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W17-P-010 What about atherosclerosis in the ascending aorta of severe aortic stenosis?
128
Workshops W17 Methods of preclinical and clinical atherosclerosis assessment
data suggest that PLTP activity is positively and independently related to coronary artery disease. Since PLTP activity is known to be increased in type 2 diabetes, we have determined whether PLTP activity is associated with endothelial dysfunction. Methods: 210 type 2 diabetic patients and 75 non-diabetic controls were recruited. Plasma PLTP activity was assayed by measuring the transfer of radiolabelled phosphatidylcholine from liposomes to HDL. Endothelium-dependent and independent vasodilation of the brachial artery were measured by high resolution vascular ultrasound Results: Type 2 diabetic patients had higher PLTP activity than nondiabetic controls (2.39 q- 0.63 umol/ml/h vs 1.80 ± 0.52 respectively, p<0.01). Both endothelium-dependent (5.2 ± 2.8% vs 8.8 ± 4.4, p<0.01) and endothelium-independent vasodilation were impaired in diabetic patients (13.4 + 4.7% vs 16.6 + 5.4, p<0.01). There was an inverse correlation between PLTP activity and endothelium-dependent vasodilation (r = -0.16, p = 0.022) and endothelium-independent vasodilation (r = -0.15, p = 0.024). Conclusion: PLTP activity is increased in type 2 diabetes and is associated with endothelial dysfunction. Prospective studies are required to determine the significance of elevated PLTP activities as a vascular disease risk factor.
hyperlipidemia, 36.3% were smokers, 33A% had diabetes, 52.4% had hypertension. Total cholesterol level was 5.75± 1.27 mmol/1, LDL cholesterol was 3.71±1.23 mmol/1. On univariate analysis positive association between aortic dimensions and male gender, height, and BAV was found. Aortic size was negatively associated with the history of hyperlipidemia, fibrinogen level, and CAD. No association between aortic dimensions and other measured variables including blood lipid levels and severity of valve disease was found. On multivariate analysis, aortic dimensions correlated positively with male gender (p<0.01), height (p<0.01) and BAV (p<0.05 at sinus and sinotubularjunction level, p<0.001 at mid-ascending aorta). Aortic dimensions correlated negatively with the history of hypedipidemia, fibrinogen level (both p<0.001), and CAD (p<0.01). Conclusions: In patients with severe aortic stenosis the size of ascending aorta is positively associated with male gender, height and presence of BAV, while the contribution of AS risk factors was opposite (hyperlipidemia, fibrinogen) or none in our study and CAD independently predicted smaller proximal aortic dimensions.
W17-P-011 ] PULSE WAVE VELOCITY AND BODY MASS INDEX IN GREEK ORTHODOX NUNS i
W17-P-0091 PREVALENCE OF AN ABNORMAL ANKLE-BRACHIAL INDEX IN RELATION TO THE CARDIOVASCULAR RISK ESTIMATED BY THE FRAMINGHAM FUNCTION M. Lahoz 1, I. Vicente s , M. Taboada 3 , A. Garcia 2, M.A. San Martin 2, ][. Tero--'~l,E Laguna 1, M.E Garcia-Iglesias 1, C. Lahoz 1.1Arteriosclerosis
Unig Hospital Carlos lIl, Madrid, Spain; 2Cardiology Departmeng Hospital Carlos IlI, Madrid; SC.S. Fuencarral, Madrid, Spain Background: An abnormal ABI (<0.9 or >1.4) is associated with the development of cardiovascular disease and cardiovascular and all-cause mortality. Despite of this, its measurement in clinical practice is underased. Objective: To evaluate the prevalence of an abnormal ABI in relation to the cardiovascular risk determined by Framingham risk function in a population in primary prevention. Methods: 1001 subjects without known cardiovascular disease attended in primary care were invited to participate in the study. Cardiovascular risk and ABI measurements were calculated in all paaicipants. Results: A low (<0.9) ABI was found in a 3.8% of the participants, 3.9% females and 3.6% males. An abnormal ABI (<0.9 or > 1.4) was found in a 6.4% of all subjects, 5.2% females and 8.8% males. In a multivariable analysis, age (OR 1.09 for each year, IC 1.03-1.15), smoking habit (OR 2.96; IC 1.51-5.80), HDL-cholesterol levels (OR 0.98 for each mg/dl; IC 0.95-0.99) and hypertension (OR 1.80; IC 1.05-3.06) were related with an abnormal ABI. Subjects were divided according to their risk stratification. The percentage of low, moderate and high-risk individuals with an abnormal ABI was 2.6%, 8.7% and 14.9% respectively. Conclusion: In primary prevention, one in ten individuals with moderate risk and one in six individuals with high risk have an abnormal ABI. In these subjects there is an indication for intensive preventive strategies and for antiagregation.
