Volume contents, subject and author index (July–December 1986)

JOURNAL

OF STEROID

AND MOLECULAR

BIOCHEMISTRY

BIOLOGY,

THE

-_ editors-in-chief

J. R. PASQUALINI

and R. SCHOLLER

Volume Contents, Subject and Author Index (July-December

1986)

Volume 25 1986

OLD ISSN: NEW ISSN: REMARKS: ARCHIVING DEPARTtt&NT

Pergamon Press

Oxlord

New York

Beijing

Frankfufl

Sk& Paulo

Sydney

Tokyo

Toronto

EDITORS-IN-CHIEF J. R. PASQUALINI and R. SCHOLLER, Foundation for Hormone Research, 26 Boulevard Brune, 7501CParis. France ASSOCIA

TE EDIT0

CORRESPONDING

A. AAKVAAG, Bergen, Norway S. ANANCHENKO, Moscow, U.S.S.R. F. AURICCHIO. Naples, Italy P. L. BALLARD, San Francisco, U.S.A. M. BEATO, Marburg/Lahn, F.R.G. P. A. BELL. Cardiff, Wales

Production

Unit,

Pergamon

EDITORS

J. A. GUSTAFSSON, Stockholm, Sweden V. HANSSON, Oslo, Norway K. B. HORWITZ, Denver, U.S.A. I. HUHTANIEMI, Helsinki, Finland D. R. IDLER, Newfoundland, Canada V. H. T. JAMES, London, England J. KATO, Yamanashi-ken, Japan B.S. KATZENELLENBOGEN,Urbana, U.S.A. A. M. KAYE, Rehovot, Israel R. J. B. KING, London, England C. P. LANTOS, Buenos Aires, Argentina S. LIAO, Chicago, U.S.A. M. E. LIPPMAN, Bethesda, U.S.A. P. C. MACDONALD, Dallas, U.S.A. B. S. MCEWEN, New York, U.S.A. W. L. MCGUIRE, San Antonio, U.S.A. E. MENINI, Rome, Italy E. MILGROM, Le Kremlin-Bic&tre, France W. R. MILLER, Edinburgh, Scotland T. MULDOON, Augusta, U.S.A. J. MOLLER, Zurich, Switzerland B. E. P. MURPHY, Montreal, Canada M. NEVES-E-CASTRO, Lisbon, Portugal M. 1. NEW, New York, U.S.A. A. W. NORMAN, Riverside, U.S.A.

E. W. BERGINK, Oss. The Netherlands J. BLAQUIER, Buenos Aires, Argentina R. BOUILLON, Leuven. Belgium S. BOURGEOIS, San Diego, U.S.A. A. BRODIE, Baltimore, U.S.A. K. J. CATT, Bethesda, U.S.A. L. CEDARD, Paris, France J. A. CIDLOWSKI, Chapel Hill. U.S.A. J. H. CLARK, Houston, U.S.A. G. DAXENBICHLER, Innsbruck, Austria E. R. DESOMBRE, Chicago, U.S.A. M. L. DUFAU, Bethesda, U.S.A. H. A. ERIKSSON. Stockholm, Sweden J. FISHMAN, New York, U.S.A. K. FOTHERBY. London, England J. W. FUNDER, Melbourne, Australia G. GREENE, Chicago, U.S.A. K. GRIFFITHS, Cardiff, Wales B. GRONER, Bern, Switzerland

Journals

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LIST OF CONTENTS JULY Editorial Addremes Steroid Nomenclature Makoto Nakao, Bunso Sato, Masrfumi Kogs, Keizo Noma, Susumu Kkvhbnoto, Minoru Matsuds, Takao Sonoda and Keishi Ma~to

Biochemical and immunological characterization of estrogen binding components in human neoplastic adrenocortical tissues

Louis Me&r, Patricia A. Miller and S. Stormy Slmons Jr

I1

Hiroshi Inano and Bun-i&i Tamaoki

21 Purification of NADPH-cytochrome P-450 reductase from microsomal fraction of rat testes, and its chemical modification by tetranitromethane

V. Albaladejo, M. 0. Pharaboz, Y. Morel and J. Andre

29 Properties of the estrogen receptors contained in the MtTF, tumor whose growth is inhibited by estradiol: 17@-estradiol, 17a-estradiol and DNA bindings

Daniel M. Sheehan, Kevin L. Medlock and C. Richard Lyttle

37 Identification of uterine nuclear type II estrogen binding sites in estrogen treated rats

Guido Verhoeven and Jean Cailleao

45

Desensitization of Sertoli cell-enriched cultures by FSH, L-isoproterenol and glucagon. Influence on subsequent stimulation of 17a-estradiol production

Chuuiia L. Heller, Edoardo Orti and Alejandro F. De Nicola

53

Regulatory factors of glucocorticoid binding in early and term rat placenta

Pierre Netchitailo, IsabeBe Lihrmmn, LsabeBePerroteau, Catherine Delarue, Francois Leboulenger and Hubert Vaudry

59

Involvement of cycloheximide-sensitive mediators action of adrenocorticotropin and angiotensin II

Paul Pearce and John W. Funder

65 Cytosol and nuclear levels of thymic progesterone receptors in pregnant, pseudopregnant and steroid-treated rats

T. S. Fisher, P. Vecsei, G.-A. Hoyer, K. Lichtwald and D. N. Kirk

71 HPLC isolation and GC-MS characterization of a compound strongly cross reacting with tetrahydroaldosterone antiserum

N. Terada, H. Kuroda, H. Nakayama, K. Matsumoto and Y. Kitamura

83 Effect of genetically defined oocyte depletion on production of androgens and oestrogens by ovaries of suckling mice

Mark L&in and Janet F. Noble

91

Solubilization and partial purification of aromatase from chicken ovary

C. Sclmeffer, A, Chabli and C. Aron

99

Endogenous progesterone and lordosis behavior in male rats given estrogen alone

Antigluc~orticoid steroids have increased agonist activity hepatoma cell lines that are more sensitive to glucocorticoids

in those

in the steroidogenic

James L. Thomas, Ebenezer Aslbey-Berko and Ronald C. Strickler

and estrone 103 The affinity alkylators, 1I~-bromoacetoxyprogesterone 3-bromoacetate, modify a common histidyl residue in the active site of human placental 17@,20a-hydroxysteroid dehydrogenase

Hannu Martikainen, Markku Al&n, Paavo Rabkila and Reija Vihko

109 Testicular responsiveness to human chorionic gonadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes

A. Ruokonen, A. Oikarinen and R. Vihko

113 Regulation of serum testosterone in men with steroid sulfatase deficiency: response to human chorionic gonadotropin

M. Takeyama, T. Ueda and K. Matsumoto

121 High activity of 17a-oxidoreductase in neonatally grafted mouse testes in adult female mice

Richard Bncala, Peter C. Ulrich, Brian T. Chait, F. AIadar Bewrath and Anthony Cerami

127 Structure of lysine adducts with 16a-hydroxyestrone

...

