subject index

Int. J. Radiation Oncology

INTERNATIONAL

JOURNAL

Biol. Phys., Vol. 31, No. 5, pp. III-XXI, 1995 Copyright 0 1995 Elsevier Science Ltd Printed in the USA. All tights reserved 0360-3016/95 $9.50 + .oo

OF

RAMATnN ONCOLOGY BIOIDGY~PHYSICS

VOLUME

3 I, NUMBER

I

JANUARY

TABLE Forthcoming

Articles

1. 1995

OF CONTENTS

and Issues

xi

Editors’ Note P. Rubin

l

I

CLINICAL

Significance Treated with L. M. Fuller. F. Swan, Jr.,

ORIGINAL

CONTRIBUTIONS

of Tumor Sii and Radiation Dose to Local Control in Stage I-III Diffuse Large Cell Lymphoma CHOP-Bleo and Radiation M. J. Krasin, W. S. Velasquez, P. K. Allen, P. McLaughlin, M. A. Rodriguez, F. B. Hagemeister. F. Cabanillas, J. L. Palmer and J. D. Coy.

Influence of Radiotherapy on Node-positive M. E. Sands, A. Pollack and Cl. K. Zagars

Prostate

Cancer Treated

with Androgen

3

Ablation 13

Observations of Pretreatment Prostate-specific Antigen Doubling Radiotherapy W. R. Lee, G. E. Hanks, B. W. Corn and T. E. Schultheiss

Time in 107 Patients

Referred

for Definitive 21

Factors Influencing Incidence of Acute Grade 2 Morbidity in Conformal Prostate Cancer G. E. Hanks, T. E. Schultheiss, M. A. Hunt and B. Epstein

and Standard

Node-positive Cervical Cancer: Impact of Pelvic Irradiation and Patterns R. G. Stock, A. S. J. Chen, J. C. Flickinger. S. Kalnicki and J. Seski

of Failure

Radiation

Treatment

of 25

31

Brachytherapy-related Complications for Medically Inoperable Stage I Endometrial Carcinoma C. K. S. Chao, P. W. Grigsby, C. A. Perez, H. M. Camel, M.-S. Kao, A. E. Galakatos and W. A. Boyle 111

37

Role of Postoperative Radiation Therapy After Stabilization of Fractures Caused by Metastatic P. W. Townsend, S. R. Smalley, S. C. Cozad, H. G. Rosenthal and R. E. S. Hassanein

43

0 BIOLOGY

ORIGINAL

CONTRiBUTIONS

The Radiation Response of the Cervical Spinal Cord of the Pig: Effects G. J. M. J. van den Aardweg, J. W. Hopewell and E. M. Whitehouse Radiation-induced Changes meability T. Siegal and M. R. Pfeffer

Disease

in the Profile of Spinal Cord Serotonin,

of Changing

Prostaglandin

the Irradiated

Volume 51

Synthesis,

and Vasdar

Per57

Radiation-induced Cognitive Dysfunction: An Experimental Model in the Old Rat I. Lamproglou, Q. M. Chen. G. Boisserie, J.-J. Mazeron, M. Poisson. F. Baillet, M. Le Poncin

and J.-Y. Delattre

Effect of Pentoxifylline on Radiation-induced Lung and Skin Toxicity in Rats W.-J. Koh, K. J. Stelzer, L. M. Peterson, B. L. Staker, W. F. Ward, K. J. Russell and T. W. Griffin

0 HYPERTHERMIA

ORIGINAL

65

71

CONTRIBUTION

Impact of “Optimized” Treatment Planning for Tandem and Ring, and Tandem and Ovoids, Using High Dose Rate Brachytherapy for Cervical Cancer W. R. Noyes, N. E. Peters, B. R. Thomadsen, J. F. Fowler, D. A. Buchler, J. A. Stitt and T. J. Kinsella III

79

0 PHASE

I/II CLINICAL

Preoperative

Radiation

J. M. Robertson,

TRIALS

Therapy

and

V. K. Sondak,

lododeoxyuridine

for Large

S. A. Weiss, J. J. Sussman,

Inhaled Recombinant Interferon Gamma in Patients miluminescence Responses of Alveolar Macrophages

M. Halme,

l

P. Maasilta.

SPECIAL

H. Repo, M. Ristola,

S. Nag. J. B. Owen.

0 BRIEF

Practice in the Society

N. Farnan,

R. Y. Kim,

E. Taskinen,

K. Mattson

United

States:

A Report

T. F. Pajak, A. Martinez,

Pelvic Potential

Radiotherapy Geographic

L. S. McGinnis.

Measurement

of Prostate

J. M. Balter,

Movement

and Effects Monocytes

and

on Che-

and K. Cantell

of the Clinical

A. Porter,

Over

the Course

J. S. McClure,

93

Research

Committee

of the

J. Blasko and L. B. Harrison

103

Sarcomas:

The Electronic

View

W. R. Bosch, J. A. Purdy

D. A. Low.

Box:

Tomography-treatment Control

R. L. S. Jennelle

of Routine

Planning

in

and M. M. Salter

Radiotherapy

Using

109

Implanted

Markers

and R. K. Ten Haken

113

Body Irradiation Versus Busulfan-Cyclophosphamide for Acute Myeloid Leukemia

P. B. McGlave,

Does

R. M. Lanciano.

INN0

Computed on Pelvic

N. K. C. Ramsay,

Con-

B. R. Blazer, J. P. Neglia, 119

of Retroperitoneal

TECHNICAL

R. F. Meredith.

of Cyclophosphamide-total Bone Marrow Transplantation

D. A. Fein, B. W. Corn,

Without Its Impact

K. Lam. R. L. Bree. A. S. Lichter

K. E. Dusenbery, K. A. Daniels. J. H. Kerscy and W. G. Woods Management

Technique Miss and

S. A. Spencer,

H. M. Sandier,

Randomized Comparison ditioning in Autologous

Dose

Escalation

S. H. Herbert,

Impact

J. P. Hoffman

on Locoregional

Control? 129

and L. R. Coia

VA TIONS AND NOTES

A Software

Tool

for Radiation

R. L. Gerber,

Therapy

J. M. Michalski.

Treatment

Verification

M. V. Graham,

C. A. Perez. W. B. Harms

and 135

The Effectiveness

G. C. Bentel.

of Immobilization

L. B. Marks,

Uniformity

During

Prostate

G. W. Sherouse.

in a Planar

R. D. Zwicker Optimum

Lung Cancer: Pharmacokinetics Peripheral Blood Neutrophils

87

COMWJNICATIONS

Conventional Four-field Cancer of the Cervix:

Dose

Sarcomas

FEATURE

Survey of Brachytherapy American Endocurietherapy

l

with and

Retroperitoneal

A. E. Chang and T. S. Lawrence

Interstitial

Irradiation

D. P. Spencer and M. S. Anscher

Implant

143

System

and R. Schmidt-Ulhich

Field

Size

and Choice

149

of Isodose

Lines

in Electron

Beam

Treatment

1. J. Das, C. W. Cheng and G. A. Healey Comparison

of High

Dose-rate

E. Gore. M. T. Gillin, Dosimetric

Consequences

A. M. Kalend, Very

Fast

Low

Reannealing

Dose-rate

Dose

Distributions

for Vaginal

Cylinders

165

and B. Erickson

of ‘%(n,

W. D. Bloomer

Simulated

S. M. Merrill,

and

K. Albano

157

(u)‘Li

Reaction

Occurring

at the Cellular

Membrane

I71

and M. W. Epperly in Radiation

Therapy

Treatment

Plan

Optimization

K. S. Lam. R. G. Lane, M. Langer and I. I. Rosen

179

0 EDITORIALS Are

Half-times

of Repair

Reliably

Shorter

for Tumors

than

for Late

Normal-tissue

Effects?

J. F. Fowler In Search

189 of the “Quality”

in Quality-of-life

Research

D. W. Bruner

191

Impact of Radiation Dose Integrated CHOP-Bleo-radiation J. D. Earle

and

Can Total tation?

be Supplanted

Body

Irradiation

Tumor Size Treatment

on Large Protocol

Cell

Lymphoma

in Complete

Response

after

193 by Busulfan

in Cytoreductive

B. Shank Androgen

Patients

Regimens

for Bone

Marrow

Transplan-

195 Ablation-50

Years

Later

M. V. Pilepich

191

IV

0 CORRESPONDENCE Potentml Reduced Late Effects for Pulsed Brnchytherapy D. J. Brenner, E. J. Hall, Y. Huang and R. K. Sachs

Compared

with Conventional

LDR 201

In Response to B. Shank K. E. Duscnbery and W. G. Woods

202

In Response to Leibel er al. G. Lawrence, J. Derdel and D. Colkitt

203

In Response to Rescigno er al. I. A. Olivotto, L. Weir and C. Kim-Sing

203

In Response to Rescigno et ul. G. S. Lederman

204

Further Characterization of Postradiotherapy J. Rescigno and B. McCormick Neutron Therapy in Prostate Cancer-Is L. J. Peters and G. K. Zagars

Cellulitis

and Efforts

at Prevention 204

the Therapeutic

Ratio Improved? 204

The Importance of Incomplete Repair, Interfractlon D. T. Huang, P.-S. Lin and R. Schmidt-Ullrich

Interval,

and Fractional

Dose 205

Response to Drs. Huang, Lin, and Schmidt-IJIIrich A. C. C. Ruifrok, K. A. Mason and H. D. Thames Comments on “Patterns of Failure Small Cell Lung Cancer” K. C. Lee In Response to Dr. Lee D. Payne, P. Coy, I. Hodson,

Following

206

Loco-regional

Radiotherapy

in the Treatment

of Limited

Stnge 207

N. Murray,

J. Pater and K. Wilson

207

Markers, CTs, Urethrograms, and the Prostatic Apex M. Roach III, J. Holland, A. Chan and D. Shrieve