M. Marcoyannopoulou Fojas 1, N. Papageorgakis 1, A. Grigoratou 1, L. Sinodinos 2, I. Sigala 3, G. Jullien 1. 1Clinical Biochemistry,
Evangelismos University Hospital, Athens, Greece; 2public Health Insurance, Volos Magnisias, Greece; SPulmanory uni~ Evangelismos University Hospital, Athens, Greece Objective: To determine the relationship between the time of Pulse Wave Velocity (PWV) and Body Mass Index (B.M.I.) among nuns living in a monastery under similar environmental conditions and diet. Method: Examinations were performed on these nuns during their non fasting period. Pulse Wave Velocity was determined using an indirect method with infrared sensors picking up the pulses over the left external carotid and left dorsalis pedis arteries simultaneously with a single lead ECG. These pulses are recorded on a computer and the time delay between them is computed. A shorter time of PWV would indicate a decrease in arterial wall elasticity. Materials: Thirty nuns were studied. Age ranged from 19 to 83 years. Of these thirty, ten had a BMI of < 25; eight - >25 to 30; and, twelve >30. Results: The time of the PWV in subjects with BMI of < 25 was 0.1580 sec.; BMI of >25 to 30 was 0.1300 sec. and BMI of >30 was 0.1262 sec. The decrease of time of PWV with increase of BMI is statistically significant with a p- value of 0.025. Conclusion: The above result shows that time of PWV decreases with increased Body Mass Index implying that arterial wall elasticity is decreased. This would indicate that these subjects would have greater risk of developing cardiovascular disease. W17-P-012 ] RELATION BETWEEN CAROTID INTIMA-MEDIA THICKNESS AND LIPID PROFILE AT PATIENTS W I T H METABOLIC SYNDROME i
I. Marian, A. Marian, L. Ardelean, R. Chiorescu, S. Blaga. Cardiology,
I W17-P-010 I WHAT ABOUT ATHEROSCLEROSIS IN THE ASCENDING AORTA OF SEVERE AORTIC STENOSIS? K. Linhartovfi 1, I. Hani~ovfi 1, F. Sefrna 2, V. Ber~nek 1, T. Hhjek 3,
M. Cepel~tk 1. l ls t Department of Medicine, Charles University, School of Medicine Hospital Plzer¢ 2Department of Statistics, School of Medicine Hospital Plzen," SDepartment of Cardiac Surgery, Charles University, School of Medicine Hospital Plzen, Czech Republic Objective: To assess the association of atherosclerosis (AS) risk factors with proximal aortic dimensions in severe aortic stenosis. Methods: Analysis of consecutive patients planned for aortic valve surgery. History, laboratory samples, transesophageal echocardiography and coronary angiography were obtained. Using univariate and multivariate analysis (linear step-wise regression), aortic dimensions were correlated with: 1. major AS risk factors, 2. number of aortic cusps, 3. echocardiographic variables, and 4. angiographicaBy significant coronary artery disease (CAD). Results: 103 patients, mean age 67.2±8 years, 68% men, 38% had bicuspid aortic valve (BAV) and 44% had CAD, 57.8% had history of
Medical Clinic No I, Cluj-Napoca, Romania Objective: Carotid intima-media thickness (IMT) determined by high resolution ultrasonography is an accepted parameter for the assessment of early atherosclerosis and appreciation of cardiovascular risk. The atherogenetic role of different lipid profile components, at the patients with metabolic syndrome (METS), is not weU established. The purpose of this study was the assessment of atherogenic potential of different components of lipid profile, at the patients with METS. For this reason, we studied the relation between IMT, measured at the level of carotid arteries, and lipid profile components. Methods: We included 81 patients who fulfill the NCEP-ATP III criteria for diagnosis of the METS. There are men and postmenopausal women, with age between 40-75 years, non-smokers, non-diabetic, without previous treatment for dyslipidaemia. Carotid IMT was considered like maxim value, measured from multiple incidences, at the level of posterior wall of common carotid arteries. We determined, for these patients, by direct measurements, the level of total cholesterol(TC), HDL-cholesterol (HDLC), LDL-cholesterol (LDL-C) and triglycerides (TG) and we calculated TG/HDL-C ratio, TC/HDL-C ratio.