111

and cortisol

Sex steroid hormone binding globulin levels and free 17/i-estradiol and testosterone in cynomolgus monkeys during different reproductive states

Donald R. Koritnik and Keith B. Marschke

13s

Marc Feuilloley, Pierre Netchitailo, lsabelle Lihrmann and Hubert Vaudry

143 Effect of vinblastine, a potent antimicrotubular by perifused frog adrenal glands

S. L. Dalterio, D. E. Suter, N. B. Schwartz, D. Mayfieid and V. B. Rettori

149 Differential effects of follicle-stimulating testosterone production by mouse testes

Aziz Chabab, Jean-Claude Nicolas and Charles Sultan

157 Aromatase activity in human skin fibroblasts: enzymatic method

Aziz Chabab, Charles Sultan, Odile Fenart and Bernard Descomps

165 Stimulation of aromatase activity by dihydrotestosterone fibroblasts

agent on steroid secretion

and luteinizing hormones

characterization

on

by an

in human skin

Forthcoming Papers AUGUST Nieolas J. Kotite, Su-Li Cheng, Neal A. Mu&o and Glen L. Gunsalus

171 Comparison of rabbit epididymal androgen binding protein and serum testosterone estradiol binding globulin-II. Immunoiogi~l properties

Michael S. Gordon and Angelo C. Notides

177 Computer modeling of estradiol interactions

Thomas F. Ogle

183 Evidence for nuclear processing of progesterone

Philip H. Petra, Pearl C. Namkung, Donald F. Senerr. David A. McCrae, Kenneth W. Ro&lang, David C. Teller and J. B. Alexander Ross

191 Molecular characterization of the sex steroid binding protein (SBP) of plasma. Re-examination of rabbit SBP and comparison with the human, macaque and baboon proteins

Lee-Hwei K. Sun and Fred R. Frankei

201 The induction of Afro-sequence transcripts by glucocorticoid in rat liver cells

Ulrike E~erle-akin, Eike Vijlck-Badouin, Jllrgen Schmitt and Gerhard Aumllller

209

Akihiro Takeda and Wendell W. Lea&t

219 Temporal effects of progesterone receptors in hamster uterus

Edward S. Umstot and Richard N. Andersen

225

Edward J. Pavlik, Katherine Nelson, Holly Galllon, John R. Van Nagell Jr, Steven Pursell, Elvis S. Donaldson, Robert C. Flanlgan and Daniel E. Kenady

231 The effects of acute administration of cytotoxic anticancer agents on the capacity for subsequent hormonal responses in the mouse uterus

M6nica H. Vazquez, Marie-Anne de Larminat, Erllo Gurpide, Carlos Scorticati and Jorge A. Blaquier

239

Androgen metabolism in the human epididymis. Effect of in viva estrogen administration

Yusuf J. Abul-Hajj and Paul L. Cisek

245

Regioselective reaction of thiols with catechol estrogens and estrogen-oquinones

Leon Milewieh and David A. Cain

249

Metabolism of dehydroisoandrosterone and androstenedione A-549 alveolar Type II epithelial-like cells

S. Murray and D. Watson

255

Bis-trifluoromethylbenzoyl derivatives for steroid analysis by gas chromatography electron capture negative ion chemical ionisation mass spectrometry

P. De Muor, A. Louwagie, D. Faict and G. Vanham

261

Steroid-carrier proteins in patients with multiple myeloma

P. L. &vine, N. S. Kelly and J. 8. Adams

265 3j3-Hydroxysteroid isomerase dehydrogenase in guinea-pig kidney: possible involvement in 1I-deoxycorticosterone formation in situ

with the estrogen receptor

receptors in rat placenta

Functional characteristics of nuclear Sa-reductase from rat ventral prostate

Nonsteroidal

domination

on estrogen and oxytocin

substances that affect Serum free testosterone

iv

by human

Avrahnm Geier, Ziva Yemlni-Blauer,

271

Characterization of the progesterone nuclease and DNase I digestion

277

Multicomponent analysis of bile acids in faeces by anion exchange and capillary column gas-liquid chromatography: application in oxytetracycline treated subjects

Short Communication Karen E. Sheppard and John W. Funder

285

Cortisol 17/I acid, transcortin, cocorticoid receptors

Book Reviews

289

Bruno Luuenfeld and Las10 Nekel

J. T. Korpelr, T. FOGS and H. Adlercreuts

Forthcoming

Papers

Announcements

receptor solubilized by micrococcal

and the heterogeneity

of rat brain glu-

i ii

SEPTEMBER Saeed Radparvar and and William S. Mellon

291

1,25Dihydroxyvitamin

Albert Grossman, Hannah Klein, Jeffrey M. Becker and Fred Naider

299

Yeast a-factor and somatostatin enhance binding of [‘Hlestradiol to proteins in rat pancreas and Succharomyces cerezlisiae

Mnsaaki Konagnya and Stephen R. Max

305

A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: studies with RU 38486, a potent and selective antiglucocorticoid

George Wm Mall Jr and Robert L. Rosenfeld

309

Estradiol inhibition of pituitary luteinizing hormone release is antagonized by serum proteins

Didier Gagne, Michel Pons and Andre Crastes de Paulet

315

Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids

M. Kaufman, L. Pinsky and D. W. Killinger

323

Ligand-specific thermal misbehavior of synthetic androgenreceptor complexes in genital skin fibroblasts of subjects with familial ligand-sensitive androgen resistance

Akira Kanda, Shigeto Ikeda, Fumio Shimura and

333

Solubilization of 1,25dihydroxyvitamin 5’-phosphate from hen intestinal mucosa

D, receptor replenishment in the chicken intestine

D,

receptor

with pyridoxal

Norimasa Hosoya Genevieve Jolivet-Jaudet and Jeanine Leloup-HPtey

343 Corticosteroid binding in plasma of Xenopus luenis. Modifications during metamorphosis and growth

Robert W. Brwggemeier

351 Androgens inhibit the formation of catechol estrogens 2-hydroxylase present in rat liver microsomal preparations

and Raymond A. Bannan

by estrogen

355

Photoaffinity labelling of androgen receptors from human foreskin and cultured genital fibroblasts with tritiated methyltrienolone [‘H]RlSSl

Jean-Francois Bowden, David A. Bender, William F. Coulson and Elizabeth K. Symes

359

Increased uterine uptake and nuclear retention of [‘Hloestradiol through the oestrous cycle and enhanced end-organ sensitivity to oestrogen stimulation in vitamin B, deficient rats

N. Bashirelahi, S. Ganesan, D. B. Ekiko, J. D. Young Jr, K. Shida, H. Yamanaka and E. Takahashi

367

Effect of 16/?-ethyl-l7/3-hydroxy-4-estren-3-one (TSAA-291) on the binding of promegestone (R5020) and methyltrienolone (RI88 I) to hyperplastic and neoplastic human prostate

John T. France, Warren Jackson and Jeffrey Keelan

375

A radioimmunoassay for plasma dehydroepiandrosterone sulphate incorporating placental steroid sulphatase as a hydrolysing reagent

Britt-Louise Sahlberg and Magnus Axelson

379

Identification and quantitation of free and conjugated steroids in milk from lactating women

Guido Verhoeven and Jean Cailleau

393

Specificity and partial purification of a factor in spent media from Sertoli cell-enriched cultures that stimulates steroidogenesis in Leydig cells

S. Gyorki, R. James, G. L. Warne and J. W. Funder

Donna W. Payne and Paul Talalay

403

A one-step enzymattc assay for the measurement 17-oxo-steroid profiles in biological samples

Campbell D. Spence, John P. Coghlan, Derek A. Denton, Eric H. M&s, Judith A. Whitworth and Bruce A. Scopgins

41 I

The effect of nivazol and cortivazol. novel synthetic steroids containing a phenylpyrazolo A-ring substitution, on blood pressure in sheep

Pemmaraju N. Rao, Angela M. Rodriguez and Dwight W. Miller

417

Synthesis of Sa-androstane-3a.

