5153207 Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same

New Patents 5153194 THIENO CYCLOHEPTAPYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE Tohru Nakao, Hirosh Tanaka, Yasuto Morimoto, Shuzo Takehara, Nakatsu, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd A thienocycloheptapyridazine compound of the formula See Patent for Chemical Structure wherein R stands for hydrogen, a halogen or a C1-4 alkyl, Ar stands for an aryl, a heteroaryl, or an aryl or a beteroaryl having as a substituent at least a halogen, a C1-4 alkyl, a C1-4 alkoxy, nitro, amino, hydroxy, trifluoromethyl and/or a C2-5 alkanoylamino; and the bond between 4position and 42-position represents a single bond or a double bond, which is useful as an antianxiety agent, amnesia-treating drug, a brain function-activating drug or an antidementiac drug.

5153201 CONDENSED THIAZOLE COMPOUNDS AND USE AS PHARMACEUTICALS Tetsuya Aono, Masahiro Suno, Go Kito, Nagaokakyo, Japan assigned to Takeda Chemical Industries Ltd A novel condensed thiazole derivative of the formula (I): See Patent for Chemical Structure (I) wherein A is a single bond or CH2; R1 is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulfonic acyl group; and R2 is hydrogen atom, or an optionally substituted aromatic cyclic or aliphatic group, or a salt thereof. The compound (I) is useful for medicines for preventing and treating various diseases such as cancer, arterial sclerosis, hepatopathy, cerebrovascular diseases, inflammatory and the like. A process of the compound of the formula (I) or a salt thereof and a pharmaceutical composition comprising the compound of the formula (I) or a pharmaceutically acceptable salt thereof as an active component are also disclosed.

xvii 5153207 PIPERIDINE DERIVATIVE, METHOD FOR PREPARATION THEREOF, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Yasuo Ito, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Hiroyuki Nishino, Jun Sakagnchi, Katsuyama, Japan assigned to Hokuriku Pharmaceutical Co Ltd A piperidine derivative represented by the following general formula (I): See Patentfor ChemicalStructure (I) wherein RI and R2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -AO-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I). 5153225 S U B S T I T U T E D B A S I C 2AMINOTETRALIN IN PHARMACEUTICALS • Rudolf Schohe, Thomas Glaser, Jorg Traber, George S Allen, Wuppertal, Federal Republic Of Germany assigned to Bayer Aktiengesellschaft For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2aminotetralins of the formula See Patent for Chemical Structure in which R1 represents hydrogen or alkyl, R2 represents hydrogen, alkyl or acyl, and R3 represents quinuclidine or a group of the formula -(CH2)a-R4, -CH2-CH double bondCH-(CH2)b-R4, -CH2-C triple