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic
Workshops W17 Methods of preclinical and clinical atherosclerosis assessment
data suggest that PLTP activity is positively and independently related to coronary artery disease. Since PLTP activity is known to be increased in type 2 diabetes, we have determined whether PLTP activity is associated with endothelial dysfunction. Methods: 210 type 2 diabetic patients and 75 non-diabetic controls were recruited. Plasma PLTP activity was assayed by measuring the transfer of radiolabelled phosphatidylcholine from liposomes to HDL. Endothelium-dependent and independent vasodilation of the brachial artery were measured by high resolution vascular ultrasound Results: Type 2 diabetic patients had higher PLTP activity than nondiabetic controls (2.39 q- 0.63 umol/ml/h vs 1.80 ± 0.52 respectively, p<0.01). Both endothelium-dependent (5.2 ± 2.8% vs 8.8 ± 4.4, p<0.01) and endothelium-independent vasodilation were impaired in diabetic patients (13.4 + 4.7% vs 16.6 + 5.4, p<0.01). There was an inverse correlation between PLTP activity and endothelium-dependent vasodilation (r = -0.16, p = 0.022) and endothelium-independent vasodilation (r = -0.15, p = 0.024). Conclusion: PLTP activity is increased in type 2 diabetes and is associated with endothelial dysfunction. Prospective studies are required to determine the significance of elevated PLTP activities as a vascular disease risk factor.
hyperlipidemia, 36.3% were smokers, 33A% had diabetes, 52.4% had hypertension. Total cholesterol level was 5.75± 1.27 mmol/1, LDL cholesterol was 3.71±1.23 mmol/1. On univariate analysis positive association between aortic dimensions and male gender, height, and BAV was found. Aortic size was negatively associated with the history of hyperlipidemia, fibrinogen level, and CAD. No association between aortic dimensions and other measured variables including blood lipid levels and severity of valve disease was found. On multivariate analysis, aortic dimensions correlated positively with male gender (p<0.01), height (p<0.01) and BAV (p<0.05 at sinus and sinotubularjunction level, p<0.001 at mid-ascending aorta). Aortic dimensions correlated negatively with the history of hypedipidemia, fibrinogen level (both p<0.001), and CAD (p<0.01). Conclusions: In patients with severe aortic stenosis the size of ascending aorta is positively associated with male gender, height and presence of BAV, while the contribution of AS risk factors was opposite (hyperlipidemia, fibrinogen) or none in our study and CAD independently predicted smaller proximal aortic dimensions.
W17-P-011 ] PULSE WAVE VELOCITY AND BODY MASS INDEX IN GREEK ORTHODOX NUNS i
W17-P-0091 PREVALENCE OF AN ABNORMAL ANKLE-BRACHIAL INDEX IN RELATION TO THE CARDIOVASCULAR RISK ESTIMATED BY THE FRAMINGHAM FUNCTION M. Lahoz 1, I. Vicente s , M. Taboada 3 , A. Garcia 2, M.A. San Martin 2, ][. Tero--'~l,E Laguna 1, M.E Garcia-Iglesias 1, C. Lahoz 1.1Arteriosclerosis
Unig Hospital Carlos lIl, Madrid, Spain; 2Cardiology Departmeng Hospital Carlos IlI, Madrid; SC.S. Fuencarral, Madrid, Spain Background: An abnormal ABI (<0.9 or >1.4) is associated with the development of cardiovascular disease and cardiovascular and all-cause mortality. Despite of this, its measurement in clinical practice is underased. Objective: To evaluate the prevalence of an abnormal ABI in relation to the cardiovascular risk determined by Framingham risk function in a population in primary prevention. Methods: 1001 subjects without known cardiovascular disease attended in primary care were invited to participate in the study. Cardiovascular risk and ABI measurements were calculated in all paaicipants. Results: A low (<0.9) ABI was found in a 3.8% of the participants, 3.9% females and 3.6% males. An abnormal ABI (<0.9 or > 1.4) was found in a 6.4% of all subjects, 5.2% females and 8.8% males. In a multivariable analysis, age (OR 1.09 for each year, IC 1.03-1.15), smoking habit (OR 2.96; IC 1.51-5.80), HDL-cholesterol levels (OR 0.98 for each mg/dl; IC 0.95-0.99) and hypertension (OR 1.80; IC 1.05-3.06) were related with an abnormal ABI. Subjects were divided according to their risk stratification. The percentage of low, moderate and high-risk individuals with an abnormal ABI was 2.6%, 8.7% and 14.9% respectively. Conclusion: In primary prevention, one in ten individuals with moderate risk and one in six individuals with high risk have an abnormal ABI. In these subjects there is an indication for intensive preventive strategies and for antiagregation.