T. K. Dhar, E. Voss and M. SchiineshGfer

423

Simultaneous enzyme immunoassay of cortisoi and dehydroepiandrostanesulphate from a single serum sample using a transferable solid phase system

Nils Brtinner, Birgit Svenstrup, Mogens Spang-Thornsen, Paul Bennett, Arne Nielsen and Jan Nielsen

429

Serum steroid levels in intact and endocrine ablated BALB/c nude mice and their intact littermates

WilIiam J. Hendry III and Benjamin J. Danzo

433

Further chara~teri~tion of a steroid receptor-active mature rabbit epididymis

A. Lanthier and V. V. Patwardhan

445

Sex steroids and 5-en-3fl-hydroxysteroids brain and cranial nerves

451

Receptor structure: a persona1 assessment of the current status

S.

455

Direct effects of heparin on basal and stimulated aldosterone production in rat adrenal glomerulosa cells

Gabriele Mezzetti, FIavia BoreUini and Takami Oka

459

Loss of plasma-generated vitamin D-binding protein in explants of mouse mammary gland in culture

Book Reviews

463

Mini

of I7S-hydroxy-

and

17fl-diol 3- and 17.glucuronides

protease from the

in speciftc regions of the human

Revieu

R. J. B. King Short Communicatiotts Azukizawa, K. Uchida, N. Imaizumi, H. Hosojima and S. Morimoto

Forthcoming Papers Papers published in

Biochimie

ii vi

OCTOBER Serge Belisle, Jean-Guy Lehoux and Diego BeBabarba

465

Decreased nuclear binding of estrogen receptors in the pituitary of mice: correlation with b~oiogi~al effects throughout aging

Philip A. Bell and Philip J. Weatherill

473

Physicochemical characteristics of the interaction of the glucocorticoid antagonist RU38486 with glucocorticoid receptors in vitro, and the role of molybdate

Richard P. Doe, Philip M. Goldman, Suzanne P. Severson and Helen M. Hruby

483 Circadian variation of cytosol glucocorticoid receptors in human polymorphonuclear leukocytes (PMN) and mononuclear cells (MN) in a normal population

P. de Moor and A. Louwagie

489

HLA antigen CW3 combined with unexplained high transcortin levels is found in patients with acute lymphoblastic leukemia but not in their parents, sibs and offspring

2. Schwartz, J. F. Guest, M. G. Elder and J. 0. White

491

Enzyme activities in the androgenized rat uterus refractory to oestrogenic stimulation

Neal B. West, David L. Hess and Robert M. Brenner

497

Differential suppression of progesterone receptors by progesterone in the reproductive tract of female macaques

Seiichi Ishizuka and Antony W. Norman

505 The difference of biological activity among four diastereoisomers of 12,25dihydroxycholecalciferol-26,23-lactone vi

Benjamin J. Danzo

511 A protease acting on the estrogen receptor may modify its action in the adult rabbit epididymis

Marilyn R. Richardson, Murray D. Mitchell, Paul C. MacDonald and M. Linette Casey

521 Gfucocorticosteroid regulation of prostagfandin biosynthesis in human myometriaf smooth muscle ceils in monolayer culture

M. E. Rafestin-Ubtin, M. Lombes, P. Lustenberger, P. Blancbardie, A. Michaud, G. Cornu and M. Claire

527 Affinity of corticosteroids for mineralocorticoid and glucocorticoid receptors of the rabbit kidney: effect of steroid substitution

Giu~ppina Mazzocchi, Claudia Robba, Piera Rebuffat, Giuseppe Gottardo and Gastone G. Nussdorfer

535 Investigations on the effects of long-term administmtion of a methionineenkephalin anafogue on the adrenal zona fascicufata of rats treated with dexamet~sone or dexamethasone and ACTH

Ragnhild Lofthus, Anne B. L. Marthinsen, Egil Hnug and Kristen B. Eik-Nes

541 Metabolism of testosterone to 17P-hydroxy-Sa-androstane-3-one and 5randrostane-3a, 17/?-diof in alveolar macrophages from rat lung--II. EiTects of intratracheaf instillation of 3.4 firno K2Cr20,

M. C. Dumasia, E. Houghton, M. S. Moss, J. Cbakraborty and V. Marks

547 The biotransformation male castrates

Hiroko Ishii-Ohba, Hiroshi Inane and Bun&hi Tamaoki

555 Purification and properties of testicular 3/j-hydroxy-S-ene-steroid genase and S-ene-4-ene isomerase

Giinter Kaufmann, Gertrud Schumann and Cl&e H&hold

561 Influence of l-double bond and I I@-hydroxy group on stereospecific microbial reductions of 4-en-3-oxo-steroids

0. Bryan Holland, Martin Risk, He& Brown, Claude Benedict and G. Steven Hammond

567 Determination of afdosterone secretion rate utilizing mixed mode and high performance liquid chromatography

A. Vaiette, J. M. Meignen, L. Mercier, J. G. Liehr and J. Boyer

575 Effects of 2-~uoroestradiof on lipid meta~lism

Emmanual Unni and M. R. S. Rao

579 Androgen binding protein levels and FSH binding to testicular membranes in vitamin A deficient rats and during subsequent replenishment with vitamin A

C. N. Theron, V. A. Russell and J. J. F. Taljaard

585 Substrate dependency of specific and non-specific estrogen-Z/4-hydroxylase activities measured by the radio-enzymatic method in rat brain microsomes

M. Motta, S. Zoppi, A. M. Brodie and L. Martini

593

Effect of 1,4,6-androstatriene-3. I7-dione (ATD), 4-hydroxy-4-androstene3, f7-dione (&OH-A) and 4-acetoxy-4-androstene-3.17-dione (4-AC-A) on the Su-reduction of androgens in the rat prostate

601

Ethynylestradiof alters lipid composition metabolism in red blood cells

and urinary excretion of dexamethasone in equine

dehydro-

in the ovariectomized rat

Short Communication

J. Le Petit-Thdvenin, D. Rahmani-Jourdheuil, 0. Nobili and J. Boyer Erratum Fo~hcomi~ Papers

and phosphatidylethanolamine

i ii ... III

NOVEMBER (PART A) B. Sablomtiere, P. M. Dame, P. Formstecher, P. Lefebvre and M. Dautrevaux

605 Physical characterization of the activated and non-activated forms of the glucocorticoid-receptor complex bound to the steroid antagonist [“H]RU 486

Riiard B. Hochberg, Jan E. Zieiinski, WiBiam L. Duax amt Phyllis Strong

6 15 The molecular structure of I~-iodo-l?~~stradjof, the estrogen receptor

J. Nelson, R. Clarke, G. R. Dickson, H. W. van den Berg and R. F. Murphy

619 The effects of Mg2+ ions or EDTA on nuclear integrity and apparent subcellular distribution of unoccupied oestrogen receptors in breast cancer cells vii

a high afinity ligand for

Timothy C. Thompson, Gerald R. Cunha, John M. Shannon and Leland W. K. Chung

627

Androgen-induced biochemical responses receptors: characterization of androgen derivative of urogenital sinus

