- Email: [email protected]
Water fluoridation and osteoporosis
165
Depsrtment of Surgery, Kuopio Universi@ Central Hospital, 70210 Kuopio, Finland FLUORIDE-QUART. REP.; 20/l (l-3)/1987/ The authors examined individually the files of all hip fracture patients and checked to make sure they actuaRy had lived in the fluoridatad area for at least 10 years prior to the fracture. Moreover, all patients with high-energy accidents, pathological fmctures, metabolic bone disease, etc., were arch&d. In some cases the international code designations were found to be completely incorrect. Obviously it is not possible to make such distinctions simply on the basis of hospital discharge data. AlthouSh less important in a large population, these factors cannot be ignored in a study such as this one. Flttally, in their histomorphometric study they found no increase in trabecular bone mass even in the hilh-fluotide area where, however, the amount of unmineralized osteoid was increased. In their study no differences in the histomorphometric parameters as well as fracture incidence between the low-fluoride and fluoridated water area was observed. Consequently, and in view of the relatively small number of cases, it is unwarranted to conclude from other studies that fluoridated water can prevent osteoporotic hip fractures. EIN TMNSDKRMALKS THRRAPEU’MSCHKS SYSTEM ZUR HORMONELLEN THERAPIE MIMAL(TERI8CHER AUSFALL!3ER!3CHEINUNGEN. MULTIZENTRISCHE STUDIE
IWIUceatrk study of a tramkmd tbefapeutk system for estrogen repkement therapy of dImmA& wmcto= Kersel C; Keller PJ Dtpartementfur Frauenheilkunde, Universitatspital, CH-8091 Zurich, Switzerland GEBURTSHILFE FRAUENHEILKD.; 47/8 (56%568)/1987/ In an open study 112 women with menopausal symptoms were treated with a transdermal therapeutic system delivering estradiol at a rate of 25, 50 or 100 m&day resp. The study, which was to measure the therapeutic efficacy and systemic and local tolerability, lasted 3 months. At the end of the treatment period 46% of the women were completely free of symptoms and a further 46% very much improved. In 64% the hot flushes disappeared entirely and in the remaining women their frequency and intensity, w&h a few exceptions. were markedly diminished. Nocturnal bouts of sweating were completely prevented in 67% of those complaining of this symptom. Pollakiuria impoved in 93%. Before commencement of the therapy 24 patients felt unwell, during the study only two. The proportion of women who felt well or very well rose from 36% to 83%. The systemic tolerability was rated good or excellent by 97% of patients and in no case was it rated poor. Blood pressure and body weight were not affected. The local tolerability was considered good or very good by 80% of the women; it was poor in 5 cases (4.6%) and only in one case did it lead to diiontinwtion of the therapy. Ninety percent of the participants wanted to continue treatment beyond the duration of the study. ckwr&taof~btllrrks Gamron L; Hansel S; Goddwin J Department of Psycholodv. Southern Illinois University, Carbondale, IL 62901. United States of America J. BEI-IAV. MED.; 10/3 (277-285)/1987/ The purpose of the present study was to examine the relationships of frequency, duration, and intensity of hot flashes with daily stress, ambient temperature, and caffeine. alcohol, and nicotine intake in menopausal women. Ten menopausal women suffering from hot flashes monitored these variables doily for 6 weeks. Intrasubject correlation analyses revealed significant relationships between hot-flash activity and stress for half of the sample; few women exhibited significant relationships betwen hotflash activity and other variables. The results are discussed with respect to theoretical implications and treatment 5trategIes.
Depsrtment of Surgery, Kuopio Universi@ Central Hospital, 70210 Kuopio, Finland FLUORIDE-QUART. REP.; 20/l (l-3)/1987/ The authors examined individually the files of all hip fracture patients and checked to make sure they actuaRy had lived in the fluoridatad area for at least 10 years prior to the fracture. Moreover, all patients with high-energy accidents, pathological fmctures, metabolic bone disease, etc., were arch&d. In some cases the international code designations were found to be completely incorrect. Obviously it is not possible to make such distinctions simply on the basis of hospital discharge data. AlthouSh less important in a large population, these factors cannot be ignored in a study such as this one. Flttally, in their histomorphometric study they found no increase in trabecular bone mass even in the hilh-fluotide area where, however, the amount of unmineralized osteoid was increased. In their study no differences in the histomorphometric parameters as well as fracture incidence between the low-fluoride and fluoridated water area was observed. Consequently, and in view of the relatively small number of cases, it is unwarranted to conclude from other studies that fluoridated water can prevent osteoporotic hip fractures. EIN TMNSDKRMALKS THRRAPEU’MSCHKS SYSTEM ZUR HORMONELLEN THERAPIE MIMAL(TERI8CHER AUSFALL!3ER!3CHEINUNGEN. MULTIZENTRISCHE STUDIE
IWIUceatrk study of a tramkmd tbefapeutk system for estrogen repkement therapy of dImmA& wmcto= Kersel C; Keller PJ Dtpartementfur Frauenheilkunde, Universitatspital, CH-8091 Zurich, Switzerland GEBURTSHILFE FRAUENHEILKD.; 47/8 (56%568)/1987/ In an open study 112 women with menopausal symptoms were treated with a transdermal therapeutic system delivering estradiol at a rate of 25, 50 or 100 m&day resp. The study, which was to measure the therapeutic efficacy and systemic and local tolerability, lasted 3 months. At the end of the treatment period 46% of the women were completely free of symptoms and a further 46% very much improved. In 64% the hot flushes disappeared entirely and in the remaining women their frequency and intensity, w&h a few exceptions. were markedly diminished. Nocturnal bouts of sweating were completely prevented in 67% of those complaining of this symptom. Pollakiuria impoved in 93%. Before commencement of the therapy 24 patients felt unwell, during the study only two. The proportion of women who felt well or very well rose from 36% to 83%. The systemic tolerability was rated good or excellent by 97% of patients and in no case was it rated poor. Blood pressure and body weight were not affected. The local tolerability was considered good or very good by 80% of the women; it was poor in 5 cases (4.6%) and only in one case did it lead to diiontinwtion of the therapy. Ninety percent of the participants wanted to continue treatment beyond the duration of the study. ckwr&taof~btllrrks Gamron L; Hansel S; Goddwin J Department of Psycholodv. Southern Illinois University, Carbondale, IL 62901. United States of America J. BEI-IAV. MED.; 10/3 (277-285)/1987/ The purpose of the present study was to examine the relationships of frequency, duration, and intensity of hot flashes with daily stress, ambient temperature, and caffeine. alcohol, and nicotine intake in menopausal women. Ten menopausal women suffering from hot flashes monitored these variables doily for 6 weeks. Intrasubject correlation analyses revealed significant relationships between hot-flash activity and stress for half of the sample; few women exhibited significant relationships betwen hotflash activity and other variables. The results are discussed with respect to theoretical implications and treatment 5trategIes.