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5001121 Cephalosporin compounds and pharmaceutical compositions thereof
New Patents
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The invention relates to benzylidenecamphor derivatives of formula: See Patent for Chemical Structure (I) where R is hydrogen or a tert-butyl residue, Rl is a Cl-C8 alkyl or alkoxy residue, and R2 and R3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.
ticularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Grampositive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
5000994 5001137 PHARMACEUTICAL ELASTOMERIC COATING Val G Romberg, Patty H Kiang, Wayne T Curry assigned to The West Company Incorporated An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.1 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.O and is capable of substantially preventing metal extraction from said elastomers.
PYRIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF Takanori Oe, Yuji Ono, Kazuyuk Kawasaki, Tohru Nakajima, Oita, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd A novel pyridine compound of the formula See Patent for Chemical Structure wherein each symbol is as defined in the specification, or a salt thereof which exhibit inhibitory activity or prolylendopeptidase and a pharmaceutical use thereof are disclosed.
5001121
5001143
CEPHALOSPORIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
PHARMACEUTICAL COMPOSITION FOR PROPHYLACTIC AND PREVENTIVE OF KETOSIS OF LIVESTOCKS
Haru Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida, Funabashi, Japan assigned to Mochida Pharmaceutical Co Ltd The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, par-
Aki Hokazono, Masahiro Shimosako, TatTakehiro Shimada, suyoshi Sugimoto, Masahiro Hayashi, Yokohama, Japan assigned to Nihon Nohyaku Co Ltd A pharmaceutical composition for prophylactic and preventive of ketosis of livestocks which contains a dithia derivative represented by the general formula (I), See Patent for Chemical Structure (I) wherein R and R’ may be the same or different and are each individually a lower alkyl group, n is an integer of 0,l or 2; and A is a group of the formula, -CH2-, See Patent for Chemical Structure (wherein M is a hydrogen atom or a salt-forming residue), -CH double bondCH-, -CH2-CH2-, See Patent for Chemical Structure
iv
The invention relates to benzylidenecamphor derivatives of formula: See Patent for Chemical Structure (I) where R is hydrogen or a tert-butyl residue, Rl is a Cl-C8 alkyl or alkoxy residue, and R2 and R3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.
ticularly a catechol carboxymethyloxyimino moiety or a catechol carboxyimino moiety, as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Grampositive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
5000994 5001137 PHARMACEUTICAL ELASTOMERIC COATING Val G Romberg, Patty H Kiang, Wayne T Curry assigned to The West Company Incorporated An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.1 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.O and is capable of substantially preventing metal extraction from said elastomers.
PYRIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF Takanori Oe, Yuji Ono, Kazuyuk Kawasaki, Tohru Nakajima, Oita, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd A novel pyridine compound of the formula See Patent for Chemical Structure wherein each symbol is as defined in the specification, or a salt thereof which exhibit inhibitory activity or prolylendopeptidase and a pharmaceutical use thereof are disclosed.
5001121
5001143
CEPHALOSPORIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
PHARMACEUTICAL COMPOSITION FOR PROPHYLACTIC AND PREVENTIVE OF KETOSIS OF LIVESTOCKS
Haru Ohnishi, Hiroshi Kosuzume, Masahiro Mizota, Yasuo Suzuki, Ei Mochida, Funabashi, Japan assigned to Mochida Pharmaceutical Co Ltd The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring, as substituents at the 3-position of the cephem skeleton, and of groups containing a catechol moiety, par-
Aki Hokazono, Masahiro Shimosako, TatTakehiro Shimada, suyoshi Sugimoto, Masahiro Hayashi, Yokohama, Japan assigned to Nihon Nohyaku Co Ltd A pharmaceutical composition for prophylactic and preventive of ketosis of livestocks which contains a dithia derivative represented by the general formula (I), See Patent for Chemical Structure (I) wherein R and R’ may be the same or different and are each individually a lower alkyl group, n is an integer of 0,l or 2; and A is a group of the formula, -CH2-, See Patent for Chemical Structure (wherein M is a hydrogen atom or a salt-forming residue), -CH double bondCH-, -CH2-CH2-, See Patent for Chemical Structure