James H. Clark and Sylvia Guthrie

635

Subcellular localization (TABS) in rat liver

Paul V. Fennessey, Adrian W. Pike, Carolina Gonzalez-Aller and Kathryn B. Horwitz

641

Progesterone metabolism in T47D, human breast cancer nan-3&6a-dial-20-one is the secreted product

Maria L. Webb, James J. Flynn, Thomas J. Schmidt, David L. Margules and Gerald Litwack

649

Decreased genetically

John G. Lewis, Peter A. Elder and K. H. James Yeo

659

A monoclonal sorbent assay determinants

H. A. M. Verheul, E. V. T&es,

66.5

Effects of steroids with different endocrine profiles morphology and function of the bursa of Fabric&s

J. Kefder and A. H. W. M. !&hums

measure

binding

ceils--l.

activation

sites

%-Prep-

in brain

of

to prednisone: use of enzyme-linked immunofor screening and characterization of antigenic

binding assay for estrogen of receptor activation potency

683

Site of gossypol

inhibition

of steroidogenesis

689

Role of granulation tissue and fibroblasts lism in the rat in vitro

695

Increased

receptor

on the development, in chickens in monolayer

in purified

culture:

mouse Leydig cells

A. Donaldson

Anita Ojanotko-Harri, Helena Hurttia and Matti-Pekka Harri Short

antiestrogen

receptor

677 Competitive

S. Stoessel and G. Leclercq

S. Pearce, S. B. Sufi, P. J. O’Shaughnessy, and S. L. Jeffcoate

of triphenylethylene

glucocorticoid binding and diabetic (MDB/MDB) mice

antibody @LISA)

in eplthelium lacking androgen receptors in the mesenchymai

in gingival

testosterone

metabo-

ratios

in denervated

striated

Communicurion

Betsy J. Hughes and Michael Krieg

glucocorticoidjandrogen

receptor

muscle 701

Book Reviews Forthcoming Papers

i

Announcement

ii

NOVEMBER I. Pepride-steroid

(PART

B)

interaction

Structure and bioactivity opiomelanocortin

of the amino-terminal

fragment

of pro-

M. A. Seger and H. P. J. Bennett

703

Tokuji ICimwa

711 Transduction of ACTH signal from plasma membrane to mitochondria in adrenocorticai steroidogenesis. Effects of peptide, phospholipid, and calcium

Alain Surieau, Monique I)lasljUnt, France Agid, Daniel Philibert, Yva Agid and Wii Rostena

717 Autoradiographic localization of glucocorticosteroid binding sites in the human post-mortem brain

E R. de Kloet, J. M. H. M. Reni,

723

F. S. W. de Ronde, M. BIaaatn A. Ratka

ai&

Pushpa S. Kalra and Satya P. Kalra

ii. wiimd

voigt

lad

Function and pIasticity of brain corticosteroid receptor systems: action of neuropeptides

733 Steroidal modulation of the regulatory neuropeptides: luteinizing hormone releasing hormone, neuropeptide Y and endogenous opioid peptides 741

lu8w-Diaer

and progesterone

Intratissuiar 749

Peptide-steroid secretion steroid

interactions in brain regulation of pulsatile gonadotropin

and hormone

dependent

cancer

Intratissular androgens in benign prostatic hyperplasia and prostatic cancer

Bar6dl .. VIII

Jack Gdlar, Junda Liu, Jerry Albert, Whitnay Fay and cllarksc.Rerry

759

Effect of antiandrogcn and/or antiestrogen blockade on human prostate epitheliai and stromal cell protein synthesis

G. Moneti, A. CootantI& A. Guam. R. S&ma, 141.Paas@, A. Nat&

765

Measurement of testosterone and its 5-alfa-reduced metabolites in human prostatic tissue using isotope dilution mass spectrometry

France M Sitvet% and Franceseo Seiarra

773

Therapeutic approaches in prostatic cancer

Christian F. Holinka, HiroId Ham,

781

Effects of estradiol on proliferation (Ishikawa line)

A.GotidMM.Suio

A&i& Gravmis, Hboy& and Erlio Gwpide

cells

%tramoto

V. H. T. James, J. M. McNeiR, P. A. Bennek, R. C. Ronney and M. J. Reed H. c. T. T.

of endometrial adenooarcinoma

Adkraeatz, T. Fobis, RansWift, K. wgltg& MPkeRi. G. Rrunnr and Hase

787 The role of tissue steroids in regulating aromatase and oestradiol I7/3-hydroxysteroid dehydrogenase activities in breast and endomctrial cancer metabolites. potential 791 Determination of urinary l&tans and phyt~tro~n antiestrogens and anti~~ino~ns, in urine of women &n various habitual diets.

A. Vermeuka, J. P. Da&era and R Paridaans

799 Steroid dynamics. in the normal and carcinomatous

Luigi CWWgIJett% Omis M, Granh, Mkhde Lo Casto, Vhceazo Mlsmmdino, Muio Cnlb and Giuseppe Carruba

803

Jeau4%rre Raynaud sod Tiiu Ojamo

8 11 The design and use of sex-steroid antagonists

w. EIger, s. K. Chwalisz. S. H. Haam, G. Neef and

83.5 Studies on the mechanisms of action of progesterone antagonists

Estrone coavcrsion rates by human endomet~~

III.

Reitr, M. FUuuicb, D. Henderson, R. Rohde

mammary gland

cancer cell lines

Sex hormone antagonists

Etknna Raalleu

847

Fertility control in women: results with RU 486 by the end of 1985

J. R. PasquaW, R-L. Nguyen, C. Rumida, N. Giambiar# and C. Msyrand

853 Tamoxifen and progesterone effects in target tissues during the perinatai period

A. M. H. Rrodie, L. Y. Wing,

859 Aromatase inhibitors and their potential clinical significance

P. Gos& M. Dowsett and R. C. Coombas 0. Han&son, U.-F. Habenidit, Y. NWim, U. Kerb ami M. F. El Etreby

867 Aromatase inhibitors and benign prostatic hyperplasia

F. Labria. A. Dupont, M. Giguere, J. P. Bormyi,

877

Advantages of the combination therapy in previously untreated and treated patients with advanced prostate cancer

F. Neammn and M. T@ert

885

Pharmacology of antiandrogens

Marcella Motta, Soda Zoppi and Lln!iMo Mmtw

897

In uirro metabolism of testosterone in the rat prostate: influence of aging

A. 3tinager, Y. hmrciem.

J.~~G.M~~

iX

DECEMBER Yoshio Yoshimoto and Anthony W. Norman

905

Biological activity of vitamin D metabolites and analogs: dose-response study of Wa transport in an isolated chick duodenum perfusion system

Kathryn B. Horwitz, Adrian W. Pike, Carolina Gonzalez-Aller and Paul V. Fennessey

911

Progesterone metabolism in T47D,, human breast cancer cells-II. cellular metabolic path of progesterone and synthetic progestins

Montserrat Puente and Kevin J. Catt

917

Inhibition of pituitary-gonadal antagonist

Patrick EnglebienMz

927

Purification and binding site characterization blastic androgen-binding protein

Robert M. Bigsby

937

Progesterone induces a secretory protein in cultured rabbit endometrial stromal cells