207

In Response to the Reply by Roach et al. H. M. Sandler and R. W. McCallum

208

Vasoactivity, S. Senan

a Potentially

Important

Variable

in the Sequencing

of Thnpazamine

(SR 4233) and Radiation 209

Response to Dr. Senan J. M. Brown

210

l

211

ANNOUNCEMENT

0 MEETINGS l

213

ADVERTISING

0 DIRECT

VOLUME

INDEX

III

RESPONSE

31, NUMBER

IV

2

JANUARY

TABLE

Forthcoming

Articles

15, 1995

OF CONTENTS .

and Issues

XUl

Dedication P. Rubin

xxxii

Editor’s Note P. Rubin

217

V

l

I994 ASTRO

PRESIDENTIAL

Through a Glass Darkly: L. J. Peters

0 CLINICAL

Predicting

ORIGINAL

ADDRESS the Future

of Radiation

Oncology 219

CONTRIBUTIONS

Radiation Therapy for Early Stage Hodgkin’s Disease: Australasian Patterns of Care M. Barton, J. Boyages, E. Crennan. S. Davis, R. ,J. Fisher, C. Hook, N. Johnson, D. Joseph, K. H. Liew, G. Morgan, P. O’Brien, S. Pendlebury, G. Pratt. Cl. Quong. D. Thornton. G. Trotter, Q. Walker and M. Wallington for the Australasian Radiation Oncology Lymphoma Group

227

The Prognostic Importance of Gleason Grade in Prostatic Adenocarcinoma: 648 Patients Treated with Radiation Therapy G. K. Zagars, A. G. Ayala, A. C. van Eschenbach and A. Pollack

237

Analysis of Failure Following Definitive H. Mameghan, R. Fisher, J. Mameghan

Radiotherapy and S. Brook

for Invasive

A Long-term

Transitional

Follow-up

Cell Carcinoma

Study of

of the Bladder 247

Adenocarcinoma of the Rectum Treated by Radical External Radiation Therapy J. D. Brierley, B. J. Cummings, C. S. Wong, T. J. Keane, B. O’Sullivan, C. N. Catton

and P. Goodman

2.55

Radical Radiotherapy for Early Nonsmall Cell Lung Cancer P. H. Graham, V. J. Gebski and A. 0. Langlands

261

A Phase HI Study of Accelerated Radiotherapy with and without Carboplatin in Nonsmall Cell Lung Cancer: An Interim Toxicity Analysis of the First 100 Patients D. Ball, J. Bishop, J. Smith, E. Crennan. P. O’Brien. S. Davis, G. Ryan, D. Joseph and Q. Walker

267

Treatment of Brain Metastases from Primary G. F. Ryan, D. L. Ball and J. G. Smith

Lung Cancer 273

Thyroid Dysfunction Following Radiotherapy S. L. Turner, K. W. Tiver and S. C. Boyages

for Head and Neck Cancer 279

Treatment Decisions in T3NOMO Glottic Carcinoma G. P. Bryant, M. G. Paulsen, L. Tripcony and G. J. Dickie

285

Conservative Therapy of Breast Cancer in Queensland M.-F. Burke, R. Allison and L. Tripcony

295

Simultaneous Adjuvant Radiation Therapy and Chemotherapy in High-risk Breast Cancer-Toxicity Modification: A Trams-Tasman Radiation Chtcology Group Multi-institution Study J. W. Denham, C. S. Hamilton, D. Christie, M. O’Brien, A. Bonaventura, J. F. Stewart, S. P. A&land, N. A. Spry, P. Dady, C. H. Atkinson, C. Wynne and D. J. Joseph Further Insights into the Natural History Carcinoma F. Boyle, S. Pendlebury and D. Bell The Importance of Postoperative J. A. Meeuwissen, R. G. Bourne

and Management

of Primary

Cutaneous

Neuroendocrine

and Dose D. S. Lamb, 305 (Merkel

315

Radiation Therapy and J. H. Kearsley

in the Treatment

of Merkel

Cell Carcinoma 325

Lymphocyte Predominant Hodgkin’s Disease: A Clinicopathologic Comparative Study of Histologic munophenotypic Subtypes E. Crennan, 1. D’Costa, K. H. Liew, J. Thompson, C. Laidlaw, 1. Cooper and G. Quong

l

BIOLOGY

ORIGINAL

Normal Tissue Radiosensitivity J. Ramsay and G. Birrell

ONCOLOGY

Dose-response H. R. Withers,

in Breast Cancer

333

Patients 339

in Four Human Melanoma Double Strand Breaks

Cell Lines

is Not Accounted

for by 345

INTELLIGENCE

Relationship for Radiation Therapy L. J. Peters and J. M. G. Taylor

Radiation and the Lung: A Reevaluation G. W. Morgan and S. N. Breit Tables of Equivalent M. Barton

and Im-

CONTRIBUTIONS

The Spectrum of In Vitro Radiosensitivity Differential Induction or Rejoining of DNA M. J. McKay and R. F. Kefford

l

Cell)

of Subclinical

353

of the Mechanisms

Dose in 2 Gy Fractions:

Disease

Mediating

Pulmonary

Injury 361

A Simple Application

of the Linear Quadratic

Formula 371

VI

l

SPECIAL

FEATURES

Efficiency Considerations in the Expansion R. D. Smith, S. Jan and A. Shiell Radiation Protection Developments W. K. Sinclair

0 BRIEF

Recommendations

of Radiation

Therapy

Services 379

on Dose Limits:

The Role of the NCRP

and the ICRP

and Future 387

COMWJNICATIONS

Treatment of Pediatric Genitourinary Institute Experience with Four Cases S. Leung

Malignancy

with Interstitial

Brachytherapy:

Peter MacCallum

Cancer 393

The Effects of Radiotherapy and Surgery L. D. Flay and J. H. L. Matthews

on the Sexual Function

of Women Treated

for Cervical

Cancer 399

Sarcomas Following Radiation Therapy for Breast Cancer: A Report of Three Cases and a Review of the Literature S. C. Pendlebury, M. Bilous and A. 0. Langlands

0 TECHNICAL

INNOVATIONS

AND NOTES

Measming Irradiated Tomography Device R. Mallik, A. Fowler

Lung and Heart

Area in Breast Tangential

Fields Using a Simulator-based

405

Computerized

and P. Hunt

411

0 EDITORIALS Current Status of Tissue Markers as Prognostic E. H. Hammond and D. J. Grignon T3NOMO Glottic G. E. Laramore

Cancer:

Are More

Treatment

Factors

in Prostatic

Adenocarcinoma 419

Modalities

Necessarily

Better? 423

What Else Don’t We Know About the Late Effects L. S. Constine

of Radiation

in Patients Treated

for Head and Neck Cancer? 427

Turning up the Heat on Nonsmall Cell Lung Cancer: Is the Toxicity and Accelerated Fractionation Acceptable? R. W. Byhardt

of Concurrent

Cispiatin-based

Chemotherapy 431

0 CORRESPONDENCE Gleason Grade and Other Prognostic Factors-Response to Drs. Hammond G. K. Zagars, A. Pollack, A. C. van Eschenbach and A. G. Ayala Reply to Editorial L. M. Fuller

and Grignon 435

by Dr. Earle 435

Local Treatment for Prostate Cancer: 90 Years Later-Response A. Pollack, G. K. Zagars and M. E. Sands

to M. V. Pilepich 436

0 ANNOUNCEMENT

437

l

MEETINGS

439

l

ONCOLIT

l

AD INDEX

l

DIRECT

VOLUME

IX

RESPONSE

3 1, NUMBER

X

3

FEBRUARY TABLE

Forthcoming

Articles

1, 1995

OF CONTENTS

and Issues

xi

Editor’s Note P. Rubin

443 VII

l

CLINICAL

ORIGINAL

Brain Tumors in Children: D. Jenkin, M. Greenberg,

CONTRIBUTIONS

Long-term Survival after Radiation Treatment H. Hoffman, B. Hendrick, R. Humphreys and A. Vatter

445

Quality-adjusted Survival Analysis of Malignant Clioma. Patients Treated with Twice-daily Radiation Carmustine: A Report of Radiation Therapy Oncology Group (RTOG) 83-02 K. J. Murray, D. F. Nelson, C. Scott, A. J. Fischbach, A. Porter, N. Farnan and W. J. Curran, Jr.

(RT) and 453

Low Grade Gliomas: Preliminary Analysis of Failure Patterns Among Patients Treated Using 3D Conformal External Beam Irradiation A. T. Pu, H. M. Sandler, E. H. Radany. M. Blaivas, M. A. Page, H. S. Greenberg, L. Junck and D. A. Ross

461

Locally Challenging Osteo- and Chondrogenic Tumors of the Axial Skeleton: Photon Radiation Therapy Using Three-dimensional Treatment Planning E. B. Hug, M. M. Fitzek, N. J. Liebsch and J. E. Munzenrider

467

Results of Combined

Proton

and

Survival Outcome Following Isolated Central Nervous System Relapse Treated with Additional Chemotherapy and Craniospinal Irradiation in Childhood Acute Lymphoblastic Leukemia P. Kumar, L. E. Kun, H. 0. Hustu, R. K. Mulhem, M. L. Hancock, D. Coffey and G. K. Rivera

417

Local Group W. F. 8. N.

