Volume 39, 1999, Volume Contents and Index

VOLUME CONTENTS Volume 39 No 1 Pharmacokinetics

1

On the determination of bioequivalence. M. Farolfi, J. D. Powers and A. Rescigno

Toxicolgy

5

Effects of the ionophore antibiotic monensin on hepatic biotransformations and target organ morphology in rats. M. Dacasto, L. Ceppa, E. Cornaglia, F. Valenza, M. Carletti, A. Bosio, S. Bosia, G. Ugazio and C. Nebbia

Autonomic System

11

Dopamine modulates peripheral purinergic neurotransmission through multiple presynaptic receptors: tissue-dependent effects. M. M. El-Mas, A. I. Elmallah, A. G. Omar and F. Sharabi

Clinical Pharmacology

21

Activation of mitogen activated protein kinase in human platelets by genistein. S. V. Kansra, M. A. Reddy, Y.-I. Weng and S. D. Shukla

Gastrointestinal Tract

33

Effect of nitric oxide modulators on pylorus-ligation-induced ulcers in the rat. C. Dixit, L. Rastogi and M. Dikshit

Inflammation

41

Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Y. Abe, S. Hashimoto and T. Horie

49

Clarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model. P. C. Y. Woo, L. W. C. Chow, E. S. K. Ma and K. Y. Yuen

55

Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. R. González, S. Rodríguez, C. Romay, O. Ancheta, A. González, J. Armesto, D. Remirez and N. Merino

61

Bilateral transections of temporo-entorhinal connections attenuate vasopressin improvement of memory in rats. M. M. Winnicka and K. Wi´sniewski

67

Protective role of DL-a-lipoic acid against mercury-induced neural lipid peroxidation. B. Anuradha and P. Varalakshmi

Neuropharmacology, Neuropsychopharmacology and Neuroendocrinology

Volume 39 No 2 Invited Review

81

Calcium alterations in Alzheimer’s disease: Pathophysiology, models and therapeutic opportunities. A. Pascale and R. Etcheberrigaray

Endocrine Pharmacology

89

Effect of bromocriptine on uterine contractility in near-term pregnant rats. A. M. Moustafa, E. M. El-Sayed, O. A. Badary, A. M. Mansour and F. M. A. Hamada

General Pharmacology

97

Effects of several drugs on the liver injury induced by delayed-type hypersensitivity to picryl chloride by regulating suppressor or helper T cells. J. Cao, J. Lu, F. Wu, X. Cheng and Q. Xu

103 Eltanolone (5-b-pregnanolone) does not trigger, and attenuates halothane triggering of, malignant hyperthermia in malignant hyperthermia susceptible swine. G. C. Harrison, R. A. Dyer, R. L. Llewellyn and M. F. M. James Immunopharmacology Respiratory Tract

107 Magnoliae flos inhibits mast cell-dependent immediate-type allergic reactions. H.-M. Kim, J.-M. Yi and K.-S. Lim 113

Cooling-induced contraction in ovine airways smooth muscle. S. M. D. Mustafa, C. W. T. Pilcher and K. I. Williams

125 Cooling-induced bronchoconstriction: The role of ion-pumps and ion-carrier systems. S. M. D. Mustafa, C. W. T. Pilcher and K. I. Williams Inflammation

137 Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide. S. K. Gupta, R. K. Bhardwaj, P. Tyagi, S. Sengupta and T. Velpandian

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Gastrointestinal Pharmacology

143 The effects of excitatory amino acids on isolated gut segments of the rat. S. M. Jankovi´c, D. Milovanovi´c, M. Matovi´c and V. Iri´c-C`upic

Cardiovascular Pharmacology

149 Bradycardia during citalopram treatment: A case report. M.-P. Favre, J. Sztajzel and G. Bertschy

Pharmacognosy

151 Prevention of ethanol-induced gastric lesions in rats by natural honey and glucose–fructose–sucrose–maltose mixture. K. Gharzouli, A. Gharzouli, S. Amira and S. Khennouf 157 Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits. M. F. Ismail, M. Z. Gad and M. A. Hamdy

