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Voice and Speech Disorders: Medical Aspects.
110
Diseases of the Chest
LEO G. RIGLER
REFERENCES SABOUR, M. S., OSMAN, L. M., GLEN, J, FAHY, T. AND LAMB, P.: "Carcinoma of the Lung: Review of 509 Cases," Dis. Chest, 41: 530, 1962.
2 RIGLER, L. G., O'LOUGHLIN, B. J AND TUCK-
ER, R. C.: "The Duration of Carcinoma of the Lung," Dis. Chest, 23: 50, 1953. 3 RIGLER, L. G.: "A Roentgen Study of the
Evolution of Carcinoma of the Lung," ]. Thor. Surg., 34:283, 1957. 4 LIEBOW, A.: "Pathology of Carcinoma of Lung as Related to the Roentgen Shadow," Amer. ]. Roentgenol. and Rad. Therapy, 74: 383, 1955. 5 GARLAND, L. H.: "The Focus of Origin of Bronchial Carcinoma," Presented at l Oth International Congress of Radiology, August 27, 1962. LEO G. RIGLER, M.D., F.C.C.P.·
·Visiting Professor of Radiology, University of California.
Los Angeles, California
Book Review Voice and Speech Disorders: Medical Aspects. By NATHANIEL M. LEVIN, M.D., Charles C Thomas, Springfield, 1962, 966 pages, $27.50. This book presents an extensive review of the subject edited by Dr. Levin with 35 contributors. Included are chapters on the basic mechanisms of voice and speech, otology and audiology and the pathology and therapy of voice and speech. At the end of each chapter is a list of important references in the current literature. The book covers many subjects in great detail with good illustrations, clearly printed on an excellent paper.
It encompasses a much wider scope of clinical material than the title indicates and some of this, especially the surgical aspects of ear disease and throat malignancy, need not have been presented in such detail. This volume should be useful and valuable not only to physicians interested in voice and speech disorders, but to many others in allied fields who are concerned with the management of patients with such disabilities. BURTON ]. SOBOROFF, M.D.
DISTRIBUTION OF CI< LABELED INH IN HEALTHY AND TUBERCULOUS GUINEA PIGS Assessment of the rate and degree of INH and Its metabolites' penetration Into Internal organs of guinea pigs was carried out using Cl4 labeled INH. The determinations were made at various Intervals within 20 hours after the administration of the drug. The level of C'4 labeled INH Increased rapidly and reached Its peak one-half hour after the administration of the drug. The elimination of the drug was also rapid. The highest level was found In the kidneys and urine. next In the blood and the liver, and
next. In the lungs, the latter after one and one-half hours. The lowest level of INH was found In the brain and then In the muscles. Twenty hours after the administration of CI< labeled INH. the traces of INH and Its metabolites could be found In the Internal organs. A preliminary experiment showed a particular affinity of the drug to the specific lesions and most markedly to the caseous masses. OSEWSKI. T.: "Distribution of 0 4 Labeled INH in Healthy and Tuberculous Guinea Pigs," Gruzlic«, 30:69~, 1962.
STUDY OF A GROUP BCG VACCINATION PROGRAM INVOLVING 7400 SCHOOL CHILDREN The BCG vaccination program carried out In Meudon, France, a suburb of Paris, has been studied. In France In 1950, BCG vaccination was made compulsory for school children. A pilot program was set up In Meudon which was thought small enough for complete coverage, and large enough to yield comprehensIve data. The program was started In 1953, and by 1959, the study covered 7400 children between the ages of 6 and 14. The
authors found that tuberculosis Is related to social conditions and standard of :Ivlng, that tuberculosis morbidity Is elevated among school-age children and that none of the vaccinated children developed tuberculosis. MANDE, R., GUILLUY, H., FILLASTRE, e. AND ORSSAUD, E.: "Protection d'une Collectivite par le a.e.G.," Re», de T'uberc., 26:~98, 1962.
