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Web alert
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Immunogenetics Transplantation Immunotherapy Web alert Martin Nemec A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Immunology. Addresses The Hospital for Sick Children, Department of Developmental Biology, 555 University Avenue, Room 8134, Toronto, Ontario M5G 1X8, Canada; e-mail: [email protected] Current Opinion in Immunology 2001, 13:521–522
The Walter and Eliza Hall Institute of Medical Research: A database of MHC binding peptides http://wehih.wehi.edu.au/mhcpep MHCPEP is a database comprising over 13,000 peptide sequences known to bind MHC molecules. Entries were compiled from published reports as well as from direct submissions of experimental data. Each entry contains the peptide sequence, its MHC specificity and, when available, experimental method, observed activity, binding affinity, source protein, anchor positions and publication references.
Immunogenetics Frontiers in Bioscience: Gene knockout database www.bioscience.org/knockout/knochome.htm Contains information outlining the impact of gene knockouts on mouse phenotype. The Jackson Laboratory: The Transgenic/Targeted Mutation Database (TBASE) www.jax.org/tbase TBASE is designed to organize information on transgenic animals and targeted mutations generated and analyzed worldwide. American Society for Histocompatibility and Immunogenetics (ASHI): HLA gene and haplotype frequencies (USA) www.ashi-hla.org/prepr/Motomi.htm This site tabulates estimated HLA-A, HLA-B and HLA-DR frequencies, as well as the frequencies of HLA-A,B and HLA-A,B,DR haplotypes. IMGT/HLA Database www.ebi.ac.uk/imgt/hla A part of the International Immunogenetics project (IMGT), the IMGT/HLA Database provides a specialist database for sequences of the human MHC and includes the official sequences for WHO HLA Nomenclature Committee alleles and sequence alignments. The site provides a number of tools and facilities for the analysis and study of the HLA system. IMGT/LIGM Database http://imgt.cnusc.fr:8104/ IMGT/LIGM-DB is a comprehensive database of immunoglobulin and TCR sequences from humans and other vertebrates, with translation for fully annotated sequences. Access to the data is facilitated by a number of online tools. Anthony Nolan Bone Marrow Trust: HLA Informatics Group www.anthonynolan.com/HIG The site provides access to HLA nomenclature information, to nomenclature updates and to HLA sequence data.
Karolinska Hospital (Laboratory for Molecular Immunogenetics): HLA-DQ Molecules www.depts.washington.edu/rhwlab/dq/intro.html Thoroughly referenced articles describe the discovery and organization of the MHC. The structure and function of the HLA-DQ molecule is treated in more detail in an article illustrated with three-dimensional molecular models. Australasian & South East Asian Tissue Typing Association www.aseatta.org.au The “Nomenclature” section contains introductory articles on HLA nomenclature, as well as the Tissue Typing Education Primer. International Histocompatibility Working Group www.ihwg.org The International HLA Workshops promote new technology and serve to disseminate both reagents and technical skills worldwide. The website features a number of articles on a variety of topics related to the human MHC. In addition, tissue-typing technologies are introduced, together with suggested protocols. UK Human Genome Mapping Project Resource Centre: GenomeWeb www.hgmp.mrc.ac.uk/GenomeWeb The GenomeWeb is the authoritative categorized collection of the best genome-related sites on the Internet.
Transplantation Kimball’s Biology Pages www.ultranet.com/~jkimball/BiologyPages/T/Transplants.html This chapter of an online biology textbook deals with transplantation immunology. South Thames Tissue Typing Home Page www.umds.ac.uk/tissue A short introduction to tissue-typing and the blood group system.
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National Marrow Donor Program (NMDP): Resources for Medical Professionals www.marrow.org/MEDICAL/resources_medical.html The “Medical Information” section contains lists of diseases treatable by stem cell transplantation and describes the different sources of stem cells. The history of stem cell transplantation is outlined in the “About the NMDP” section. Baylor College of Medicine: Transplantation Primer www.bcm.tmc.edu/transplant Covers topics such as lung, heart, kidney and liver transplantation, transplantation immunology, and immunosuppresive and prophylaxis therapy. University of Pittsburgh: Transplant Pathology Internet Services (TPIS) http://tpis.upmc.edu/tpis TPIS is intended to serve as a collaborative tool for transplantation physicians. The content serves as an educational
resource for healthcare professionals interested in the field of transplantation medicine, with an emphasis on pathology.
Immunotherapy National Cancer Institute: Cancer Facts http://rex.nci.nih.gov/INFO_CANCER/Cancer_facts/Section7/ FS7_2.html Basic information on the different ways in which immunotherapy is used to treat cancer. Allergy, Asthma & Immunology Online: Fact Sheet http://allergy.mcg.edu/patients/factSheet.html Information on the efficacy and safety of immunotherapy as it applies to the treatment of allergies. Cancer Vaccines: A Primer About an Emerging Therapy www.cancernews.com/vaccines/ This article gives a review of vaccination and its use to treat cancer.
Newsletters — a new service from BioMedNet, Current Opinion and Trends Now available, direct to your e-mail box: free e-mail newsletters highlighting the latest developments in rapidly moving fields of research. A team of editors from the Current Opinion and Trends journals have combined to compile Evolution of Infectious Disease Newsletter — from emerging infectious diseases, host–pathogen interactions and the impact of genomics to the evolution of drug resistance. Each newsletter features news articles from the BioMedNet newsdesk, as well as highlights from the review content of the Current Opinion and Trends journals. Access to full text journal articles is available through your institution.