Volume 39 No 3 Invited Review

167 Drugs preventing Na+ and Ca2+ overload. U. Ravens and H. M. Himmel

Chemotherapy

175 Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma. I. Navis, P. Sriganth and B. Premalatha 181 Examination of antibacterial activity of the photoactivated arginine haematoporphyrin derivative. K. Lasocki, M. Szpakowska, J. Grzybowski and A. Graczyk

Pharmacoeconomy

185 The economic consequences of smoking in Ontario. X. Xie, L. Robson, E. Single, J. Rehm and J. Paul

Pharmacokinetics

193 Bioequivalence of levothyroxine tablets administered to a target population in steady state. R. Cerutti, G. Rivolta, L. Cavalieri, C. Di Giulio, E. Grossi, T. Vago, G. Baldi, V. Righini and A. Marzo 203 Pharmacodynamic modelling of levodopa, 3-O-methyldopa and their effects: An application of the Dixon equation. G. Wu and M. Furlanut

General Pharmacology

211

Trimetazidine ameliorates the hepatic injury associated with ischaemia-reperfusion in rats. A. Settaf, D. Morin, F. Lamchouri, A. Elimadi, Y. Cherrah and J.-P. Tillement

217 Mechanism of vasodilation by cochlear nerve stimulation. Role of calcitonin gene-related peptide. J. Szilvassy, G. Jancso and P. Ferdinandy Respiratory tract

221 Detection of nitric oxide in exhaled air of different animal species using a clinical chemiluminescence analyser. M. Bernareggi, G. Rossoni, E. Clini, E. Pasini, T. Bachetti, G. Cremona, N. Ambrosino and F. Berti

Cardiovascular Pharmacology

225 Cardioprotective effect of enantiomers of cicletanine (BN50417, BN50418) in ischaemic/reperfused isolated working rat hearts: Interaction with glibenclamide. P. Ferdinandy, Z. Szilvássy, T. Csont, M. Koltai and M. T. Droy-Lefaix

Renal Pharmacology

233 Effect of captopril on doxorubicin-induced nephrotoxicity in normal rats. M. A. Mansour, H. A. El-Kashef and O. A. Al-Shabanah

Neuropharmacology, Neuropsychopharmacology and Neuroendocrinology

239 Effects of some natural extracts on the acetylcholine release at the mouse neuromuscular junction. L. Re, S. Barocci, C. Capitani, C. Vivani, M. Ricci, L. Rinaldi, G. Paolucci, A. Scarpantonio, O. S. León-Fernández and M. A. Morales

Gastrointestinal Pharmacology

247 Antioxidant status in experimental peritonitis: Effects of alpha tocopherol and taurolin. D. Konukoglu, H. Iynem and E. Ziylan

Volume 39 No 4 Invited Review

253 Pharmacologic modulation of protein kinase C isozymes: The role of racks and subcellular localisation. M. Csukai and D. Mochly-Rosen

Gastrointestinal Pharmacology

261 Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Y. Ohta, T. Kobayashi and I. Ishiguro

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Clinical Pharmacology

269 Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy. E. El Desoky, M. R. Kandil, A.-H. M. Afifi and O. A. Mostafa

Cardiovascular Pharmacology

275 Lithium chloride-induced cardiovascular changes in rabbits are mediated by adenosine triphosphate-sensitive potassium channels. A. O. Abdel-Zaher and M. M. Abdel-Rahman 283 Midazolams cardiac depressant effects and their lack of reversal by flumazenil in isolated rabbit hearts. T. Ozturk, Y. Tuncok, S. Kalkan, H. Guven and G. Aran 289 Reversal of doxorubicin-induced cardiac metabolic damage by L-carnitine. M. M. Sayed-Ahmed, S. Shaarawy, S. A. Shouman and A.-M. M. Osman

