5112806 Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical

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N e w Patents

an actwe pnnople, stud mlcropartlcles being coated with a coating m~xture comprising ethyl cellulose and an acryhc resin which is a polymenzate of acryhc and methacryhc ester, haxqng a molecular weight of at least 100,000 and compnsmg umts of formula See Patent for Chemtcal Structure whereto R1 ~s hydrogen or methyl, R2 Is methyl or ethyl, R3 is methyl, and R4 is -CH2CH2N(CH3)3CI the resin contammg 5% of tnmethylammonmm methacrylate chloride umts by weight

of a physiologically acceptable preparatmn, a pharmaceutical preparation of aprotanm being particularly preferred

5112806 ANTIBIOTIC, MERSACIDIN, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS A PHARMACEUTICAL

5112804 PHARMACEUTICAL COMPOSITION AND METHOD OF INTRANASAL ADMINISTRATION Hanna R Kowarskl assigned to Temple Umverslty of the Commonwealth System of Higher Educatmn A composmon and method for nasal adnumstratmn of pharmaceutacals uUhzes glycyrrhetlmc acad as an absorptaon enhancer The composmon comprises an effectwe amount of the pharmaceuUcally active substance, glycyrrhetlmc acid, in anamount effectwe for enhancing permeatmn of the actwe substance across the nasal membrane, and a basic salt of an amino acid as an adjuvant The composmon may be aglmmlstered to the nasal cawty m the form of a spray by using an atommer, nebuhzer, spayer, dropper or other dexace which ensures contact of the composmon w~th the nasal mucus membrane

5112805 PHARMACEUTICAL PREPARATION FOR PROMOTING EPITHELIAL HEALING AND PREVENTION OF EPITHELIAL DESTRUCTION Eeva-Marjatta Salonen, Espoo, Finland assigned to Labsystems Oy A method of determining the presence of eplthehal lesions is prowded whereto a sample of a body fired taken from an epithelial region suspected to have stud lesmns is tested for the presence of a proteolytlc actlwty The lesion Is then treated by applying a therapeutacally effective amount of a protemase inhibitor m the form

Sukurnar Chatterjee, Sugata Chatterjee, Blmal N Ganguh, Deepak K Chatterjee, Rajendra K H Jam, Richard H Rupp, Hans-Wolfram Fehlhaber, Herbert Kogler, Gerhard Selbert, Volker Teetz, Bombay, Indm assigned to Hoechst Aktlengesellschaft Mersacldm, a cychc pepUde of the formula I See Patent for Chemwal Structure (I) COCH2SCHCH3NHCHCON HCH2CH(CH3)2CHCON CHCOCHNHCOCH(CH3)2CHNHCOCH2NH COCH2NHCOC H2NHCOCH2NH NHCH3CHSCHCON HCH2CH(CH3)2CHCONHCH3CH SCHCONHCH2CC ONHCO2HCH2CH2CHCON HCHCH2COCHCHNHCOCH CH3C2H5CHNH has antlblot~c actlwty

5112815 9 ALPHA- HYDROXY-3-OXO-4,24 (25)- S T I G M A S T A D I E N - 2 6 - O I C ACID DERIVATIVES, A PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Gabor Ambrus, Andrea Maderspach, Antalne Javor Andra Jekkel, Eva Ilkoy, Gyorg Hajos, Laszlo Nagy Jozsef Szporny, Gyula Horvath, Imre Moravcslk, Budapest, Hungary assigned to Racher Gedeon Vegyeszet The invention relates to novel 9 alpha-hydroxy3-oxo-4, 24(25)-stlgmasta&en-26-olc acid derivatives of the formula (I), See Patent for Chemwal Structure (I) whereto M stands for hydrogen, C1-4 alkyl or a pharmaceutically accteptable cation to a process for repamng these compounds and to composmons containing stud compounds which exert an ant~hypercholesteremlc effect