=1987>been " XBD=2535 XBD=1442 XBD=1609 XBD=1651 XBD=1805 XBD=1976 XBD=2053 XBD=2175 XBD=2325 XBD=2380 XHG=1354 XHG=1458 XHG=1625 XHG=1666 XHG=1820 XHG=1991 XHG=2068 XHG=2191 XHG=2341 XHG=2396 YBD=2063 YBD=2054 YBD=2061 YBD=2053 YHG=2026>with YHG=2026>vitamin YHG=2026>C YHG=2027>rapidly YHG=2026>restored YHG=2025>the YHG=2024>blood YHG=2025>picture YHG=2027>to YHG=2025>normal. XBD=210 XHG=738 XBD=263 XBD=349 XBD=591 XBD=679 XBD=723 XBD=810 XBD=980 XBD=1077 XBD=1154 XBD=1293 XHG=825 XHG=92 XHG=225 XHG=278 XHG=366 XHG=607 XHG=693 XHG=996 XHG=1093 XHG=1170 YBD=2054 YBD=2054 YBD=2055 YBD=2063 YBD=2055 YBD=2055 YHG=2025>tested YHG=2026>in YHG=2026>this YHG=2026>department YHG=2027>and YHG=2027>it YHG=2036>was YHG=2027>thought YHG=2027>that YHG=2027>the YHG=2027>failure XBD=1442 XBD=1575 XBD=1688 XBD=1897 XBD=1978 XBD=2105 XBD=2232 XBD=2304 XBD=2409 XHG=1355 XHG=1462 XHG=1596 XHG=1707 XHG=1917 XHG=1998 XHG=2126 XHG=2252 XHG=2338 XHG=2434 YBD=2094 YBD=2092 YBD=2093 YBD=2101 YHG=2065>Five YHG=2066>weeks YHG=2066>after YHG=2065>admission YHG=2065>the YHG=2064>blood YHG=2066>count YHG=2065>is YHG=2064>Hb. YHG=2064>82% :; " XBD=2535 XBD=132 XHG=796 XBD=300 XBD=430 XBD=537 XBD=641 XBD=725 XBD=780 XBD=889 XBD=1049 XBD=1292 XHG=93 XHG=149 XHG=315 XHG=445 XHG=552 XHG=658 XHG=741 XHG=903 XHG=1066 YBD=2093 YBD=2101 YBD=2102 YBD=2095 YBD=2094 YBD=2095 YBD=2103 YHG=2067>to YHG=2066>respond YHG=2065>might YHG=2066>have YHG=2066>been YHG=2067>due YHG=2068>to YHG=2066>their YHG=2067>relative YHG=2067>impotency ; 0-78.
" XBD=1806 XBD=1418 XBD=1515 XBD=1731 XHG=1357 XHG=1435 XHG=1533 XHG=1762 YBD=2139 YBD=2133 YHG=2106>red YHG=2105>cells YHG=2106>5,280,000 YHG=2104>CI ; XBD=157 XHG=844 XBD=309 XBD=393 XBD=579 XBD=731 XBD=831 XBD=865 XBD=1105 XBD=1158 XBD=1294 XHG=94 XHG=170 XHG=321 XHG=406 XHG=591 XHG=743 XHG=878 XHG=1118 XHG=1166 YBD=2133 YBD=2142 YBD=2134 YBD=2142 YBD=2134 YBD=2135 YHG=2105>the YHG=2105>patient YHG=2115>was YHG=2106>therefore YHG=2107>treated YHG=2106>with YHG=2115>a YHG=2106>preparation YHG=2107>of YHG=2106>known
" " " " " " " " " " " " " " "
XBD=1294XHG=764 XBD=249 XBD=307 XBD=457 XBD=533 XBD=742 XBD=846 XBD=1080 XBD=1140 XHG=94 XHG=269 XHG=329 XHG=479 XHG=555 XHG=867 XHG=1103 XHG=1165 YBD=2182 YBD=2173 YBD=2182 YBD=2174 YBD=2174 YBD=2174 YHG=2147>potency YHG=2145>in YHG=2145>dosage YHG=2145>far YHG=2146>exceeding YHG=2146>that YHG=2146>established YHG=2155>as YHG=2145>&dquo; stanXBD=220 XBD=297 XBD=388 XBD=632 XBD=768 XBD=881 XBD=1016 XBD=1146 XBD=1295 XHG=96 XHG=242 XHG=316 XHG=408 XHG=656 XHG=790 XHG=906 XHG=1064 XHG=1168 YBD=2212 