4383996 Derivative of thiazolo(3,2-a)pyrimidine and a process for the preparation thereof and a drug containing it

New Patents

pound which inhibits influx of extracellular C A + + into red blood cells, or enhances the A T P content of ATP-depleted red blood cells.

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4383996 DERIVATIVE OF THIAZOLO(3,2A ) P Y R I M I D I N E AND A PROCESS FOR T H E P R E P A R A T I O N T H E R E O F AND A DRUG C O N T A I N I N G IT Takeo Oba; Kiyosh Bannai; Toshio Tanaka; Kenz Watanabe; Tatsuyuki Naruchi; Keiji Komoriya; Seizi Kurozumi; Kenji Hoshina assigned to Teijin Limited

This invention relates to the derivatives of the following formula: in which R, R', R1, R2 are hydrogen atoms or hydrocarbonated radicals, and X is an oxo, hydroxy, imino or aminal radical. These compounds have anti-fibrillating activity. 4383992 W A T E R - S O L U B L E STEROID COMPOUNDS John Lipari

R~or RI2 R7 ]--Ro R ~ - R t 0 II

R

O R|- ~ A derivative of thiazolo (3,2-a) pyrimidine expressed by formula (I) (1) (where R indicates a phenyl group or a benzyl group which has a halogen atom, a lower alkyl or lower alkyloxy group as a substituent group, an alicyclic group or an arythethyl group), and a process for the preparation of a compound of formula (I) comprising cyclizing a compound expressed by formula (II) by application of heat (II) (where a definition of R is as same as that given in case of formula (I) and R' indicates a halogen atom or lower alkyloxy group). A drug which contains this compound as active ingredient is useful for curing autoimmune diseases such as rheumatoid arthritis, nephritis, etc.

4383995

C Y C L O H E P T A FURAN DERIVATIVES AND A P P L I C A T I O N T H E R E O F AS A N T I - F I B R I L L A T I N G AGENTS Delbarre;

Loui

Beta-cyclodextrin forms a water-soluble complex or inclusion compund with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure of beta-cyclodextrin. The resulting inclusion compounds can be used for a variety of applications including aqueous topical ophthalmic preparations and topical dermatological ointments. 4383990 A N T I V I R A L AGENTS, T H E I R P R E P A R A T I O N AND USE Paul Coe; Albert S Jones; Stewart A Noble; Richard T Walker assigned to Beecham Group Limited

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(4,5) 4H-BENZO (1,2-B)

Bernard Gomes

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