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Vitamin E status in patients on intravenous hyperalimentation
0.93 VITAMIN E STATUS IN PATIENTS ON INTRAVENOUS HYPERALIMENTATION M. Vandewoude, G. Ieven, I. De Leeuw (Laboratory of Endocrinology Belgium)
and Nutrition, Univexity
of Antwerp
(UIA),
Vitamin E status was evaluated in 16 patients before and after a 2-week-period of intravenous hyperalimentation and compared to sex and age matched controls. Analysis of the different tocopherol isomers was performed in plasma and in samples of the used lipid emulsion by high performance liquid chromatography with electrochemical detection using 6-tocopherol as an internal standard. Plasma total tocopherol activity (defined as a-tocopherol t 0.2 V-tocopherol + 0.01 g-tocopherol) was considerably lower in the patient group as compared to the controls (0.94 + 0.58 mg/dl vs 1.45 t 0.66 mg/dl; p < 0.02). Pre-treatment vitamin E deficiency (total Tocopherol activity T 0.5 mg/dl) was found in 19 % of the patients, and borderline deficiency (0.5 0.7 mg/dl) in another 25 %, mainly in patients with gastrointestinal disorders. mean total vitamin E levels were reduced and After a period of hyperalimentation, biologically less active vitamin E isomers (V , 6 -tocopherol) made up a more important part of total tocopherol concentration, although the mean daily vitamin E supplementation (15.24 + 3.14 mg a-tocopherol equivalent) exceeded the RDA (10 mg a-tocopherol equivalent).The intravenous lipid emulsion contained only 7.9 % as a-tocopherol (6 t Y-tocopherol = 68.6 %; 6-tocopherol = 23.5 %). These results suggest that the large amounts of non d-, less biologically active isomers in commonly used commercial products do not provide enough vitamin E to meet A supplemental source of cl-tocopherol seems to be necessary in the requirements. patients on intravenous hyperalimentation.
0.84 Serum vitamins in grossly obese adelescents after 3 weeks weight reduction - 6 months follow-up1 2 K.Zwiauer , K.Widhalm', G.Brubacher*. ’ Dept.of Ped.Univ.of Vienna. Dept.Nutr.Vit.amin Research, HcjfmannLa Roche, Basel. The frequent therapeutic use of weight reducing regimens in the management of excessive body weight resulted in numerous investigations concerning protein- and carbohydrate metabolism. However, few reports exist in regards to vitamin blood concentrations during and after a rapid weight reduction in obese adolescent patients. Therefore we determined serum vitamin concentrations (A,E,C) and plasma transport proteinstretinol binding globulin, RBG; Transferrin,TF and Prealbumin,PA) in 16 obese adolescent boys (45211 S overweight, 12.1t1.2 years old) during a 3 week diet camp and after 6 months follow-up regime. The diet on the summer camp provided 800 Kcal(32oo KJ) consisting of 35 g protein and 60 g carbohydrate. Mean body weight loss was calculated to be 5.321.3 kg during the camp, after the camp the mean weight gain of the patients was 2.321.9 kg. Results: Vit.A Vit.E Vit.C TP mg/dl RBG 9.8+2.1,, begin 505+%,* l-1+0.4 334+46, 5.3+1.1** end 252+60,, 5.9X7,, 1.21;0.8 286+43 3.0+0.6,, 6 months 432584 9.4T2.0 1.270.4 263+62 5.4Tl.l ** p:o.O01 * p
and Nutrition, Univexity
of Antwerp
(UIA),
Vitamin E status was evaluated in 16 patients before and after a 2-week-period of intravenous hyperalimentation and compared to sex and age matched controls. Analysis of the different tocopherol isomers was performed in plasma and in samples of the used lipid emulsion by high performance liquid chromatography with electrochemical detection using 6-tocopherol as an internal standard. Plasma total tocopherol activity (defined as a-tocopherol t 0.2 V-tocopherol + 0.01 g-tocopherol) was considerably lower in the patient group as compared to the controls (0.94 + 0.58 mg/dl vs 1.45 t 0.66 mg/dl; p < 0.02). Pre-treatment vitamin E deficiency (total Tocopherol activity T 0.5 mg/dl) was found in 19 % of the patients, and borderline deficiency (0.5 0.7 mg/dl) in another 25 %, mainly in patients with gastrointestinal disorders. mean total vitamin E levels were reduced and After a period of hyperalimentation, biologically less active vitamin E isomers (V , 6 -tocopherol) made up a more important part of total tocopherol concentration, although the mean daily vitamin E supplementation (15.24 + 3.14 mg a-tocopherol equivalent) exceeded the RDA (10 mg a-tocopherol equivalent).The intravenous lipid emulsion contained only 7.9 % as a-tocopherol (6 t Y-tocopherol = 68.6 %; 6-tocopherol = 23.5 %). These results suggest that the large amounts of non d-, less biologically active isomers in commonly used commercial products do not provide enough vitamin E to meet A supplemental source of cl-tocopherol seems to be necessary in the requirements. patients on intravenous hyperalimentation.
0.84 Serum vitamins in grossly obese adelescents after 3 weeks weight reduction - 6 months follow-up1 2 K.Zwiauer , K.Widhalm', G.Brubacher*. ’ Dept.of Ped.Univ.of Vienna. Dept.Nutr.Vit.amin Research, HcjfmannLa Roche, Basel. The frequent therapeutic use of weight reducing regimens in the management of excessive body weight resulted in numerous investigations concerning protein- and carbohydrate metabolism. However, few reports exist in regards to vitamin blood concentrations during and after a rapid weight reduction in obese adolescent patients. Therefore we determined serum vitamin concentrations (A,E,C) and plasma transport proteinstretinol binding globulin, RBG; Transferrin,TF and Prealbumin,PA) in 16 obese adolescent boys (45211 S overweight, 12.1t1.2 years old) during a 3 week diet camp and after 6 months follow-up regime. The diet on the summer camp provided 800 Kcal(32oo KJ) consisting of 35 g protein and 60 g carbohydrate. Mean body weight loss was calculated to be 5.321.3 kg during the camp, after the camp the mean weight gain of the patients was 2.321.9 kg. Results: Vit.A Vit.E Vit.C TP mg/dl RBG 9.8+2.1,, begin 505+%,* l-1+0.4 334+46, 5.3+1.1** end 252+60,, 5.9X7,, 1.21;0.8 286+43 3.0+0.6,, 6 months 432584 9.4T2.0 1.270.4 263+62 5.4Tl.l ** p:o.O01 * p