YBD=2221 YBD=2213 YBD=2220 YBD=2213 YBD=2222 YHG=2183>dard YHG=2184>for YHG=2184>this YHG=2185>department YHG=2185>(Della YHG=2185>Vida YHG=2185>1942). YHG=2185>This YHG=2185>dosage &dquo; XBD=1460 XBD=1539 XBD=1646 XBD=1749 XBD=1867 XBD=2048 XBD=2157 XBD=2291 XBD=2539 XHG=1406 XHG=1472 XHG=1552 XHG=1660 XHG=1761 XHG=1880 XHG=2061 XHG=2170 XHG=2304 YBD=2241 YBD=2234 YHG=2205>At YHG=2204>the YHG=2204>time YHG=2204>that YHG=2204>these YHG=2204>patients YHG=2213>were YHG=2204>under YHG=2204>observation XBD=276 XBD=370 XBD=400 XBD=514 XBD=594 XBD=878 XBD=1114 XBD=1294 XHG=97 XHG=287 XHG=378 XHG=408 XHG=523 XHG=601 XHG=885 XHG=1120 YBD=2260 YBD=2252 YBD=2253 YBD=2261 YBD=2260 YBD=2261 YHG=2224>produced YHG=2225>only YHG=2233>a YHG=2224>slight YHG=2225>and YHG=2225>unsatisfactory YHG=2225>reticulocyte YHG=2233>response. XBD=1633 XBD=1786 XBD=1853 XBD=1938 XBD=2116 XBD=2300 XBD=2480 XBD=2543 XHG=1566 XHG=1658 XHG=1809 XHG=1872 XHG=1963 XHG=2138 XHG=2324 XHG=2503 YBD=2274 YBD=2281 YBD=2273 YHG=2244>spring YHG=2244>of YHG=2244>the YHG=2244>present YHG=2253>year-a YHG=2243>number YHG=2243>of Redoxon ’ XBD=257 XBD=299 XBD=351 XBD=428 XBD=535 XBD=612 XBD=990 XBD=1077 XBD=1178 XBD=1297 XHG=97 XHG=274 XHG=314 XHG=366 XHG=444 XHG=551 XHG=843 XHG=1006 XHG=1092 XHG=1194 YBD=2291 YBD=2293 YBD=2292 YBD=2300 YBD=2292 YBD=2301 YHG=2263>Vitamin YHG=2264>C YHG=2264>in YHG=2264>the YHG=2264>form YHG=2264>of YHG=2264>(Roche) YHG=2273>was YHG=2264>then YHG=2265>given ’ XBD=1532 XBD=1669 XBD=1917 XBD=2115 XBD=2352 XBD=2431 XBD=2539 XHG=1359 XHG=1569 XHG=1706 XHG=1955 XHG=2153 XHG=2389 XHG=2466 YBD=2321 YBD=2313 YBD=2320 YBD=2314 YHG=2283>sufferers YHG=2284>from YHG=2283>pernicious YHG=2284>anaemia YHG=2283>attending YHG=2284>at YHG=2282>this XBD=134 XBD=259 XBD=322 XBD=406 XBD=499 XBD=631 XBD=777 XBD=1045 XBD=1108 XBD=1187 XBD=1297 XHG=95 XHG=159 XHG=282 XHG=343 XHG=428 XHG=525 XHG=678 XHG=800 XHG=1069 XHG=1126 XHG=1211 YBD=2331 YBD=2331 YBD=2332 YBD=2341 YBD=2333 YBD=2333 YBD=2332 YHG=2302>in YHG=2303>doses YHG=2304>of YHG=2304>300 YHG=2313>mg. YHG=2305>daily. YHG=2304>With YHG=2304>continuation YHG=2304>of YHG=2304>the YHG=2305>liver XBD=1604 XBD=1717 XBD=1857 XBD=1917 XBD=2033 XBD=2097 XBD=2212 XBD=2340 XBD=2536 XHG=1360 XHG=1621 XHG=1736 XHG=1875 XHG=1935 XHG=2054 XHG=2113 XHG=2230 XHG=2358 YBD=2361 YBD=2352 YBD=2360 YBD=2353 YHG=2324>department YHG=2332>were YHG=2323>found YHG=2323>in YHG=2323>spite YHG=2323>of YHG=2323>their YHG=2324>usual YHG=2323>maintene XBD=1191 XBD=1297 XHG=1020 YBD=2380 YHG=2343>dosage XBD=1454 XHG=1236 XBD=1613 XBD=1678 