Endocrine Pharmacology

297 Modifications of receptor concentrations for adrenaline, steroid hormones, prostaglandin F2a and gonadotropins in hypophysis and ovary of dairy cows with ovarian cysts. R. Odore, G. Re, P. Badino, A. Donn, D. Vigo, B. Biolatti and C. Girardi

Neuropharmacology, Neuropsychopharmacology and Neuroendocrinology

305 Absence epilepsy and regional blood–brain barrier permeability: The effects of pentylenetetrazole-induced convulsions. N. Ates,, N. Esen and G. Ilbay 311

Gastrointestinal Tract

The importance of the number of NMDA receptors in the development of supersensitivity or tolerance to and dependence on morphine. H. Koyuncuog˘lu, A. Nurten, P. Yamantürk and R. Nurten

321 Antibacterial activity of gentamicin and ciprofloxacin against Gram-negative bacteria: Interactions with pig and calf sera. P. A. Miglioli, R. Silini, O. Carzeri, E. Grabocka and F. Allerberger 325 Preventive effect of teprenone on stress-induced gastric mucosal lesions and its relation to gastric mucosal constitutive nitric oxide synthase activity. K. Nishida, Y. Ohta and I. Ishiguro

Volume 39 No 5 Editorial

333 Searching for the Ideal SERM. A. Poletti

Invited Review

335 New vs old fashioned oestradiol antagonists in mammary carcinoma: ‘in vitro’ and ‘in vivo’ pharacological approaches. A. de Cupis, G. Schettini and R. E. Favoni

Gastrointestinal Pharmacology

345 Atypical b-adrenoceptors mediating relaxation in the human colon: functional evidence for b3-rather than b4-adrenoceptors. F. de Ponti, C. Modini, G. Gibelli, F. Crema and G. Frigo

Endocrine Pharmacology

349 The in vivo interaction between gliclazide and glibenclamide and insulin on glucose disposal in the rat. M. O. M. Tanira and B. L. Furman

General Pharmacology

357 Effects of moxonidine and clonidine on potassium excretion in Sprague–Dawley rats. H. Hohage, T. Mehrens, F. Matzkies, M. Steinmetz and J. Greven

Cardiovascular Pharmacology

363 Differential effects of some cell signalling inhibitors upon nitric oxide synthase expression and nuclear factor-kB activation induced by lipopolysaccharide in rat aortic smooth muscle cells. J. Zhou, A. D. Struthers and G. A. Lyles

Gastrointestinal Tract

375 Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Y. Nagakura, S. Akuzawa, K. Miyata, T. Kamato, T. Suzuki, H. Ito and T. Yamaguchi

Neuropharmacology, Neuropsychopharmacology and Neuroendocrinology

383 Relationship between cerebrospinal fluid pressure and plasmatic ADH. A. Satta, M. V. Varoni, D. Palomba, A. Pala, M. P. Demontis, R. Faedda and V. Anania

Autonomic System

385 Distinct functional muscarinic receptors in guinea-pig gallbladder, ileum and atria. A. Karaalp, A. Akici, H. Akbulut, N. B. Ulusoy and S. Oktay

v

Molecular and Cellular Pharmacology

397 Mast cell degranulation in rat mesenteric venule: effects of L-NAME, methylene blue and ketotifen. M. Kimura, H. Mitani, T. Bandoh, T. Totsuka and S. Hayashi

Volume 39 No 6 Editorial

403 Genetic models in pharmacology: present status and future. R. P. Gainetdinov and M. G. Caron

Invited Review

405 Genetically modified mice in neuropharmacology. R. Brusa

Cardiovascular Pharmacology

421 The influence of lidocaine and verapamil on haemodynamic parameters after intravenous administration of midazolam in rabbits. A. Wiktorowska, J. Owczarek and D. Orszulak-Michalak 431 Atenolol depresses post-ischaemic recovery in the isolated rat heart. S. Allibardi, G. Merati, S. Chierchia and M. Samaja