485

Tumor Control in Rhabdomyosarcoma Following Lowdose III Patients Regine, J. Fontanesi, P. Kumar, D. Ayers, L. C. Bowman, Rao and L. E. Kun

Irradiation:

of Group

A. S. Pappo. D. H. Coffey,

Hyperfractionated Radiation in the Treatment of Squamous Cell Carcinomas of Two Fractionation Schedules A. S. Garden, W. H. Morrison, K. K. Ang and L. J. Peters Does Pathologic Node Status Affect Local Control in Patients with Radical Surgery and Postoperative Radiotherapy? M. S. Rudoltz. A. Benammar and M. Mohiuddin

Comparison

II and Select

L. Avery,

of the Head and Neck: A Comparison 493

with Carcinoma

of the Head and Neck Treated 503

Fractionated or Single-dose Total Body Irradiation in 171 Acute Myeloblastic Leukemias in First Complete Remission: Is There a Best Choice? M. Resbeut, D. Cowen, D. Blaise, E. Gluckman, J.-M. Cosset, B. Rio, F. Pew, N. Milpied. J.-C. Cuilltre, J. Reiffers and P. Richaud for the SFGM (Societe Francaise de Greffe de Moelle)

e BIOLOGY

ORIGINAL

CONTRIBUTIONS

In I’irro Radiation Sensitivity of Mouse Lung Fibroblasts P. C. Keng, R. Phipps and D. P. Penney Exogenous Lactate Interferes H. P. Rutz and J. B. Little

with Cell-cycle

Control

Isolated

by Flow Cytometry 519

in Balb/3T3

Mouse

Fibroblasts 525

Gamma-interferon Administration After goYttrium Radiolabeled Antibody Toxicity Studies G. E. Thomas, J. M. Esteban, A. Raubitschek and J. Y. C. Wong

Therapy:

Survival

and Hematopoietic 529

Relative Biological Effectiveness of Proton Medical Beam at Moscow Synchrotron Determined by the Chinese Hamster Cells Assay P. N. Yashkin, D. I. Silin, V. A. Zolotov, V. 1. Kostjuchenko, D. F. Nichiporov, T. P. Feoktistova, K. S. Martirosov, Y. I. Minakova, V. S. Khoroshkov, P. B. Polonski and L. V. Zinovyeva

l

PHYSICS

ORIGINAL

PHASE

I/II CLINICAL

BRIEF

COMMUNICA

for 541

TRIALS

Sphincter Preservation with Preoperative Radiation Therapy B. D. Minsky, A. M. Cohen, W. E. Enker and P. Paty

l

535

CONTRIBUTION

Pbarmacokinetlcs and Dose Estimates Following Intrathecal Administration of ‘3’I-Monoclonal Antibodies the Treatment of Central Nervous System Malignancies V. Papanastassiou, B. L. Pizer, C. L. Chandler, T. F. Zananiri, J. T. Kemshead and K. I. Hopkins

l

509

and Coloanal

Anastomosis 553

TIONS

A Prospective Neurocognitive Evaluation of Children Treated with Additional Chemotherapy and Craniospinal Irradiation Following Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukemia P. Kumar, R. K. Mulhern, W. F. Regine, G. K. Rivera and L. E. Kun

561

Transforming Growth Factor Alpha Expression as a Potential Survival Adenocarcinoma Receiving High-dose Radiation and Chemotherapy E. R. Sauter, L. R. Coia, B. L. Eisenberg and G. E. Hanks

567

VIII

Prognosticator

in Patients with Esophageal

Results of Radiotherapy and Vitamin E in the Treatment C. 1. Rodrigues, K. H. Njo and A. B. M. F. Karim

of Peyronie’s

Disease 571

Base of Skull and Cervical Spine Chordomas in Children Treated by High-dose V. Benk, N. J. Liebsch, J. E. Munzenrider, J. Etird, P. McManus and H. Suit

l

TECHNICAL

INNOVATIONS

of Dynamic Wedge and J. A. Purdy

Imaging

583

Device for Exit Dosimetry

and Quality

Control

Measurements 593

Three-dimensional Conformal Pancreas Treatment: Comparison P. D. Higgins, J. W. Sohn. R. M. Fine and M. C. Schell Asymmetric L. Grimard.

577

AND NOTES

Dosimetry and Clinical Implementation E. E. Klein, D. A. Low, A. S. Meigooni The Use of an Electronic Portal M. C. Kirby and P. C. Williams

Irradiation

of Four- to Six-field

Techniques 605

Arc Technique for Posterior Pharyngeal Wall and Retropharyngeal J. Szanto, A. Guard, M. Howard, L. Eapen and L. Gerig

Space Tumors 611

Evaluation of Linear Accelerator Radiosurgical Techniques Using Biophysical F. Colombo, P. Francescon, S. Corn. A. Testolin and G. Chierego

Parameters

Photoneutrons from High Energy Medical a Miniature Proportional Counter P. Kliauga and H. Amols

of the Spectrum

Single Isocenter Treatment Planning Linear Accelerator Radiosurgery G. Luxton and G. Jozsef

l

SPECIAL

Linear

Accelerators:

Measurement

(NTCP

and TCP) 617

and Dose Using 629

for Homogeneous

Dose Delivery

to Nonspherical

Targets

in Multiarc 635

FEATURES

Radiation Oncologists Can Assist Head and Neck Cancer Patients P. M. Harari, N. J. O’Connor, M. C. Fiore and T. J. Kinsella

with Smoking

Cessation 645

Echographic Monitoring of Response of Extraocular Muscles to Irradiation in Graves’ B. A. Erickson, G. J. Harris, M. F. Lewandowski, K. J. Murray and B. M. Massaro

0 ONCOLOGY

Ophthalmopathy 651

INTELLIGENCE

Oral Pilocarpine for Radiation-induced Xerostomia: Integrated Efficacy and Safety Results from Two Prospective Randomized Clinical Trials J. W. Rieke, M. D. Hafermann, J. T. Johnson, F. G. LeVeque, R. Iwamoto, B. W. Steiger, C. Muscoplat and S. C. Gallagher

l

EDITORIALS

Brain Tumors in Children-Lifetime M. Brada and M. Hawkins

for Patients

How Much is Enough? The Continuing J. R. Cassady Radical Nonoperative Management T. A. Rich and L. L. Gunderson Concurrent Cisplatinum A. A. Forastiere

and Investigators 671

Central Nervous System Relapse in Children W. A. Bleyer and D. G. Tubergen

l

661

with Acute Lymphoblastic

Evolution

Leukemia 673

of Therapy

in Childhood

Rhabdomyosarcoma

and its Refinement 675

of Early Rectal Cancer

and Radiation

677 for Advanced

Head and Neck Cancer 679

CORRESPONDENCE

Retrospective Results Need Prospective W. F. Regine and L. E. Kun In Response to Dr. Forastiere A. S. Glicksman, J. Clark, N. Coachman, and M. Posner

Confirmation 681

H. Wanebo,

J. Koness, C. Doolittle

III, E. DeRosa,

G. Slotman.

M.D. 681

In Response to Dr. Forastiere M. R. Posner

681

IX

Comments on Radiotherapy for Nprophmyngeaal Rutio S. H. Cheng, J. J. Jian and A. T. Huang

Carcinoma:

Shielding

the Pit&my

May

Improve

Therapeutic 682

In Response to Cheng et ul. J. Sham, D. L. W. Kwong and D. Choy

683

Concerns Regarding Technique Using Parallel-opposed High-energy Electron Near the Spinal Cord (Recurrent Hodgkin’s Lymphoma) K. R. Hogstrom, R. E. Steadham, Jr., E. A. Strom and M. D. McNeese Response to Hogstrom et al. M. Gosselin. E. B. Podgorsak,

of Histologically

of Tumors 683

M. D. C. Evans, M. Pla and G. Shenouda

In Response to Dr. Rajan e# al. Regarding The Management Gliomas with Radiotherapy (IJROBP 2WO5-413; 1994) F. W. Kreth, Ch.R. Schiitz, P. C. Wamke and Ch.B. Ostertag Management M. Brada

Reams for Reirradiation

Unverified

Gliomas:

684

of Histologically

Unvenfird

Presumed

Cerebral 685

Reply to Dr. Kreth

and Colleagues 686

Letter to the Editor A. B. M. F. Karim Some Common R. J. Yaes

686

Causes of Treatment

Prolongation 686

Actual Versus Ideal Treatment Time in Radiotherapy S. M. Bentzen and M. Overgaard In Response to Drs. Yaes, Rentzen, P. M. Harari Response to Dr. Schmidt-Ullrich Schmidt-Ullrich et al. IJROBP R. U. Peter

for Head and Neck Cancer:

Catching

Up with the Gaps 687

and Overgaard 688

et al.-Re: 29~813-819;

Altered 1994

Erpnssion

of Epidermaf

Growth

Factor Receptor.

. . ; 688

In Response to the Reply by Dr. Peter R. Schmidt-Ullrich and K. Valerie In Response J. T. Leith

to Chiing

689

et al. 689

Reply to Leith C.-S. Chiang

690

Radiotherapy in Vietnam: Regarding IJROBP 28:773-775; 1994 L. Tran

Reflcetons

on Radiothempy

in Vietnam: Political

Lessons Still to be Learned. 690

Response to Tran N. A. Janjan

690

In Response to Janjan et al. P. G. Yuile

691

In Response to Janjan et al.: Rejlections on Radiotherapy IJROBP 28~773-775; 1994 R. R. Love. J. H. C. Ho, J. McCaffrey and N. E. Hen

in Vietnam:

Political

Lessons Still

to be L-earned. 691

In Response to Love et al. N. A. Janjan

692

Response to the Letter W. R. Sigmon, Jr.

692

of Dr. Cohen

In Response to Sigmon et a/. B. R. Cohen In Response to Flickinger M. R. Pfeffer

693

et al. 693

Response to Dr. Pfeffer J. C. Flickinger

693

X

Response to the Editorial of Pellegrini 744; 1994 M. H. Seegenschmiedt and P. Martus

Radiation

Prophylaxis

of Heterotopic

Ossification.