Newsletters are sent out 6 times a year. To sign up for Newsletters and other alerts via e-mail, visit http://news.bmn.com/alerts
Immunogenetics Transplantation Immunotherapy Web alert Martin Nemec A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Immunology. Addresses The Hospital for Sick Children, Department of Developmental Biology, 555 University Avenue, Room 8134, Toronto, Ontario M5G 1X8, Canada; e-mail: [email protected] Current Opinion in Immunology 2001, 13:521–522
The Walter and Eliza Hall Institute of Medical Research: A database of MHC binding peptides http://wehih.wehi.edu.au/mhcpep MHCPEP is a database comprising over 13,000 peptide sequences known to bind MHC molecules. Entries were compiled from published reports as well as from direct submissions of experimental data. Each entry contains the peptide sequence, its MHC specificity and, when available, experimental method, observed activity, binding affinity, source protein, anchor positions and publication references.
Immunogenetics Frontiers in Bioscience: Gene knockout database www.bioscience.org/knockout/knochome.htm Contains information outlining the impact of gene knockouts on mouse phenotype. The Jackson Laboratory: The Transgenic/Targeted Mutation Database (TBASE) www.jax.org/tbase TBASE is designed to organize information on transgenic animals and targeted mutations generated and analyzed worldwide. American Society for Histocompatibility and Immunogenetics (ASHI): HLA gene and haplotype frequencies (USA) www.ashi-hla.org/prepr/Motomi.htm This site tabulates estimated HLA-A, HLA-B and HLA-DR frequencies, as well as the frequencies of HLA-A,B and HLA-A,B,DR haplotypes. IMGT/HLA Database www.ebi.ac.uk/imgt/hla A part of the International Immunogenetics project (IMGT), the IMGT/HLA Database provides a specialist database for sequences of the human MHC and includes the official sequences for WHO HLA Nomenclature Committee alleles and sequence alignments. The site provides a number of tools and facilities for the analysis and study of the HLA system. IMGT/LIGM Database http://imgt.cnusc.fr:8104/ IMGT/LIGM-DB is a comprehensive database of immunoglobulin and TCR sequences from humans and other vertebrates, with translation for fully annotated sequences. Access to the data is facilitated by a number of online tools. Anthony Nolan Bone Marrow Trust: HLA Informatics Group www.anthonynolan.com/HIG The site provides access to HLA nomenclature information, to nomenclature updates and to HLA sequence data.
Karolinska Hospital (Laboratory for Molecular Immunogenetics): HLA-DQ Molecules www.depts.washington.edu/rhwlab/dq/intro.html Thoroughly referenced articles describe the discovery and organization of the MHC. The structure and function of the HLA-DQ molecule is treated in more detail in an article illustrated with three-dimensional molecular models. Australasian & South East Asian Tissue Typing Association www.aseatta.org.au The “Nomenclature” section contains introductory articles on HLA nomenclature, as well as the Tissue Typing Education Primer. International Histocompatibility Working Group www.ihwg.org The International HLA Workshops promote new technology and serve to disseminate both reagents and technical skills worldwide. The website features a number of articles on a variety of topics related to the human MHC. In addition, tissue-typing technologies are introduced, together with suggested protocols. UK Human Genome Mapping Project Resource Centre: GenomeWeb www.hgmp.mrc.ac.uk/GenomeWeb The GenomeWeb is the authoritative categorized collection of the best genome-related sites on the Internet.
Transplantation Kimball’s Biology Pages www.ultranet.com/~jkimball/BiologyPages/T/Transplants.html This chapter of an online biology textbook deals with transplantation immunology. South Thames Tissue Typing Home Page www.umds.ac.uk/tissue A short introduction to tissue-typing and the blood group system.
522
Web alert
National Marrow Donor Program (NMDP): Resources for Medical Professionals www.marrow.org/MEDICAL/resources_medical.html The “Medical Information” section contains lists of diseases treatable by stem cell transplantation and describes the different sources of stem cells. The history of stem cell transplantation is outlined in the “About the NMDP” section. Baylor College of Medicine: Transplantation Primer www.bcm.tmc.edu/transplant Covers topics such as lung, heart, kidney and liver transplantation, transplantation immunology, and immunosuppresive and prophylaxis therapy. University of Pittsburgh: Transplant Pathology Internet Services (TPIS) http://tpis.upmc.edu/tpis TPIS is intended to serve as a collaborative tool for transplantation physicians. The content serves as an educational
resource for healthcare professionals interested in the field of transplantation medicine, with an emphasis on pathology.
Immunotherapy National Cancer Institute: Cancer Facts http://rex.nci.nih.gov/INFO_CANCER/Cancer_facts/Section7/ FS7_2.html Basic information on the different ways in which immunotherapy is used to treat cancer. Allergy, Asthma & Immunology Online: Fact Sheet http://allergy.mcg.edu/patients/factSheet.html Information on the efficacy and safety of immunotherapy as it applies to the treatment of allergies. Cancer Vaccines: A Primer About an Emerging Therapy www.cancernews.com/vaccines/ This article gives a review of vaccination and its use to treat cancer.
Newsletters — a new service from BioMedNet, Current Opinion and Trends Now available, direct to your e-mail box: free e-mail newsletters highlighting the latest developments in rapidly moving fields of research. A team of editors from the Current Opinion and Trends journals have combined to compile Evolution of Infectious Disease Newsletter — from emerging infectious diseases, host–pathogen interactions and the impact of genomics to the evolution of drug resistance. Each newsletter features news articles from the BioMedNet newsdesk, as well as highlights from the review content of the Current Opinion and Trends journals. Access to full text journal articles is available through your institution.
Newsletters are sent out 6 times a year. To sign up for Newsletters and other alerts via e-mail, visit http://news.bmn.com/alerts