Neuropharmacology, Neuropsychopharmacology and Neuroendocrinology

437 Comparative behavioural effects of benzodiazepine and non-benzodiazepine anxiolytics in rhesus monkeys. R. Kumar, G. Palit, J. R. Singh and B. N. Dhawan 445 Dopaminergic projection to the central amygdala mediates the facilitatory effect of CCK-8US and caerulein on memory in rats. M. M. Winnicka and K. Wi´sniewski 451 Effect of fluoxetine on maximal electroshock seizures in mice: acute vs chronic administration. S. S. Raju, A. R. Noor, S. Gurthu, C. R. Giriyappanavar, S. B. Acharya, H. C. Low and S. H. Quah 455 Neurochemical characteristics and behavioral responses to psychological stress in ovariectomized rats. J. Zhang, M. Inazu, K. Tsuji, E. Yamada, H. Takeda and T. Matsumiya

Autonomic System

Pharmacokinetics and Methods

463 Studies on the spasmolytic and uterine relaxant actions of N-ethyl and N-benzyl-1,2-diphenyl ethanolamines: elucidation of the mechanisms of action. D. M. Bakheet, K. E. H. El Tahir, M. I. Al-Sayed, H. A. El-Obeid and K. A. Al-Rashood 471 Compartmental analysis revisited. A. Rescigno 479 [3H]Tyramine uptake by rat liver slices. D. M. Tchercansky, M. C. Rubio and C. Acevedo

Autonomic Pharmacology

487 Pharmacological analysis of 5-hydroxytryptamine effects on human isolated ureter. S. GIdener, M. Gümüs,tekIn and Z. Kirkali 493 Announcement i

Volume contents and index

vi

INDEX Note: Author names are in italic type. 3OMD (3-O-methyldopa) 203 Abdel-Rahman, MM 275 Abdel-Zaher, AO 275 Abe, Y 41 absence epilepsy 305 absorption, extent/rate 1 acetic acid 55 acetylcholine 239 Acevedo, C 479 Acharya, SB 451 acid secretion 151 acute admistration, fluoxetine 451 adenosine triphosphate (ATP) 211 ADH (antidiuretic hormone) 383 adrenaline 297 a2-adrenoceptors 11, 357 b3-adrenoceptors 345 Afifi, A-HM 269 airway smooth muscle 113, 125 Akbulut, H 385 Akici, A 385 Akuzawa, S 375 Al-Rashood, KA 463 Al-Sayed, MI 463 Al-Shabanah, OA 233 alanine aminotransferase (ALAT) 211 Allerberger, F 321 allergic reactions, immediate-type 107 Allibardi, S 431 alpha-tocopherol 247 Alzheimer's disease 81 Ambrosino, N 221 amino acids, excitatory 143 Amira, S 151 amygdala, central 445 anaesthesia 103, 421 Anania, V 383 Ancheta, O 55 anti-dinitrophenyl 107 anti-inflammatories 55, 137 antibacterial photodynamic effect 181 antibiotics, monensin 5 anticonvulsant dose (ED50), phenytoin 451 antidiuretic hormone (ADH) 383 antiepileptic drugs 269 antioestrogens 333, 335 antioxidants 67, 247 Anuradha, B 67 anxiolytics 437 aorta 275, 363 aortic strips 275 Aran, G 283 area under the curve 1 arginine haematoporphyrin derivative 181 L-arginine 33 L-arginine methyl ester (L-NAME) 397 Armesto, J 55 arrhythmias 167, 421 ASAT (aspartate aminotransferase) 211