M. Marcoyannopoulou Fojas 1, N. Papageorgakis 1, A. Grigoratou 1, L. Sinodinos 2, I. Sigala 3, G. Jullien 1. 1Clinical Biochemistry,
Evangelismos University Hospital, Athens, Greece; 2public Health Insurance, Volos Magnisias, Greece; SPulmanory uni~ Evangelismos University Hospital, Athens, Greece Objective: To determine the relationship between the time of Pulse Wave Velocity (PWV) and Body Mass Index (B.M.I.) among nuns living in a monastery under similar environmental conditions and diet. Method: Examinations were performed on these nuns during their non fasting period. Pulse Wave Velocity was determined using an indirect method with infrared sensors picking up the pulses over the left external carotid and left dorsalis pedis arteries simultaneously with a single lead ECG. These pulses are recorded on a computer and the time delay between them is computed. A shorter time of PWV would indicate a decrease in arterial wall elasticity. Materials: Thirty nuns were studied. Age ranged from 19 to 83 years. Of these thirty, ten had a BMI of < 25; eight - >25 to 30; and, twelve >30. Results: The time of the PWV in subjects with BMI of < 25 was 0.1580 sec.; BMI of >25 to 30 was 0.1300 sec. and BMI of >30 was 0.1262 sec. The decrease of time of PWV with increase of BMI is statistically significant with a p- value of 0.025. Conclusion: The above result shows that time of PWV decreases with increased Body Mass Index implying that arterial wall elasticity is decreased. This would indicate that these subjects would have greater risk of developing cardiovascular disease. W17-P-012 ] RELATION BETWEEN CAROTID INTIMA-MEDIA THICKNESS AND LIPID PROFILE AT PATIENTS W I T H METABOLIC SYNDROME i
I. Marian, A. Marian, L. Ardelean, R. Chiorescu, S. Blaga. Cardiology,
I W17-P-010 I WHAT ABOUT ATHEROSCLEROSIS IN THE ASCENDING AORTA OF SEVERE AORTIC STENOSIS? K. Linhartovfi 1, I. Hani~ovfi 1, F. Sefrna 2, V. Ber~nek 1, T. Hhjek 3,
M. Cepel~tk 1. l ls t Department of Medicine, Charles University, School of Medicine Hospital Plzer¢ 2Department of Statistics, School of Medicine Hospital Plzen," SDepartment of Cardiac Surgery, Charles University, School of Medicine Hospital Plzen, Czech Republic Objective: To assess the association of atherosclerosis (AS) risk factors with proximal aortic dimensions in severe aortic stenosis. Methods: Analysis of consecutive patients planned for aortic valve surgery. History, laboratory samples, transesophageal echocardiography and coronary angiography were obtained. Using univariate and multivariate analysis (linear step-wise regression), aortic dimensions were correlated with: 1. major AS risk factors, 2. number of aortic cusps, 3. echocardiographic variables, and 4. angiographicaBy significant coronary artery disease (CAD). Results: 103 patients, mean age 67.2±8 years, 68% men, 38% had bicuspid aortic valve (BAV) and 44% had CAD, 57.8% had history of
Medical Clinic No I, Cluj-Napoca, Romania Objective: Carotid intima-media thickness (IMT) determined by high resolution ultrasonography is an accepted parameter for the assessment of early atherosclerosis and appreciation of cardiovascular risk. The atherogenetic role of different lipid profile components, at the patients with metabolic syndrome (METS), is not weU established. The purpose of this study was the assessment of atherogenic potential of different components of lipid profile, at the patients with METS. For this reason, we studied the relation between IMT, measured at the level of carotid arteries, and lipid profile components. Methods: We included 81 patients who fulfill the NCEP-ATP III criteria for diagnosis of the METS. There are men and postmenopausal women, with age between 40-75 years, non-smokers, non-diabetic, without previous treatment for dyslipidaemia. Carotid IMT was considered like maxim value, measured from multiple incidences, at the level of posterior wall of common carotid arteries. We determined, for these patients, by direct measurements, the level of total cholesterol(TC), HDL-cholesterol (HDLC), LDL-cholesterol (LDL-C) and triglycerides (TG) and we calculated TG/HDL-C ratio, TC/HDL-C ratio.
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic