Volume contents and author index, Volume 29

LIST OF CONTENTS 1991 Vol . 29, No . 1 1

Instructions for Contributors to Toxicon

J. L~u and K. M. BLUMENTFfAL

l3

Identification of oleic acid binding sites in cytolysis A-III from the heteronemertine Cerebratulus lacteus

O. B. STABELL, V. HORMAZABAL, I. SÎEFFENAK and K. PrnEtesr:N

21

Diarrhetic shellfish toxins: improvement of sample clean-up for HPLC determination

J.-L. HUANG and W. R. TRUNIHLE

31

Cardiotoxin from cobra venom affects the Ca-Mg-ATPase of cardiac sarcolemmal membrane vesicles

M. T. C. RUNNEGAR, R. G. GFrt~FS and I. R. FAU~xex

43

The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes

J. MAHAR, G. L. Lutcncs, Y. Lt, S. HALL and E. MoczvnWwstu

53

Pharmacological and biochemical properties of saxiphilin, a soluble saxitoxin-binding protein from the bullfrog (Rang catesbeiana)

Y. YAHUKt, Y. Ocucti~ and H. TAtcwHASH~

73

Purification of a kininogenase (kininogenase-2) from the venom of Agkistrodon caliginosus (Kankoku-Mamushi)

B. FtrAxc~s, T. R. JOHN, C. SF~BART and I. I. KA~sex

85

New toxins from the venom of the common tiger snake (Notechis scutatus scutatus)

M. K. BRAT, S. KASTUR~ and T. V. GOWDA

97

Structure-function relationships among neurotoxic phospholipases : NN-XIII-PLA z from Indian cobra (Naja naja naja) and VRV PL-V from Russell's viper (Vipers russelli) venoms

E. SncuR, A. M~t~tAtt and J. SncuR

107

ß-Fibrinogenase from the venom of Vipern lebetina

Short Communications l. VARGAS-VILLARREAL, J. J. MARTIN-POW, E. REYNAUU and A. C. Auoont

119

A new affinity adsorbent for the purification of phospholipases A, and A, from animal venoms

S. SoFex, H. StiAr.ev, Z. WEIZMAN, E. Stu,tutc and M. GueeoN

l25

Acute pancreatitis in children following envenornation by the yellow scorpion Leierrus quinquestriatus

M. KLUG and J. Weave

129

An extract from Hydra vulgaris (Cnidaria) nematocysts increases cytoplasmic CaZ+ levels in fibroblasts

D. K. STtvexs and R. I . KtttEC©t

134

Effect of route of exposure and repeated doses on the acute toxicity in mice of the cyanobacterial nicotinic alkaloid anatoxin-A

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Vol. 29, No. 2 T. Pant

l39

Review article-Netuotoxic kinins from wasp and ant venoms

J. S'rüRZ~ct~tt, U. NEUMANN and J.'Meutt

l51

Inhibition of the protein C activator ProtacR, a sense proteinase from the venom of the southern copperhead snake Agkistrodon contortrix contortriz

IV N . ODA, H . NAKAMURA, S . SAKAMOTO, S.-Y . Ltu, H . Ktt~tt~, C.-C . C~twtvc and M . Oxxo

157

Amino acid sequence of a phospholipase A z from the venom of Trimeresurus gramirteus (green hatiu snake)

D . K . StEVEnrs and R . I . KtetECtae

167

Stability studies on the cyanobacterial nicotinic alkaloid antitoxin-A

P . Mix, G. ERDMANN and H . BtGALKE

l8l

The translocation of Botulinum A neurotoxin by chromal&n cells is promoted in low ionic strength solution and is insensitive to trypsin

C . T~x~tct, H . YOSEIIDA, T. SFüMAZU, T. TEteuuCxy M . Toxte~ and N . TAMIYA

I9l

Studies on the venom components of the long-glanded coral snake, Maticora bivirgata

K . T~turt0, F . Kttecttrtett and M . MtzorE

201

Intact inhibition of the stretch reflex during general tetanus

M . N~o~bt~ and J . SAKtIRAt

211

Distribution of labeled Clostridium perJringens epsilon toxin in mice

M° F . D . Futtr~no, M . MARUYAMA, A . S . KAMIGUTI and L . C . Atvrotvt0

219

Comparative study of nine Bothrops snake venoms from adult female snakes and their offspring

S . A . WEtrts~tEtx, J . J . Scrn~T, A . W . BFatntx©tom and L . A. StKtrtt

227

Charactervation and amino acid sequences of two lethal peptides isolated from venom of Wagler's pit viper, Trimeresurus wagleri

G . LANDAN, A . Bnot.~x, Z . WOLLBERG, E . Kocxv~ and D . Graute

237

Evolution of the sarafotoxin/endothelia superfamily of proteins

R . HAF~N, GING-KUO WANG, B . I. $4tAPIRO and G . SrxtcEUxrz

245

Alterations in sodium channel gating produced by the venom of the marine mollusc Cones striates

Short Communications N . Yotcosnw~, K . Tsuzuta, B . SYUTO, N . Funt, K . KttKUtu and K . Oau~t~

261

Binding of botulinum type C1, D and E neurotoxins to neuronal cell lines and synaptosomes

S . D . Atxn, W. G. KxuooEt, and I . I . KwtsEe

265

Multiple myotoxia sequences from the venom of a single prairie rattlesnake (Crotales viridis viridis)

J . PurtcEte~ete, D. Koxnt?±, B . ~TRUICEIJ, NING-SttpavG Lt~rro and F. GvBtw~Etc

269

Cloning and nucleotide sequence of a cDNA encoding ammodytoxin A, the most toxic phospholipase AZ from the venom of long-nosed viper (Vipers ammodytes)

Meeting Announcement

275

Fumonisins: A Current Perspective and a View to the Future, 24-25 April 1991, Raleigh, NC, U .S .A .

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ol . 29, No. 3 Letter to the Editor S . P . H~WSEte, G . A . Coran, D . G . C~t~ot~e and E. J . CtterEtv~tER

277

A neurotoxic factor associated with the bloom-forming cyanobacterium Trichodermitott

Report and Abstracts

279

Ninth European Symposium on Animal, Plant and Microbial Toxins, Lohusalu, Estonia, 23-26 September 1990

P. K. KrtoEFEI.

30l

Review article-Abati's work on the amA~ng nature of the viper and its miraculous powers

A . DE Luce, M . J . RAND, J . J . REtn and D . F . $TORY

311

Differential sensitivities of avian and mammalian neuromuscular jt>nofions to inhibition of cholinergic tranamiasion by m-conotoxin GVIA

G. MA3IROMEI, C. BAReER[o, S. Prsrot.ES[ and G. DeLFtrw

321

A bactericidal protein in Bambino twrit gata pachypus skin venom

G. B. t2u[srAO, C. C. REtr[t?R, W. S. Stc[N[vER, P. A. DEN[vts, S. SUWANRIJMPHA and E. W. Fu

329

Paralytic and insecticidal toxins from the funnel web spider, Hololena carra

G. A. M[uRA, N. A. RoawsoN, W. B. LAWRENCE and J. G. PACE

337

Hepatotoxicity of microcystin-LR in fed and fasted rats

W. M. VALEN'[7NE, D. J. $CHAEFPPR and V. R. BEAS[.Etr

347

Electromyographic assessment of the netuomusc[ilar blockade produced ix vitro by antitoxin-a in the rat

J. L. M[pDLEBROOR

359

Preparation and characterization of monoclonal antibodies against pseudexin

Short Communications E. G. ROWAN, A. L. HARVEY and A. MENEZ

371

Netuomuscular effects of t> ;gexine, a basic phospholipese A~ from Nafa nigricollis venom

l. A. PEAR90N, M. I. TYLP.R and M. E. H. HOWUEN

375

Immunological relationships between the subunits of texlilotoxin and rabbit antiaera raised against textilotoxin and some snake venoms

J. S . KueceeERC and T. M. DAVID90N

379

Envenomation by the colubrid snake .ltractaspis bübronü: a case report

S. SoeER, E. SIiAt[AIC, A. SLONIM and M. GuERON

382

Myocardial injury without heart failure following envenomation by the scorpion Leituwt gttirtqueatriatty in children

M. WACt[SMAN, L. AUREL[AN and J. W. BIJRNEI'r

386

Human immunosuppression induced by sea nettle (Chrysaora ytdngteecirrha) venom

Reviews

391

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Vol . 29, No . 4/5 Letter to the Editor N. C. BUCKNALL

397

Electrical treatment of venomous bites and stings

S. A. WE[NSTEIN, D. CÎi1SZAR, R. C. BELL and L. A. SM[r[t

401

Lethal potency and fractionation oC Duvernoy's secretion from the brown trce snake, Boiga irregtrlaris

A. R. MArroc[cs, S. CROSwE[.[., R. Jutctx and R. J. HuxTAecE

409

Identity of a biGary metabolite formed from monocrotaline in isolated, perfused rat liver

W. MALORNI, S. PARADLSI, M. L. Duru[s, C. F[oRENnx[ and C. RAMONI

417

Enhancement of cell-mediated cytotoxicity by Clostriditun dtj/icile toxin A: an in vitro study

S. NISHIDA and N. TAM[YA

429

Tryptophan residues oC phospholipase At from the venom of an Australian elapid snake (Paettdcchis oestrous)

V. CtIOUMET, M. S. JIANG, I. $PECiCER and C. Box

441

Immunochemical cross-reactivity of two phospholipese Az neurotoxins, agkistrodotoxin and aotoxin

C. BARDA-Fn)ALCO, J. A. GtnMAR~s and C. R. CARLIN[

453

Lipoxygenase-mediated secretary effect of canatoxin the toxic protein from Canavalia eruijormis seeds

Y. SAMEI[MA, Y. Aox[ and D. MEes

461

Amino acid sequence of a myotoxin from venom of the eastern diamondback rattlesnake (Crotales ad~amartteus)

VI C. F. H. HOL.MES

469

Liquid chromatography-linked protein phosphatase bioassay; a highly sensitive marine bioscreen for okadaic acid and related diarrhetic shellfish toxins

K. HARADA, K. tiGAWA, K. MArsuutA, H. NACAI, H. MUR,ArA, M. Suzuxt, Y. ITEZONO, N. NAICAYAMA, M. SHIAAI and M. NAKANO

479

Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K-139

L. YA, YuxEtsoN, G. TANS, M . C. L. G. D. THOMASSEN, H. C. HEMKne and J. ROS~NO

491

Procoagulant activities in venoms from central Asian snakes

B. G. Srit.FS

503

A non-radioactive receptor assay for snake venom postsynaptic neurotoxins

Short Communications M . A. BENI7FZ, E. NAVARRO, M. FExu, J. Taunt.t.o and J. BOADA

51 I

Pharmacological study of the muscle paralyzing activity of the juice of the banana trunk

F. DUCANCEL, E. G. ROWAN, E. CAESAR, A. L. HARVEY, A. Mi:NEZ and J.-C. BOULAIN

516

Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence

E. KARt.ssoN, C. RISINGER, M. JOLKKONEN, C. WERNSTEDr and A. AOEM

521

Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor

M . BARRAL-Nerro and R. L. voN SOHSrEN

527

Serum kinetics of crotoxin from Crotalus durissus ternfrcus venom in mice : evidence for a rapid clearance

D. K. VEST, S. P. MACICESSY and K. V. KARDONG

532

The unique Duvernoy's secretion of the brown tree snake (Boiga bregularis)

H. P. DESMOND, J. M. CRAMPTON and R. D. G. THEAKSTON

536

Rapid isolation and partial characterization of two phospholipases from Kenyan Echis carinafus leakeyé (Leakey's saw-scaled viper) venom

Announcement

541

1st International Workshop on Pore Forming Tozins, Castel Ivano, 26-29 September 1991, Ivano Fracena, Trento, Italy

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Vol . 29, No. 6 C. FIORENTINI and M. TNELBSCAM

543

Review article-Clostridium dt~cile toxin A and its effects on cells

S. M. CARNtmto, V. R. Putto, C. JAR®, L. A. B. M. Lut.A, F. P. FAR1A and A. SFS70

569

Morphometric studies on venom secretory cells from Bothrops jararacossu (Jararacuçu) before and after venom extraction

B. ICAUtrMArt, D. C. WRtaxr, W. R. BAt.t.ou and D. MONf~T

581

Protection against tetrodotoxin and saxitoxin intoxication by a crossprotective rabbit anti-tetrodotoxin antiserum

S. B. Hoos~, M. S. Kuta.Erncta~anT, A. M. DAftt,ne, V. R. BEA9FY, W. W. CARMICHAEI. and W. M. HASCta:~

589

Uptake and subcellular locsli7ation of tritiated dihydro-microcystinLR in rat Gver

D. D. Stn~wwc¢, C. A. Pees, E. J. MYt.ecxARANE, I. SPENCE, R. G.AA.9aENS, M. R. BROwN, A. Cocas and M. E. H. Hownw

603

Protection of monkeys against the lethal effects of male funnel-web spider (Atrax robustus) venom by immunization with a toxoid

R. D. CROSUNn

613

F .ttect of drugs on the lethality in mice of the venoma and neurotoxins from sundry snakes

K. TEawO, E. Iro, M. OARADA, Y. IswaAStU, A.-M. LECiRAND and T. YASUxOTO

633

Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning

R. M. DAVID, N. R. KRISHNA and D. D. WATT

645

Characterization of cationic binding sites of neurotoxins from venom of the scorpion (Certtrwoides sculptroatrv Ewing) using lanthanidea as binding probes

S. V. $AàlPA(O, E. C. ARANTES, W. A. PRAno, F. R. Nero and J. R. Glal.lo

663

Further characterization of toxins T,IV ('I'aTX-III) and TiIV from Tityeer .urrnlatus scorpion venom

M. M. TANIZAKI, H. KAWASAKI, K. Suztna and F. R. MANDELaAUx

673

Purification of a proteinase inhibitor from the plasma of Bothropr jararaca (jararaca)

H. M. CHS(v, A. L. GUAN and F. S. MARKLANn, JR

683

Itnmunological properties of the fibrinolytic enzyme (fibrohule) from southern copperhead (dgkirtrodal contortrix cor(tortrix) venom and its purification by immunoatfinity chromatography

B. LoxoNre, J. M. GtrrnéRREZ ; G. ROIAS and L. CALDeR6N

695

Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms

K. YONAHA, M. II(A, Y. TOxUIARA, M. NozAKI and M. YAxAKAWA

703

Characterization of three hemorrhagic factors from the venom of Okinawa habu (Trimeresurw Jlauovlridis)

A. M. MOURA-DA-SILVA, H. Dt?ßxorro, G. LAING and R. D. G. TImASSroN

713

Isolation and wmparison of myotoxins isolated from venoma of different species of Bothrops snakes

E. Gt .usA, H. BRAUNS and K. SrocKER

725

Endothelium-dependent relaxant effect of thrombocytin, a aerine proteinase from Botlvops atrox snake venom, on isolated pig coronary arteries

A. S. KxPCr e

733

Detection of a cytolytic toxin in the venom of the atonefish (Synorecria trachynis)

F. At.ARD, S. Gt~r(s et L. TRtssr

745

Toxicite d' .lmbrosia maritinra L., organismes aquatiques non~iblea

N. Suctxoro, YuN-Maya CHelv, SHU-Yus Lam, M. MATSUDA and CHIAI-YUAN LLE

751

Pathodynamics of intoxication in rats and mis by enterotoxin of Cloatridlum perfrirRgens type A

M. J. Hol.xi~s, R. J. Lew(s, M. A. Pou and N. C. Gu .tESrm

761

Strain dependent production of ciguatoxin precursors (gambiertoxins) by Gambierdiacus toxlcrv (Dinophyceae) in culture

G. S. BAUEV, A. AL-JouFl, S. RAWAT and D. C. Snant

777

Neutralization of kinin-releasing enzymes of crotaGd venoms by monospecific and polyspecific andvenoms

783

Susceptibility of different strains of mice to South American rattiesnake (Crotalua durtrsua terrificus) venom: correlation between lethal effect and creatine kinase release

787

Zone-apxific hepatotoxicity of gosaypol in perfused rat liver

Short Communications M. R. D'IxréRlo LastA, M. C. nos $ANi+OS, D. V. TAx>aouxal, T. MARQtres, W. DtAS nA Su.vA and T. K(rx(s S. MANAae, D. C. NueOt and Y. C. LIN Software Survey Section International Society on ToxinologyMembership Application

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plante

molluscicide,

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VIII

ol . 29, No. 7 C. R. C+At .nvt and J. A. Gunuttxes

791 Review article-Plant and microbiai toxic proteinr as hemilectins: emphasis on canatoxin

S. Wta~temea, M. Ovenu, G. Ft.~®t and E. Kocxve

807 Antihemorrhagic factors from the blood serum of the western diamondback rattlesnake Crotales atrox

V. M. MwFnvnt and E. P.

819 Structure-toxicity relationshipa of neumtoxin RTX-III from the sea anemone Radiantlrus macrodactylus: modification of amino groups

KOZIAVSCAYA

A. Gwa~a, M. KAaOUI, Z. B~n.w~ety H. KeAOUt, M. F~. Ave and K. D~.uat

827 Puntflcation and characteriTation of a flbrinogenax from Vipera lebettna (desert adder) venom

H. Ta~ne, F. Setuve~u, M. Yox, T. Hornre and T. MIWATANI

837 Tryptophan 65 is essential for hemolytic activity of the thermostabk direct hemolytin from Yibria parahaemolyticus

T. Noaucttl, A. E. Ata, O. Anexewe, K. Mtxezewe, S. Kexasi, Y. SmDe, S. N>s~o and K. iIw~catn

845 Tetrodonic ecid-like substance; a possible precursor of tetrodotoxin

K. H. Muxvtc~, S. S~tvaortvvet.u, P. N. Mermox, R. A. M. MY~es, J. W. Bunxerr and L. Meazm.t.e

857 Pathophysiology of sea nettle (Clvysaora quinqurcirrlw), envenooration in a rat model and the effects of hyperbaric oxygen and ve~apamil treatment

W. K. Hexes

867 Ontogeny of striking, pray-handling aad envenomation behavior of prairie rattlesoakea (Crotahu v. viridis)

P. Berg, A. Oasc~~, P. Meute, C. v. Et~Srte~~e, M. R. PonoFn and E. HeeexxetvN

877 A comparative biochemical, pharmacological and immunological study of Costridhon novyi a-toxin, C. difficile toxin B and C. sorde!!ü lethal toxin

Short Communications M. K. Betn~e

889 Toxicity of adductor muscles from the purple hinge rack scallop (Crassadonw gigantea) along the Pacific coast of North America

K. Serretvu, S. Lwomoeme~ne, K. Lno'wxwieruwNwtur, O. Sexawexr ox, S. Sunewet~eve, B. Axut~tervateenn. and S. l:~sront~

895 Toxicity of the freshwater puffer fleh Tetroodore faagi and T. palanbangeruh from Thailand

P. E. Gaeivu~ and M, Rtctteteneox

898 Chymotrypsin treatment increases the activity of Clartridirrm perfrbcgens enterotoxin

T. Lexeaes, C. M. Coos:, J. E. Exussox, J. A. O. Mmtu uo'ro aad M. Ho~t+ocxe

901 Computer modelling of the 3~imen~onal structures of the cyanobacterial hepatotoxinr microcystin-LR and noduhuin

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Vol . 29, No. 8 D. S. C~+rtdwx

907 In Memoriam-Po~l Agerhohn Christenren

In Appreciation

911

R. V. Cor~s~nexe and L. L.

$IMPrON

913 Review article--cellular and molecular actions of binary toxins possessing ADP-ribosyltranrferase activity

IX S.-R. LIx and C.-C. Ct~uNa

937

Studies on the status of amino groups in a-bungarotoxin

H . ZERROUK, P. E. Houals, B. Cé~xn, A . Beis-ntexE and M . F. MARTIN-EAUCLAIRE

951

Analysis by high-performance liquid chromatography of Androctw+us mawctanicur maurctanicus (black scorpion) venom

A . S . KAIQGUTI, J. L . C. CARDOSO, R . D. G. T~AICSI'ON, I . S . SeNo-Mnnnxs, R . A . Htrrrox, F . P. Ruaetv+N, D . A . WAQRRLi and C . R. M . H~Y

%1

Coagulopathy and haemorrhage in human victims of Bothrops jararaca envenoming in Brazil

L. L . Deox, C . S . S~a~ter and I . I . Kelsete

973

Specific binding of crotoxin to brain synaptosomes and synaptosomal membranes

G . M . SrIUIN, T . G . $N1I~R, B . L . TeDroItn and G . H . Cofna

989

Hyperbaric oxygen eEècts on brown recluse spider (Loxosccles reclusa ) envenomation in rabbits

C. L. FoRrrt~s-DI~s, H . C. B . FONSECA .

997

Purification and properties of an antivenom factor from the plasma of the South American rattlesnake (Crolalus dwissur terrificus)

Ç . P. RoatNSOx, D . R . FRANZ and M . E . BONDURA

1009

Efl'ects of lyngbyatoxin A from We blue-green alga Lyngbya majuscule on rabbit aorta contractions

D. F . HWANG, K . P. TAI, C . H . Ctitrett, L. C . LIN and S. S . Jexc

1019

Tetrodotozin and derivatives in several species of We gastropod Naticidae

M .-P . SAUVIAT, D. LAURENT, F . Koxt.ele and F . PeLI-ECrtIx

1025

Fumonisin, a toxin from the fungus Fusarium monUifornu Sheld blocks both the calcium current and the mechanical activity in frog atrial muscle

C. L. Ho and L. L . HWANG

1033

Local edema induced by the black-bellied hornet (Vespa basalis) venom and its wmponents

Short Communication I. H . AL-Aantn.u, A. M . and J . LANDON

1043

An indirect haemolytic assay for assessing antivenoms

E. Kocxv~ and C . R . Dtxtz

SIUxI

Reviews

1047

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Letter to the Editor E. Kocltve

1049

The burrowing asps genus .ltractaspis belongs to a separate family of venomous snakes-the Atractaspididae

R . S . Noarox

1051

Review article-Structure and structure-function rolationships of sea anemone proteins that interact with the sodium channel

M . Mvlur~, F . Gusovstcv, M . Seams, A . YosoveMe, T. YesuMOTO and J. W . DeI.Y

1085

Eflèct of maitotoxin analogues on calcium influx and phosphoiaositide breakdown in cultured cells

A . S . KwAnotm, R. D. G. THEeIL4i'ON, H . DESMOND and R . A. Htm'oN

1097

Systemic haemoahage in rats induced by a haemorrhagic fraction from BotJuops jararaca venom

G. S . Borrov, S. P. McCoteeacte, M . N . B~exn and J . J . Pesrtu

1107

Murine lymphocyte proliferation impaired by substituted neosohuvols and calonectrins-Fusariwn metabolites associated with trichothecene biosynthesis

R. 1 . LewLC, M. SELLIN, M. A. Pou, R . S. NORTON, J. K . MACLwD and

1115

Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicur, Muraenidae)

B. G. S17LE.4, F. W. $EXTOx and S. A. WEIx31Elx

1129

Antibacterial effects of different snake venoms : purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom

H . C . CASrRo-FAR1A-NEro, M. A. MARTtxS,

l 143

Pro-inftammatory activity of enterolobin: a haemolytic protein purified from seeds of the Brazilian tree Enterolobium contortisiliquum

Short Communications P. ORFJUELA, A. ZAVALEI'A, M . SALAS and N. MARSH

1151

Thrombin-like activity in snake venoms from Peruvian Bothrops and Lachesis genera

N. ZILBERHERG, E. ZLOTKIx and M. GvREVrrz

1155

The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus

M. M. SHEIL

P. T. BozzA, S. A. C. PEREZ, A. C. V. CORREA-DA-SILVA, M. C . R . LIMA, H . N. CRUZ, R . S . B. CORDEIRO, M. V. SousA and L. MORHY

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Vol . 29, No . 10 Report and Abstracts

1159

Third International Symposium on Neurotoxins in Neurobiology, Piriapolis, Uruguay, 16-20 March 1991

G. B. DOMONT, J. PERALES and H. MoussATCH~é

1183

Review article-Natural anti-snake venom proteins

B. G. STILFS, B. C. LIDGERDING, F. W. $EXTON and S. B. Gt,~sr

1195

Production and characterization of monoclonal antibodies against Naja naja atra cobrotoxin

U . ANTHONI, C. CHRISTOPHERSEN, L. GRAM, N. H . NIELSEN and P. NIEtsEly

1205

Poisonings from flesh of the Greenland shark Somniosus microcephalus may be due to trimethylamine

A. SITCENFELD, H . RAVENT()S, R. CRUZ and J . M. GUTIÉRREZ

1213

DNase activity in Costa Rican crotaline snake venoms : quantification of activity and identification of electrophoretic variants

L. REZENDE IR, M . N. CORDEIRO, E. B. OLIVEtRA and C. R. DINIz

1225

Isolation of neurotoxic peptides from the venom of the 'armed' spider Phontutria nigriventer

S. HYSLOP and N. A. MARSH

1235

Comparison of the physiological effocts in rabbits of Baboon viper (Bills gabonica) venoms from different sources

A. S. BAau and T. VEERABASAPPA GOWDA

1251

Effects of chemical modification on enzymatic and toxicological properties of phospholipases Az from Naja naja naja and Vipers russelli snake venoms

Short Communications D. A. WARRELL, J. SHAHEEN, P. D. HILLYARD and D. JONFS

1263

Neurotoxic envenoming by an immigrant spider (Stearoda nobilis) in southern England

1266

Frequency-dependent neuromuscular blockade by textilotoxin in :~irn

D. R. LLOYD, G. M . NICHOLSON, I . SPENCE, M . CONNGR, M . I . TYLER and M . E. H . HGwuEx

XI M . GUREVITZ, D . IJRBA('H, E . ZLOrKtx and N . ZILBERBERG

1270

Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinyuestriatus hebraeus

J . M . GVTIÉRREZ, M . C . uos SANTOS, M . uE FATIMw FURTAIX) and G . Raves

1273

Biochemical and pharmacological similarities between the venoms of newborn Crotales duri.ssus duri.ssus and adult Crotales duricsus rerriJicus rattlesnakes

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J.-P . CHIPPAUX, V . WtLLWN3 and

ol. 29, No. 11 J . WrnrE

1279

Review article-Snake venom variability: methods of study, results and interpretation

D. Avtcrmzzex and N . GILBOA-GARBER

1305

Antitumoral effects of Pseudomonas aeruginosa lectins on Lewis lung carcinoma cells cultured in vitro without and with marine splenocytes

S . A . WEtxsretx, J . J . Scxtmnr and L . A . Starrx

1315

Lethal toxins and cross-neutralization of venoms from the African water cobras, Boulengerina annulata annulata and Boulengerina christyi

K. A . Voss and L . H . BRENNECKE

1329

Toxicological and he ~gical effects of sicklepod (Cassia obtusifolia) seeds in Sprague-Lrawley rats : a subchronic feeding study

C . C . Ywxc, L. S. Ct~twxo and F . S . Wu

1337

Venom constituents of Notechis scutatus scutatus (Australian tiger snake) from differing geographic regions

M . K. Bw+r, B . N . PRASAI) and T. V . GOWDA

1345

Purification and characterization of a neurotoxic phospholipase A, from Indian cobra (Naja naja naja) venom

R . V . COx31DINE, C. M. HANDLER, L . L . $tMP90x and J . R . Sr~Rwtx

1351

Tetanus toxin inhibits neurotensin-induced mobilization of cytosolic protein kinase C activity in NG-108 cells

C. SEVCtK and A . J . MUwRES

1359

Methods for correlation analysis of toxins and species present in random samples of phytoplankton

I . FERNANDE$, H . A . TwKEHARA and i . Morve

1373

Isolation of IgGT from hyperimmune horse anti-snake venom serum : its protective ability

QIAN XIAOHONG and Mw LtREN

1381

Fibrinolytic enzyme from Agkistrodon halt's brevicaudus (Korean mamushi) snake venom

V . L . TRAINFR and D . G . BAUEx

1387

An enzyme immunoassay for the detection of Florida red tide brevetoxins

J . R . Gtixttw-MELO, N . H . TOPPA, P . MwRnxs, C. N. COLARES, Y. S . Cw3TR0 and L. FREIRE-Mwtw

1395

Acute gastric mucosal injury induced by toxins from Tityus serrulatus scorpion venom : a novel experimental model in the rat

1403

Chloride channel inhibition by the venom of the scorpion Leiurus

J . YATSUNAMt, H . FwtKt, M . SuGwxusrw, S. N~rwwxt, M . OnKw, K . Ywnf ww and L . L.EVINE

1409

Binding competition of okadaic acid derivatives to anti-okadaic acid antibody

Announcement

1413

Botulinum, Tetanus Neurotoxins : Neurotransmission and Biomedical Aspects-International Conference I1-13 May 1992, Madison, Wiswnsin, U.S .A .

