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Weight gain is associated with worse knee symptoms in community-based men and women: A longitudinal study
S50
Oral Abstracts Below n = 23
FETAL Size (mm) Head circumferencea Biparietal diametera Abdominal circumferencea Femur lengtha Body composition (areas, cm2 ) Abdominal fat Abdominal lean Mid-thigh fat Mid-thigh lean
Within n = 49
Above n = 85
Pa
Median [interquartile range] 320.3 88.7 319.0 68.2
[14.9] [5.4] [33.0] [5.3]
324.7 88.7 330.6 69.2
[18.7] [4.3] [18.0] [3.7]
325.4 89.8 332.2 69.6
[14.1] [6.0] [26.2] [4.7]
.099 .041* .015* .054
13.5 65.4 8.5 9.2
[6.9] [13.4] [3.0] [2.5]
15.4 69.4 9.5 9.7
[3.7] [10.4] [4.0] [2.7]
16.1 71.6 8.9 10.1
[3.8] [11.8] [2.2] [2.9]
.463 .024* .372 .728
a ANCOVA models adjusted for pre-pregnancy BMI, gestational age, fetal sex, smoking, parity, diabetes, and socio-economic status from postcode.
Conclusions: Maternal weight gain, independent of pre-pregnancy BMI, is important for the growth of a large but lean fetus. Prenatal counselling should focus on achieving a healthy BMI prior to conception because normal weight pregnant women are advised to gain more weight than overweight and obese women. doi:10.1016/j.orcp.2011.08.151 O74 Weight gain is associated with worse knee symptoms in community-based men and women: A longitudinal study S.K. Tanamas 1,∗ , A.E. Wluka 1 , M. Davies-Tuck 1 , Y. Wang 1 , B.J. Strauss 2 , J. Proietto 3 , J.B. Dixon 4 , G. Jones 5 , F.M. Cicuttini 1 1 School
of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia 2 Body Composition Laboratory, Monash Medical Centre, Department of Medicine, Monash University, Melbourne, Australia 3 Department of Medicine, University of Melbourne, Austin Health Melbourne, Australia 4 Baker IDI Heart and Diabetes Institute, Melbourne, Australia 5 Menzies Research Institute, Hobart, Australia Aim: To examine the association between change in weight and change in WOMAC pain, stiffness and function scores. Methods: 250 subjects aged 25—62 years were recruited. Subjects completed a questionnaire at
baseline and ∼2 years later. Pain, stiffness and function were assessed by the Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Results: Fifty-two subjects (21%) were of acceptable weight (BMI < 25 kg/m2 ), 46 subjects (18%) were overweight (BMI 20—25 kg/m2 ) and 148 subjects (59%) were obese (BMI ≥30 kg/m2 ). At baseline, those who were obese had greater median WOMAC scores compared to those who were acceptable weight or overweight. One hundred and ninety-eight subjects (79%) were followed up. Fiftyeight subjects (29%) lost ≥5% of baseline weight, 110 subjects (56%) remained stable (±<5% baseline weight) and 30 subjects (15%) gained ≥5% of baseline weight. Losing ≥5% of baseline weight was associated with reduced WOMAC stiffness score compared to those who remain stable (mean difference −13.4 mm, 95% CI −25.3, −1.6 mm). Similar trends were observed in those non-obese and without radiographic OA (ROA). Gaining ≥5% of baseline weight was associated with increased WOMAC pain score by 26.0 mm (95% CI 2.6, 49.3 mm) and WOMAC function score by 87.8 mm (95% CI 6.7, 168.9 mm) compared to remaining stable weight. Similar trends were observed in the obese and ROA subgroups. Conclusion: This study demonstrates that weight gain is associated with worse knee symptoms, with a more modest benefit of weight loss, thus highlighting the potential benefit of avoiding weight gain in the management of knee pain. Conflict of interest: None. doi:10.1016/j.orcp.2011.08.152
Available online at www.sciencedirect.com
Oral Abstracts Below n = 23
FETAL Size (mm) Head circumferencea Biparietal diametera Abdominal circumferencea Femur lengtha Body composition (areas, cm2 ) Abdominal fat Abdominal lean Mid-thigh fat Mid-thigh lean
Within n = 49
Above n = 85
Pa
Median [interquartile range] 320.3 88.7 319.0 68.2
[14.9] [5.4] [33.0] [5.3]
324.7 88.7 330.6 69.2
[18.7] [4.3] [18.0] [3.7]
325.4 89.8 332.2 69.6
[14.1] [6.0] [26.2] [4.7]
.099 .041* .015* .054
13.5 65.4 8.5 9.2
[6.9] [13.4] [3.0] [2.5]
15.4 69.4 9.5 9.7
[3.7] [10.4] [4.0] [2.7]
16.1 71.6 8.9 10.1
[3.8] [11.8] [2.2] [2.9]
.463 .024* .372 .728
a ANCOVA models adjusted for pre-pregnancy BMI, gestational age, fetal sex, smoking, parity, diabetes, and socio-economic status from postcode.
Conclusions: Maternal weight gain, independent of pre-pregnancy BMI, is important for the growth of a large but lean fetus. Prenatal counselling should focus on achieving a healthy BMI prior to conception because normal weight pregnant women are advised to gain more weight than overweight and obese women. doi:10.1016/j.orcp.2011.08.151 O74 Weight gain is associated with worse knee symptoms in community-based men and women: A longitudinal study S.K. Tanamas 1,∗ , A.E. Wluka 1 , M. Davies-Tuck 1 , Y. Wang 1 , B.J. Strauss 2 , J. Proietto 3 , J.B. Dixon 4 , G. Jones 5 , F.M. Cicuttini 1 1 School
of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia 2 Body Composition Laboratory, Monash Medical Centre, Department of Medicine, Monash University, Melbourne, Australia 3 Department of Medicine, University of Melbourne, Austin Health Melbourne, Australia 4 Baker IDI Heart and Diabetes Institute, Melbourne, Australia 5 Menzies Research Institute, Hobart, Australia Aim: To examine the association between change in weight and change in WOMAC pain, stiffness and function scores. Methods: 250 subjects aged 25—62 years were recruited. Subjects completed a questionnaire at
baseline and ∼2 years later. Pain, stiffness and function were assessed by the Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Results: Fifty-two subjects (21%) were of acceptable weight (BMI < 25 kg/m2 ), 46 subjects (18%) were overweight (BMI 20—25 kg/m2 ) and 148 subjects (59%) were obese (BMI ≥30 kg/m2 ). At baseline, those who were obese had greater median WOMAC scores compared to those who were acceptable weight or overweight. One hundred and ninety-eight subjects (79%) were followed up. Fiftyeight subjects (29%) lost ≥5% of baseline weight, 110 subjects (56%) remained stable (±<5% baseline weight) and 30 subjects (15%) gained ≥5% of baseline weight. Losing ≥5% of baseline weight was associated with reduced WOMAC stiffness score compared to those who remain stable (mean difference −13.4 mm, 95% CI −25.3, −1.6 mm). Similar trends were observed in those non-obese and without radiographic OA (ROA). Gaining ≥5% of baseline weight was associated with increased WOMAC pain score by 26.0 mm (95% CI 2.6, 49.3 mm) and WOMAC function score by 87.8 mm (95% CI 6.7, 168.9 mm) compared to remaining stable weight. Similar trends were observed in the obese and ROA subgroups. Conclusion: This study demonstrates that weight gain is associated with worse knee symptoms, with a more modest benefit of weight loss, thus highlighting the potential benefit of avoiding weight gain in the management of knee pain. Conflict of interest: None. doi:10.1016/j.orcp.2011.08.152
Available online at www.sciencedirect.com