aspartate 143 aspartate aminotransferase (ASAT) 211 atenolol 431 Ates¸, N 305 atherosclerosis 157 ATP (adenosine triphosphate) 211 atria 385 avoidance, passive 445 b-blockers 431 Bachetti, T 221 Badary, OA 89 Badino, P 297 Bakheet, DM 463 Baldi, G 193 Bandoh, T 397 Barocci, S 239 baroreceptors 383 benzodiazepines 437 Bernareggi, M 221 Berti, F 221 Bertschy, G 149 Bhardwaj, RK 137 bioenergetics 431 bioequivalence 1, 193 Biolatti, B 297 bladder 11 blood-brain barrier 305 Bosia, S 5 Bosio, A 5 bradycardia 149 breast cancer 333, 335 bromocriptine 89 bronchiole 113 bronchoconstriction, cooling-induced 113, 125 Brusa, R 405 buspirone 437 Ca 81, 113, 239 Ca2+ channels 463 Ca2+ overload 167 caerulein (CER) 445 calcitonin gene-related peptide (CGRP) 217 calcium 81, 113, 167, 239, 463 calf serum 321 Canada, smoking 185 cancer, breast 333, 335 Cao, J 97 Capitani, C 239 captopril 233 carbachol 385 cardiac function arrhythmia 167, 421 midazolam 283 protein kinase C 253 cardiomyopathy, fatty acid oxidation 289 cardiovascular function, lithium chloride 275 Carletti, M 5 L-carnitine 289

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Caron, MG 403 Carzeri, O 321 Cavalieri, L 193 CC50 (convulsive current) 451 CCK-8US (cholecystokinin unsulphated octapeptide) 445 central amygdala 445 Ceppa, L 5 CER (caerulein) 445 cerebrospinal fluid pressure 383 Cerutti, R 193 CGRP (calcitonin gene-related peptide) 217 chemiluminescence analyser 221 chemokine 41 Cheng, X 97 Cherrah, Y 211 Chierchia, S 431 chlordiazepoxide 437 cholecystokinin unsulphated octapeptide (CCK8US) 445 Chow, LWC 49 chronic admistration, fluoxetine 451 cicletanine 225 cimetidine 97 ciprofloxacin 321 cisplatin 175 citalopram 149 clarithromycin 49 Clini, E 221 clonidine 357 clozapine 385 cochlear stimulation 217 colitis 55 colon, relaxation 345 compartmental analysis 471 compound 48/80 107, 261 conditional knockouts 405 contractions cooling-induced 113, 125 uterine 89 convulsions 305 convulsive current (CC50) 451 cooling-induced contraction 113, 125 Cornaglia, E 5 coronary occlusion 225 cost of illness, smoking 185 cows 297, 321 Crema, F 345 Cremona, G 221 Csont, T 225 Csukai, M 253 curcumin 41, 175 cysts, ovarian 297 cytoprotection, GFSM/honey 151 DA2-dopaminoceptors 11 Dacasto, M 5 dairy cows 297 de Cupis, A 335 de Ponti, F 345 delayed-type hypersensitivity 97 Demontis, MP 383 dependence, morphine 311

Dhawan, BN 437 Di Giulio, C 193 diazepam 437 dietary curcumin 175 Dikshit, M 33 dilution factor 471 diphenhydramine 97 Dixit, C 33 Dixon equation 203 Donn, A 297 dopamine 11 doxorubicin 233, 289 Droy-Lefaix, MT 225 drug interaction, L-carnitine/doxorubicin 289 drug metabolism, monensin 5 Dyer, RA 103 economic cost, smoking 185 ED50 (anticonvulsant dose), phenytoin 451 El Desoky, E 269 El Tahir, KEH 463 El-Kashef, HA 233 El-Mas, MM 11 El-Obeid, HA 463 El-Sayed, EM 89 Elimadi, A 211 Elmallah, AI 11 eltanolone 103 enantiomers 225 endocrinotherapy 335 enzymic antioxidants 67 epilepsy 269, 305 Esen, N 305 Etcheberrigaray, R 81 ethanol 151 excitatory amino acids 143 exhaled air 221 exploratory behaviour, oviarectomized rats 455 extent of absorption 1 extraneuronal uptake, tyramine 479 extrapancreatic 349

Faedda, R 383 Farolfi, M 1 fatty acid oxidation 289 Favoni, RE 335 Favre, M-P 149 Ferdinandy, P 217, 225 fibrosarcoma 175 flumazenil 283 fluoxetine 451 Frigo, G 345 Furlanut, M 203 Furman, BL 349 Gad, MZ 157 Gainetdinov, RR 403 gallbladder 385 garlic 157 gastric mucosal lesion 261, 325 gastric ulcers 33, 151 gastrointestinal prokinetic benzamides 375 gemfibrozil 157