IJROBP

30: 743693

Clarification Regarding Radiation-induced S. S. Donaldson and R. S. Cox

Height

Impairment

in Pediatric

Hodgkin’s

Disease 694

l

ANNOUNCEMENT

695

l

MEETINGS

697

l AD INDEX 0 DIRECT

VOLUME

I RESPONSE

3 1, NUMBER

II

4

FEBRUARY

TABLE

Forthcoming

Articles

15, 1995

OF CONTENTS

and Issues

xi

Editor’s Note P. Rubin

l

CLINICAL

701

ORIGINAL

CONTRIBUTIONS

Irradiation Alone or Combined with Surgery in Stage IB, HA, and IIB Carcinoma Update of a Nonrandomized Comparison C. A. Perez. P. W. Grigsby, H. M. Camel, A. E. Galakatos, D. Mutch and M. A. Lockett Severe Radiation Morbidity Previous Surgery B. A. Fine, R. E. Hempling,

in Carcinoma

of the Cervix:

M. S. Piver, T. R. Baker,

Late Rectal Complication Following I. Ogino. T. Kitamura, N. Okamoto,

Impact

M. McAuley

of Pretherapy

of Uterine

Cervix: 703

Surgical

Staging

and

and D. Driscoll

717

High Dose Rate Intracavitary Bracbytherapy in Cancer K. Yamasita, Y. Aikawa. H. Okajima and S. Matsubara

of the Cervix 725

High Dose Rate Brachytherapy for Carcinoma of the Uterine Cervix: Comparison of Two Different Fractionation Regimens C. Le Pechoux, Y. Akine, M. Sumi. K. Tokuuye. H. Ikeda, M. Yajima. T. Yamada, K. Tanemura, R. Tsunematsu, K. Ohmi and T. Sonoda

735

Heuristically Derived Tumor Burden Score as a Prognostic Factor for Stage IIIB Carcinoma D. Arthur, N. Kaufman, R. Schmidt-Ullrich, B. Kavanagh. P. Simpson, M. Hill and M. Ali

743

Factors Influencing Cosmetic Results After M. E. Taylor, C. A. Perez, K. J. Halverson, R. J. Myerson, D. Radford and C. Rush

of the Cervix

Conservation Therapy for Breast Cancer R. R. Kuske, G. W. Philpott, D. M. Garcia,

J. E. Mortimer. 753

Breast Conservation Treatment of Early Stage Breast Cancer: Patterns F. Leborgne, J. H. Leborgne, B. Ortega. R. Doldan and E. Zubizarreta Tamoxifen with and Without Radiation After Partial Mastectomy A. L. Cooke. F. Perera. B. Fisher, A. Opeitum and N. Yu Breast Cancer in Elderly Women: A Retrospective Analysis Once-weekly Irradiation M. Maher, F. Campana. V. Mosseri. H. Dreyfus, J. R. Vilcoq,

of Failure 765

in Patients

with Involved

Nodes 777

of Combined C. Gautier.

Treatment B. Asselain

with Tamoxifen

and

and A. Fourquet

783

Outcome and Prognostic Factors for Local Recurrence in Mammographically Detected Ductal Carcinoma in situ of the Breast Treated with Conservative Surgery and Radiation Therapy J. White, A. Levine. G. Gustafson, K. Wimbish, I. Ingold. J. Pettinga. R. Matter, A. Martinez and F. Vicini

791

A Phase II Trial Evaluating Selective Use of Altered Radiation Unresectahle Rhabdomyosarcoma W. F. Regine, J. Fontanesi, P. Kumar, K. Zeitzer, C. Greenwald, L. E. Kun

799

XI

Dose and Fractionation L. Bowman,

D. N. Shapiro,

in Patients

with

B. N. Rao and

l

PHASE I/II CLINICAL

TRIALS

Interdigitating Versus Concurrent Chemotherapy and Radiotherapy for Limited Small Cell Lung Cancer R. Komaki, D. M. Shin, 9. S. Glisson, F. V. Fossella, W. K. Murphy, A. S. Garden, M. J. Oswald, W. K. Hong, J. A. Roth, L. J. Peters, P. V. Holoye and N. Ellerbroek

807

Mitomycin, Cisplatin, and Vindesine Followed by Radiotherapy Combined with Cisplatin In Stage III Nonsmall Cell Lung Cancer: Long-term Results M. Tejedor. J. J. Valerdi, R. Lopez, M. A. Dominguez, F. Arias, J. J. Illarramendi and E. Martinez

813

Phase I/II Study of Treatment of Locally Advanced (T3/T4) Non-oat Cell Lung Cancer with Concomitant Boost Radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): Long-term Results M. V. Graham, T. E. Pajak, A. M. Herskovic, B. Emami and C. A. Perez

819

Pilot Study of Human Recombinant Interferon Gamma and Accelerated Hyperfractionated Thoracic Radiation Therapy in Patients with Unresectable Stage IIIA/B Nonsmall Cell Lung Cancer E. G. Shaw, R. L. Deming, E. T. Creagan, S. Nair, J. Q. Su, R. Levitt. P. D. Steen, M. Wiesenfeld and J. A. Mailliard

827

l

BIOLOGY

ORIGINAL

CONTRIBUTIONS

The Decreased Influence of Overall Treatment Time on the Response of Human Following Prolongation of the Potential Doubling Time (T,,) J. N. Sarkaria, J. F. Fowler, M. J. Lindstrom, V. C. Jordan and R. T. Mulcahy The Intrinsic Radiosensitivity C. M. L. West, S. E. Davidson, Repopulation Kinetics During Time, T, A. K. Speke and R. P. Hill

of Cervical Carcinoma: Correlations P. A. Burt and R. D. Hunter Fractionated

Irradiation

833

Clinical

Data 841

and the Relationship

on Repopulation

to the Potential

During

Fractionated

Morphometric H. D. Thames,

Analysis

Irradiation

of Glomerular

and Tubular

R. E. Price, L. J. Peters and K. K. Ang

Intracavitary

ORIGINAL

Model 883

CONTRIBUTIONS

Simultaneous Delivery of Electron Beam Therapy and Ultrasound Hyperthermia tors: A Feasibility Study E. G. Moros, W. L. Straube, E. E. Klein, M. Yousaf and R. J. Myerson Thermal Response and Hyperthermic Radiosensitization M. D. O’Hara, M. D. Pollard, G. Wheatley, W. F. Regine, l

Irradla87.5

Analysis of Clinical Complication Data for Radiation Hepatitis Using a Parallel Architecture A. Jackson, R. K. Ten Haken, J. M. Robertson, M. L. Kessler, G. J. Kutcher and T. S. Lawrence

HYPERTHERMIA

865

CONTRIBUTIONS

Clinical Evaluation of an Interstitial Remote Afterloading Device for Multichannel tion P. W. Grigsby, E. D. Slessinger, S. P. Teague. J. F. Williamson and C. A. Perez

l

Doubling

857

Radiation Nephropathy in the Rhesus Monkey: Alterations L. C. Stephens, M. E. C. Robbins, D. A. Johnston,

PHYSICS ORIGINAL

Xenografts

847

The Effects of Clamping and Reoxygenation A. K. Speke and R. P. Hill

l

with

Breast Tumor

Using Scanning

Reflec893

of Scid Mouse Bone Marrow CFU-C M. Mohiuddin and D. B. Leeper

905

BRIEF COMMUNICATIONS

Follow-up of Cognitive Functioning in Patients A. G. M. van Oosterhout, P. J. Boon, P. J. How, The Effect of Irradiation on Lung R. P. Abratt and P. A. Willcox

Function

with Small Cell Lung Cancer G. P. M. ten Velde and A. Twijnstra

and Perfusion

in Patients

with Lung

911

Cancer 915

Concurrent Radiotherapy and Chemotherapy with Protracted Continuous Infusion of W’luorouracil in Inoperable Esophageal Squamous Cell Carcinoma K. Sakai, H. Inakoshi, H. Sueyama, J.-I. Oda, T. Ito, E. Tsuchida, T. Sugita, Y. Matsumoto, M. Saito and A. Saito

921

Radiation Therapy for Primary Orbital C. K. S. Chao, H.-S. Lin, V. R. Devineni

929

Lymphoma and M. Smith

XII

0 TECHNICAL

INNOVATIONS

AND NOTES

The Use of Digitally Reconstructed Simulation J. M. Galvin, C. Sims, G. Dominiak

Radiographs

for

Three-dimensional

Treatment

935 and On-line

Megavoltage

Tomographic

Method of Localization and Implantation of the Lumpectomy After Conservative Surgery for Tl and T2 Breast Cancer F. Perera. F. Chisela, J. Engel and V. Venkatesan

Site for High

High Dose-rate MicroSelectron Molds in the Treatment V. H. J. Svoboda, J. Kovarik and F. Morris

GOLD MEDAL

The Effects of Health G. E. Hanks

.

Use for Volume,

Dose Rate Brachytherapy 959

of Skin Tumors 967

States in 1973, 1978, and 1983: 973

INTELLIGENCE

Neuropsychological Effects of Cranial D. D. Roman and P. W. Sperduto

The Function E. J. Hall

Imaging:

FEATURES

ONCOLOGY

. ASTRO

Evaluation

953

Long-term Results of Treatment of Cervical Carcinoma in the United Patterns of Care Study (PCS) R. Komaki, T. J. Brickner, A. L. Hanlon, J. B. Owen and G. E. Hanks

.

Treatment

943

Quantitative Bremsstrahlung Single Photon Emission Computed Activity, and Absorbed Dose Calculations J. A. Siegel, L. S. Zeiger, S. E. Order and P. E. Wallner

SPECIAL

and CT-

and J. S. Cooper

A New Model for “Accept or Reject” Strategies in Off-line D. Yan, J. W. Wong, G. Gustafson and A. Martinez

l

Planning

Care

Radiation:

Current

Knowledge

and Future

Directions 983

ADDRESSES Reform

on Academic

Medical

Centers:

1994 Gold Medal

Address 999

of the Radiation

Biologist

is to Make

the Clinician

Think:

1993 Gold Medal

Address 1005

EDITORIALS

Irradiation Alone or Combined Answer? P. J. Eifel and M. Morris Surgical Staging, R. A. Potish Width

Extended

with

Surgery

in Carcinoma

of the Cervix:

When

Will

We Know

the 1007

Field Radiation,

and Enterlc

Morbidity

in the Treatment

of Cervix

Cancer 1009

of the Therapeutic

Window:

What

is the Optimal

Dose-per-Fraction

for High

Dose Rate Cervix

Cancer Brachytherapy? C. G. Orton An Assessment Breast Cancer B. Fowble

101 I

of Treatment

Options

l

Conservation

in the Elderly

Woman

with

Early

Stage 1015

What Have We Accomplished the Lung? W. T. Sause Interstitial Brachytherapy J.-C. Horiot

for Breast

in the Management

of Patients

with

Small

Cell Anapkistic

Carcinoma

of 1019

in Velo-tonsillar

Tumors:

The Ultimate

Boost 1021

CORRESPONDENCE

Response to J.-C. Horiot M. Pemot

1023

Letter to the Editor Regarding C. McLean and W. Duncan In Response to McLean 1. F. Bosset, E. Pelissier,

Editorial

by Basset ef

al.

