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Volume 12 Keyword index
Volume 12 2004: Keyword Index Cathepsin B, 239 Cell death, 106, 131, 245, 485, 577 Cell line, 924 Cell migration, 834 Chondroadherin, 149 Chondrocalcinosis, 321 Chondrocyte mechanotransduction, 937 Chondrocyte pellet culture, 599 Chondrocyte, 1, 17, 25, 56, 74, 117, 448, 543, 711, 779, 870, 917, 924, Chondrogenesis, 476, 525, 834 Chondrogenic repair, 586 Chondroinduction, 497 Chondroitin sulfate, 269 Chondrolysis, 149 Chondro-osteophyte, 771 Chondrosarcoma, 924 Clinical Trials Response Criteria Initiative, 389 Clinical trials, 225 Co-contraction, 745 Col11a1, 314 Collagen arcades, 97 Collagen, 74, 667, 752, 887, 904, 956 Collagenase, 239 COMP, 818 Computed radiography, 256 Computer measurement, 765 Confocal, 17 Coupling activity, 142 Coupling-factor, 142 COX-1, 2, 658 Coxarthrosis, 704 COXcyclooxygenase, 658 CPPD, 321 Cryoprotectants, 787 CTGF/Hcs24/CCN2, 771 Cultured chondrocytes, 568 Cytokine, 409 Cytokines, 729 Cytoskeleton, 17
A (V+C)- fibronectin, 818 AAarachidonic acid, 658 Acetabular labrum, 419 ADAMTS-4, 5, 599 Adenosine Deaminase, 349 Adenosine, 349 Adenoviral gene transfer, 599 Adipocytes, 25 Adult, 25 Age, 636 Aggrecan, 536, 904 Aggrecanase, 296, 720, 1006 Aging, 917 Alginate cultures, 559 Alginate, 448 Animal model, 160, 419, 614 ANOVAanalysis of variance, 160 Apoptosis, 1, 131, 245, 448, 779, 779, 917 Arthritis, 863 Articular cartilage, 106, 232, 314, 336, 543, 577, 793, 826, 834, 917 Articular chondrocytes, 525 Atomic force microscopy, 947 Attachment, 56 Autologous cell transplantation, 525 Autologous chondrocyte transplantation, 559 B Bilateral knee arthroplasty, 400 Biochemical markers, 263, 277 Biomarker, 818, 843 Biomechanics, 667, 826, 956 BMP, 559 Bone mineral density, 986 Bone resorption, 201 Bone–cartilage relationship, 752 Bovine aggrecanase, 599 bpbase pairs, 658 C Calcitonin, 904 Cartilage mechanics, 65 Cartilage mechanobiology, 937 Cartilage oligomeric matrix protein, 149 Cartilage radiography, 97 Cartilage repair, 191 Cartilage resurfacing, 201 Cartilage, 17, 38, 74, 97, 160, 169, 177, 296, 349, 374, 433, 485, 771, 779, 787, 801, 843, 870, 878, 924, 947, 982, 986, 1006 Caspase-3, 1, 448
D Dedifferentiated chondrocytes, 683 dedifferentiation, 306 Degradation, 349 Degraded collagen, 314 Demineralized bone, 497 Dermal fibroblast, 497 Differentiation, 476 Diffraction enhanced imaging, 97 Diffusion, 787 Disability, 366, 459
XXI
XXII Disease modification, 515 Drugs, 263 Dynamic loading, 65 Dysplasia, 650 E Eicosanoids, 469 Electron microscopy, 245 Electronic data capturing (EDC), 912 Electronic WOMAC 3.1, 912 ELISAenzyme-linked immunosorbent assay, 160, 658 EMF, 793 Endo180, 74 Epidemiology and coxarthrosis, 698 Epidemiology, 692 Equine, 826 ERTestrogen replacement therapy, 160 Exercise training, 826 Exercise, 779 Experimental osteoarthritis, 284, 779 F FGF-2, 834 Fibrin, 117 Fibroblast growth factor, 586, 963 Fibrochondrocyte, 736, 956 Fibronectin fragment, 149 FISH, 982 Focal adhesions, 56 