XBD=1788 XBD=1849 XBD=1918 XBD=2106 XBD=2151 XBD=2401 XBD=2485 XBD=2541 XHG=1361 YBD=2372 XHG=1475 XHG=1634 XHG=1693 XHG=1807 XHG=1870 XHG=1938 XHG=2127 XHG=2169 XHG=2420 XHG=2503 YBD=2399 YHG=2344>the YBD=2400 YBD=2393 YBD=2392 YHG=2372>ance YHG=2363>dosage YHG=2363>of YHG=2362>liver YHG=2363>to YHG=2362>be YHG=2362>showing YHG=2372>a YHG=2362>progressive YHG=2362>fall YHG=2363>in XBD=1123 XBD=1296 XHG=1016 XHG=1149 YBD=2412 YBD=2411 YHG=2383>blood YHG=2383>condiXBD=1426 XBD=1597 XBD=1740 XBD=1900 XBD=1940 XBD=2122 XBD=2269 XBD=2328 XBD=2498 XBD=2538 XHG=1361 XHG=1443 XHG=1612 XHG=1789 XHG=1916 XHG=1954 XHG=2140 XHG=2285 XHG=2340 XHG=2514 YBD=2439 YBD=2433 YBD=2432 YHG=2403>the YHG=2402>red-cell YHG=2403>count. YHG=2402>After YHG=2412>a YHG=2403>month’s YHG=2412>course YHG=2402>of YHG=2402>vitamin YHG=2402>C XBD=1093 XBD=1297 XHG=1017 YBD=2452 YHG=2423>tion XBD=1431 XHG=1114 XBD=1527 XBD=1652 XBD=1720 XBD=1844 XBD=2031 XBD=2213 XBD=2307 XBD=2486 XBD=2540 XHG=1364 YBD=2460 XHG=1451 XHG=1547 XHG=1670 XHG=1738 XHG=1862 XHG=2048 XHG=2230 XHG=2324 XHG=2503 YBD=2480 YHG=2423>improved YBD=2473 YBD=2472 YHG=2443>100 YHG=2452>mg. YHG=2442>daily YHG=2442>all YHG=2442>these YHG=2443>patients YHG=2443>without YHG=2451>any YHG=2442>increase YHG=2442>in
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XBD=2541 XBD=1460 XBD=1745 XBD=1856 XBD=1922 XBD=2033 XBD=2203 XBD=2375 XBD=2420 XBD=1075 XBD=1145 XBD=1298 XBD=1528 XBD=1600 XBD=1675 XBD=1746 XBD=1967 XBD=2062 XBD=2178 XBD=2273 XBD=2424 XBD=2541 XBD=1156 XBD=1199 XBD=1298 XBD=1653 XBD=1951 XBD=2012 XBD=2098 XBD=2269 XBD=2429 XBD=1120 XBD=1248 XBD=1299 XBD=1445 XBD=1582 XBD=1645 XBD=1727 XBD=1959 XBD=2363 XBD=2542 XBD=1300
" XBD=2068 XHG=1834 YBD=2187 YHG=2164>DISCUSSION
I
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-during
.,_ _
" XBD=1298 XBD=1057 XHG=1262 XBD=1220 XHG=1019 YBD=2491 XHG=1100 YBD=2492 YHG=2464>in YHG=2473>as YHG=2464>shown
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XBD=2542 XBD=1563 XBD=1651 XBD=1917 XBD=2081 XBD=2169 XBD=2358 XBD=1123 XBD=1300 XBD=1444 XBD=1547 XBD=1698 XBD=1779 XBD=1923 XBD=1982 XBD=2085 XBD=2180 XBD=2236 XBD=2276 XBD=2403 XBD=2543 XBD=1112 XBD=1300 XBD=1452 XBD=1510 XBD=1613 XBD=1653 XBD=1890 XBD=1946 XBD=2064 XBD=2229 XBD=2266 XBD=2541 XBD=1097 XBD=1297 XBD=1404 XBD=1490 XBD=1625 XBD=1817 XBD=1951 XBD=2064 XBD=2151 XBD=2271 XBD=2335 XBD=2417 XBD=2543 XBD=1213 XBD=1301 XBD=1506 XBD=1564 XBD=1764 XBD=1102 XBD=1300