Short Communications J. A . DEBtx and G. R . SrRtctiwRrz

quinquestriatus

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ol . 29 . No . 12 Letter from the Editor P. ROSENHERG

1415

Professor Alan L. Harvey assumes Editorship

1417

Report on the Status of Toxicon

R. D. G. TxFJ+xsrox and D. A. WARRELL

1419

Antivenoms : a list of hyperimmune sera currently available for the treatment of envenoming by bites and stings

A. M. MOURA-DA-SILVA, D. F. Cnxnoso, M . M. TAN~ZAK~ and I. MOTS

1471

Neutralization of myotoxic activity of Bothrops venoms by antisera to purified myotoxins and to crude venoms

J. L. MIDDLEBROOK

1481

Cross-neutralizations of phospholipase A~ neurotoxins from snake venoms

J. E. Fr.erctmx, MINGSHI JIANG, Qr-Hug GoNC, M. L. YUDROW3RY and S. J. W~L~rro

1489

Effects of a cardiotoxin from Naja naja kaouthia venom on skeletal muscle: involvement of calcium-induced calcium release, sodium ion currents and phospholipases A, and C

R. B. Zorz, D. Mees, H. Htttcr~ and D. PAR

1501

Hemostatic changes due to the venom gland extract of the red-necked keelback snake (Rhabdophis subminiatus)

Short Communications A. At.-Joue, G. S . B~a.~r, K. Reoot and D. C . SMITFI

1509

Neutralization of kinin-releasing enzymes from viperid venoms by antivenom IgG fragments

R. N. L. Pmro, N. J. u~ SILVA, JR and S. D. A~w

1512

Human envenomation by the South American opisthoglyph Clelia cleüa plumbea (Wied)

D. L. SwTT, A. Actt~et, P. A. Ce~usTeNSer~, C. C. V~IJOEIV and P. B. Sio~a

1517

Crystallization and preliminary diffraction analysis of caudoxin and notexin; two monomeric phospholipase A, neurotoxins

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Volume Contents and Author Index, Volume 29

I

AUTHOR INDEX Achari, A. 1517 Adem, A. 521 Aird, S. D. 265, 1512 Al-Abdulla, I. H. 1043 Al-Joufi, A. 777, 1509 Alagon, A. C. 119 Alard, F. 745 Ali, A. E. 845 Antboni, U. 1205 Antonio, L. C. 219 Anuchatvorakul, B. 895 Aoki, Y. 461 Arakawa, O. 845 Arantes, E. C. 663 Aureliaa, L. 386 Avichezer, D. 1305 Ayeb, M. El 827 Babu, A. S. 1251 Baden, D. G. 1387 Bailey, G. S. 777, 1509 Ballou, W. R. 581 Barberio, C. 321 Barja-Fidalgo, C. 453 Barrel-Netto, M. 527 Bdolah, A. 237 Beasley, V. R. 347, 589 Beitler, M. K. 889 Bell, R. C. 401 Benitez, M. A. 511 Benlasfar, Z. 827 Benslimane, A. 951 Beremand, M. N. 1107 Bernheimer, A. W. 227 Bette, P. 877 Bhat, M. K. 97, 1345 Bigalke, H. 181 Blumenthal, K. M. 13 Boada, J. 511 Bon, C. 441 Bondura, M. E. 1009 Bondy, G. S. 1107 Bongis, P. E. 951 Boulain, J.-C . 516 Bozza, P. T. 1143 Brauns, H. 725 Brennecke, L. H. 1329 Brown, M. R. 603 Bucknall, N. C. 397 Burnett, J. W. 386, 857

Calderdn, L. 695 Capone, D. G. 277 Cardoso, D. F. 1471 Cardoso, J. L. C. 961 Carlini, C. R. 453, 791 Carmichael, W. W. 589 Carneir~o, S. M. 569 Carpenter, E. J. 277 Caesar, E. 516 Castro, Y. S. 1395 Castro-Faria-Neto, H. C. 1143 Céard, B. 951 Chang, C.-C . 157, 937 Chang, L. S. 1337 Chapman, D. S. 907 Cbea, H. M. 683 Chea-Yuan Lee 751 Chippaux, J.-P. 1279 Chis7ar, D. 401 Choumet, V. 441 Christessea, P. A. 1517 Christopherses, C. 1205 t hueh, C. H. 1019 Claassens, R. 603 Codd, G. A. 277 Cohn, G. H. 989 Colares, C. N. 1395 Corms, A. 603 Connor, M. 1266 Considine, R. V. 913, 1351 Cook, C. M. 901 Cordeiro, M. N. 1225 Cordeiro, R. S. B. 1143 Cornea-Da-Silva, A. C. V. 1143 Crampton, J. M. 536 Croeland, R. D. 613 Croswell, S. 409 Cruz, H. N. 1143 Cruz, R. 1213 Cunha-Melo, J. R. 1395 D'Império Lima, M. R. Dahlem, A. M. 589 Daly, J. W. 1085 David, R. M. 645 Davidsoa, T. M. 379 De Luca, A. 311 DeBin, J. A. 1403 Degn, L. L. 973 Delfino, G. 321 XIII

783

XIV

Dellagi, K. 827 Dennis, P. A. 329 Desmond, H. 536, 713, 1097 Dias da Silva, W. 783 Diniz, C. R. 997, 1225 Domont, G. B. 1183 Ducancel, F. 516 Dupuis, M. L. 417 Eichel-Streiter, C. v. Erdmann, ß. 181 Eriksson, J. E. 901

877

Falconer, I. R. 43 Faria, F. P. 569 Fatima Furtado, M. de 1273 Feria, M. 511 Fernendes, I. 1373 Fiorentini, C. 417, 543 Fleminger, G. 807 Fletcher, J. E. 1489 Fonseca, B. C. B . 997 Fortes-Dias, C. L. 997 Francis, B. SS Franz, D. R. 1009 Freire-Mais, L. 1395 Fu, E. W. 329 Fujü, N. 261 Fujiki, H. 1409 Furtado, M. F. D. 219 Gasuri, A. 827 Geerta, S. 745 Gardes, R. G. 43 Giglio, J. R. 663 Gilboa-Garb~, N. 1305 Gillespie, N. C. 761 Ging-Kou Wang 245 Glusa, E. 725 Gowda, T. V. 97, 1251, 1345 Gram, L. 1205 Granum, P. E. 898 Graur, D. 237 Guan, A. L. 683 Gubenllek, F. 269 Guenon, M. 125, 382 Guest, S. B. 1195 Guimafäes, J. A. 453, 791 Gurevitz, M. 1155, 1270 Gusovsky, F. 1085 Gutiérrez, J. M. 695, 1213, 1273

Habermann, E. 877 Hahin, R. 245 Hall, S. 53 Handler, C. M. 1351 Harada, K. 479 Harvey, A. L. 371, 516 Haschek, W. M. 589 Hashimoto, K. 845 Hawser, S. P. 277 Hay, C. R. M. 961 Hayes, W. K. 867 Hemker, H. C. 491 Hillyard, P. D. 1263 Hirche, H. 1501 Ho, C. L. 1033 Holmes, C. F. B. 469 Holmes, M. J. 761 Honda, T. 837 Hooser, S. B. 589 Horma7nbal, V. 21 Hotokka, M. 901 Howden, M. E. H. 375, 603, 1266 Huang, J.-L. 31 Hutton, R. A. 961, 1097 Huxtable, R. J. 409 Hwang, D. F. 1019 Hwang, L. L. 1033 Hyslop, S. 1235 Iha, M. 703 Ishibashi, Y. 633 Itezono, Y. 479 Ito, E. 633 Jared, C. 569 Jeng, S . S. 1019 Jiang, M. S . 441 John, T. R. 85 Jolkkonen, M. 521 Jones, D. 1263 Jukes, R. 409 Kaiser, I. I. 85, 265, 973 Kamiguti, A. S. 219, 961, 1097 Kanoh, S. 845 Kardong, K. V . 532 Karlsson, E. 521 Karoui, H. 827 Karoui, M. 827 Kalturii, S. 97 Kaufuran, B. 581 Kawasaki, H. 673 Kihara, H. 157

Kimura, K. 261 Kipnis, T. 783 Kit+chberg, J. S. 379 Kirchner, F. 201 Klug, M. 129 Kncefel, P. K. 301 Kochva, E. 237, 807, 997, 1049 Kohler, F. 1025 Kordi~, D. 269 Kozlovskaya, E. P. 819 Kreger, A. S. 733 Krieger, R. I. 134, 167 Krishna, N. R. 645 Kruggel, W. G. 265 Kuhlenschmidt, M. S. 589 Laing, G. 713 Lanaras, T. 901 Landen, G. 237 Landen, J. 1043 Laobhripatr, S. 895 Laurent, D. 1025 Lawrence, W. B. 337 Leelasitom, S. 895 Legrand, A.-M. 633 Levine, L. 1409 Lewis, R. J. 761, 1115 Li, Y. 53 Lidgerding, B. C. 1195 Lima, M. C. R. 1143 Limpekarnjanarat, K. 895 Lin, L. C. 1019 Lin, S.-R . 937 Lin, Y. C. 787 Liu, J. 13 Liu, S.-Y. 157 Lloyd, D. R. 1266 Lomonte, B. 695 Lukâcs, G. L. 53 Lula, L. A. B. M. 569 Ma Lirea 1381 Mackessy, S. P. 532 MacLe+od, J. K. 1115 Miihar, A. 107 Mähar, J. 53 Mahnir, V. M. 819 Malomi, W. 417 Manabe, S. 787 Mandelbaum, F. R. 673 Manson, P. N. 857 Markland, F. S. Jr 683 Marques, T. 783

Marsh, N. 1151, 1235 Martin-Eauclaira, M. F. 951 Martin-Polo, J. J. 119 Martins, M. A. 1143 Martins, P. 1395 Maruyama, M. 219 Marxea, P. 181 Marrella, L. 857 Mastromoi, G. 321 Matsuda, M. 751 Matsuura, K. 479 Mattocks, A. R. 409 Mauler, F. 877 McComck, S. P. 1107 Mebs, D. 461, 1501 Meier, J. 151 Méaez, A. 371, 516 Meriluoto, J. A . O. 901 Middlebrook, J. L. 359, 1481 Mijares, A. J. 1359 Ming-Shi Jiang 1489 Miura, G. A. 337 Miwatani, T. 837 Miyazawa, K. 845 Mizote, M. 201 Moczydlowski, E. 53 Monheit, D. 581 Morhy, L. 1143 Mota, I. 1373, 1471 Moura-da-Silva, A. M. 713, 1471 Moussatché, H. 1183 Muhvich, K. H. 857 Murata, H. 479 Murate, M. 1085 Myers, R. A. M. 857 Mylecharano, E. J. 603 Nagahama, M. 211 Nagai, H. 479 Nakamura, H. 157 Nakano, M. 479 Nakayama, N. 479 Navarro, E. 511 Neto, F. R. 663 Neumann , U. 151 Nicholson, G. M. 1266 Nielsea, N. H. 1205 Niolsen, P. 1205 Ning-Sh~g Liang 269 Nishida, S. 429 Nishio, S. 845 Nishiwaki, S. 1409 Noguchi, T. 845

XVI

Norton, R. S. 1051, 1115 No7aki, M. 703 Nuber, D. C. 787 Oarada, M. 633 0~~ . 15 K 479 Oguchi, Y. 73 Oguma, K. 261 Ohno, M. 157 Ojika, M. 1409 Oksche, A. 877 Oliveira, E. B. 1225 Orejuela, P. 1151 Ovadia, M. 807 Paar, D. 1501 Pace, J. G. 337 Paradisi, S. 417 Pearnon, J. A. 375 Pedersea, K. 21 Pellegrm, ~ F. 1025 Perales, J. 1183 Perez, S. A. C. 1143 Pestka, J. J. 1107 Phillips, C. A. 603 Piek, T. 139 Pinto, R. N. L. 1512 Pinto, V. R. 569 Pistolesi, S. 321 Poli, M. A. 761, 1115 Popoff, M. R. 877 Prado, W. A. 663 Prasad, B. N. 1345 Punger+~ar, D. 269 Qi-Hua Gong 1489 Qian Xiaohong 1381 Quistad, G. B. 329 Ramoni, C. 417 Rand, M. J. 311 Raveatßs, H. 1213 Rawat, S. 777 Reddi, K. 1509 Reid, J. J. 311 Renter, C. C. 329 Reynaud, E. 119 Rezeade, L. Jr 1225 Richardaon, M. 898 Risinger, C.~ 521 Robineon, C. P. 1009 Robineon, N. A. 337

Rojas, G. 695, 1273 Rosenberg, P. 1415, 1417 Rosing, J. 491 Rowaa, E. G. 371, 516 Rugman, F. P. 961 Runnegar, M. T. C. 43 Saitanu, K. 895 Sakamoto, S. 157 Sakiyama, F. 837 Sakurai, J. 211 Salas, M. 1151 Samejima, Y. 461 Sampaio, S. V. 663 Sangwanloy, O. 895 Saao-Martins, I. S. 961 Santos, M. C. dos 783, 1273 Sasaki, M. 1085 Sauviat, M.-P. 1025 Schaeffer, D. J. 347 Schmidt, J. J. 227, 1315 Scott, D. L. 1517 Seebart, C. 85, 973 Sellin, M. 1115 Sengottuvelu, S. 857 Sesso, A. 569 Sevcik, C. 1359 Sexton, F. W. 1129, 1195 Shahak, E. 125, 382 Shahe~, J. 1263 Shalev, H. 125 Shapiro, B. I. 245 Sheil, M. M. 1115 Sherwin, J. R. 1351 Sheumack, D. D. 603 Shida, Y. 845 Shimazu, T. 191 Shirai, M. 479 Shu-Yue Lee 751 Sidki, A. M. 1043 Sigler, P. B. 1517 Sügur, E. 107 Sügur, J. 107 Silva, N. J. da Jr 1512 Simpson, L. L. 913, 1351 Sittenfeld, A. 1213 Skinner, W. S. 329 Slonim, A. 382 Smith, D. C. 777, 1509 Smith, L. A. 227, 401, 1315 Snider, T. G. 989 Sofer, S. 125, 382 Sohsten, R. L. von 527

Sousa, M. V. 1143 Speckar, I. 441 Speace, I. 603, 1266 Stabell, O. B. 21 Steffenak, I. 21 Stevens, D. K. 134, 167 Stiles, B. G. 503, 1129, 1195 Stocker, K. 725 Story, D. F. 311 Strain, G. M. 989 Strichartz, G. 245, 1403 ~trukelj, B. 269 Shirzebecher, J. 151 Sudhasaneya,S . 895 Suganuma, M. 1409 Sugitnoto, N. 751 Suwanrumpha, S. 329 5uzuki, K. 673 Suzuki, M. 479 Syuto, B. 261 Tai, K. P. 1019 Takahashi, H. 73 Takano, K. 201 Takasaki, C. 191 Takehara, H. A. 1373 Tambourgi, D. V. 783 Tamiya, N. 191, 429 Tanizaki, M. M. 673, 1471 Tans, G. 491 Tedford, B. L. 989 Terao, K. 633 Teruuchi, T. 191 Theakston, R. D. G. 536, 713, 961, 1097, 1419 Thelestam, M. 543 Thomassen, M. C. L. G. D. 491 Toda, H. 837 Tomihara, Y. 703 Toppa, N. H. 1395 Toriba, M. 191 Trainer, V. L. 1387 Triest, L. 745 Trujillo, J. 511 Trumble, W. R. 31 Tsuwki, K. 261

Tyler, M. I. 375, 1266 Urbach, D.

1270

Valentine, W. M. 347 Vargas-Villarr~l, J. 119 Vest, D. K. 532 Viljoea, C. C. 1517 Voss, K. A. 1329 Wachsmaa, M. 386 Wertall, D. A. 961, 1263, 1419 Watt, D. D. 645 Weber, J. 129 Weinstein, S. A. 227, 401, 1129, 1315 Waisenberg, S. 807 Weizman, Z. 125 Warnstadt, C. 521 White, J. 1279 Wieland, S. J. 1489 Williams, V. 1279 Wollberg, Z. 237 Wright, D. C. 581 Wu, F. S. 1337 Yabuki, Y. 73 Yamada, K. 1409 Yamakawa, M. 703 Yang, C. C. 1337 Yasumoto, T. 633, 1085 Yatsunami, J. 1409 Yoh, M. 837 Yokosawa, N. 261 Yokoyama, A. 1085 Yonaha, K. 703 Yoshida, H. 191 Yudkowsky, M. L. 1489 Yukelson, L. Ya. 491 Yun-Ming Chen 751 Zavaleta, A. 1151 Zerrouk, H. 951 Zilberberg, N. 1155, 1270 Zlotkin, E. 1155, 1270 Zotz, R. B. 1501