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4455297 Method for producing pertussis toxoid
PATENT ABSTRACTS
398
4454228 BIOLOGICALLY PURE CULTURE OF STREPTOMYCES MICROSPINUS N R R L 12524 CAPABLE OF PRODUCING ANTIBIOTIC U-64,815
4455296 HYBRID CELL LINES PRODUCING MONOCLONAL ANTIBODIES DIRECTED AGAINST HAEMOPHILUS INFLUENZAE
Howard A Whaley. William C Snyder, John C Greenfield, John H Coats assigned to The Upjohn Company
Eric J Hansen, John R Kettman. Stella M Robertson assigned to Board of Regents the University of Texas System
Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Grampositive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus. antibiotic U-64.815 can be used in various environments to eradicate or control such bacteria.
Continuous hybrid cell hnes for producing monoclonal antibodies directed against outer membrane antigens of Haemophilus influenzae type b have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with outer membrane antigens of Haemophilus influenzae type b with hybridoma cells. The resulting fused cells were cloned and characterized as to antibody specificity against antigenic determinants of outer membranes of Haemophilus influenzae type b. One hybrid produces a monoclonal antibody which is capable of conferring passive immunity on Hib infected hosts.
4455297 METHOD FOR PRODUCING PERTUSSIS TOXOID
4455290 INHIBITION OF FIBRIN POLYMERIZATION BY A PEPTIDE ISOLATED FROM F I B R I N F R A G M E N T D1 Stephanie A Olexa, Andrei Z Budzynski assigned to Research Corporation A purified peptide isolated from fibrinogen Fragment DI and having the amino acid sequence Thr-Arg-Trp-Tyr-Ser-Met-Lys-LysThr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Le u-Thr- lle-Gly-Glu-Gly-Gln-Gln-His-His-LeuGly-Gly-Ala-Lys-Gln-Ala-Gly-Asp- Val. The peptide is isloated by degrading Fragment D l of fibrinogen with plasmin followed by separation of the resulting peptides on the basis of molecular weight and affinity for bound fibrin monomer. The purified peptide is useful as an anticoagulant and, when suitably labeled with a gamma-emitting radioisotope, as a thrombus imaging agent.
Yukio Syukuda, Hideo Watanabe. Shigeo Matsuyama, Hikari, Japan assigned to Takeda Chemical Industries Ltd A pertussis toxoid is produced by removing endotoxin from a culture supernatant of a Bordetella pertussis phase I strain or a concentrate thereof and flocculating pertussis exotoxin in the resultant fluid by permitting formaldehyde to act upon the fluid in the substantial absence of basic amino acid. The thus-obtained pertussis toxoid is low in toxicity and has a high immunizing potency.
4455301 ANTIHEMOPHILIC FACTOR CONCENTRATE Gauta Mitra, John Lundblad assigned to Cutter Laboratories Inc
398
4454228 BIOLOGICALLY PURE CULTURE OF STREPTOMYCES MICROSPINUS N R R L 12524 CAPABLE OF PRODUCING ANTIBIOTIC U-64,815
4455296 HYBRID CELL LINES PRODUCING MONOCLONAL ANTIBODIES DIRECTED AGAINST HAEMOPHILUS INFLUENZAE
Howard A Whaley. William C Snyder, John C Greenfield, John H Coats assigned to The Upjohn Company
Eric J Hansen, John R Kettman. Stella M Robertson assigned to Board of Regents the University of Texas System
Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Grampositive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus. antibiotic U-64.815 can be used in various environments to eradicate or control such bacteria.
Continuous hybrid cell hnes for producing monoclonal antibodies directed against outer membrane antigens of Haemophilus influenzae type b have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with outer membrane antigens of Haemophilus influenzae type b with hybridoma cells. The resulting fused cells were cloned and characterized as to antibody specificity against antigenic determinants of outer membranes of Haemophilus influenzae type b. One hybrid produces a monoclonal antibody which is capable of conferring passive immunity on Hib infected hosts.
4455297 METHOD FOR PRODUCING PERTUSSIS TOXOID
4455290 INHIBITION OF FIBRIN POLYMERIZATION BY A PEPTIDE ISOLATED FROM F I B R I N F R A G M E N T D1 Stephanie A Olexa, Andrei Z Budzynski assigned to Research Corporation A purified peptide isolated from fibrinogen Fragment DI and having the amino acid sequence Thr-Arg-Trp-Tyr-Ser-Met-Lys-LysThr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Le u-Thr- lle-Gly-Glu-Gly-Gln-Gln-His-His-LeuGly-Gly-Ala-Lys-Gln-Ala-Gly-Asp- Val. The peptide is isloated by degrading Fragment D l of fibrinogen with plasmin followed by separation of the resulting peptides on the basis of molecular weight and affinity for bound fibrin monomer. The purified peptide is useful as an anticoagulant and, when suitably labeled with a gamma-emitting radioisotope, as a thrombus imaging agent.
Yukio Syukuda, Hideo Watanabe. Shigeo Matsuyama, Hikari, Japan assigned to Takeda Chemical Industries Ltd A pertussis toxoid is produced by removing endotoxin from a culture supernatant of a Bordetella pertussis phase I strain or a concentrate thereof and flocculating pertussis exotoxin in the resultant fluid by permitting formaldehyde to act upon the fluid in the substantial absence of basic amino acid. The thus-obtained pertussis toxoid is low in toxicity and has a high immunizing potency.
4455301 ANTIHEMOPHILIC FACTOR CONCENTRATE Gauta Mitra, John Lundblad assigned to Cutter Laboratories Inc