XHG=2440 XHG=1361 XHG=1480 XHG=1768 XHG=1879 XHG=1938 XHG=2055 XHG=2224 XHG=2396 YBD=2514 YBD=2513 YBD=2512 YBD=2520 YHG=2483>their YHG=2481>maintenance YHG=2482>dose YHG=2482>of YHG=2482>liver YHG=2483>extract YHG=2483>showed YHG=2492>a YHG=2481>rapid XHG=1018 XHG=1117 XHG=1207 YBD=2540 YBD=2531 YBD=2530 YHG=2504>fig. YHG=2505>1. YHG=2503>The XHG=1361 XHG=1555 XHG=1622 XHG=1703 XHG=1777 XHG=1996 XHG=2092 XHG=2206 XHG=2302 XHG=2452 YBD=2557 YBD=2559 YBD=2551 YBD=2552 YHG=2522>increase YHG=2522>of YHG=2531>up YHG=2522>to YHG=2522>1,000,000 YHG=2521>red YHG=2522>cells YHG=2531>per YHG=2531>c.mm. YHG=2522>with XHG=979 XHG=1170 XHG=1220 YBD=2581 YBD=2571 YBD=2570 YHG=2543>patient YHG=2542>is YHG=2551>now XHG=1362YBD=2618 XHG=1673 XHG=1971 XHG=2032 XHG=2120 XHG=2290 YBD=2591YHG=2583>well YBD=2599 YBD=2592 YHG=2561>corresponding YHG=2561>improvement YHG=2561>in YHG=2561>the YHG=2562>general YHG=2562>health. XHG=979 XHG=1155 XHG=1277 YBD=2610 YBD=2609 YHG=2582>and YHG=2590>a XHG=1409 XHG=1465 XHG=1602 XHG=1661 YBD=2630YHG=2622>bloodYHG=2601>A YHG=2601>study YHG=2601>the XHG=1916 XHG=1975 XHG=2382 YBD=2631 YBD=2638 YBD=2639 YHG=2601>of YHG=2601>pernicious-anaemia YHG=2601>patients t XHG=979 YBD=2651 count
records
XHG=2381 XHG=1363 XHG=1585 XHG=1674 XHG=1937 XHG=2104 XHG=2191 YBD=2677 YBD=2670 YHG=2640>attending YHG=2640>the YHG=2640>department YHG=2641>reveals YHG=2641>the YHG=2641>hitherto XHG=1019 YBD=2671 XHG=1153 YBD=2691 YHG=2640>unnoted YBD=2690 YHG=2662>four YHG=2661>weeks XHG=1362 YBD=2710 XHG=1459 XHG=1562 XHG=1712 XHG=1795 XHG=1938 XHG=1996 XHG=2103 XHG=2195 XHG=2253 XHG=2291 XHG=2418 YBD=2716 YBD=2717 YBD=2709 YBD=2711 YHG=2680>fact YHG=2680>that YHG=2679>during YHG=2680>the YHG=2680>spring YHG=2680>of YHG=2680>1941 YHG=2680>and YHG=2681>to YHG=2690>a YHG=2681>lesser XHG=1020 XHG=1173 YBD=2730 YHG=2681>extent YBD=2729 YHG=2702>after YHG=2701>admisXHG=1363 XHG=1466 XHG=1523 XHG=1629 XHG=1666 XHG=1904 XHG=1957 XHG=2077 XHG=2243 XHG=2281 YBD=2756 YBD=2749 YBD=2750 YHG=2719>that YHG=2719>of YHG=2719>1940 YHG=2719>proportion YHG=2720>of YHG=2720>them YHG=2720>showed YHG=2729>a YHG=2720>deterioration XHG=979 YBD=2771 XHG=1134 YBD=2770YHG=2730>sion YHG=2740>showed : XHG=1363 XHG=1423 XHG=1510 XHG=1645 XHG=1852 XHG=1972 XHG=2084 XHG=2171 XHG=2293 XHG=2351 XHG=2436 YBD=2788 YBD=2796 YBD=2797 YBD=2789 YBD=2790 YHG=2759>in YHG=2759>the YHG=2754>picture YHG=2760>after YHG=2759>July YHG=2760>state YHG=2760>of YHG=2760>the YHG=2759>blood XHG=979 XHG=1240 YBD=2818 YBD=2808 YHG=2775>’ YHG=2779>red Hb.80%;; XHG=1364 XHG=1523 XHG=1581 YBD=2828 YBD=2836 YHG=2798>tended YHG=2799>to YHG=2799>improve. XHG=979 YBD=2863 XHG=1112 YBD=2854YHG=2821>cells YHG=2820>4,170,000.