IJROEP 29:205-208; 1994 1023

and Duncan G. Mantion, J. J. Pavy, J. C. Horiot.

XIII

H. P. Hamers

and H. Bartelink

1024

Letter to the Editor Regarding Wang and Efird, ZJROBP 25:657-660; S. Bridgman, F. Z. Liberman, M. Suntharalingam and R. J. Yaes In Response C. C. Wang

to Bridgman

1994 1025

et al. 1025

One Step Forward and Two Steps Back G. E. Hanks and W. R. Lee One Step Forward, J. A. Cox

No Steps Back:

1026

In Response

to Drs. Hanks

and Lee 1027

Watch Your Step: In Response to Drs. Hanks L. D. Wilson, R. E. Peschel and R. D. Ennis

and Lee 1027

l ANNOUNCEMENT

1029

. MEETINGS

1031

. AD INDEX

V

l DIRECT

VOLUME

RESPONSE

3 1, NUMBER

VI

5

MARCH

TABLE LATE Forthcoming Dedication P. Rubin

Articles to George

EFFECTS

OF CONTENTS

OF NORMAL

TISSUES

CONSENSUS

CONFERENCE vii

and Issues Casarett

xxix xxxi

Acknowledgements Participating

Cooperative

Groups

and Consensus

Conference

xxxii

Attendees

Editor’s Note P. Rubin

1035

Introduction: Joint Statement of Mission by RTOG/EORTC P. Rubin, L. S. Constine, L. F. Fajardo, T. L. Phillips, J.-C. Horiot, F. Momex, J. Overgaard and J.-J. Pavy

Working Groups T. H. Wasserman, H. Btielink,

EORTC Late Effects Working Group-Late Effects Toxicity Scoring: J.-J. Pavy, J. Denekamp, J. Letschert, B. Littbrand, F. Momex, J. Bemier, M. Bolla and H. Bartelink

.

Soma Scales for All Anatomic

SPECIAL

FEATURES-LATE

Tissues (LENT)

Scoring

System 1041

The Soma Scale D. Gonzales-Gonzales,

J-C. Horiot, 1043 1049

Sites

EFFECTS

J. Denekamp, 1037

RTOG Late Effects Working Group-Overview: Late Effects of Normal P. Rubin, L. S. Constine, L. F. Fajardo, T. L. Phillips and T. H. Wasserman

LENT

30, 199.5

CONSENSUS

CONFERENCE

Radiation Response of the Central Nervous System T. E. Schultheiss, L. E. Kun, K. K. Ang and L. C. Stephens

1093

Chronic Neuroendocrinological C. A. Sklar and L. S. Constine

1113

Sequelae

of Radiation

Late Effects of Radiation on the Eye and Ocular K. B. Gordon, D. H. Char and R. H. Sagerman

Therapy

Adnexa 1123

Late Effects of Radiation Therapy in the Head and Neck J. S. Cooper, K. Fu, J. Marks and S. Silverman Thyroid Abnormalities After Therapeutic External S. L. Hancock, I. R. McDougall and L. S. Constine

Region

1141

Radiation 1165 XIV

Pathophysiology of Irradiated Skin and Breast J. 0. Archambeau, R. Pezner and T. Wasserman

1171

Injury to the Lung from Cancer Therapy: Clinical Scoring Systems S. McDonald, P. Rubin, T. L. Phillips and L. B. Marks Radiation Injury to the Heart J. R. Stewart, L. F. Fajardo, S. M. Gillette Late Effects of Radiation L. R. Coia, R. J. Myerson

Syndromes,

Endpoints,

and Potential 1187

120.5

and L. S. Constine

Therapy on the Gastrointestinal and J. E. Tepper

Tract 1213

Hepatic Toxicity Resulting From Cancer Treatment T. S. Lawrence, J. M. Robertson, M. S. Anscher, R. L. Jirtle, Clinical Radiation J. R. Cassady

Measurable

W. D. Ensminger

1237

and L. F. Fajardo

Nephropathy 1249

The Response of the Urinary Bladder, Urethra, and Ureter L. B. Marks, P. R. Carroll, T. C. Dugan and M. S. Anscher

to Radiation

and Chemotherapy 1257

Late Injury of Cancer Therapy on the Female Reproductive Tract P. W. Grigsby, A. Russell. D. Bruner, P. Eifel, W.-J. Koh, W. Spanos, J. Stetz, J. A. Stitt and J. Sullivan

1281

Response of Growing Bone to Irradiation: A Proposed P. J. Eifel, S. S. Donaldson and P. R. M. Thomas

1301

Late Effects

Scoring

System

Late Radiation Injury to Muscle and Peripheral Nerves E. L. Gillette, P. A. Mahler, B. E. Powers, S. M. Gillette and Z. Vujaskovic

1309

Hematopoietic Stem Cell Compartment: P. Mauch, L. Constine, J. Greenberger,

1319

l

Acute and Late Effects of Radiation Therapy and Chemotherapy W. Knospe, 1. Sullivan, J. L. Liesveld and H. J. Deeg

EDITORIALS

Toxicity Criteria of the Radiation Therapy Oncology Research and Treatment of Cancer (EORTC) J. D. Cox, J. Stetz and I. F. Pajak LENT: A Good Beginning C. B. Scott and T. F. Pajak

But.

Group

(RTOG)

and the European

Organization

for 1341

. . 1347

Complicating Issues in Complication Reporting L. J. Peters, H. R. Withers and B. W. Brown The Impact on Quality of Life by Radiation D. W. Bruner and T. Wasserman

I349 Late Effects

Understanding Radiation Damage in Late Effect Normal Complication Terrain or Waiting for Godot? C. C. Ling, G. J. Kutcher and R. Mohan l

1353 Tissues:

to Negotiate

the Dos+Volume1357

APPENDIX

Cooperative

Group

Common

l

MEETINGS

l

LIST OF CONTENTS,

Toxicity

Criteria

1361 1365

AUTHOR

INDEX, AND SUBJECT INDEX

0 ONCOLIT

DIRECT

FOR VOLUME

31, I995

I

XXIII

0 ADVERTISING l

Learning

INDEX

XL1

RESPONSE

XL11

xv

Abratt, R. P., 915 Ackland, S. P., 305 Aikawa, Y., 725 Akine, Y., 735 Albano, K., 165 Ah, M., 743 Allen, P. K., 3 Allison, R., 295 Amols, H., 629 Ang, K. K., 1093, 493, 865 Anscher, M. S., 1237, 1257, Archambeau, J. 0.. 1171 Arias, F., 813 Arthur, D., 743 Asselain, B., 783 Atkinson, C. H., 305 Avery, L., 485 Ayala, A. G., 237 Ayers, D., 485 Baillet, F., 65 Baker, T. R., 717 Ball, D., 267 Ball, D. L., 273 Balter, J. M., 1 13 Bartehnk, H., 1037, 1043 Barton, M., 227, 371 Bell, D., 315 Benammar, A., 503 Benk, V., 577 Bentel, G. C.. 143 Bemier, J., 1043 Bilous, M., 405 Birrell, G., 339 Bishop, J., 267 Blaise, D., 509 Blaivas, M., 461 Blasko, J., 103 Blazar, B. R., I19 Bloomer, W. D., 171 Boisserie, G., 65 Bolla, M., 1043 Bonaventura, A., 305 Boon, P. J., 911 Bosch, W. R., 135 Boume. R. G., 325 Bowman, L., 799 Bowman, L. C., 485 Boyages, J., 227 Boyages, S. C., 279 Boyle, F., 315 Boyle, W. A., III, 37 Bree, R. L., 113 Breit, S. N., 361 Brickner, T. J., 973 Brierley, J. D., 255 Brook, S.. 247 Brown, B. W., 1349 Bnmer, D., 1281 Bruner, D. W., 1353

AUTHOR

INDEX

Volume

31,1994

Bryant, G. P., 285 Buchler, D. A., 79 Burke, M.-F., 295 Burt, P. A., 841 Byhardt, R. W., 431

143

Doldan, R., 765 Dominiak, G., 935 Domfnguez, M. A., 813 Donaldson, S. S., 1301 Dreyfus, H., 783 Driscoll, D., 717 Dugan, T. C., 1257 Dusenbery, K. E., 119

Cabanillas, F., 3 Camel, H. M., 37. 703 Campana, F., 783 Cantell, K., 93 Carroll, P. R., 1257 Cassady, J. R., 1249 Catton, C. N., 255 Chandler, C. L., 541 Chang, A. E., 87 Chao, C. K. S., 37, 929 Char, D. H., 1 I23 Chen, A. S. J., 31 Chen, Q. M., 65 Cheng. C. W., 157 Chierego, G., 617 Chisela, F., 959 Christie, D., 305 Coffey, D., 477 Coffey, D. H., 485 Cohen, A. M., 553 Coia, L. R., 1213, 129, 567 Colombo, F., 617 Constine, L., III. 1319 Constine, L. S., 1205, 427 Constine, L. S., III, 1037, 1041, 1113, 1165 Cooke, A. L., 777 cooper, I., 333 Cooper, J. S., 1141, 935 Cora, S., 617 Corn, B. W., 21, 129 Cosset, J.-M., 509 Cowen, D., 509 Cox, J. D., 3, 1341 Cozad, S. C.. 43 Creagan, E. T., 827 Crennan, E., 227, 267, 333 Cuilltre, J.-C., 509 Cummings, B. J., 255 Cut-ran, W. J., Jr.. 453