Diseases of the Chest
LEO G. RIGLER
REFERENCES SABOUR, M. S., OSMAN, L. M., GLEN, J, FAHY, T. AND LAMB, P.: "Carcinoma of the Lung: Review of 509 Cases," Dis. Chest, 41: 530, 1962.
2 RIGLER, L. G., O'LOUGHLIN, B. J AND TUCK-
ER, R. C.: "The Duration of Carcinoma of the Lung," Dis. Chest, 23: 50, 1953. 3 RIGLER, L. G.: "A Roentgen Study of the
Evolution of Carcinoma of the Lung," ]. Thor. Surg., 34:283, 1957. 4 LIEBOW, A.: "Pathology of Carcinoma of Lung as Related to the Roentgen Shadow," Amer. ]. Roentgenol. and Rad. Therapy, 74: 383, 1955. 5 GARLAND, L. H.: "The Focus of Origin of Bronchial Carcinoma," Presented at l Oth International Congress of Radiology, August 27, 1962. LEO G. RIGLER, M.D., F.C.C.P.·
·Visiting Professor of Radiology, University of California.
Los Angeles, California
Book Review Voice and Speech Disorders: Medical Aspects. By NATHANIEL M. LEVIN, M.D., Charles C Thomas, Springfield, 1962, 966 pages, $27.50. This book presents an extensive review of the subject edited by Dr. Levin with 35 contributors. Included are chapters on the basic mechanisms of voice and speech, otology and audiology and the pathology and therapy of voice and speech. At the end of each chapter is a list of important references in the current literature. The book covers many subjects in great detail with good illustrations, clearly printed on an excellent paper.
It encompasses a much wider scope of clinical material than the title indicates and some of this, especially the surgical aspects of ear disease and throat malignancy, need not have been presented in such detail. This volume should be useful and valuable not only to physicians interested in voice and speech disorders, but to many others in allied fields who are concerned with the management of patients with such disabilities. BURTON ]. SOBOROFF, M.D.
DISTRIBUTION OF CI< LABELED INH IN HEALTHY AND TUBERCULOUS GUINEA PIGS Assessment of the rate and degree of INH and Its metabolites' penetration Into Internal organs of guinea pigs was carried out using Cl4 labeled INH. The determinations were made at various Intervals within 20 hours after the administration of the drug. The level of C'4 labeled INH Increased rapidly and reached Its peak one-half hour after the administration of the drug. The elimination of the drug was also rapid. The highest level was found In the kidneys and urine. next In the blood and the liver, and
next. In the lungs, the latter after one and one-half hours. The lowest level of INH was found In the brain and then In the muscles. Twenty hours after the administration of CI< labeled INH. the traces of INH and Its metabolites could be found In the Internal organs. A preliminary experiment showed a particular affinity of the drug to the specific lesions and most markedly to the caseous masses. OSEWSKI. T.: "Distribution of 0 4 Labeled INH in Healthy and Tuberculous Guinea Pigs," Gruzlic«, 30:69~, 1962.
STUDY OF A GROUP BCG VACCINATION PROGRAM INVOLVING 7400 SCHOOL CHILDREN The BCG vaccination program carried out In Meudon, France, a suburb of Paris, has been studied. In France In 1950, BCG vaccination was made compulsory for school children. A pilot program was set up In Meudon which was thought small enough for complete coverage, and large enough to yield comprehensIve data. The program was started In 1953, and by 1959, the study covered 7400 children between the ages of 6 and 14. The
authors found that tuberculosis Is related to social conditions and standard of :Ivlng, that tuberculosis morbidity Is elevated among school-age children and that none of the vaccinated children developed tuberculosis. MANDE, R., GUILLUY, H., FILLASTRE, e. AND ORSSAUD, E.: "Protection d'une Collectivite par le a.e.G.," Re», de T'uberc., 26:~98, 1962.