" XBD=2543 XBD=1515 XHG=2500 XBD=1609 XBD=1718 XBD=1789 XBD=1883 XBD=2060 XBD=2313 XBD=2474 XHG=1414 YBD=2868 XHG=1542 XHG=1638 XHG=1746 XHG=1814 XHG=1912 XHG=2088 XHG=2341 YBD=2867 YHG=2839>be YBD=2875 YBD=2877 YBD=2869 YHG=2838>That YHG=2838>the YHG=2838>diet YHG=2838>of YHG=2847>our YHG=2839>general YHG=2838>population YHG=2838>should i " XBD=1186 XHG=1069 YBD=2904 YHG=2875>CASE " XBD=1302 XBD=1543 XHG=1218 XBD=1604 XBD=1789 XBD=1837 XBD=1996 XBD=2151 XBD=2291 XBD=2402 XBD=2540 XHG=1367 YBD=2902 XHG=1563 XHG=1624 XHG=1810 XHG=1860 XHG=2015 XHG=2170 XHG=2324 XHG=2423 YBD=2915 YHG=2874>2.YBD=2907 YBD=2908 YHG=2877>deficient YHG=2877>in YHG=2877>vitamin YHG=2878>C YHG=2877>during YHG=2878>winter YHG=2871>under YHG=2887>war YHG=2878>condi-
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XBD=1174 XBD=1303 XHG=1023 YBD=2947 XHG=1223 XHG=1284 YBD=2948 YHG=2918>been YBD=2949 YBD=2940 YHG=2915>Female, ; YHG=2922>age YHG=2922>e XBD=2545 XHG=2456 XBD=1468 XBD=1564 XBD=1627 XBD=1696 XBD=1924 XBD=2049 XBD=2162 XBD=2349 XBD=2436 XHG=1366 XHG=1487 XHG=1585 XHG=1648 XHG=1716 XHG=1960 XHG=2068 XHG=2182 XHG=2368 YBD=2955 YBD=2954 YHG=2917>tions YHG=2926>was YHG=2918>to YHG=2917>be YHG=2917>expected YHG=2917>that YHG=2917>such YHG=2917>actually YHG=2918>has XBD=1079 XBD=1304 XHG=1026 YBD=2987 XHG=1112 YBD=2982 YHG=2956>and YHG=2955>67. YHG=2953>OnadmisXBD=1433 XBD=1543 XBD=1636 XBD=1758 XBD=2145 XBD=2301 XBD=2450 XBD=2544 XHG=1366 XHG=1459 XHG=1567 XHG=1661 XHG=2091 XHG=2169 XHG=2330 XHG=2474 YBD=2986 YBD=2994 YBD=2993 YHG=2957>the YHG=2966>case YHG=2957>has YHG=2957>been YHG=2956>by YHG=2956>Harris YHG=2957>(1942) I-Blood XBD=161 XBD=446 XBD=486 XBD=647 XBD=725 XBD=841 XBD=880 XBD=988 XHG=109 XHG=319 XHG=455 XHG=499 XHG=659 XHG=737 XHG=852 XHG=890 YBD=3002 YBD=3000 YBD=2995 YBD=2997 YBD=2998 YBD=2999 YHG=2973>Fig. YHG=2979>response YHG=2977>to YHG=2974>parenteral YHG=2973>liver YHG=2980>extract YHG=2975>of YHG=2975>known XBD=1183 XBD=1304 XHG=1137 XHG=1226 XHG=1285 YBD=3022 YBD=3021 YHG=2996>to YHG=2993>the YHG=3002>e sion XBD=442 XHG=746 XBD=536 XBD=602 XBD=729 XBD=778 XHG=328 XHG=460 XHG=553 XHG=620 YBD=3032 YBD=3031 YBD=3026 YBD=3027 YHG=3008>potency YHG=3003>(PLE) YHG=3003>and