Friction, 947 G Gait, 745 Gene expression, 336 Gene transfer, 217, 711 Genetics, 360 GFAT, 217 Glucosamine sulfate, 506 Glucosamine, 217 Glucose intolerance, 506 Glyceryl trinitrate, 974 Growth factor, 627, 736 H Hand osteoarthritis, 843 Hand, 360, 366 Handicap, 366, 459 Heat shock protein, 779 Hexosamine pathway, 506 Hip osteoarthritis, 704 Hip, 515, 650, 692, 698, 704 Histology, 667 Human articular cartilage, 852 human articular chondrocytes, 374 Human chondrocytes, 336, 729, 895 hyaluronan hexasaccharides, 374 Hyaluronan network, 142 Hyaluronan synthase, 374 Hyaluronan, 142, 904 Hyaluronate, 232 hyaluronic acid, 277, 642
Keyword Index Hyaluronidase, 1006 Hypoxia, 336, 433 I IGF-1 resistance, 863 IGFBPinsulin-like growth factor binding protein, 160 IGF-I, 793 IGFinsulin-like growth factor, 160 IL-1, 217 ILinterleukin, 658 Image registration, 614 Imaging, 177, 239 In situ hybridization, 811 In vivo, 636 Inflammation, 658 Inflammatory markers, 469 Insoles, 46 Insulin-like growth factor binding protein (IGFBP), 160 Insulin-like growth factor receptor, 863 Inter-alpha-trypsin inhibitor, 142 Interleukin 1, 284, 956 Interleukins, 801 Interstitial fluid pressurization, 947 Intra-articular injection, 636 Intra-articular, 642 Iodoacetate-induced arthritis, 720 ITI coupling, 142 ITI, 142 J joint space narrowing, 269 Joint space width, 515, 692, 698 Joint space, 765 Joint surfaces, 56 K Keratan sulfate, 904 Knee meniscus, 956 Knee osteoarthritis, 225, 269, 536, 745 Knee, 46, 86, 459, 642, 765, 997 KOS-ADLSknee outcome survey–activities of daily living scale, 745 L Late-stage osteoarthritis, 852 Laxity, 745 Lequesne’s algo-functional index, 269 Load-induced injury, 485 Loading sites, 752 Lower limb, 46 M Macrophage, 627 Magnetic Resonance Imaging, 86, 191, 614, 650, 878, 986, 997 Matrix metalloproteinase, 720, 963, 284, 729, 1006 Matrix synthesis, 106 Matrix, 924 m-Calpain, 895 Mechanical compression, 117, 887 Mechanical damage, 577
Osteoarthritis and Cartilage Vol. 12, Issue 12 Mechanical injury, 245 Mechanical loading, 729 Meniscectomy, 667 Meniscus, 736 Mesenchymal cell, 811 Microarray, 525 Micro-computed tomography, 614, 986 Minerals, 752 MMP, 38, 409 MRI, 177, 887 Murine oesteoarthritis, 131 Musculoskeletal, 86, 997 N nasal septum chondrocytes, 306 Near-infrared fluorescence, 239 Neoepitopes, 720 NF-kappaB (NF-_B), 552 NF-_B, 568 Nitric oxide, 469, 536, 552, 577, 863, 974 NMR, 787 NPP1, 321 N-propeptide IIA, 440 NRnormalized ratio, 658 NSAIDnonsteroidal anti-inflammatory drugs, 658 O OA, 419 OAosteoarthritis, 160, 745 Oncostatin M, 801 Organelle deformation, 937 Orthoses, 46 Osteoarthritis, 1, 17, 38, 46, 86, 160, 169, 177, 232, 239, 263, 277, 296, 314, 336, 360, 366, 389, 400, 409, 440, 459, 469, 515, 543, 552, 614, 627, 642, 658, 683, 692, 729, 765, 771, 801, 818, 870, 878, 904, 963, 974, 982, 986, 997 Osteochondral defect, 586, 811 Osteochondral graft, 201 osteogenic protein-1, 374 Osteophytes, 627 Outcome measures, 366 Outcomes, 225, 389 Ovine, 667 Oxidized LDL, 568 Oxygen tension, 306 P Pain, 459 Pannus, 38 Patient costs, 400 Patient self-assessment, 912 PC-1, 321 PCRpolymerase chain reaction, 658 pentosidine, 277 Perlecan, 852 PGE2, 895 PGprostaglandin, 658 Photograph, 360 Photooxidation, 201 Physiological stress levels, 65
XXIII Progenitor, 25 progression, 277 Proinflammatory cytokines, 683 Proliferation, 106 Proteoglycan degradation, 485 Proteoglycan, 667, 793, 852, 956 Proteoglycans, 232, 284 Proteoglycans, 878 Q QUALITOUCH method, 912 R Rabbit, 232, 986 Radiograph, 169, 765 Radiographic measurement, 256 Radiography of hip, 698 Radiography, 515 Radiologic epidemiology, 704 Randomized controlled trial, 642 RArheumatoid arthritis, 658 Rat model, 284 redifferentiation, 306, 448 Redifferentiation, 476, 525 relaxation, 887 Registration, 263 Response, 636 Rheumatoid arthritis, 440 RIAradioimmunoassay, 160 Rofecoxib, 912 ROS, 568 RTreverse transcription, 658 RUNX2, 963 S Schuss, 765 Scoring, 177 SEstandard error, 658 Shc/Erk1/2, 448 Sodium hyaluronate, 536 Static compression, 736 Strain, 956 Stress, 956 Stretch, 956 Stromelysin-1, 485 Structure modification, 515 Studies, 263 Subchondral bone, 201, 543, 974 Superficial zone protein, 947 Supplementation, 506 Synovial fibroblast, 409 Synovial fluid, 142, 818 Synovitis, 658 T T2 mapping, 2, 191 Testican, 870 Tetracycline-inducible gene regulation, 711 TGF, 296, 321 Thickness, 650 Tibio-femoral angle, 256
XXIV Tissue engineering, 117, 476, 559, 711 Tissue regeneration, 419 TNF-, 895 TNFtumor necrosis factor alpha, 658 Transgenic animal, 811 Translation, 459 Trauma, 106 Treatment, 263, 46 Trisomy 7, 982 TSG-6, 142 TUNEL, 245 Type II collagen, 440 U Unconfined compression, 65 uPARAP, 74
Keyword Index V Validation, 225 VEGF, 433, 683 Vimentin, 17 VLLGvastus lateralis–lateral gastrocnemius co-contraction, 745 VLLHvastus lateralis–lateral hamstrings co-contraction, 745 VMMGvastus medialis–medial gastrocnemius co-contraction, 745 VMMHvastus medialis–medial hamstrings co-contraction, 745 W Wnt, 497 WOMAC Index, 225 Wound margin, 106 X X-ray, 515
A (V+C)- fibronectin, 818 AAarachidonic acid, 658 Acetabular labrum, 419 ADAMTS-4, 5, 599 Adenosine Deaminase, 349 Adenosine, 349 Adenoviral gene transfer, 599 Adipocytes, 25 Adult, 25 Age, 636 Aggrecan, 536, 904 Aggrecanase, 296, 720, 1006 Aging, 917 Alginate cultures, 559 Alginate, 448 Animal model, 160, 419, 614 ANOVAanalysis of variance, 160 Apoptosis, 1, 131, 245, 448, 779, 779, 917 Arthritis, 863 Articular cartilage, 106, 232, 314, 336, 543, 577, 793, 826, 834, 917 Articular chondrocytes, 525 Atomic force microscopy, 947 Attachment, 56 Autologous cell transplantation, 525 Autologous chondrocyte transplantation, 559 B Bilateral knee arthroplasty, 400 Biochemical markers, 263, 277 Biomarker, 818, 843 Biomechanics, 667, 826, 956 BMP, 559 Bone mineral density, 986 Bone resorption, 201 Bone–cartilage relationship, 752 Bovine aggrecanase, 599 bpbase pairs, 658 C Calcitonin, 904 Cartilage mechanics, 65 Cartilage mechanobiology, 937 Cartilage oligomeric matrix protein, 149 Cartilage radiography, 97 Cartilage repair, 191 Cartilage resurfacing, 201 Cartilage, 17, 38, 74, 97, 160, 169, 177, 296, 349, 374, 433, 485, 771, 779, 787, 801, 843, 870, 878, 924, 947, 982, 986, 1006 Caspase-3, 1, 448