Gillette, S. M., 1205, 1309 Gillin, M. T., 165 Girard, A., 611 Glisson, B. S., 807 Gluckman, E., 509 Gonzales-Gonzales, D., 1043 Goodman, P., 255 Gordon, K. B., 1123 Gore, E., 165 Graham, M. V., 135, 819 Graham, P. H.. 261 Greenberg, H. S., 461 Greenberg, M., 445 Greenberger, J., 1319 Greenwald, C., 799 Griffin, T. W.. 71 Grignon, D. J., 419 Grigsby, P. W., 37, 1281, 703, 875 Grimard, L., 61 I Gustafson, G., 791, 943

Eapen, L., 611 Efird, J., 577 Eifel, P., 1281 Eifel, P. J., 1301 Eisenberg, B. L., 567 Ellerbroek, N., 807 Emami, B., 819 Engel, J., 959 Enker, W. E., 553 Ensminger, W. D., 1237 Epperly, M. W., 171 Epstein, B., 25 Erickson, B., 165 Erickson, B. A., 651 Esteban, J. M., 529 Fajardo, L. F., 1037, 1041, 1237 Farnan, N., 103, 453 Fein, D. A., 129 Feoktistova, T. P., 535 Fine, B. A., 717 Fine, R. M.. 605 Fiore, M. C., 645 Fischbach, A. J., 453 Fisher, B., 777 Fisher, R., 241 Fisher, R.J., 227 Fitzek, M. M., 467 Flay. L. D., 399 Flickinger, J. C., 31 Fontanesi, J., 485, 799 Fossella, F. V., 807 Fourquet, A., 783 Fowble, B., 1015 Fowler, A., 411 Fowler, J. F., 79, 833 Francescon, P., 617 Fu, K., 1141 Fuller, L. M., 3

Dady, P., 305 Daniels, K. A., 119 Das, I. J., 157 Davidson, S. E.. 841 Davis, S., 227, 267 D’Costa, I., 333 Deeg, H. J., 1319 Delattre, J.-Y., 65 Deming, R. L., 827 Denekamp, J., 1037, 1043 Denham, J. W., 305 Devineni. V. R., 929 Dickie, G. J., 285

Galakatos, A. E., 37, 703 Gallagher, S. C., 661 Calvin, J. M., 935 Garcia, D. M., 753 Garden, A. S., 493, 807 Gautier, C., 783 Gebski, V. J., 261 Gerber, R. L.. 135 Gerig, L., 611 Gillette, E. L., 1309 XVI

1205,

Hafermann, M. D., 661 Hagemeister, F. B., 3 Hall, E. J., 1005 Halme, M., 93 Halverson, K. J., 753 Hamilton, C. S., 305 Hammond, E. H., 419 Hancock, M. L., 477 Hancock, S. L., 1165 Hanks, G. E., 21, 25, 567, 973, 999 Hanlon, A. L., 973 Harari, P. M., 645 Harms, W. B., 135 Harris, G. J., 651 Harrison, L. B., 103 Hassanein, R. E. S., 43 Healey, G. A., 157 Hempling, R. E., 717 Hendrick, B., 445 Herbert, S. H., 129 Herskovic, A. M., 819 Higgins, P. D., 605 Hill, M., 743 Hill, R. P., 847, 857 Hoffman, H., 445 Hoffman, J. P., 129 Holoye, P. V., 807 Hong, W. K., 807 Hook, C., 227 Hopewell, J. W., 51 Hopkins, K. I., 541 Horiot, J.-C., 1021, 1037 Horiot, J-C., 1043 Houx, P. J., 911 Howard, M.. 611 Hug, E. B.. 467 Humphreys, R., 445

Hunt, M. A., 25 Hunt, P., 411 Hunter, R. D., 841 Hustu, H. 0.. 477 Ikeda, H., 735 Illarramendi, J. J., 813 Inakoshi, H., 921 Ingold, J., 791 Ito, T., 921 Iwamoto, R., 661 Jackson, A., 883 Jan, S., 379 Jenkin, D., 445 Jennelle, R. L. S., 109 Jirtle, R. L., 1237 Johnson, J. T., 661 Johnson. N., 227 Johnston, D. A., 865 Jordan, V. C., 833 Joseph, D., 227, 267 Joseph, D. J., 305 Jozsef. G., 635 Junck, L., 461 Kalend, A. M., 171 Kalnicki, S., 31 Kao, M.-S., 37 Karim. A. B. M. F., 571 Kaufman, N., 743 Kavanagh, B., 743 Keane, T. J., 255 Kearsley, J. H., 325 Kefford, R. F., 345 Kemshead, J. T., 541 Keng, P. C., 519 Kersey, J. H., 119 Kessler, M. L., 883 Khoroshkov, V. S., 535 Kim. R. Y., 109 Kinsella, T. J., 79, 645 Kirby, M. C.. 593 Kitamura, T., 725 Klein, E. E., 583, 893 Kliauga, P., 629 Knospe, W., 1319 Koh, W.-J., 71, 1281 Komaki, R., 807, 973 Kostjuchenko, V. I., 535 Kovarik, J., 967 Krasin, M. J., 3 Kumar, P., 477,485, 561, 799 Kun, L. E., 1093, 477, 485, 561. 799 Kuske, R. R., 753 Kutcher, G. J., 1357, 883 Laidlaw, C., 333 Lam, K., 113 Lam, K. S., 179 Lamb, D. S., 305 Lamproglou, I., 65 Lanciano, R. M., 129 Lane, R. G., 179 Langer, M.. 179 Langlands, A. 0.. 261, 405 Laramore, G. E., 423

Lawrence, T. S., 87. 1237, 883 Leborgne, F., 765 Leborgne, J. H., 765 Lee, W. R., 21 Leeper, D. B., 905 Le Pechoux, C., 735 Lc Poncin, M., 65 Letschert, J., 1043 Leung, S., 393 LeVeque, F. G., 661 Levine, A., 791 Levitt, R., 827 Lewandowski, M. F., 651 Lichter, A. S., 113 Liebsch, N. J., 467, 577 Liesveld, J. L., 1319 Liew, K. H., 227, 333 Lin, H., 929 Lindstrom, M. J., 833 Ling, C. C., 1357 Littbrand, B., 1043 Little, J. B., 525 Lockett, M. A., 703 L6pcz. R., 813 Low, D. A., 135. 583 Luxton, G., 635

Moros, E. G., 893 Morrill, S. M., 179 Morris, F., 967 Morrison, W. H., 493 Mortimer, J. E., 753 Mosseri, V., 783 Mulcahy, R. T., 833 Mulhem, R. K., 477, 561 Munzemider, J. E., 467, 577 Murphy, W. K., 807 Murray, K .J., 453 Murray, K. J., 651 Muscoplat, C., 661 Mutch, D., 703 Myerson, R. J., 1213, 753, 893

Piver, M. S., 717 Pizer, B. L., 541 Poisson, M., 65 Pollack, A.. 13, 237 Pollard, M. D., 905 Polonski, P. B., 535 Porter, A., 103, 453 Potish, R. A., 1009 Poulsen, M. G., 285 Powers, B. E., 1309 Pratt, G., 227 Price, R. E., 865 Pu, A. T., 461 Purdy, J. A., 135. 583 Quong,

Nag, S., 103 Nair, S., 827 Neglia, J. P., 119 Nelson, D. F., 453 Nichiporov, D. F., 535 Njo, K. H.. 571 Noyes, W. R., 79 O’Brien, M., 305 O’Brien, P., 227, 267 O’Connor, N. J., 645 Oda, J.-I., 921 Ogino, I., 725 O’Hara. M. D., 905 Ohmi, K., 735 Okajima, H., 725 Okamoto, N., 725 Opeitum, A., 777 Order, S. E., 953 Ortega, B., 765 Orton, C. G., 1011 O’Sullivan, B., 255 Oswald, M. J., 807 Overgaard, J., 1037 Owen, J. B., 103, 973

Maasilta, P.. 93 Maher, M., 783 Mahler. P. A., 1309 Mailliard, J. A., 827 Mallik, R., 41 1 Mameghan. H., 247 Mameghan, J., 247 Marks, J., 1141 Marks, L. B.. 1187, 1257, 143 Martinez, A., 103, 791, 943 Martirosov, K. S., 535 Martinez, E., 813 Massaro, B. M., 651 Matsubara. S., 725 Matsumoto. Y., 921 Matter, R., 791 Matthews, J. H. L., 399 Mattson, K., 93 Mauch, P., 1319 Mazeron, J.-J., 65 McAuley, M., 717 McClure, J. S., 119 McDonald, S., 1187 McDougall, I. R., 1165 McGinnis, L. S., 109 McGlave, P. B., 119 McKay, M. J., 345 McLaughlin, P., 3 McManus, P., 577 Meeuwissen, J. A., 325 Meigooni, A. S., 583 Meredith, R. F., 109 Michalski, J. M., 135 Milpied, N., 509 Minakova, Y. I., 535 Minsky, B. D., 553 Mohan, R., 1357 Mohiuddin, M., 503, 905 Morgan, G., 227 Morgan, G. W., 361 Momex, F., 1037, 1043

