4443452 Dibenzodiazepinones, pharmaceutical compositions thereof and method of use thereof

vi

New Patents CH3--CH2--CH2~CH I C3H?

C--O~CH2--O--C~C(CH3)3 II II O O

The compound pivaloyloxymethyl 2-propylpentanoate of formula I: See Patent for Chemical Structure I is described. The process for the preparation consists of reacting 2-propyl-pentanoic acid with chloromethyl pivalate and isolating the pivaloyloxymethyl 2-propyl-pentanoate from the reaction mixture. Pharmaceutical compositions with antiepileptic and anticonvulsant activity containing an effective amount of compound I are described.

4443448 INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF PREPARATION Klaus P Bogeso, Lyngby, Denmark assigned to Kefalas A/S

Soldato Piero del, Biberach, Federal Republic Of Germany assigned to Dr Karl Thomae GmbH H I N

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N I C~O I X~R

This invention relates to compounds of the formula See Patent for Chemical Structure wherein X is oxygen, -NH-, or-NCH3-and R is 1-methyl4-piperidinyl, 4-methyl-l-piperazinyl, endo-8methyl-8-azabicyclo(3.2.1)oct-3-yl, or exo-8methyl-8-acabicyclo(3.2.1 )oct-3-yl, each of which may optionally have an additional methyl substitutent, a diastereomer or enantiomer thereof, or a non-toxic, pharmacologically acceptable acid addition salt thereof with an inorganic or organic acid.

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The present invention relates to novel 1piperazino-3-phenyl-indane derivatives which have pronounced psychopharmacological activity such as neuroleptic activity, analgesic activity, antidepressant activity and, at the same time, a low degree of undesired side-effects, methods for the preparation of said indane derivatives, pharmaceutical compositions containing same, and methods for the treatment of psychic disorders, such as psychoses and depressions and pain, by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.

4443452 DIBENZODIAZEPINONES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF Wolfhard Engel, Gunter Trummlitz, Gunther Schmidt, Wolfgang Eberlein, Rudolf Hammer,

4443453 QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH C O M P O U N D S , AND METHODS FOR TREATING CARDIOVASCULAR CONDITIONS WITH THEM Hans B Trijzelaar, Bode Ronus de, Handricus B A Welle, Zeist, Netherlands assigned to ACF Chemiefarma N V A~ B~CH2---~

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The invention is concerned with novel quinoline derivatives of the formula See Patent for Chemkal Slructure 1 or a salt thereof, in which A-B is CH2-CH2-, -CHOH-CH2-, -CH2-CHOH-, CH2-C(O)-, -C(NOR4)-CH2or -CH2C(NOR4)-, R1 is hydrogen, hydroxy or lower alkoxy, R2 is lower alkyl, R3 is ethyl or vinyl, R4 is lower alkyl, whereby the substituents at the 3and 4-position of the piperidine ring are in the cis-position. The compounds of the formula may be in the form of the optically active enantiomers and/or their therapeutically acceptable salts. Furthermore the invention provides pharmaceutical compositions possessing cardiovascular activities in which as active compound at least a