YHG=3005>vitamin YHG=3004>C. XBD=1522 XBD=1607 XBD=1798 XBD=1946 XBD=2076 XBD=2175 XBD=2322 XBD=2384 XBD=2546 XHG=1366 XHG=1531 XHG=1617 XHG=1812 XHG=1998 XHG=2087 XHG=2185 XHG=2331 XHG=2392 YBD=3026 YBD=3033 YBD=3034 YBD=3027 YHG=2996>Francis YHG=2997>and YHG=2996>Wormall YHG=2996>(1942). YHG=2996>The YHG=2996>part YHG=2996>played YHG=2996>by YHG=2997>vitamin XBD=1304 XHG=2377 XHG=1027 YBD=3066 YBD=3070 YHG=3037>observaYHG=3033>Royal H o s XBD=1450 XBD=1720 XBD=1765 XBD=1860 XBD=2099 XBD=2229 XBD=2364 XBD=2540 XHG=1408 XHG=1461 XHG=1732 XHG=1777 XHG=1872 XHG=2151 XHG=2242 YBD=3074 YBD=3073 YHG=3036>in YHG=3036>haemopoiesis YHG=3036>is YHG=3036>well YHG=3036>recognised. YHG=3036>The YHG=3036>above XBD=198 XHG=848 XBD=344 XBD=528 XBD=630 XBD=806 XBD=986 XBD=1072 XBD=1305 XHG=108 XHG=238 XHG=388 XHG=569 XHG=672 XHG=1031 XHG=1108 YBD=3100 YBD=3099 YBD=3108 YBD=3109 YBD=3100 YBD=3109 YHG=3072>pital YHG=3072>blood YHG=3072>showed YHG=3072>the YHG=3072>typical YHG=3074>picture YHG=3073>of YHG=3072>pernicious XBD=1470 XBD=1600 XBD=1666 XBD=1948 XBD=2061 XBD=2125 XBD=2358 XBD=2546 XHG=1367 XHG=1494 XHG=1624 XHG=1692 XHG=1973 XHG=2084 XHG=2147 XHG=2382 YBD=3106 YBD=3105 YBD=3112 YBD=3110 YHG=3075>tions YHG=3085>serve YHG=3076>to YHG=3075>demonstrate YHG=3076>that YHG=3076>in YHG=3075>pernicious YHG=3076>anaemia, XBD=280 XBD=380 XBD=507 XBD=596 XBD=690 XBD=905 XBD=978 XBD=1094 XBD=1180 XBD=1303 XHG=109 XHG=308 XHG=397 XHG=534 XHG=610 XHG=707 XHG=997 XHG=1122 XHG=1194 YBD=3140 YBD=3148 YBD=3145 YBD=3139 YBD=3145 YBD=3140 YBD=3148 YHG=3111>ansemia YHG=3112>Hb. YHG=3110>49% YHG=3111>red YHG=3111>cells YHG=3112>1,650,000 YHG=3112>CI YHG=3112>1-48 YHG=3111>CV YHG=3111>24% ; ; : ; XBD=1465XHG=933 XBD=1585 XBD=1737 XBD=1903 XBD=1975 XBD=2065 XBD=2332 XBD=2544 XHG=1368 XHG=1490 XHG=1613 XHG=1766 XHG=1931 XHG=1999 XHG=2093 XHG=2360 YBD=3153 YBD=3145 YBD=3152 YHG=3124>even YHG=3115>with YHG=3115>ample YHG=3114>dosage YHG=3115>of YHG=3114>the YHG=3114>antianaemic YHG=3115>principle, 8-5 u; YHG=3150>reticulocytes MD XBD=205 XBD=292 XBD=408 XBD=930 XBD=1017 XBD=1134 XBD=1304 XHG=108 XHG=231 XHG=310 XHG=945 XHG=1043 XHG=1160 YBD=3178 YBD=3190 YBD=3186 YBD=3179 YBD=3178 YBD=3187 YHG=3150>MCV