D Dedifferentiated chondrocytes, 683 dedifferentiation, 306 Degradation, 349 Degraded collagen, 314 Demineralized bone, 497 Dermal fibroblast, 497 Differentiation, 476 Diffraction enhanced imaging, 97 Diffusion, 787 Disability, 366, 459
XXI
XXII Disease modification, 515 Drugs, 263 Dynamic loading, 65 Dysplasia, 650 E Eicosanoids, 469 Electron microscopy, 245 Electronic data capturing (EDC), 912 Electronic WOMAC 3.1, 912 ELISAenzyme-linked immunosorbent assay, 160, 658 EMF, 793 Endo180, 74 Epidemiology and coxarthrosis, 698 Epidemiology, 692 Equine, 826 ERTestrogen replacement therapy, 160 Exercise training, 826 Exercise, 779 Experimental osteoarthritis, 284, 779 F FGF-2, 834 Fibrin, 117 Fibroblast growth factor, 586, 963 Fibrochondrocyte, 736, 956 Fibronectin fragment, 149 FISH, 982 Focal adhesions, 56 Friction, 947 G Gait, 745 Gene expression, 336 Gene transfer, 217, 711 Genetics, 360 GFAT, 217 Glucosamine sulfate, 506 Glucosamine, 217 Glucose intolerance, 506 Glyceryl trinitrate, 974 Growth factor, 627, 736 H Hand osteoarthritis, 843 Hand, 360, 366 Handicap, 366, 459 Heat shock protein, 779 Hexosamine pathway, 506 Hip osteoarthritis, 704 Hip, 515, 650, 692, 698, 704 Histology, 667 Human articular cartilage, 852 human articular chondrocytes, 374 Human chondrocytes, 336, 729, 895 hyaluronan hexasaccharides, 374 Hyaluronan network, 142 Hyaluronan synthase, 374 Hyaluronan, 142, 904 Hyaluronate, 232 hyaluronic acid, 277, 642
Keyword Index Hyaluronidase, 1006 Hypoxia, 336, 433 I IGF-1 resistance, 863 IGFBPinsulin-like growth factor binding protein, 160 IGF-I, 793 IGFinsulin-like growth factor, 160 IL-1, 217 ILinterleukin, 658 Image registration, 614 Imaging, 177, 239 In situ hybridization, 811 In vivo, 636 Inflammation, 658 Inflammatory markers, 469 Insoles, 46 Insulin-like growth factor binding protein (IGFBP), 160 Insulin-like growth factor receptor, 863 Inter-alpha-trypsin inhibitor, 142 Interleukin 1, 284, 956 Interleukins, 801 Interstitial fluid pressurization, 947 Intra-articular injection, 636 Intra-articular, 642 Iodoacetate-induced arthritis, 720 ITI coupling, 142 ITI, 142 J joint space narrowing, 269 Joint space width, 515, 692, 698 Joint space, 765 Joint surfaces, 56 K Keratan sulfate, 904 Knee meniscus, 956 Knee osteoarthritis, 225, 269, 536, 745 Knee, 46, 86, 459, 642, 765, 997 KOS-ADLSknee outcome survey–activities of daily living scale, 745 L Late-stage osteoarthritis, 852 Laxity, 745 Lequesne’s algo-functional index, 269 Load-induced injury, 485 Loading sites, 752 Lower limb, 46 M Macrophage, 627 Magnetic Resonance Imaging, 86, 191, 614, 650, 878, 986, 997 Matrix metalloproteinase, 720, 963, 284, 729, 1006 Matrix synthesis, 106 Matrix, 924 m-Calpain, 895 Mechanical compression, 117, 887 Mechanical damage, 577
