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4465665 Detoxified E. coli neurotoxin, preparation thereof and immunological preparations containing it
405
PATENT ABSTRACTS
instability and the presence of impurities. An initial Factor VIIi containing aqueous solution such as blood plasma is purified by subjecting a Factor VIII containing aqueous migrant solution to continuous flow electrophoresis wherein flow takes place in an annular separation chamber and is stabilized by means of an angular velocity gradient; and collecting a separated Factor Vlll component. In order to separate the Factor VIII from albumin and firbrinogen, while obtaining good recoveries of Factor VIII (e.g. 60o/o), the migrant solution is prepared by precipitating Factor VIII from the initial solution using ethanol, and removing and redissolving the precipitate in an aqueous medium and adjusting the pH to be within the range of 7.5 to 8.6, preferably 8.3 to 8.6.
4465622 METHOD FOR PURIFYING INTERFERON Masahiro Nobuhara, Kiyoshi Yamaguchi, Ei Mochida, Saitama, Japan assigned to Mochida Pharmaceutical Co Ltd A method for purifying interferon having anticancer effects or anti-viral effects, wherein highly purified interferon can be easily obtained by a single operation in a recovery of about 100?../O.In this method, interferon ts obtained by specifically adsorbing interferon onto a carrier containing acrylonitrile polymer and eluting the adsorbed interferon with an appropriate buffer.
4465624 PROCESS FOR PRODUCING ERYTHROPOIETIN Hideo Chiba, Ryuzo Sasaki, Masatsugu Ueda, Uji, Japan assigned to Snow Brand Milk Products Co Ltd Disclosed herein is a process for producing erythropoietin, comprising bringing a material containing erythropoietin into contact with an adsorbent having a monoclonal antierythropoietin antibody, adsorbing erythropoietin on the adsorbent, and eluting the absorbed erythropoietin from the adsorbent.
4465665 D E T O X I F I E D E. C O L I NEUROTOXIN, PREPARATION THEREOF AND IMMUNOLOGICAL P R E P A R A T I O N S C O N T A I N I N G IT Lucia Dobrescu. Brussels, Belgium asmgned to Smithkline-Rit Detoxified but still immunogenic E. coli neurotoxin is prepared by bringing E. coli neurotoxin into contact with gluturaldehyde in mild operative conditions, the reaction being stopped where no more than 90°0 of the neurotoxin are inactivated. The obtained detoxified neurotoxin is valuable for immunizing piglets against oedema disease. 4465670 METHOD FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND PRIMARY GLOMERULONEPHRITIS AND AGENT THEREFOR Tetsuzo Sugisaki, Shinichi Morisue. Urawa. Japan assigned to Dainippon Pharmaceutical Co Ltd A method for the treatment of diseases such as systemic lupus erythematosus and primary glomerulonephritis by administering a gammaglobulin having Fc fragment to patients suffeting from such diseases in parenteral route (particularly intravenously) and a preparation useful for the treatment. The gamma-globulin having Fc fragment is usually used in the form of a preparation thereof in admixture with a conventional liquid carrier on diluent for injection, including a plasmin-treated human gammaglobulin preparation, a sulfonated human gamma-globulin preparation and a polyethylene glycol-treated human gamma-globulin preparation. 4465776 MONOCLONAL ANTIBODIES TO V I T A M I N 116 A N D IMMUNOASSAY METHOD John A Cidlowski, Dac Viceps-Madore assigned to Research Corporation
PATENT ABSTRACTS
instability and the presence of impurities. An initial Factor VIIi containing aqueous solution such as blood plasma is purified by subjecting a Factor VIII containing aqueous migrant solution to continuous flow electrophoresis wherein flow takes place in an annular separation chamber and is stabilized by means of an angular velocity gradient; and collecting a separated Factor Vlll component. In order to separate the Factor VIII from albumin and firbrinogen, while obtaining good recoveries of Factor VIII (e.g. 60o/o), the migrant solution is prepared by precipitating Factor VIII from the initial solution using ethanol, and removing and redissolving the precipitate in an aqueous medium and adjusting the pH to be within the range of 7.5 to 8.6, preferably 8.3 to 8.6.
4465622 METHOD FOR PURIFYING INTERFERON Masahiro Nobuhara, Kiyoshi Yamaguchi, Ei Mochida, Saitama, Japan assigned to Mochida Pharmaceutical Co Ltd A method for purifying interferon having anticancer effects or anti-viral effects, wherein highly purified interferon can be easily obtained by a single operation in a recovery of about 100?../O.In this method, interferon ts obtained by specifically adsorbing interferon onto a carrier containing acrylonitrile polymer and eluting the adsorbed interferon with an appropriate buffer.
4465624 PROCESS FOR PRODUCING ERYTHROPOIETIN Hideo Chiba, Ryuzo Sasaki, Masatsugu Ueda, Uji, Japan assigned to Snow Brand Milk Products Co Ltd Disclosed herein is a process for producing erythropoietin, comprising bringing a material containing erythropoietin into contact with an adsorbent having a monoclonal antierythropoietin antibody, adsorbing erythropoietin on the adsorbent, and eluting the absorbed erythropoietin from the adsorbent.
4465665 D E T O X I F I E D E. C O L I NEUROTOXIN, PREPARATION THEREOF AND IMMUNOLOGICAL P R E P A R A T I O N S C O N T A I N I N G IT Lucia Dobrescu. Brussels, Belgium asmgned to Smithkline-Rit Detoxified but still immunogenic E. coli neurotoxin is prepared by bringing E. coli neurotoxin into contact with gluturaldehyde in mild operative conditions, the reaction being stopped where no more than 90°0 of the neurotoxin are inactivated. The obtained detoxified neurotoxin is valuable for immunizing piglets against oedema disease. 4465670 METHOD FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND PRIMARY GLOMERULONEPHRITIS AND AGENT THEREFOR Tetsuzo Sugisaki, Shinichi Morisue. Urawa. Japan assigned to Dainippon Pharmaceutical Co Ltd A method for the treatment of diseases such as systemic lupus erythematosus and primary glomerulonephritis by administering a gammaglobulin having Fc fragment to patients suffeting from such diseases in parenteral route (particularly intravenously) and a preparation useful for the treatment. The gamma-globulin having Fc fragment is usually used in the form of a preparation thereof in admixture with a conventional liquid carrier on diluent for injection, including a plasmin-treated human gammaglobulin preparation, a sulfonated human gamma-globulin preparation and a polyethylene glycol-treated human gamma-globulin preparation. 4465776 MONOCLONAL ANTIBODIES TO V I T A M I N 116 A N D IMMUNOASSAY METHOD John A Cidlowski, Dac Viceps-Madore assigned to Research Corporation