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Volume 40 (1982) contents
385 dGuo and 4-dimethylamino-dThd following in vitro reaction of dimethylcarbamyl chloride with calf thymus DNA and 6-diethylcarbamyloxy-dGuo following in vitro reaction of diethylcarbamyl chloride with calf thymus DNA, 209 Seidegard, J. and J.W. DePierre, The effect of trans-stilbene oxide and other structurally related inducers of drugmetabolizing enzymes on glucuronidation, 15 Seki, H., see Kitagawa, S. Selkirk, J.K., see MacLeod, M.C. Shinnick, F.L., Jr., see Wrighton, S.A. Singh, D., D.P. Loven and R.H. Stevens, Adenosine 3',5'-cyclic monophosphate dependen t and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer, 169 Solomon, J.J., see Segal, A. Stevens, R.H., see Singh, D. Sullivan, P.D., L.E. Ellis, L.M. Calle and I.J. Ocasio, Chemical and enzymatic oxidation of alkylated b e n z o [ a ] pyrenes, 177
Sussmuth, R., see Ackermann-Schmidt, B. Tanaka, M., see Hibasami, H. Van Duuren, B.L., see Segal, Warren, D.L., D.L. Brown, Jr. and A.R. Buckpitt, Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene, 287 Webb, M., see Mogilnicka, E.M. Wendel, A., see Reiter, R. Widdifield, M., see Lipkowitz, K.B. Wilhelm, N., see Oesch, F. Wilson, V.L., R.E. Larson and M.J. Moldowan, A non-invasive method for the study of hepatic drug metabolism in rodents: antineoplastic drug effects on antipyrine metabolism in mice, 159 Wrighton, S.A., W.E. Fahl, F.L. Shinnick, Jr. and C.R. Jefcoate, Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide, 345
CHEMICO-BIOLOGICAL INTERACTIONS VOLUME 40 (1982) CONTENTS Effects of lindane treatment on drug metabolizing enzymes and liver weight of CF1 mice in which it evoked hepatomas and in non-susceptible rodents by F. Oesch, T. Friedberg, M. Herbst, W. Paul, N. Wilhelm and P. Bentley (Mainz and Ingelheim, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The effect of trans~stilbene oxide and other structurally related inducers of drugmetabolizing enzymes on glucuronidation by J. Seidegard and J.W. DePierre (Stockholm, Sweden) . . . . . . . . . . . . . . . . . Metabolism and nucleic acid binding of 7-fluoro-2-acetamidofluorene in rats: oxidative defluorination and apparent dissociation from hepatocarcinogenesis of 8-(N-arylamide)guanine adducts on DNA by J.D. Scribner, N.K. Scribner and G. Koponen (Seattle, WA) . . . . . . . . . . . . Metabolism of 2,4',5-trichlorobiphenyl: enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal fluid of pregnant mice by I. Brandt, P.O. Darnerud, /~. Bergman and Y. Larsson (Uppsala and Stockholm, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 15
27
45
386 Force field conformational analysis of aminofluorene and acetylaminofluorene substituted deoxyguanosine by K.B. Lipkowitz, T. Chevalier, M. Widdifield and F.A. Beland (Indianapolis, IN and Jefferson, AR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Interaction between Li, Ni and Sr content in human cancellous bone by M. Knuuttila, R. Lappalainen, S. Lammi, E. Alhava and H. Olkkonen (Kuopio, Finland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of 1,1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide] on the genome and on the synthesis of nucleic acids and proteins in the bacterial cells by B. Ackermann-Schmidt, R. Siissmuth and F. Lingens (Stuttgart-Hohenheim, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chemical interactions with herpes simplex type 2 virus: enhancement of transformation by hydrazine and 1,2-dimethylhydrazine by F.B. Johnson (Provo, UT) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Short Communication DNA backbone conformation in A A F modified dCpdG: variable conformational modes of achieving base displacement by S. Broyde and B.E. Hingerty (New York, NY and Oak Ridge, TN) . . . . . . . . Erratum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Metabolism of 2,4',5-trichlorobiphenyl: role of the intestinal microflora in the formation of bronchial-seeking methyl sulphone metabolites in mice by ~. Bergman, A. Biessmann, I. Brandt and J. Rafter (Stockholm and Uppsala, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Tetraalkylammonium ions: protection of murine L1210 leukemia and bone marrow progenitor cells in vitro against mechlorethamine cytoxicity and inhibition of the choline transport system by S.A. Naujokaitis, J.M. Fisher and