YHG=3151>145 YHG=3151>c.jM; YHG=3151>less YHG=3151>than YHG=3150>1/1000 ; XBD=1628XHG=686 XBD=1785 XBD=1848 XBD=2042 XBD=2100 XBD=2263 XBD=2318 XBD=2399 XBD=2494 XBD=2548 XHG=1368 XHG=1645 XHG=1801 XHG=1864 XHG=2058 XHG=2117 XHG=2278 XHG=2334 XHG=2414 XHG=2509 YBD=3192 YBD=3185 YBD=3184 YHG=3154>hsemopoiesis YHG=3155>cannot YHG=3154>be YHG=3154>returned YHG=3155>to YHG=3154>normal YHG=3154>in YHG=3155>the YHG=3155>face YHG=3153>of XBD=216 XHG=761 XBD=330 XBD=450 XBD=726 XBD=870 XBD=1162 XBD=1304 XHG=108 XHG=250 XHG=364 XHG=485 XHG=916YBD=3228 XHG=1195 YBD=3218 YBD=3219 YBD=3226 YBD=3227 YBD=3227 YHG=3190>white YHG=3179>cells YHG=3191>5400 YHG=3189>(polymorphs YHG=3189>62% YHG=3190>lymphocytes YHG=3190>34% ; ; XBD=1393 XBD=1629 XBD=1703 XBD=1893 XBD=1963 XBD=2093 XBD=2376 XBD=2449 XBD=2569 XHG=1369 XHG=1424 XHG=1660 XHG=1729 XHG=1924 XHG=2014 XHG=2123 XHG=2406 XHG=2473 YBD=3225 YBD=3223 YBD=3231 YBD=3224 YBD=3233 YHG=3204>a YHG=3194>deficiency YHG=3195>of YHG=3194>vitamin YHG=3194>C. YHG=3194>The YHG=3194>implications YHG=3194>of YHG=3194>this XBD=419 XHG=868 XBD=663 XBD=804 XBD=855 XBD=930 XBD=1035 XBD=1086 XBD=1158 XBD=1306 XHG=109 XHG=446 XHG=712 XHG=816 XHG=942YBD=3257 XHG=1048 XHG=1098 XHG=1170 YBD=3265 YBD=3256 YBD=3266 YBD=3256 YBD=3257 YHG=3230>monocytes YHG=3228>eosins2%). YHG=3228>Shift YHG=3231>to YHG=3229>the YHG=3229>right YHG=3229>in YHG=3229>the YHG=3229>Arneth 2% ; XBD=1613 XBD=1725 XBD=1783 XBD=1866 XBD=2093 XBD=2154 XBD=2379 XBD=2550 XHG=1370 XHG=1629 XHG=1742 XHG=1800 XHG=1884 XHG=2111 XHG=2168 XHG=2398 YBD=3264 YBD=3270 YBD=3263 YHG=3233>observation YHG=3234>both YHG=3234>in YHG=3234>the YHG=3233>treatment YHG=3233>of YHG=3234>pernicious YHG=3234>anaemia basophilic XBD=1307 XHG=1140 YBD=3305 YHG=3268>stippling XBD=259 XHG=829 XBD=519 XBD=805 XBD=901 XHG=109 XHG=279 XHG=543 YBD=3301 YBD=3305 YBD=3304 YBD=3295 YHG=3270>count YHG=3268>anisocytosis, YHG=3267>poikilocytosis YHG=3268>and ; XBD=1447 XBD=1512 XBD=1599 XBD=1764 XBD=1828 XBD=1941 XBD=2226 XBD=2306 XBD=2549 XHG=1370 XHG=1470 XHG=1533 XHG=1620 XHG=1784 XHG=1847 XHG=1962 XHG=2246 XHG=2320 YBD=3302 YBD=3310 YHG=3273>and YHG=3273>in YHG=3273>the YHG=3273>testing YHG=3273>of YHG=3273>liver