Page, M. A.. 461 Pajak, T. E., 819 Pajak, T. F., 103, 1341, 1347 Palmer, J. L.. 3 Papanastassiou, V., 541 Pappo, A. S., 485 Paty, P., 553 Pavy, J.-J., 1037, 1043 Pendlebury, S., 227, 315 Pendlebury, S. C., 405 Pene, F., 509 Penney, D. P., 519 Perera, F., 777, 959 Perez, C. A., 37, 135, 703, 753, 819, 875 Peters, L. J., 1349, 219, 353, 493, 807, 865 Peters, N. E., 79 Peterson, L. M., 71 Pettinga, J., 791 Pezner, R., 117 1 Pfeffer, M. R.. 57 Pharm, B.. 361 Phillips, T. L., 1037, 1041, 1187 Philpott, G. W., 753 Phipps, R., 519 XVII

G., 227, 333

Radany, E. H., 461 Radford, D., 753 Ramsay, J., 339 Ramsay, N. K. C., 119 Rao. B. N., 485, 799 Raubitschek, A., 529 Regine, W. F., 485, 561, 799, 905 Reiffers, J., 509 Repo, H., 93 Resbeut, M.. 509 Richaud, P.. 509 Rieke, J. W., 661 Rio, B., 509 Ristola, M.. 93 Rivera, G. K., 477, 561 Robbins, M. E. C., 865 Robertson, J. M., 87, 1237, 883 Rodrigues, C. I.. 571 Rodriguez, M. A.. 3 Roman, D. D., 983 Rosen, I. I., 179 Rosenthal, H. G., 43 Ross, D. A.. 461 Roth, J. A., 807 Rubin, P., 1035. 1037, 1041, 1187 Rudoltz, M. S.. 503 Rush, C., 753 Russell, A., 1281 Russell, K. J., 71 Rutz, H. P., 525 Ryan, G., 267 Ryan, G. F., 273 Sagerman, R. H., 1123 Saito, A., 921 Saito, M., 921 Sakai, K., 921 Salter, M. M., 109 Sandler, H. M., 113, 461 Sands, M. E., 13 Sarkaria, J. N., 833 Sause, W. T., 1019 Sauter, E. R., 567 Schell, M. C., 605 Schmidt-Ullrich, R., 149, 743 Schultheiss, T. E., 21, 25, 1093 Scott, c., 453 Scott, C. B., 1347 Seski, J., 31

Shapiro, D. N., 799 Shaw, E. G., 827 Sherouse, G. W., 143 Shiell, A., 379 Shin, D. M., 807 Siegal, T., 57 Siegel, J. A., 953 Silin, D. I., 535 Silverman, S., 1141 Simpson, P., 743 Sims, C., 935 Sinclair, W. K., 387 Sklar, C. A., 1113 Slessinger, E. D., 875 Smalley, S. R., 43 Smith, J., 267 Smith, J. G., 273 Smith, M., 929 Smith, R. D., 379 Sohn, J. W., 605 Sondak, V. K., 87 Sonoda, T., 735 spanos, w., 1281 Speke, A. K., 847, 857 Spencer, D. P., 143 Spencer, S. A., 109 Sperduto, P. W., 983 Spry, N. A., 305 Staker, B. L., 71 Stat, M., 261 Steen, P. D., 827 Steiger, B. W., 661

Stelzer, K. J., 71 Stephens, L. C., 1093, 865 Stetz, J., 1281, 1341 Stewart, J. F., 305 Stewart, J. R., 1205 Stitt, J. A., 79, 1281 Stock, R. G., 31 Straube, W. L., 893 Su, J. Q., 827 Sueyama, H., 921 Sugita, T., 921 Suit, H., 577 Sullivan, J., 1281, 1319 Sumi, M., 735 Sussman, J. J., 87 Svoboda, V. H. J., 967 Swan, F., Jr., 3 Szanto, J., 611

Thomas, P. R. M., 1301 Thompson, J., 333 Thornton, D., 227 Tiver, K. W., 279 Tokuuye, K., 735 Townsend, P. W., 43 Tripcony, L., 285, 295 Trotter, G., 227 Tsuchida, E., 921 Tsunematsu, R., 735 Turner, S. L., 279 Twijnstra, A., 911 Valerdi, J. J., 813 van den Aardweg, G. J. M. J., 51 van Oosterhout, A. G. M., 911 Vatter, A., 445 Velasquez, W. S., 3 Venkatesan, V., 959 Vicini, F., 791 Vilcoq, J. R., 783 von Eschenbach, A. C., 237 Vujaskovic, Z., 1309

Tanemura, K., 735 Taskinen, E., 93 Taylor, J. M. G., 353 Taylor, M. E.. 753 Teague, S. P., 875 Tejedor, M., 813 Ten Haken, R. K., 113, 883 ten Velde, G. P. M., 911 Tepper, J. E., 1213 Testolin, A., 617 Thames, H. D., 865 Thomadsen, B. R., 79 Thomas, G. E., 529

Walker, Q., 227, 267 Wallington, M., 227 Wallner, P. E., 953 Ward, W. F., 71 Wasserman, T., 1171, 1353 Wasserman, T. H., 1037, 1041 Weiss, S. A., 87 West, C. M. L., 841

XVIII

Wheatley, G., 905 White, J., 791 Whitehouse, E. M., 51 Wiesenfeld, M., 827 Willcox, P. A., 915 Williams, P. C., 593 Williamson, J. F., 875 Wimbish, K., 791 Withers, H. R., 1349, 353 Wong, C. S., 255 Wong, J. W., 943 Wong, J. Y. C., 529 Woods, W. G., 119 Wynne, C., 305 Yajima, M., 735 Yamada, T., 735 Yamasita, K., 725 Yan, D., 943 Yashkin, P. N., 535 Yousaf, M., 893 Yu, N., 777 Zagars, G. K., 13, 237 Zananiri, T. F., 541 Zeiger, L. S., 953 Zeitzer, K., 799 Zinovyeva, L. V., 535 Zolotov, V. A., 535 Zubizarreta, E., 765 Zwicker, R. D., 149

A Accelerated fractionation, 267 Accelerated radiotherapy, 827 “Accept or reject” decisions, 943 Acute lymphoblastic leukemia, 477, 561, 983 Acute morbidity, 25 Acute myeloblastic leukemia, 509 Acute myeloid leukemia, 119 Adenocarcinoma of the prostate, 143 Adjuvant radiation therapy, 305 Adjuvant therapy, 353, 553 Androgen ablation, 13 Anthracycline, 1205 Atherosclerosis, 1205 Attenuation correction, 953 Autologous bone marrow transplantation, 119 B

B-cell markers, 333 Beam hardening, 583 Benign and malignant thyroid neoplasms, 1165 Biologically effective dose, 725 Bladder, 1257 Bladder preservation, 247 Bone, 1141 Bone marrow, 1319 Bone marrow transplantation, 1249 Bone marrow transplant, 509 Boron capture therapy, 171 Bowel complications of radiation, 1213 Brachytherapy, 37, 79, 103, 875, 973 Brain metastases, 273 Brain tumors, 445 Breast, 959 Breast cancer, 295, 305, 339, 405, 765, 783 Breast neoplasm/radiotherapy, 777 Breast radiation response, 117 1 Breast tangents, 411 Bremsstrahlung, 953 Bronchoalveolar lavage, 361 C Cancer, 983 Cancer of the cervix, 399, 725 Capillary, 1205 Capital investment, 379 Carboplatin, 267 Carcinoma of the cervix, 841 Cell-cycle, 525 Cell subpopulations, 5 19 Central nervous system (CNS) malignancies, 541 Central nervous system abnormalities,

983

SUBJECT

INDEX

Volume

31, 1995

Cervical cancer, 79, 109, 717, 973 Cervix, 1281, 875 Cervix cancer, 31 CFU-c, 905 Charged particle therapy, 467 Chemo/radiation interactions, 1249 Chemoradiotherapy, 807, 813 Chemotherapy. 1257, 1281, 305, 315, 485, 799, 911 Chemotherapy effects, 1187 Chemotherapy intensification, 477 Children, 445 Chinese hamster, 535 Chondrosarcoma, 467 CHOP-Bleo, 3 Chordoma, 467, 577 Clamping, 857 Classical pneumonitis, 36 1 Classification system, I 123 Clinical trials, 353 CNS, 51 Cognitive impairment, 911 Combined modality therapy, 503 Combined treatment, 807 Complications, 37, 1123, 735 Computed tomography, 109 Conformal, 461 Conformal radiation therapy, 935 Conformal radiotherapy, 605 Conformal therapy, 25, 113 Conservative surgery and radiation, 791 Conservative treatment, 295, 765 Coronary artery, 1205 Coronary artery disease, 1205 Cranial irradiation, 65 Craniospinal irradiation, 477, 561 CT planning, 411 CT-simulation, 935 Cultured cells, 535 Curative radiotherapy, 26 1 Cytokines, 1319, 361 D Diffuse histopathology, 333 Diffuse large cell lymphoma, 3 Digitally reconstructed radiographs, DNA double strand breaks, 345 DNA repair, 345 Dose, 129 Dose fractionation, 735 Dose prescription, 157 Dose response, 353 Dose tolerance of breast, 1171 Dose tolerance of skin, I 17 1 Dose-volume histograms, 1249 Dose volume histograms, 883 Dosimetry, 541, 629, 635. 953 DRR, 935 Ductal carcinoma in situ, 791 Dynamic wedge, 583 XIX

935

E Echography, 65 I Efficacy, 661 Efficiency, 379 Elderly, 783 Elderly rats, 65 Elective treatment, 353 Electron beam, 157 Electronic portal imaging, 135 Electrons, 893 Endometrial carcinoma, 37 Endometrium, 875 Endothehal cell, 1205 Esophageal adenocarcinoma, 567 Esophageal carcinoma, 921 Esophageal stricture, 12 13 Exit dosimetry, 593 Extraocular muscles, 65 1 Eye, I 123 F Fallopian tube, 1281 Female reproductive tract, 1281 Fibroblasts, 525 Fibrosis, 1187, 1205, 571 Film dosimetry, 583 Five-fluorouracil, 921 Flow cytometry, 519 Fractionated irradiation, 833, 847, 857 Fractionated radiation therapy, 143 G Gamma-interferon, 529 Gastric ulceration, 1213 Gastrointestinal radiation injury, Gene transcription, 361 Giant cell tumor, 467 Gleason grade, 237 Glomerular capillary endothelial Glottis carcinoma, 285 Graves’ disease, 1165 Graves’ ophthalmopathy, 65 1 Growing bone, 1301 Growth arrest, 1249 Growth factors, 361, 567 Growth kinetics. 847 H HDR brachytherapy, 959 Head and neck cancer, 661 Head and neck carcinomas, 503 Head and neck neoplasms, 279 Health physics, 629 Heart, 1205 Hematopoiesis, 13 19

12 13

cell,

865

Hematopoietic toxicity, 529 Hepatic irradiation, 1237 High dose rate, 79, 165 High-dose-rate afterloader, 967 High dose rate brachytherapy, 735 High dose rate intracavitary brachythcrapy, 725 High energy protons, 535 Hodgkin’s disease, 227 Hyperfractionated radiation therapy, 453 Hyperfractionated radiotherapy, 827 Hyperfractionation, 493 Hyperrenninemic hypertension, 1249 Hypersensitivity pneumonitis, 361 Hyperthermia, 893, 905 Hyperthyroidism, 1165 Hypertrophy, 1249 Hypopharynx, 493 Hypopituitarism, 1165 Hypothalamus, 1113 Hypothyroidism, 1165, 279 Hypoxia, 857 I

Image display, 135 Image registration, 113 Immobilization device, 143 Implant, 875 Implantation, 959 Induction chemotherapy, 8 13 Inhalation, 93 Injury, 1257 Intelligence, 983 Interferon-gamma, 827 Interstitial brachytherapy, 149, 393 Intrinsic radiosensitivity, 841 Iododeoxyuridine, 87 Iridium-192, 149 Irradiated lung and heart areas, 411 Irradiation, 703 Irradiation and surgery, 703 Irradiation effect, I 14 1 Isolated central nervous system relapse, 477 Isolated CNS relapse, 561 K

Kidney,

865

L

Lactate, 525 Larynx, 493 Late effects, 1187, 1237, 1281, Late effects breast, 1171 Late effects skin, 1171 Late radiation injury, 1309 Learning, 65 Linear accelerator, 635 Linear quadratic formula, 371 Liver, 883 Local control, 503 Localization, 959 Locally advanced nonsmall cell cancer, 813

1353

Local recurrence, 247 Long-term follow-up, 973 Long-term results, 8 13 Low-dose irradiation, 485 Low dose rate, 165 Low grade gliomas, 461 Lung cancer, 267, 273, 819 Lung fibroblasts, 5 19 Lung functions, 915 Lung irradiation, 9 15 Lymph node metastases, 31 Lymph node status. 503 Lymphocyte predominant Hodgkin’s disease. 333 Lymphocytes, 339 M Malignant gliomas, 453 Malignant lymphoma, 929 Malignant melanoma, 345 Mammary tumor xenograft, 833 Marrow transplantation, 13 19 Measurement variation, 943 Megavoltage on-line imaging, 943 Memory, 65 Merkel cell carcinoma, 325 Mesangial cell, 865 Metastases, 247 Metastatic disease, 43 Micro-dosimetry, 17 1 Microdosimetry, 629 Microvessel response to irradiation, 117 1 Monoclonal antibodies, 17 1, 529 Monoclonal antibodies (MoAbs), 541 Monte Carlo, 17 1 Morphometry, 865 MR T2-signal abnormality, 461 Mucosa, 1141 Multicenter trials. 661 Murine tumors, 847 Muscle, 1309 Myocardium, 1205 N Nasopharyngeal carcinoma, 611 Natural history, 21 Nerve, 1309 Neurocognitive assessment, 561 Neuroendocrine, 1113 Neuroendocrine (Merkel cell) carcinoma, 315 Neuropsychological impairment, 983 Neurotoxicity, 911 Node positive, 13 Nodular, 333 Nonsmall cell, 267 Nonsmall cell lung cancer, 261, 827 Normalization, 157 Normal tissue toxicity, 1301 NTCP, 51, 883 Nuclear grade, 791

Optimization, 179, 617 Optimize, 79 Orbit, 1123 Organ preservation, 553 Orthopedic stabilization, 43 Orthovoltage radiotherapy, 571 Osteogenic sarcoma, 467 Ovary, 1281 Overall treatment time, 833 Oxygen radical production, 93 P 22P. 953 Pancreas, 605 Parallel architecture, 883 Pathological fracture, 43 Pathophysiology of irradiated skin, 117 1 Patterns of care, 103 Patterns of failure, 461, 765 Pediatric genitourinary malignancy, 393 Pediatric radiation renal tolerance, 1249 Pelvic failure, 109 Pelvic irradiation, 31 Penile induration, 57 1 Pentoxifylline, 71 Pericarditis, 1205 Pericardium, 1205 Peyronie’s disease, 571 Phagocyte, 93 Pharmacokinetics, 93, 541 Pilocarpine, 661 Pituitary, 1113 Ploidy, 841 Pneumonitis, 71 Portal imaging, 593 Posterior pharyngeal wall carcinoma, 611 Postoperative radiotherapy, 43 Potential doubling time, 833 Potential doubling time CT&, 847 Predictive assays, 841 Preoperative radiation therapy, 87 Primary orbital lymphoma, 929 Primate, 865 Prognosis, 247, 567 Prognostic factors, 765 Prognostic parameters, 743 Proliferation, 525 Prophylactic cranial irradiation, 911 Prostaglandins, 57 Prostate cancer, 13, 21, 25, 237 Prostate movement, 113 Proton irradiation, 535 Proton therapy, 577 Proximal tubule, 865 PSA, 21 PSA doubling time, 21 Psychometric testing, 911 Pulmonary fibrosis, 71, 361 Pulsed field gel electrophoresis, 345

Q

0 lung

Ocular adnexa, 1123 Once-weekly irradiation,

xx

783

Quality control, 593 Quality of life, 1353, 453 Quantitative SPECT imaging,

953

S Rabbit, 1205 Radiation, 57, 1123, 1205, 1257, 1281, 273, 295, 493, 651, 661, 865, 893, 905, 983 Radiation dose limit, 387 Radiation fractionation, 799 Radiation hepatitis, 883 Radiation-induced bone sarcomas, 405 Radiation-induced cancer, 387 Radiation-induced heart disease, 1205 Radiation-induced liver disease, 1237 Radiation injury, 71, 1165, 1205 Radiation nephritis, 1249 Radiation nephropathy, 1249 Radiation pneumonitis, 1187, 361 Radiation protection, 387 Radiation sensitivity, 5 19 Radiation sensitizers, 87 Radiation therapy, 37, 103, 109, 1113, 129, 1301, 135, 1353, 237, 325, 353, 379, 467, 717, 743 Radical radiation therapy, 255 Radioimmunotherapy. 529 Radionuclide therapy, 953 Radiosensitivity, 339 Radiosensitizer. 827 Radiosurgery, 617 Radiotherapy, 3, 13, 21, 43, 227. 247, 267, 279, 285, 315, 371, 399, 503, 577, 617, 629, 735, 777, 819, 921, 973 Radiotherapy technique, 6 11 RBE, 535 Rectal cancer, 255, 553 Rectal complication, 725 Rectal reference point, 725 Reflectors, 893 Relative biological effectiveness, 535 Remote afterloading, 875 Reoxygenation, 857 Repopulation, 833, 847, 857 Results of therapy, 703 Retroperitoneal, 129 Retroperitoneal rarcoma, 87 Review, 1257 Rhabdomyosarcoma, 485, 799 r-IFN-gamma, 93

Safety, 661 Salivary glands, 1141 Salvage cystectomy, 247 Sarcoma, 129 Secondary non-Hodgkin’s lymphoma, 333 Serotonin, 57 Severe combined immunodeficient, 905 Sexual dysfunction, 399 Sexuality, 399 Side effects, 399 Simulated annealing, 179 Simulator based CT, 411 Simultaneous, 893 Skin functional unit, 1171 Skin irradiation response, 1171 Skin molds and applicators, 967 Skin scoring, 1171 Skull neoplasm, 577 Small-cell lung cancer, 807 Small cell lung cancer, 911 Soft tissue sarcomas, 405 Spinal cord, 51, 57 Sporadic pneumonitis, 361 Spread out Bragg peak, 535 Stem cells, 1319 Stereotactic radiosurgery, 635 Steroids, 273 Subclinical metastases, 353 Superlicial, 893 Surgery, 1281, 285, 325, 399, 485, 799 Surgical staging, 717 Survey, 103 Survival, 445

XXI

U Ultrasound, 65 1, 893 Uniformity index, 157 Ureter, 1257 Ureteric obstruction. 247 Urethra, 1257 Uterine cervical carcinoma, Uterine cervix, 703 Uterine cervix carcinoma, Uterus, 128 1

743 735

V Vagina, 128 1 Vaginal cylinder, 165 Vascular permeability, 57 Veno-occlusive disease, 1237 Virtual simulation, 935 Volume effect, 883 Vulva, 128 1

T

Tamoxifen, 777, 783 Target coverage, 157 Teeth, 1141 Thermoradiotherapy, 893 Thermotolerance, 905 3D radiotherapy, 605 3D treatment planning, 935 Three-dimensional radiation therapy, Thyroid diseases, 1165

Thyroidectomy, 1165 Thyroiditis, 1165 Time-dose factor, 725 Timing of thoracic radiotherapy, 807 Tolerance, 1249, 1257 Tolerance doses and volumes, 1187 Total body irradiation, 119, 1319, 509 Toxicity, 247 Toxicity scoring, 1187 Transitional cell carcinoma, 247 Treatment, 445, 577 Treatment outcome, 929 Treatment planning, 109, 179, 583, 635 Treatment setup variation, 943 Treatment verification, 135 Tumor control, 973 Tumor control probability, 353 Tumor proliferation, 833

X 461 Xerostomia,

661