M. Rabinovitz (Bethesda, MD) . . . . . . . . . Effect of caffeine on nucleotide pools in Escherichia coli by I. Sandlie and K. Kleppe (Bergen, Norway) . . . . . . . . . . . . . . . . . . . . . . . DNA-methylation by nitrosocimetidine and N-methyl-N'-nitro-N-nitrosoguanidine in the intact rat by C.T. Gombar and P.N. Magee (Philadelphia, PA) . . . . . . . . . . . . . . . . . . . . A non-invasive method for the study of hepatic drug metabolism in rodents: antineoplastic drug effects on antipyrine metabolism in mice by V.L. Wilson, R.E. Larson and M.J. Moldowan (Los Angeles, CA and Corvallis, OR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ~................ Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer by D. Singh, D.P. Loven and R.H. Stevens (Iowa City, IA) . . . . . . . . . . . . . . . Chemical and enzymatic oxidation of alkylated benzo[a ]pyrenes by P.D. Sullivan, L.E. Ellis, L.M. Calle and I.J. Ocasio (Athens, OH) . . . . . . . . . Metabolic activation of carbon tetrachloride: induction of cytochrome P-450 with phenobarbital or 3-methylcholanthrene and its effect on covalent binding by H. Frank, H.J. Haussmann and H. Remmer (Tiibingen, F.R.G.) . . . . . . . . . . Formation of 6-dimethylcarbamyloxy-dGuo, 6-dimethylamino-dGuo and 4-dimethylamino-dThd following in vitro reaction of dimethylcarbamyl chloride with calf thymus DNA and 6-diethylcarbamyloxy-dGuo following in vitro reaction of diethylcarbamyl chloride with calf thymus DNA by A. Segal, J.J. Solomon, U. Mat~ and B.L. Van Duuren (New York, NY) . . . . . Identification of an arene oxide metabolite of 2,2',5,5'-tetrachlorobiphenyl by gas chromatography-mass spectroscopy by S.T. Forgue and J.R. Allen (Madison, WI) . . . . . . . . . . . . . . . . . . . . . . . . The effects of cadmium and copper on the renal uptake and metallothionein binding of gold in the rat and hamster by E.M. Mogilnicka and M. Webb (Carshalton, U.K.) . . . . . . . . . . . . . . . . . . .
57
77
85
97
113 121
123
133 141
149
159
169 177
193
209
233
247
387 Thyroid hormone-induced changes in the hepatic monooxygenase system, heme oxygenase activity and epoxide hydrolase activity in adult male, female and immature rats by J.E.A. Leakey, H. Mukhtar, J.R. Fouts and J.R. Bend (Research Triangle Park, NC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Uptake of hexavalent chromium by bovine erythrocytes and its interaction with cytoplasmic components; the role of glutathione by S. Kitagawa, H. Seki, F. Kametani and H. Sakurai (Toknshima, Japan) . . . . . Time course of metabolism of benzo[e]pyrene by hamster embryo cells and the effect of chemical modifiers by M.C. MacLeod, B.K. Mansfield and J.K. Selkirk (Oak Ridge, TN) . . . . . . . . . Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene by D.L. Warren, D.L. Brown, Jr. and A.R. Buckpitt (Irvine, CA) . . . . . . . . . . . Rat liver microsomal metabolites of 7-methylbenz[c ] acridine by C.M. Ireland, H.T.A. Cheung, A.J. Ryan and G.M. Holder (Sydney, Australia) Kinetic studies on inhibition of arninopropyltransferases by aurintricarboxylic acid in vitro by H. Hibasami, M. Tanaka and J. Nagai (Tsu, Japan) . . . . . . . . . . . . . . . . . . . The inhibition of renal ATPase by cisplatin and some biotransformation products by P.T. Daley-Yates and D.C.H. McBrien (Uxbridge, U.K.) . . . . . . . . . . . . . . . Effects of dietary paraffin, squalane, and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats by E. Richter, B. Fichtl and S.G. Sch~fer (Munchen, F.R.G.) . . . . . . . . . . . . . . Characteristics of microsomal reduction of benzo [a ] pyrene 4,5-oxide by S.A. Wrighton, W.E. Fahl, F.L. Shinniek, Jr. and C.R. Jefcoate (Madison, WI) . . . . . . . . . . : ......................................... Effects of phenobarbital and sodium salicylate on cytochrome P-450 mixed function oxygenase and glutathione S-transferase activities in rat brain by P. Chand and J. Clausen (Copenhagen, Denmark) . . . . . . . . . . . . . . . . . . . Chemically-induced glutathione depletion and lipid peroxidation by R. Reiter and A. Wendel (Tiibingen, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . Short Communication Observation of metabolites of reduced lantadene A in bile canalicular membranes of rats with triterpene-induced cholestasis by M.A. Pass and M.W. Goosem (Queensland, Australia) . . . . . . . . . . . . . . . . .