Osteoarthritis and Cartilage Vol. 12, Issue 12 Mechanical injury, 245 Mechanical loading, 729 Meniscectomy, 667 Meniscus, 736 Mesenchymal cell, 811 Microarray, 525 Micro-computed tomography, 614, 986 Minerals, 752 MMP, 38, 409 MRI, 177, 887 Murine oesteoarthritis, 131 Musculoskeletal, 86, 997 N nasal septum chondrocytes, 306 Near-infrared fluorescence, 239 Neoepitopes, 720 NF-kappaB (NF-_B), 552 NF-_B, 568 Nitric oxide, 469, 536, 552, 577, 863, 974 NMR, 787 NPP1, 321 N-propeptide IIA, 440 NRnormalized ratio, 658 NSAIDnonsteroidal anti-inflammatory drugs, 658 O OA, 419 OAosteoarthritis, 160, 745 Oncostatin M, 801 Organelle deformation, 937 Orthoses, 46 Osteoarthritis, 1, 17, 38, 46, 86, 160, 169, 177, 232, 239, 263, 277, 296, 314, 336, 360, 366, 389, 400, 409, 440, 459, 469, 515, 543, 552, 614, 627, 642, 658, 683, 692, 729, 765, 771, 801, 818, 870, 878, 904, 963, 974, 982, 986, 997 Osteochondral defect, 586, 811 Osteochondral graft, 201 osteogenic protein-1, 374 Osteophytes, 627 Outcome measures, 366 Outcomes, 225, 389 Ovine, 667 Oxidized LDL, 568 Oxygen tension, 306 P Pain, 459 Pannus, 38 Patient costs, 400 Patient self-assessment, 912 PC-1, 321 PCRpolymerase chain reaction, 658 pentosidine, 277 Perlecan, 852 PGE2, 895 PGprostaglandin, 658 Photograph, 360 Photooxidation, 201 Physiological stress levels, 65
XXIII Progenitor, 25 progression, 277 Proinflammatory cytokines, 683 Proliferation, 106 Proteoglycan degradation, 485 Proteoglycan, 667, 793, 852, 956 Proteoglycans, 232, 284 Proteoglycans, 878 Q QUALITOUCH method, 912 R Rabbit, 232, 986 Radiograph, 169, 765 Radiographic measurement, 256 Radiography of hip, 698 Radiography, 515 Radiologic epidemiology, 704 Randomized controlled trial, 642 RArheumatoid arthritis, 658 Rat model, 284 redifferentiation, 306, 448 Redifferentiation, 476, 525 relaxation, 887 Registration, 263 Response, 636 Rheumatoid arthritis, 440 RIAradioimmunoassay, 160 Rofecoxib, 912 ROS, 568 RTreverse transcription, 658 RUNX2, 963 S Schuss, 765 Scoring, 177 SEstandard error, 658 Shc/Erk1/2, 448 Sodium hyaluronate, 536 Static compression, 736 Strain, 956 Stress, 956 Stretch, 956 Stromelysin-1, 485 Structure modification, 515 Studies, 263 Subchondral bone, 201, 543, 974 Superficial zone protein, 947 Supplementation, 506 Synovial fibroblast, 409 Synovial fluid, 142, 818 Synovitis, 658 T T2 mapping, 2, 191 Testican, 870 Tetracycline-inducible gene regulation, 711 TGF, 296, 321 Thickness, 650 Tibio-femoral angle, 256
XXIV Tissue engineering, 117, 476, 559, 711 Tissue regeneration, 419 TNF-, 895 TNFtumor necrosis factor alpha, 658 Transgenic animal, 811 Translation, 459 Trauma, 106 Treatment, 263, 46 Trisomy 7, 982 TSG-6, 142 TUNEL, 245 Type II collagen, 440 U Unconfined compression, 65 uPARAP, 74
Keyword Index V Validation, 225 VEGF, 433, 683 Vimentin, 17 VLLGvastus lateralis–lateral gastrocnemius co-contraction, 745 VLLHvastus lateralis–lateral hamstrings co-contraction, 745 VMMGvastus medialis–medial gastrocnemius co-contraction, 745 VMMHvastus medialis–medial hamstrings co-contraction, 745 W Wnt, 497 WOMAC Index, 225 Wound margin, 106 X X-ray, 515