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Whither Ethology? Perspectives in Ethology, Volume 8
Camp. Bbchem. Physiol. Vol. 95A, No. 2, pp. 307-308, Printed in Great Britain
1990
BOOK
0300-9629/90 $3.00 + 0.00 Q 1990 Pergamon Press plc
REVIEWS Immunoglobulin Gene-Edited by T. HONJO, F. W. ALT and T. H. RABBITTS.410 pp. 1989. Academic Press, London. E40.
Whither Ethology?-Edited by P. P. G. BATESONand P. H. KLOPFER. 278 pp. 1989. Plenum Press, New York. $49.50. Perspectives in Ethology, Volume 8
This book has chapters on B cell differentiation and B lymphocyte lineage; long term lymphoid cultures; heavy chain variable region locus; light chain genes; constant region genes; molecular mechanisms of class switching; chicken antibodies; Ig in lower vertebrates; Ig deficiencies; B-cell neoplasias; chimaeric Ig genes; Ig in transgenic mice; factors regulating Ig transcription; J chains; and Ig superfamilies. The study of Ig has developed from analysis into two heavy and two light chains, the light chain having a common segment and a variable segment; and the application of DNA recombinant technology leads to two genes/one polypeptide. These studies have had a great impact not only on immunology but also on molecular biology.
After the flush of enthusiasm following the work of Lorenz, Tinbergen and von Frisch, ethology has seemed to wither away in minor controversies, and arguments about terminology. Whither Ethology.’ asks where ethology is going. It contains many interesting and stimulating articles. Has sociobiology killed ethology or revitalized it? The future of ethology: how many legs are we standing on? The comparative approach in ethology: aims and limitations. A brief history of the study of animal behavior in North America. Animal psychology: the tyranny of anthropocentrism. Recognition learning in birds. Psychoimmunology: relations between brain, behavior and immune function. Do gender diferences in behavior develop? Behavioral development: towards understanding processes. The book will also be very valuable in helping the reader understand the often aggressive behavior of ethologists.
Immunological Diseases, 4th Edition-Edited by M. SAMTER, D. W. TALMAGE, M. M. FRANK, K. F. AUSTEN and H. N. CLAMAN. Two volumes: 1 (978 pp.), 2 (1066 pp.). 1988. Little, Brown and Co., Waltham, MA. fl45. The previous editions of this standard work appeared in 1965, 1971 and 1978. There have been many advances in our understanding of immunological diseases over the past 10 years and these are reflected in the present two volumes which have been brought up-to-date by the 123 contributors. Volume 1 contains two main sections: (1) basic immunology (the immune system, immunogens and antigens, structure of antibodies, antigen recognition by T cells, regulation of the immune response, mucosal immune system, IgE synthesis, mast cells and hypersensitivity, complement system, immune complex injury, delayed hypersensitivity, eosinophil, transplantation, immunological tolerance, immunology of reproduction, detection and measurement of the immune response, HLA system); and (2) nonatopic immunological disorders (immunodeficiency diseases-primary and acquired transplantation of bone marrow, transplantation of solid organs, tumor immunology, lympho-proliferation, multiple myeloma and plasma cell dyscrasias, amyloidosis, immunosuppressives and immunoadjuvants, allergic reactions to drugs, host resistance to infection, neutrophils, intracellular parasites and mononuclear phagocytes, bacteria, mycobacterial infection, fungal infection, host responses to viruses, immunoparasitology, adverse responses to immunization. infection of the comprised host). Volume 2 contains Section 3, atopic diseases (antigens that cause atopic diseases, IgE, genetics of atopic disease, allergic rhinitis, bronchial asthma, anaphylactic syndrome, reactions to aspirin and aspirin like drugs, reactions to foods, insect venom allergy); section (4) allergic reaction patterns of skin (urticaria and angiodema, atopic dermatitis, allergic contact dermatitis, erythema nodosum, erythema multiforme and Stevens-Johnson syndrome, cutaneous necrotising venulitis, bullous skin diseases, mastocytosis); and Section (5) diseases with immunological features (systemic lupus erythematosus, rheumatoid arthritis, systemic vasculitis, Sjogren’s syndrome, ankylosing spondylitis, cardiovascular disease including rheumatic fever, infiltrative lung disease, sarcoidosis, autoimmune hemolytic anemia, platelet disorders, blood groups and hazards of transfusion, hemolytic disease of newborn, cryopathies, cryoglobulins and cryofibrinogenemia. thyroid, autoimmune polyendocrinopathies,
Interrelations among Metal Ions, Enzymes and Gene Expression-Edited by H. SIGEL and A. SIGEL. 557 pp. 1989. Marcel Dekker, New York. $135 (USA and Canada); $162 (elsewhere). Metal Ions in Biological Systems, Volume 25 This volume surveys the molecular mechanisms of metal ion induced mutagenesis in &ro; metallonucleases; metalloregulatory proteins; yeast metallothionein; zinc binding proteins involved in nucleic acid replication; zinc fingers; EF-hand calcium binding proteins; site directed mutagenesis of alcohol dehydrogenase; carboxypeptidase A; alkaline phosphatase; heme proteins; and cytochrome c peroxidase. In many cells the synthesis of metallothioneins is induced at the transcriptional level by the same metals that subsequently bind to the expressed protein. The role of the metal responsive switches in the cell is fully discussed in this interesting volume.
Basis and Mechanisms of Regulation of Cytochrome P-450Edited by K. RUCKPAUL and H. REIN. 252 pp. 1989. Taylor and Francis, London. f30. Frontiers in Biotransformation, Volume 1. Over the last 10 years more than 10,000 papers have been published on P-450. This volume summarises much of this information. The main chapters are on regulation mechanisms; catalytically active metalloporphyrin models; structural multiplicity (induced by barbiturates, polycyclic aromatics, steroids, ethanol, chlofibrate); multiple activities (C-hydroxylation, heteroatom oxidation, heteroatom release, epoxidation. oxidative group migration, heme alkylation); sexually differentiated hepatic drug and steroid metabolism; and evolution, structure and gene regulation of P-450. The average rate of amino acid replacement in P-450 is calculated to be 1.8 x lo-” replacements per site per year. The variation in rates in different animal lines differs from this. indicating functional and structural constraints on the system. This might be expected in a key enzyme of xenobiotic transformation. 307
1990
BOOK
0300-9629/90 $3.00 + 0.00 Q 1990 Pergamon Press plc
REVIEWS Immunoglobulin Gene-Edited by T. HONJO, F. W. ALT and T. H. RABBITTS.410 pp. 1989. Academic Press, London. E40.
Whither Ethology?-Edited by P. P. G. BATESONand P. H. KLOPFER. 278 pp. 1989. Plenum Press, New York. $49.50. Perspectives in Ethology, Volume 8
This book has chapters on B cell differentiation and B lymphocyte lineage; long term lymphoid cultures; heavy chain variable region locus; light chain genes; constant region genes; molecular mechanisms of class switching; chicken antibodies; Ig in lower vertebrates; Ig deficiencies; B-cell neoplasias; chimaeric Ig genes; Ig in transgenic mice; factors regulating Ig transcription; J chains; and Ig superfamilies. The study of Ig has developed from analysis into two heavy and two light chains, the light chain having a common segment and a variable segment; and the application of DNA recombinant technology leads to two genes/one polypeptide. These studies have had a great impact not only on immunology but also on molecular biology.
After the flush of enthusiasm following the work of Lorenz, Tinbergen and von Frisch, ethology has seemed to wither away in minor controversies, and arguments about terminology. Whither Ethology.’ asks where ethology is going. It contains many interesting and stimulating articles. Has sociobiology killed ethology or revitalized it? The future of ethology: how many legs are we standing on? The comparative approach in ethology: aims and limitations. A brief history of the study of animal behavior in North America. Animal psychology: the tyranny of anthropocentrism. Recognition learning in birds. Psychoimmunology: relations between brain, behavior and immune function. Do gender diferences in behavior develop? Behavioral development: towards understanding processes. The book will also be very valuable in helping the reader understand the often aggressive behavior of ethologists.
Immunological Diseases, 4th Edition-Edited by M. SAMTER, D. W. TALMAGE, M. M. FRANK, K. F. AUSTEN and H. N. CLAMAN. Two volumes: 1 (978 pp.), 2 (1066 pp.). 1988. Little, Brown and Co., Waltham, MA. fl45. The previous editions of this standard work appeared in 1965, 1971 and 1978. There have been many advances in our understanding of immunological diseases over the past 10 years and these are reflected in the present two volumes which have been brought up-to-date by the 123 contributors. Volume 1 contains two main sections: (1) basic immunology (the immune system, immunogens and antigens, structure of antibodies, antigen recognition by T cells, regulation of the immune response, mucosal immune system, IgE synthesis, mast cells and hypersensitivity, complement system, immune complex injury, delayed hypersensitivity, eosinophil, transplantation, immunological tolerance, immunology of reproduction, detection and measurement of the immune response, HLA system); and (2) nonatopic immunological disorders (immunodeficiency diseases-primary and acquired transplantation of bone marrow, transplantation of solid organs, tumor immunology, lympho-proliferation, multiple myeloma and plasma cell dyscrasias, amyloidosis, immunosuppressives and immunoadjuvants, allergic reactions to drugs, host resistance to infection, neutrophils, intracellular parasites and mononuclear phagocytes, bacteria, mycobacterial infection, fungal infection, host responses to viruses, immunoparasitology, adverse responses to immunization. infection of the comprised host). Volume 2 contains Section 3, atopic diseases (antigens that cause atopic diseases, IgE, genetics of atopic disease, allergic rhinitis, bronchial asthma, anaphylactic syndrome, reactions to aspirin and aspirin like drugs, reactions to foods, insect venom allergy); section (4) allergic reaction patterns of skin (urticaria and angiodema, atopic dermatitis, allergic contact dermatitis, erythema nodosum, erythema multiforme and Stevens-Johnson syndrome, cutaneous necrotising venulitis, bullous skin diseases, mastocytosis); and Section (5) diseases with immunological features (systemic lupus erythematosus, rheumatoid arthritis, systemic vasculitis, Sjogren’s syndrome, ankylosing spondylitis, cardiovascular disease including rheumatic fever, infiltrative lung disease, sarcoidosis, autoimmune hemolytic anemia, platelet disorders, blood groups and hazards of transfusion, hemolytic disease of newborn, cryopathies, cryoglobulins and cryofibrinogenemia. thyroid, autoimmune polyendocrinopathies,
Interrelations among Metal Ions, Enzymes and Gene Expression-Edited by H. SIGEL and A. SIGEL. 557 pp. 1989. Marcel Dekker, New York. $135 (USA and Canada); $162 (elsewhere). Metal Ions in Biological Systems, Volume 25 This volume surveys the molecular mechanisms of metal ion induced mutagenesis in &ro; metallonucleases; metalloregulatory proteins; yeast metallothionein; zinc binding proteins involved in nucleic acid replication; zinc fingers; EF-hand calcium binding proteins; site directed mutagenesis of alcohol dehydrogenase; carboxypeptidase A; alkaline phosphatase; heme proteins; and cytochrome c peroxidase. In many cells the synthesis of metallothioneins is induced at the transcriptional level by the same metals that subsequently bind to the expressed protein. The role of the metal responsive switches in the cell is fully discussed in this interesting volume.
Basis and Mechanisms of Regulation of Cytochrome P-450Edited by K. RUCKPAUL and H. REIN. 252 pp. 1989. Taylor and Francis, London. f30. Frontiers in Biotransformation, Volume 1. Over the last 10 years more than 10,000 papers have been published on P-450. This volume summarises much of this information. The main chapters are on regulation mechanisms; catalytically active metalloporphyrin models; structural multiplicity (induced by barbiturates, polycyclic aromatics, steroids, ethanol, chlofibrate); multiple activities (C-hydroxylation, heteroatom oxidation, heteroatom release, epoxidation. oxidative group migration, heme alkylation); sexually differentiated hepatic drug and steroid metabolism; and evolution, structure and gene regulation of P-450. The average rate of amino acid replacement in P-450 is calculated to be 1.8 x lo-” replacements per site per year. The variation in rates in different animal lines differs from this. indicating functional and structural constraints on the system. This might be expected in a key enzyme of xenobiotic transformation. 307