YHG=3272>preparations YHG=3272>for YHG=3273>therapeutic XBD=153 XBD=236 XBD=317 XBD=426 XBD=552 XBD=640 XBD=778 XBD=976 XBD=1137 XBD=1306 XHG=112 XHG=174 XHG=254 XHG=335 XHG=473 XHG=573 XHG=662 XHG=1010 XHG=1156 YBD=3336 YBD=3343 YBD=3335 YBD=3344 YHG=3307>of YHG=3307>the YHG=3307>red YHG=3308>cells. YHG=3307>Van YHG=3307>den YHG=3307>Bergh YHG=3306>reaction YHG=3307>faintly YHG=3308>positive : XBD=1435XHG=795 XBD=1519 XBD=1582 XBD=1757 XBD=2022 XHG=1373 XHG=1455 XHG=1539 XHG=1595 XHG=1774 YBD=3342 YBD=3343 YBD=3350 YHG=3320>use YHG=3321>are YHG=3312>of YHG=3312>obvious YHG=3312>importance. XBD=272 XHG=834 XBD=519 XBD=738 XBD=816 XBD=906 XBD=1020 XHG=111 XHG=318 XHG=536 XHG=770 XHG=924YBD=3373 YBD=3375 YBD=3374YHG=3345>free YHG=3346>indirect. YHG=3347>Fractional YHG=3346>test-meal YHG=3355>no YHG=3346>HC1. : XBD=240 XHG=797 XBD=394 XBD=448 XBD=647 XBD=686 XBD=779 XBD=837 XBD=1044 XBD=1209 XBD=1307 XHG=157 XHG=257 XHG=411 XHG=467 XHG=663 XHG=702 XHG=849YBD=3413 XHG=1061 XHG=1226 YBD=3415 YBD=3414 YBD=3422 YBD=3421 YBD=3414 YHG=3385>This YHG=3387>seemed YHG=3395>so YHG=3386>definitely YHG=3394>a YHG=3394>case YHG=3385>of YHG=3385>pernicious YHG=3386>anaemia YHG=3386>that XBD=142 XHG=975 XBD=230 XBD=399 XBD=471 XBD=652 XBD=731 XBD=902 XBD=960 XBD=998 XBD=1123 XBD=1182 XBD=1308 XHG=108 XHG=159 XHG=249 XHG=416 XHG=488 XHG=669 XHG=749 XHG=922 XHG=1015 XHG=1142 XHG=1195 YBD=3455 YBD=3454 YBD=3453 YBD=3461 YBD=3452 YBD=3451 YBD=3453 YBD=3452 YBD=3462 YHG=3426>it YHG=3434>was YHG=3426>selected YHG=3425>for YHG=3425>assaying YHG=3425>the YHG=3427>potency YHG=3424>of YHG=3433>a YHG=3424>batch YHG=3425>of YHG=3426>newly !VIr’I.,l
" XBD=1310 XBD=282 XHG=823 XBD=391 XBD=549 XBD=633 XBD=714 XBD=801 XBD=867 XBD=1120 XBD=1217 XHG=111 XHG=304 XHG=410 XHG=568 XHG=653 XHG=735 XHG=889YBD=3491 XHG=1167 XHG=1239 YBD=3502 YBD=3493 YBD=3492 YBD=3500 YBD=3501 YBD=3492 YBD=3492YHG=3473>on YBD=3493 YHG=3466>prepared YHG=3465>liver YHG=3467>extract YHG=3466>not YHG=3467>yet YHG=3467>put YHG=3462>the’market. YHG=3465>To YHG=3465>this
demonstrated -
’C
! L
: I
REFERENCES
Della Vida, B. L. (1942) Lancet, ii, 275. Francis, G. E. C. and Wormall, A. (1942) Ibid, i, 647. Harris, L. J. (1942) Ibid, i, 642.