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gene targeting 403, 405 genetic models 403, 405 genetically altered mice 403, 405 genistein 21 gentamicin 321 GFSM (glucose—fructose—sucrose—maltose) mixture 151 Gharzouli, A 151 Gharzouli, K 151 Gibelli, G 345 GIdener, S 487 ginseng 157 Girardi, C 297 Giriyappanavar, CR 451 glibenclamide 217, 225, 275, 349 gliclazide 349 glucose disposal 349 glucose—fructose—sucrose—maltose (GFSM) mixture 151 glutamate 143 glutathione 247 gonadotropins 297 González, A 55 González, R 55 Grabocka, E 321 Graczyk, A 181 gram-negative bacteria 321 Greven, J 357 Grossi, E 193 Grzybowski, J 181 guinea-pigs muscarinic receptors 385 surgical trauma 49 Gümüs¸tekIn, M 487 Gupta, SK 137 Gurthu, S 451 gut 143 Guven, H 283 haematoporphyrin derivative 181 haemodynamic parameters 421 halothane 103 Hamada, FMA 89 Hamdy, MA 157 Harrison, GC 103 Hashimoto, S 41 Hayashi, S 397 heart, isolated rabbit 283 helper T cells 97 hepatic uptake, tyramine 479 high-energy phosphate 431 Himmel, HM 167 histamine 97, 107, 261 Hohage, H 357 honey 151 Horie, T 41 hormones 297 5-hydroxytryptamine (5-HT) 375, 455, 487 5-hydroxytryptamine (5-HT)3 receptors 375 5-hydroxytryptamine (5-HT)4 receptors 375 hypercholesterolemia 157 hyperthermia, malignant 103 hypophysis 297

hypoxia 167 IgE see immunoglobulin E IL-1 see interleukin-1 Ilbay, G 305 ileum 385 imidazoline 357 immediate-type allergic reaction 107 immunoglobulin E (IgE) 107 Inazu, M 455 inflammation 41, 49, 137 insulin 349 interleukin-1 (IL-1) 41 intestinal motility 345, 463 propulsion 375 intracranial pressure 383 ion pumps 125 ion-carrier systems 125 Iri´c-C`upic, V 143 ischaemia, low-flow 431 ischaemia/reperfusion 167, 211, 225, 431 Ishiguro, I 261, 325 Ismail, MF 157 isozymes 253 Ito, H 375 Iynem, H 247

James, MFM 103 Jancso, G 217 Jankovi´c, D 143 K+ channels 275 K+ excretion 357 kainic acid 143 Kalkan, S 283 Kamato, T 375 Kandil, MR 269 Kansra, SV 21 Karaalp, A 385 ketotifen 397 Khennouf, S 151 Kim, H-M 107 Kimura, M 397 kinases 253 Kirkall, Z 487 Kobayashi, T 261 Koltai, M 225 Konukoglu, D 247 Koyuncuogˇlu, H 311 Kumar, R 437 L-NAME (L-arginine

methyl ester) 397 Lamchouri, F 211 Lasocki, K 181 León-Fernández, OS 239 levodopa 203 levothyroxine 193 levotriiodothyronine 193 lidocaine 421 ligation 33 Lim, K-S 107 lipid peroxidation 67

ix

DL-a-lipoic

acid 67 lipopolysaccharide 33, 363 lithium chloride 275 liver 97, 211, 479 Llewellyn, RL 103 locomotor activity 61 loose patch clamp 239 lorazepam 437 Low, HC 451 low-flow ischaemia 431 Lu, J 97 Lyles, GA 363

Ma, ESK 49 McN-A-343 385 macrophages 41 Magnoliae flos 107 malignant hyperthermia 103 malondialdehyde 247 Mansour, AM 89 Mansour, MA 233 MAP kinase 21 marker enzymes 175 Marzo, A 193 mast cells 107, 397 Matovi´c, M 143 Matsumiya, T 455 Matzkies, F 357 maximal electroshock seizures 451 maximum concentration 1 Mehrens, T 357 memory 61, 445 menopausal syndrome 455 Merati, G 431 mercuric chloride 67 Merino, N 55 mesenteric venule 397 3-O-methyldopa (3OMD) 203 methylene blue 397 mice genetically altered 403, 405 maximal electroshock seizures 451 neuromuscular junction acetylcholine 239 transgenic 403, 405 microcirculation 397 midazolam 283, 421 Miglioli, PA 321 Milovanovi´c, D 143 Mitani, H 397 mitogen activated protein kinase 21 Miyata, K 375 MK801 311 Mochly-Rosen, D 253 modelling, pharmacodynamic 203 Modini, C 345 monensin 5 monocytes 41 Morales, MA 239 Morin, D 211 morphine 311 morphology 5 Mostafa, OA 269 Moustafa, AM 89

moxonidine-clonidine-imidazoline receptor agonists 357 muscarinic receptors 385 muscle, smooth 113, 125, 143 Mustafa, SMD 113, 125 myocardial function 225

N-benzyl-1,2-diphenyl ethanolamine 463 N-ethyl-1,2-diphenyl ethanolamine 463 N-methyl-D-aspartate (NMDA) 143, 311 Na+ Ca2+-exchanger 167 H+-exchanger 167 K+-ATPase 167 Nagakura, Y 375 naltrexone 311 natural extracts 239 Navis, I 175 Nebbia, C 5 NEFA see non-esterified fatty acids nephrotoxicity 233 neural vasorelaxation 217 neurological disease 403, 405 neuromuscular junction 239 neuronal uptake, tyramine 479 neutrophil infiltration 325 NF-kB (nuclear factor-kB) 363 nimesulide 137 Nishida, K 325 nitric oxide (NO) 33, 221, 397 nitric oxide (NO) synthase 325, 363 nitro-L-arginine methyl ester 33 NMDA (N-methyl-D-aspartate) 143, 311 NO see nitric oxide (NO) non-enzymic antioxidants 67 non-esterified fatty acids (NEFA) 349 Noor, AR 451 nuclear factor-kB (NF-kB) 363 Nurten, A 311 Nurten, R 311 Odore, R 297 oestradiol 333, 335 oestrogens 335 6-OHDA lesions 445 Ohta, Y 261, 325 Oktay, S 385 Omar, AG 11 Ontario, smoking 185 Orszulak-Michalak, D 421 Osman, A-MM 289 ouabain 125 ovarian cysts 297 oviarectomy 455 ovine models 113 Owczarek, J 421 oxidative stress 247 oxotremorine 385 oxytocics 463 oxytocin 89 Ozturk, T 283 Pala, A 383

x

Palit, G 437 Palomba, D 383 Paolucci, G 239 Parkinson's disease 203 Pascale, A 81 Pasini, E 221 passive avoidance 61, 445 Paul, J 185 pectin 157 pentylenetetrazole 305 peripheral cells 81 peritonitis 247 pharmacodynamic modelling 203 phenytoin, ED50 451 phycocyanin 55 picryl chloride 97 pigs malignant hyperthermia 103 serum 321 Pilcher, CWT 113, 125 plasma levels, antiepileptic drugs 269 platelets 21 Poletti, A 333 potassium channels 275 potassium excretion 357 Powers, JD 1 pp60c-src 21 pregnancy 89 5-b-pregnanolone 103 Premalatha, B 175 presynaptic receptors 11 prostaglandin F2a 297 protective effects, trimetazidine 211 protein kinase C 253 Pseudomonas aeruginosa 181 psychological stress 455 purinergic transmission 11 pylorus ligation 33 Quah, SH 451 rabbits hypercholesterolemia 157 lithium chloride 275 midazolam 283, 421 RACKs 253 Raju, SS 451 Rastogi, L 33 rate of absorption 1 rats aorta 363 colitis 55 dopaminergic modulation of purinergic transmission 11 effects of excitatory amino acids on gut 143 gastric mucosal lesion 261 gastric ulcers 33, 151 glucose disposal 349 hearts 211, 225 ischaemia 431 K+ excretion 357 liver 211 mast cell degranulation 397

