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What Makes an Osteoclast Special?
Developmental Cell
PaperPick What Makes an Osteoclast Special? Gerard Karsenty1 1Department of Genetics and Development, Columbia University, New York, NY 10027, USA DOI 10.1016/j.devcel.2011.05.005
A paper published in Developmental Cell that I have continuously enjoyed over the years is ‘‘Induction and Activation of the Transcription Factor NFATc1 Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts’’ by Takayanagi et al. I like this paper for many reasons. The first one is that it asks without preconceived idea a simple question: why the osteoclast differentiation factor RANKL, and not IL-1, triggers osteoclast differentiation, because both cytokines affect seemingly the same signaling cascade and transcription factors NF-KB and c-FOS. The approach was simple: a microarray of bone marrow stromal cells treated or not with RANKL or IL-1 to induce osteoclast differentiation. This analysis identified NFATc1, which the authors showed is the target of both c-FOS and NF-KB in osteoclasts. The authors checked all the boxes that need to be checked for a transcription factor determining cell differentiation, and more. Indeed, they identified calcium signaling as an activator of NFATc1, as well as genes whose expression is regulated by both c-FOS and NFATc1. This paper is beautifully written, the question posed is important, the experiments are of superb quality, and the advance for the field is highly significant. I always thought it was one of the better papers published in Developmental Cell pertaining to skeleton development. This PaperPick refers to ‘‘Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts,’’ by H. Takayanagi, S. Kim, T. Koga, H. Nishina, M. Isshiki, H. Yoshida, A. Saiura, M. Isobe, T. Yokochi, J.-i. Inoue, E.F. Wagner, T.W. Mak, T. Kodama, and T. Taniguchi, published in December 2002.
e2 Developmental Cell 20, May 17, 2011 ª2011 Elsevier Inc.
PaperPick What Makes an Osteoclast Special? Gerard Karsenty1 1Department of Genetics and Development, Columbia University, New York, NY 10027, USA DOI 10.1016/j.devcel.2011.05.005
A paper published in Developmental Cell that I have continuously enjoyed over the years is ‘‘Induction and Activation of the Transcription Factor NFATc1 Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts’’ by Takayanagi et al. I like this paper for many reasons. The first one is that it asks without preconceived idea a simple question: why the osteoclast differentiation factor RANKL, and not IL-1, triggers osteoclast differentiation, because both cytokines affect seemingly the same signaling cascade and transcription factors NF-KB and c-FOS. The approach was simple: a microarray of bone marrow stromal cells treated or not with RANKL or IL-1 to induce osteoclast differentiation. This analysis identified NFATc1, which the authors showed is the target of both c-FOS and NF-KB in osteoclasts. The authors checked all the boxes that need to be checked for a transcription factor determining cell differentiation, and more. Indeed, they identified calcium signaling as an activator of NFATc1, as well as genes whose expression is regulated by both c-FOS and NFATc1. This paper is beautifully written, the question posed is important, the experiments are of superb quality, and the advance for the field is highly significant. I always thought it was one of the better papers published in Developmental Cell pertaining to skeleton development. This PaperPick refers to ‘‘Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts,’’ by H. Takayanagi, S. Kim, T. Koga, H. Nishina, M. Isshiki, H. Yoshida, A. Saiura, M. Isobe, T. Yokochi, J.-i. Inoue, E.F. Wagner, T.W. Mak, T. Kodama, and T. Taniguchi, published in December 2002.
e2 Developmental Cell 20, May 17, 2011 ª2011 Elsevier Inc.