Patrick G. Quinn and Anita H. Payne

943

High affinity binding of substrate and effector ligands to testicular microsomal cytochrome P-450

H. C. Potgieter, T. Klein, F. Magagane, N. Savage and J. L. Wittliff

951

Molybdate and the molecular properties of the Vervet monkey estrogen receptor

S. R. Crosby, W. A. Ratcliffe, G. N. Smith and A. White

957

Characterisation of monoclonal and polyclonal antibodies conjugates of testosterone with corresponding radioligands

Yolande Berthois, Natalie Po~reau~h~ider, Philippe Ga~i~n, Herve Mittre, Nicole Tubiana and Pierre M. Martin

963

Estradiol membrane binding sites on human breast cancer cell lines. Use of a fluorescent estradiol conjugate to demonstrate plasma membrane binding systems

J. Rozhin, J. D. Corombos, J. P. Horwitz and S. C. Brooks

973

Endocrine steroid sulfotransferases: steroid alcohol sulfotransferase human breast carcinoma cell line MCF-7

M. Ayub and S. R. Stitch~

981

Effect of ketoconazole on placental aromatase, 3~-hydroxysteroid dehydrogenase-isomerase and 17~-hydroxysteroid dehydrogenase

H. Y. Choi and R. Hobkirk

985

Chromatofocusing

Indra Rajagopalon, Engeline Kok, Bertram I. Cohen and Norman B. Javitt

991

26-Hydroxycholesterol neonate

Shashi B. Mahato and Sukdeb Banerjee

995

Metabolism of 1I-deoxycortisol

lntra-

function in male rats by a potent GnRH of the circulating tropho-

to I9-linked

of mammalian estrone sulfate sulfohydrolase

from

activity

disulfate: metabolism and excretion in the normal

by a

Bacillus

species

Michael H. Simonian

1001 ACTH and thyroid hormone regulation of 3@-hydroxysteroid dehydrogenase activity in human fetal adrenocortical cells

Stanley Snowball and William Taylor

1007 The effect of a progestin-only oral contraceptive on biliary lipid composition in the cat

S. T. H. Chan and W. S. B. Yeung

1013 A new method for the simultaneous determination of androstenedione, testosterone, 1I-oxotestosterone and 1l/?-OH-testosterone in fish plasma using combined techniques of Celite chromatography and radioimmunoassay

Short

Communication

K. Purvis. I. Brekke. H. Rui and A. Sunde

1023 Sa-Reductase in the non-secretory cells of the rat ventral prostate epithelium

Book Reviews

1027

Forthcoming Papers

i

X

SUBJECT INDEX 4-Acetoxy-4-androstene-3,17-dione effect on .&reduction of androgens in the rat prostate, 593 ACTH and thyroid hormone regulation of 3~-hydroxysteroid dehydrogenase activity in human fetal adrenocortical cells, 1001 involvement of cycloheximide-sensitive mediators in the steroidogenic action of. 59 signal from plasma membrane to mitochondria in adrenocortical steroidogenesis, 71 I Adrenal zona fasciculata effects of methionine enkephalin analogue on, of rats treated with dexamethasone or dexamethasone and ACTH, 535 Aldosterone effect of heparin on, in rat adrenal glomerulosa cells, 455 secretion rate of, using HPLC, 567 Androgen(s) a new method for the simultaneous determination of, 1013 binding proteins in circulating trophoblast, 927 in rabbit epididymis, 171 inhibition of catechol estrogens biosynthesis by, 351 metabolism of, in the human epididymis, 239 receptor characterization in the mesenchymal derivative of urogenitail sinus, 627 in genital skin fibroblasts, 323 photoaffinity iabelling of, from human foreskin and cultured genital fibroblasts, 355 So-Androstane-3a, 17/3-dial, 3- and 17-glucuronides, 417 synthesis of, 417 2,4,6-Androstatriene-3,17-dione effect of, on the So-reduction of androgens in the rat prostate, 593 Anti-androgen(s) effect of, on human prostate cell protein synthesis, 759 pharmacology of, X8.5 Anti-estrogen(s) localization of binding sites to, 635 Antiglucocorticoidfs) agonist activity in hepatoma cells, 11 relation between receptor binding affinity and antagonist efficacy of, 315 Aromatase and benign prostatic h~erplasia, 861 effect of ketoconazole on placental, 981 inhibitors and their potential clinical significance, 859 in human skin hbroblasts, 157 solubilization and partial purification of, from chicken ovary, 91 stimulation of, activity by dihydrotestosterone in human skin fibroblasts, 165 Benign prostatic hyperplasia aromatase inhibitors in, 861 intratissular androgens in, 749 Bile acids multicomponent analysis of, in faeces, 277 Brain autoradiographic localization of glucocorticosteroid and progesterone binding sites in human. post-mortem, 717 giu~ocorticosteroid receptor function and plasticity of, 717 in rat, 285

peptide-steroid interactions in, reguiation of pulsatile gonadotropin secretion, 741 sex steroids in specific regions of, in the human, 445 Breast cancer role of steroids in, 787 steroid dynamics in, 799 Breast cancer cells metabolism of progesterone in the T47D, 641 progesterone metabolism in T47D human, 911 Catechol estrogens inhibition of the synthesis of, by androgens, 351 regioselective reaction of thiols with, 245 Contraceptive(s) effect of a progestin-only oral, on biliary lipid composition in the cat, 1007 Corticosteroid(s) binding, in plasma of Xenopus laevis, 343 Cortisol enzyme immunoassay of, 423 structure of Iysine adducts with, 127 Cortivazol effect of, on blood pressure in sheep, 411 Cytochrome P-450 high affinity binding of substrate and effector ligands to testicular microsomal, 943 Cytotoxic anticancer agents effects of administration of, on hormnal responses in the mouse uterus, 231 Dehydroepiandrosterone sulfate enzyme immunoassay of, 423 radioimmunoassay in plasma, 375 Dehydroisoandrosterone metabolism of, by human A-549 alveolar Type II epithelial-like cells, 249 ll-Deoxycortisol metabolism of, by a Bacillus species, 995 Dexamethasone biotransformation and urinary excretion of, in equine male castrates, 547 1~,25-dihydroxycholecalciferol-24,23-lactone difference of biological activity among four diastereoisomers of, SO5 I,25-Dihydroxyvitamin D, receptor replenishment in the chicken intestine, 291 solubilization of, with pyridoxal 5’-phosphate, 333 Endometrial adenocarcinoma effects of estradiol on proliferation of, cells, 781 estrone conversion rates, 803 role of tissue steroids in, 787 4-en-3-oxo-Steroids influence of l-double bond and Ill-hydroxy group on stereospecific microbial reductions Estradiol binding in rat pancreas, 299 to membrane sites on human breast cancer cell lines, 963 effects of, in endometrial adenocarcinoma cells, 781 uterine uptake and nuclear retention of, 359 Estrogen(s) receptors binding to 16ol-iodo-17B-estradiol, 615 competitive binding assay for, in monolayer culture, 677 computer modeling of estradiol interactions with, 177 decreased nuclear binding of, in the pituitary of mice, 465 effect of molybdate on, in the Vervet monkey, 951 effect of protease on, in adult rabbit epididymis, 511 identification of uterine nuclear type II, in estrogen treated rats, 37 xii

of,561

in breast cancer cells, effect of Mg’+ ions or EDTA, 619 properties of, contained in the MtTF., tumor, 29 Estrogen-2/4-hydroxyIases specific and non-specific activities of, in rat brain microsomes, 585 Estrone conversion rates of, by human endometrial cancer cell lines, 803 Estrone sulfate sulfohydrolase activity of, in mammals, 985 Ethynylestradioi effect on lipid composition and phosphatidylethanolamine metabolism in red blood cells, 601 2-Fluoroestradiol effects of, on lipid metabolism in the ovariectomized rat, 575 FSH binding of, to testicular membranes in vitamin A deficient rats, 579 effect of, on testosterone production by mouse testes, 149 Gas chromatography - mass spectrometry steroid analysis by, 2.55 Glucocorticoid(s~ effects in rat liver cells, 201 receptors affinity for, in the rabbit kidney, 527 autoradiographic localization of, in human post-mortem brain, 717 decreased activation of, in brain of genetically diabetic mice, 649 in early and term placenta, 53 in human polymorphonuclear cells, 483 in rat brain, 28.5 GnRH and steroid interctions, 733 antagonist, effect in the pituitary-gonadal function in male rats, 917 Gonadotropin peptide-steroid interactions in brain regulation of pulsatile, secretion, 741 HPLC isolation and GC-MS characterization of a com~und strongly cross reacting with tetrahydroaldosterone antiserum, 71 Human chorionic gonadotropin testicular responsiveness to, in power athletes, 109 4-Hydroxy-4-androstene,3.17-dione effect on 5u-reduction of androgens in the rat prostate, 593 17P_Hydroxy- and 17-oxo-steroid profiles measurement in biological samples, 403 16-Hydroxycholesterol disulfate metabolism and excretion in the neonate, 991 16~-Hydroxyestrone structure of lysine adducts with, 127 17P-Hydroxysteroid dehydrogenase effect of ketoconazole on placental, 981 17~,20~-hydroxysteroid dehydrogenase in the human placenta, 103 3p-Hydroxysteroid dehydrogenase-isomerase effect of ketoconazole on placental, 981 in guinea-pig kidney, 265 purification and properties of testicular, 555 Leydig cells factor(s) involved in steroidogenesis in, 393 site of gossypol inhibition of steroidogenesis in purified, of mouse, 683 LH effects of, on testosterone production by mouse testes, 149 estradiof inhibition of pituitary, release, 309 Lignans and phyto-estrogen urinary metabolites, in women on various habitual diets, 791 ... XIII

Lung metabolism of testosterone in alveolar macrophages of rat, 541 MCF-7 breast cancer cell line steroid sulfotransfer~~ses in, 973 Methyltrienolene (~~H~Rl~81) used for androgen receptor determination. by photoaffinity labelling of androgen receptors from human foreskin. 3% Milk Identification and quantitation of free and conjugated steroids in, from lactating women, 379 Monoclonal antibody characterisation of, to 19-linked conjugates of testosterone, 957 to prednisone, 659 Myeloma steroid-carrier proteins in patients with multiple, 261 NADPH-cytochrome P-450 reductase purification of, from microsomal fraction of rat testes, 21 Neoplastic adrenocortical tissues biochemical and immunological characterization of estrogen binding in human, 1 Neoplastic human prostate effect of IbP-ethyl-17@-hydroxy-4-estren-j-one on the binding of promegestone and methyltrienolone to, 367 Nivazol effect of. on blood pressure in sheep, 411 Ovaries production of androgens and oestrogens by, of suckling mice, X3 17a-Oxidoreductase activity of, in neonatally grafted mouse testes in adult female mice. 121 Oxytocin receptors in hamster uterus. 219 Pancreas binding of [‘Hlestradiol to proteins in rat, 299 Pituitary estrogen receptors in, of mice, 465 Placenta glucocorticoid binding in earty and term rat, 53 progesterone receptors in rat. 183 Progesterone antagonists, studies on the mechanism of action of, 835 effects of, domination on estrogen and oxytocin receptors in hamster uterus, 219 endogenous, and lordosis behavior in male rats given estrogen, 99 induces a secretory protein in cultured rabbit endometrial stromal cells, 937 metabolism in T47D human breast cancer cells, 911 receptor(s) autoradiographic localization of, in human post-mortem brain, 717 characterization of, solubilized by micrococcal nuclease and DNase I digestion, 271 differential suppression of, by progesterone in the reproductive tract of female macaques, 497 in rat placenta, 183 in thymus of pregnant, pseudopregnant and steroid-treated rats, 65 Pro-opiomelan~~cortin structure and bioactivity of the amino-terminal fragment of. 703 Prostaglandin(s) glucocorticosteroid regulation of, biosynthesis in human myometrial smooth muscle cells. 521 Prostate effect of ant~androgen and/or antiestrogen blockade on human, epithelial and stromal cell protein synthesis, 759 measurement of testosterone and its Sew-reduced metabolites in human, tissue, 765 Prostate cancer intratissular androgens in. 749 therapeutic approaches in, 773 treatment in patients with advanced, 877 xiv

Receptor(s) androgen(s) characterization in the mesenchymal derivative of urogenitat sinus, 627 complexes in genital skin hbroblasts, 323 photoaffinity labelling of, from human foreskin and cultured genital fibroblasts, 355 1,25 dihydroxyvitamin D3 replenishment in the chicken intestine, 291 solubilization of, with pyridoxal 5’-phosphate from hen intestinat mucosa, 3 estrogen(s) binding to 16~-iodo-17~-estradiol, 615 competitive binding assay for, in monolayer culture, 677 computer modeling of estradiol interactions with, 177 decreased nuclear binding of, in the pituitary of mice, 465 effect of a protease on, in the adult rabbit epididymis, 511 identification of uterine nuclear type 11, in estrogen treated rats, 37 properties of, contained in the MtTF,, tumor, 29 gIucocorticoid(s) affinity of corticosteroids for mineralocorticoid and, of the rabbit kidney, 527 -androgen ratios in denervated striated muscle, 695 in early and term rat placenta, 53 in rat brain, 285 interactions of, with the antagonist RU 38486, 473 variation of cytosol, in human polymorphonuclear leukocytes and mononuclear cells, 483 progesterone characterization of the, soiubilized by micrococcal nuclease and DNase I digestion, 271 differential suppression of, by progesterone in the reproductive tract of female macaques, 497 in rat placenta, 183 in the thymus of pregnant, pseudopregnant and steroid-treated rats, 65 structure a personal assessment of the current status, 451 5cr-reductase from rat ventral prostate, 209 in the non-secretory cells of the rat ventral prostate epithelium, 1023 of androgens in the rat prostate, 593 RU 38486 effect in the rat levator ani muscle, 305 fertility control in women, 847 glucocorticoid-receptor binding to, 605 interaction of, with the glucocorticoid receptors, 473 Sertoli ceils effect of FSH, t-isoproterenol and glucagon, 45 Sex-steroid antagonists the design of new, 811 Sex steroid hormone binding in monkeys during different reproductive states, 135 molecular ~haracte~~ation of the, of plasma, 191 Steroid(s) effects of, on the bursa of Fabricius in chickens, 665 free and conjugated, in milk from lactating women, 379 receptor further characterization of a, -active protease from the mature rabbit epididymis, 43 secretion, by perifused frog adrenal glands, 143 serum, levels in intact and endocrine ablated BALB/c nude mice and their intact littermates, 429 Steroid sulfatase deficiency regulation of serum testosterone in men with, 113 Tamoxifen effects in target tissues during the perinatal period, 853 Testosterone evaluation in human prostatic tissue, 765 xv

gingival, metabolism in the rat in virro, 689 metabolism of, in alveolar macrophages from rat lung, 541 metabolism of. in rat prostate, 897 nonsteroidal substances that affect serum free, 225 regulation of serum, in men with steroid sulfatase deficiency, 113 Transcortin levels in patients with acute lymphoblastic leukemia, 489 Uterus enzyme activities in the androgenized rat, refractory to oesetrogenic stimulation. Vitamin D -binding protein in explants of mouse mammary gland in culture, 459 biological activity of, metabulites in chick duodenum 905 We wish to thank the following persons for their kind cooperation

of Steroid

491

in reviewing papers for the Jolrrnal

Biochemistry:

Drs H. L. Bradlow, New York, U.S.A.: D. Bronzert, Bethesda, U.S.A.; M. M. Compton. Chapel Hill, U.S.A.; A. Crastes de Paulet, Montpellier, France; L. Dehennin. Fresnes, France; R. De Hertogh. Louvain, Belgium; W. L. Duax, Buffalo, U.S.A.; D. P. Edwards, Denver, U.S.A.; P. V. Fennessey, Denver, U.S.A.; H. Fleming, New York. U.S.A.; S. Franks, London, England; F. French, Chapel Hill, U.S.A.; E. F. Hahn, New York, U.S.A.; R. A. Hiipakka. Chicago, U.S.A.; C. HBrhold, Jena, German Democratic Republic; T. Ojasoo, Paris, France; K. Ruckpaul, Jena. German Democratic Republic; S. Saez, Lyon, France; C. A. Strott, Bethesda, U.S.A.

XVi

AUTHOR INDEX Abul-Hajj Y. J. 245 Adams 1. B. 265 Adlercreutz H. 277, 791 Agid F. 717 Agid Y. 717 Albaladejo V. 29 Albert J. 759 Alert M. 109 Andersen R. N. 225 Andre J. 29 Aron C. 99 Asibey-Berk E. 103 Aumiiller G. 209 Axelson M. 379 Ayub M. 981 Azukizawa S. 45.5 Banerjee S. 995 Bannan R. A. 3.51 Bannwart C. 791 Bartsch W. 749 Bashirelahi N. 367 Baulieu E. 847 Becker J. M. 299 Beier S. 835 Belanger A. 877 Belisle S. 465 Bell P. A. 473 Bellabarba D. 465 Bencsath F. A. 127 Bender D. A. 359 Benedict C. 567 Bennett H. P. J. 703 Bennett P. 429 Beranek P. A. 787 van den Berg H. W. 619 Berry C. C. 759 Berthois Y. 963 Bigsby R. M. 937 Blanchardie P. 527 Blaquier J. A. 239 Bloemers M. 723 Bonnev R. C. 787 Borellini F. 459 Borsanvi J. P. 877 Bowden J-F. 359 Boyer J. 575, 601 Brekke I. 1023 Brenner R. M. 497 Brodie A. M. 593 Brodie A. M. H. 859 Brooks S. C. 973 Brown H. 567 Brueggemeier R. W. 351 Brunner N. 429 Brunow G. 791 Bucala R. 127 Cailleau J. 45, 393 Cain D. A. 249 Calb M. 803 Carruba G. 803 Casey M. L. 521 Castagnetta L. 803 Catt K. J. 917 Cerami A. 127 Chabab A. 157, 16.5 Chabli A. 99 Chait B. T. 127

~hakraborty J. 547 Chan S. T. H. 1013 Cheng S-L. 171 Choi H. Y. 985 Chung L. W. K. 627 Chwalisz K. 835 Cisek P. L. 245 Claire M. 527 Clark J. H. 635 Clarke R. 619 Coghlan J. P. 411 Cohen B. I. 991 Coombes R. C. 859 Cornu G. 527 Corombos J. D. 973 Costantini A. 765 Co&on W. F. 3.59 Crastes de Paulet A. 315 Crosby S. R. 957 Culler M. D. 741 Cunha G. R. 627 Dalterio S. L. 149 Danze P. M. 605 Danzo B. J. 433, 511 Dautrevaux M. 605 De Moor P. 261 De Nicola A. F. 53 Delarue C. 59 Denton D. A. 411 Descomps B. 165 Deslypere J. P. 799 Devine P. L. 265 Dhar T. K. 423 Di Silverio F. 773 Dickson G. R. 619 Doe R. P. 483 Donaldson A. 683 Donaldson E. S. 231 Dowsett M. 859 Duax W. L. 615 Dumasia M. C. 547 DuPont A. 877 Dussaillant M. 717 Eik-Nes K. B. 541 Ekiko D. B. 367 El Etreby M. F. 867 Elder M. G. 491 Elder P. A. 659 Elger W. 835 Emond J. 877 Enderle-Schmitt IJ. 209 Englebienne P. 927 Fahnrich M. 835 Faict D. 261 Fay W. 759 Fenart 0. 165 Fennessey P. V. 641, 911 Feuilloley M. 143 Fisher T. S. 71 Flanigan R. C. 231 Flynn J. J. 649 Formstether P. 605 Fotsis T. 277, 791 France J. T. 37.5 Frankel F. R. 201 Funder .I. W. 65, 285, 355 xvii

Gagne D. 315 Gallion H. 231 Gandilhon P. 963 Ganesan S. 367 Geier A. 271 Geller J. 759 Giambiagi N. 853 Giguere M. 877 Goldman P. M. 483 Gonzalez-Aller C. 641, 91 I Gordon M. S. 177 Goss P. 859 Goti A. 765 Gottardo G. 535 Granata 0. M. 803 Gravanis A. 781 Grossman A. 299 Guarna A. 765 Guest J. F. 491 Gunsalus G. L. 171 Gurpide E. 239, 781 Guthrie S. 635 Gyorki S. 355 Habenicht U.-F. 867 Hammond G. S. 567 Harri M.-P. 689 Hasan S. H. 835 Hase T. 791 Hata H. 781 Haug E. 541 Heller C. L. 53 Henderson D. 835, 867 Hendry W. J. III 433 Hess D. L. 497 Hobkirk R. 985 Hochbera R. B. 615 Holinka ‘c. F. 781 Holland 0. B. 567 Hdrhold C. 561 Horwitz J. P. 973 Horwitz K. B. 911 Horwitz K. E. 641 Hosojima H. 455 Hosoya N. 333 Houghton E. 547 Hoyer G.-A. 71 Hruhy H. M. 483 Hughes B. J. 695 Hurttia H. 689 Ikeda S. 333 Imaizumi N. 455 inane H. 21 555 Ishii-Ohba H. 555 Ishizuka S. 505 Jackson W. 375 James R. 355 James V. H. T. 787 Javitt N. B. 991 Jeffcoate S. L. 683 Jolivet-Jaudet G. 343 Kalra P. S. 733 Kalra S. P. 733 Kanda A. 333 Kaufman M. 323 Kaufmann G. 561

Kcelan J. 375 Kelder J. 665 Kelly N. S. 265 Kenady D. E. 231 Kerb U. 867 Killinger D. W. 323 Kimura T. 711 King R. J. B. 451 Kirk D. N. 71 Kishimoto S. I Kitamura Y. 83 Klein H. 299 Klein T. 951 de Kloet E. R. 723 Koga M. I Kok E. 991 Konaeava M. 305 Koritnik D. R. 135 Korpela J. T. 277 Kotite N. J. 171 Krieg M. 695 Kuramoto H. 781 Kuroda H. 83 Lahrie F. 877 Lacourciere Y. 877 Lanthier A. 445 de Larminat M-A. 239 Le Petit-Thevenin J. 601 Leavitt W. W. 219 Leboulenger F. 59 Leclercq G. 677 L,efebvrk P. 605 Lehoux J-G. 465 Leloup-Hatey J. 343 Leshin M. 91 Lewis J. G. 659 Lichtwald K. 71 Liehr J. G. 575 Lihrmann I. 59, 143 Litwack G. 649 Liu J. 759 Lo Casto M. 803 Lofthus R. 541 Lombes M. 527 Louwagie A. 261, 489 tuncnfeld 3. 271 Lustenberger P. 527 Lyttle C. R. 37 MacDonald P. C. 521 Magagane F. 951 Mahato S. B. 995 Makehi T. 791 Margules D. L. 649 Marks V. 547 Marschke K. 8. 135 Marthinsen A. B. L. 541 Martikainen H. 109 Martin P. M. 963 Martini L. 593, 897 Masotto C. 741 Matsuda M. i Matsumoto K. 1, 83, I21 Max S. R. 305 Mavtield D. I49 Mailrand C. 853 Mazzocchi G. 535 McCrac D. A. 191

McNeil1 J. M. 787 Medlock K. L. 37 Meignen J. M. 575 Mellon W. S. 291 Mercier L. I I. 575 Mezzetti G. 359 Michaud A. 527 Milewich L. 249 Miller 13. W. 417 Miller P. A. Ii Mills E. H. 41 t Miserendino V. St13 Mitchell M. D. 521 Mittre H. 963 Moll G. W. Jr 309 Moneti G. 765 Monfette G. X77 de Moor P. 489 Morel Y. 29 Morimoto S. 455 Moss M. S. 547 Motta M. 593, X97 Murphv R. F. 619 Murray S. 255 Musto N. A. I71 I

d

Naider F. 299 Nakao M. I Nakayama H. 83 Namkung P. C. 191 Natali AT 765 Nehel L. 271 Neef G. 835 Negro-Viiar A. 741 Nelson J. 619 Nelson K. 231 Netchitailo P. 59. 143 Neumann F. 885 Nguyen B.-L. X53 Nicolas J.-C. I57 Nielsen A. 429 Nielsen J. 429 Nishino Y. 867 Nobili 0. 601 Noble J. F. 91 Noma K. 1 Norman A. W. 505. 90.5 Notides A. C. 177 Nussdorfer G. G. 535 Ogle T. F. IX3 Oikarinen A. 113 Ojanotko-Harri A. 689 Ojasoo T. 81 I Oka T. 459 Orti E. 53 O’Shaughnessy P. J. 683 Paridaens R. 799 Pasqualini J. R. 853 Patwardhan V. V. 445 Pavlik E. J. 231 Payne A. H. 943 Payne D. W. 403 Pazzagli M. 765 Pearce P. 65 Pearce S. 6X3 Perroteau I. 59 Petrn P. H. 191

...

xv111

Pharaboz M. 0. 29 Philihcrt D. 717 Pike A. W. hJl. 911 Pinsky L. 323 Porn M. 315 Potgicter H. c’. 951 Pourreau-Schneider N. 963 Puente M. 917 Purse11 S. 231 Purvis K. 1023 Quinn P. G. 943 Radparvar S. 291 Rafestin-Oblin M. E. 527 Rahkila P. 109 Rahmani-Jourdheuil D. 601 Rajagopalan I. 991 Rao M. R. S. 579 Rao P. N. 417 Ratcliffe W. A. 957 Rntka A. 723 Raynaud J.-P. 811 Rcbuffat P. 535 Reed M. J. 787 Rettori V. B. 149 Reul J. M. H. M. 723 Richardson M. R. 521 Risk M. 567 Robba C. 535 Rodriguez A. M. 417 Rohde R. 835 de Ronde F. S. W. 723 Rosenfield R. L. 309 Ross J. B. A. 191 Rostene W. 717 Rousslang K. W. 191 Rozhin J, 973 Rui H. 1023 Ruokonen A. 113 Russell V. A. 585 Sablonniere B. 605 Sahlbera B-L 379 Salerno-R. 765 Sarrieau A. 717 Sato B. I Savage N. OS1 Schaeffer C. 99 Schmidt T. J. 649 Schmitt J. 209 Schdneshofer M. 423 Schumann G. Shl Schuurs A. H. W. M. 665 Schwartz N. B. 149 Schwartz Z. 491 Sciarra F. 773 Scoggins B. A. 411 Scorticati C. 239 Seger M. A. 703 Senear D. F, 191 Serio M. 765 Severson S. P. 483 Shannon J. M. 627 Sheehan D. M. 37 Sheppard K. E. 285 Shida K. 367 Shimura F. 333 Simonian M. H. 1001

Simons S. S. Jr. 11

Teller D. C. 191 Terada N. 83 Theron C. N. 585 Thomas J. L. 103 Thompson T. C. 627 Tittes E. V. 665 Tiipert M. 885 Tubiana N. 963

Smith G. N. 957 Snowball S. 1007 Sonoda T. 1 Spang-Thomsen M. 429 Spence C. D. 411 Stitch SR. 981 Stoessel S. 677 Strickler R. C. 103 Strong P. 615 Sufi S B. 683 Sultan C. 157. 165 Sumida C. 853 Sun L-H. K. 201 Sunde A. 1023 Suter D, E. 149 Svenstrup B. 429 Symes E. K. 359

Uchida K. 455 Ueda T. 121 Ulrich P. C. 127 Umstot E. S. 225 Unni E. 579 Valette A. 575 Van NagelI J. R. Jr. 231 Vanham G. 261 Vaudrv H. 59. 143 Vazqukz M. H. 239 Vecsei P. 71 Verheul H. A. M. 665 Verhoeven G. 45. 393 Vermeulen A. 799 Vihko R. 109, 113

Takahashi E. 367 Takeda A. 219 Takeyama M. 121 Talalav P. 403 Talja&d J. J. F. 585 Tamaoki B-i. 21 55.5 Taylor W. 1007

Voigt K.-D. 749 Volck-Badouin E. 209 Voss E. 423 WIhiihi K. 791 Warne G. L. 355 Watson D. 255 Weatherill P. J. 473 Webb M. L. 649 West N. B. 497 White A. 957 White J. 0. 491 Whitworth J. A. 411 Wing L. Y. 859 Wittliff J. L. 951 Yamanaka H. 367 Yemini-Blauer Z. 271 Yeo K. H. J. 659 Yeung W. S. B. 1013 Yoshimoto Y. 905 Young J. D. Jr 367 Zielinski J. E. 615 Zoppi S. 593, 897

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