257
265
275
287 305
319 325
335
345
357 365
375
Subject Index Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
379
Author Index Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
383
Volume Contents Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
385
Sussmuth, R., see Ackermann-Schmidt, B. Tanaka, M., see Hibasami, H. Van Duuren, B.L., see Segal, Warren, D.L., D.L. Brown, Jr. and A.R. Buckpitt, Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene, 287 Webb, M., see Mogilnicka, E.M. Wendel, A., see Reiter, R. Widdifield, M., see Lipkowitz, K.B. Wilhelm, N., see Oesch, F. Wilson, V.L., R.E. Larson and M.J. Moldowan, A non-invasive method for the study of hepatic drug metabolism in rodents: antineoplastic drug effects on antipyrine metabolism in mice, 159 Wrighton, S.A., W.E. Fahl, F.L. Shinnick, Jr. and C.R. Jefcoate, Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide, 345
CHEMICO-BIOLOGICAL INTERACTIONS VOLUME 40 (1982) CONTENTS Effects of lindane treatment on drug metabolizing enzymes and liver weight of CF1 mice in which it evoked hepatomas and in non-susceptible rodents by F. Oesch, T. Friedberg, M. Herbst, W. Paul, N. Wilhelm and P. Bentley (Mainz and Ingelheim, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The effect of trans~stilbene oxide and other structurally related inducers of drugmetabolizing enzymes on glucuronidation by J. Seidegard and J.W. DePierre (Stockholm, Sweden) . . . . . . . . . . . . . . . . . Metabolism and nucleic acid binding of 7-fluoro-2-acetamidofluorene in rats: oxidative defluorination and apparent dissociation from hepatocarcinogenesis of 8-(N-arylamide)guanine adducts on DNA by J.D. Scribner, N.K. Scribner and G. Koponen (Seattle, WA) . . . . . . . . . . . . Metabolism of 2,4',5-trichlorobiphenyl: enrichment of hydroxylated and methyl sulphone metabolites in the uterine luminal fluid of pregnant mice by I. Brandt, P.O. Darnerud, /~. Bergman and Y. Larsson (Uppsala and Stockholm, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 15
27
45
386 Force field conformational analysis of aminofluorene and acetylaminofluorene substituted deoxyguanosine by K.B. Lipkowitz, T. Chevalier, M. Widdifield and F.A. Beland (Indianapolis, IN and Jefferson, AR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Interaction between Li, Ni and Sr content in human cancellous bone by M. Knuuttila, R. Lappalainen, S. Lammi, E. Alhava and H. Olkkonen (Kuopio, Finland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of 1,1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide] on the genome and on the synthesis of nucleic acids and proteins in the bacterial cells by B. Ackermann-Schmidt, R. Siissmuth and F. Lingens (Stuttgart-Hohenheim, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chemical interactions with herpes simplex type 2 virus: enhancement of transformation by hydrazine and 1,2-dimethylhydrazine by F.B. Johnson (Provo, UT) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Short Communication DNA backbone conformation in A A F modified dCpdG: variable conformational modes of achieving base displacement by S. Broyde and B.E. Hingerty (New York, NY and Oak Ridge, TN) . . . . . . . . Erratum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Metabolism of 2,4',5-trichlorobiphenyl: role of the intestinal microflora in the formation of bronchial-seeking methyl sulphone metabolites in mice by ~. Bergman, A. Biessmann, I. Brandt and J. Rafter (Stockholm and Uppsala, Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Tetraalkylammonium ions: protection of murine L1210 leukemia and bone marrow progenitor cells in vitro against mechlorethamine cytoxicity and inhibition of the choline transport system by S.A. Naujokaitis, J.M. Fisher and M. Rabinovitz (Bethesda, MD) . . . . . . . . . Effect of caffeine on nucleotide pools in Escherichia coli by I. Sandlie and K. Kleppe (Bergen, Norway) . . . . . . . . . . . . . . . . . . . . . . . DNA-methylation by nitrosocimetidine and N-methyl-N'-nitro-N-nitrosoguanidine in the intact rat by C.T. Gombar and P.N. Magee (Philadelphia, PA) . . . . . . . . . . . . . . . . . . . . A non-invasive method for the study of hepatic drug metabolism in rodents: antineoplastic drug effects on antipyrine metabolism in mice by V.L. Wilson, R.E. Larson and M.J. Moldowan (Los Angeles, CA and Corvallis, OR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ~................ Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer by D. Singh, D.P. Loven and R.H. Stevens (Iowa City, IA) . . . . . . . . . . . . . . . Chemical and enzymatic oxidation of alkylated benzo[a ]pyrenes by P.D. Sullivan, L.E. Ellis, L.M. Calle and I.J. Ocasio (Athens, OH) . . . . . . . . . Metabolic activation of carbon tetrachloride: induction of cytochrome P-450 with phenobarbital or 3-methylcholanthrene and its effect on covalent binding by H. Frank, H.J. Haussmann and H. Remmer (Tiibingen, F.R.G.) . . . . . . . . . . Formation of 6-dimethylcarbamyloxy-dGuo, 6-dimethylamino-dGuo and 4-dimethylamino-dThd following in vitro reaction of dimethylcarbamyl chloride with calf thymus DNA and 6-diethylcarbamyloxy-dGuo following in vitro reaction of diethylcarbamyl chloride with calf thymus DNA by A. Segal, J.J. Solomon, U. Mat~ and B.L. Van Duuren (New York, NY) . . . . . Identification of an arene oxide metabolite of 2,2',5,5'-tetrachlorobiphenyl by gas chromatography-mass spectroscopy by S.T. Forgue and J.R. Allen (Madison, WI) . . . . . . . . . . . . . . . . . . . . . . . . The effects of cadmium and copper on the renal uptake and metallothionein binding of gold in the rat and hamster by E.M. Mogilnicka and M. Webb (Carshalton, U.K.) . . . . . . . . . . . . . . . . . . .
57
77
85
97
113 121
123
133 141
149
159
169 177
193
209
233
247
387 Thyroid hormone-induced changes in the hepatic monooxygenase system, heme oxygenase activity and epoxide hydrolase activity in adult male, female and immature rats by J.E.A. Leakey, H. Mukhtar, J.R. Fouts and J.R. Bend (Research Triangle Park, NC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Uptake of hexavalent chromium by bovine erythrocytes and its interaction with cytoplasmic components; the role of glutathione by S. Kitagawa, H. Seki, F. Kametani and H. Sakurai (Toknshima, Japan) . . . . . Time course of metabolism of benzo[e]pyrene by hamster embryo cells and the effect of chemical modifiers by M.C. MacLeod, B.K. Mansfield and J.K. Selkirk (Oak Ridge, TN) . . . . . . . . . Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene by D.L. Warren, D.L. Brown, Jr. and A.R. Buckpitt (Irvine, CA) . . . . . . . . . . . Rat liver microsomal metabolites of 7-methylbenz[c ] acridine by C.M. Ireland, H.T.A. Cheung, A.J. Ryan and G.M. Holder (Sydney, Australia) Kinetic studies on inhibition of arninopropyltransferases by aurintricarboxylic acid in vitro by H. Hibasami, M. Tanaka and J. Nagai (Tsu, Japan) . . . . . . . . . . . . . . . . . . . The inhibition of renal ATPase by cisplatin and some biotransformation products by P.T. Daley-Yates and D.C.H. McBrien (Uxbridge, U.K.) . . . . . . . . . . . . . . . Effects of dietary paraffin, squalane, and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats by E. Richter, B. Fichtl and S.G. Sch~fer (Munchen, F.R.G.) . . . . . . . . . . . . . . Characteristics of microsomal reduction of benzo [a ] pyrene 4,5-oxide by S.A. Wrighton, W.E. Fahl, F.L. Shinniek, Jr. and C.R. Jefcoate (Madison, WI) . . . . . . . . . . : ......................................... Effects of phenobarbital and sodium salicylate on cytochrome P-450 mixed function oxygenase and glutathione S-transferase activities in rat brain by P. Chand and J. Clausen (Copenhagen, Denmark) . . . . . . . . . . . . . . . . . . . Chemically-induced glutathione depletion and lipid peroxidation by R. Reiter and A. Wendel (Tiibingen, F.R.G.) . . . . . . . . . . . . . . . . . . . . . . Short Communication Observation of metabolites of reduced lantadene A in bile canalicular membranes of rats with triterpene-induced cholestasis by M.A. Pass and M.W. Goosem (Queensland, Australia) . . . . . . . . . . . . . . . . .
257
265
275
287 305
319 325
335
345
357 365
375
Subject Index Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
379
Author Index Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
383
Volume Contents Volume 40 (1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
385