memory 61, 445 monensin 5 nephrotoxicity 233 nimesulide 137 oviarectomized 455 Sprague-Dawley 357 tyramine uptake by liver slices 479 uterine contractions 89 WAG/Rij 305 Ravens, U 167 Re, G 297 Re, L 239 Reddy, MA 21 Rehm, J 185 Remirez, D 55 Rescigno, A 1, 471 Rhesus monkeys 437 Ricci, M 239 Righini, V 193 Rinaldi, L 239 Rivolta, G 193 Robson, L 185 Rodríguez, S 55 Romay, C 55 Rossoni, G 221 Rubio, MC 479

Samaja, M 431 Satta, A 383 Sayed-Ahmed, MM 289 Scarpantonio, A 239 Schettini, G 335 seizures, maximal electroshock 451 Sengupta, S 137 sepsis 247 serotonin 261, 487 serum calves 321 concentration 193 pigs 321 Settaf, A 211 Shaarawy, S 289 Sharabi, F 11 Shouman, SA 289 Shukla, SD 21 Silini, R 321 Singh, JR 437 Single, E 185 smoking 185 smooth muscle 363 cooling-induced contraction 113, 125 excitatory amino acids 143 relaxants 345 sodium ions 167 sodium nitroprusside 33 Sprague-Dawley rats 357 Sringanth, P 175 Staphylococcus aureus 181 Steinmetz, M 357 steroid anaesthesia 103 steroid hormones 297 stress gastric mucosal lesion 325

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oxidative 247 psychological 455 Struthers, AD 363 sulphonylurea drugs (SUs) 349 superoxide dismutase 247 supersensitivity, morphine 311 suppressor T cells 97 surgical trauma 49 SUs (sulphonylurea drugs) 349 Suzuki, T 375 Szilvassy, J 217 Szilvássy, Z 225 Szpakowska, M 181 Sztajzel, J 149 T cells, helper/supressor 97 Takeda, H 455 tamoxifen 333, 335 Tanira, MOM 349 taurolin 247 Tchercansky, DM 479 temporo-entorhinal connections 61 teprenone 325 thyroid hormones 193 Tillement, J-P 211 TNF-a (tumour necrosis factor-a) 41 tolerance 97, 311 Totsuka, T 397 trachea 113 transfer time 471 transgenic mice 403, 405 translocation 253 trauma, surgical 49 trimetazidine 211 Tsuji, K 455 tumour marker enzymes 175 tumour necrosis factor-a (TNF-a) 41 Tuncok, Y 283 turnover time 471 Tyagi, P 137 tyramine 479 tyrosine kinase 21

Ugazio, G 5 ulcers, gastric 33, 151

Ulusoy, NB 385 unanaesthetised rats 261 uncontrolled epilepsy 269 ureter 487 urinary bladder 11 uterine contractions 89 uterus 89, 463 Vago, T 193 Valenza, F 5 Varalakshmi, P 67 Varoni, MV 383 vas deferens 11 vascular smooth muscle cells 363 vasopressin 61 vasorelaxation, neural 217 Velpandian, T 137 ventricular fibrillation 225 verapamil 421 Vigo, D 297 Vivani, C 239 WAG/Rij rat 305 Weng, Y-I 21 Wiktorowska, A 421 Williams, KI 113, 125 Winnicka, MM 61, 445 Wi´sniewski, K 61, 445 Woo, PCY 49 Wu, F 97 Wu, G 203

Xie, X 185 Xu, Q 97 Yamada, E 455 Yamaguchi, T 375 Yamantürk, P 311 Yi, J-M 107 Yuen, KY 49 Zhang, J 455 Zhou, J 363 Ziylan, E 247

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