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4563453 Thiazine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
New Patents
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4563477
ACETYLSALICYLIC ACID THIOESTERS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PROCESS FOR THE PREPARATION OF ALPHA-(NPYRROLYL)-DERIVATIVE ACIDS, THE SALTS AND ESTERS THEREOF; ALPHA-(NPYRROLYL)-PHENYLACETIC ACIDS, THE ESTERS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTICAL APPLICATIONS THEREOF
Marino Gobetti, Guido Vandoni, Milan, Italy assigned to Edmond Pharma S r 1 Acetylsalicylic acid thioesters having antipyretic activity and useful for the symptomatic treatment of influenza of formula: See Patent for Chemical Structure wherein n is zero or 1, R1 is hydrogen, methyl or carboxy and R2 is hydrogen or an acetamido group; a process for their preparation by reacting a functional derivative of acetylsalicylic acid with the suitable thiol; and pharmaceutical compositions containing them as active ingredient.
4563453 THIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Ikuo Ueda, Masayuki Kato, Yosiharu Kasai, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Co Ltd New thiazine derivatives of the formula: See Patent for Chemical Structure wherein R 1 is hydrogen or acyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, hydroxy, halogen, lower alkyl or lower alkoxy, Z is taken together with the adjacent carbon atoms to form an unsaturated heterocyclic ring which may be substituted with phenyl, halogen, acyl or lower alkyl, and the heavy solid line means single or double bond, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same. These derivatives and salts thereof are useful as antiinflammatory, analgesic and antirheumatic agents.
Francisco S Maldonado, PlaLuis , Jose L F Puentes, Jose M F Sousa-Faro, Le Spaia assigned to Antibioticos S A A process for the preparation of alpha-(Npyrrolyl)-derivative acids, the salts and esters thereof, of the formula See Patent for Chemical Structure in which R, R1, R2, R3 and R4 are hydrogen atoms or substituted or unsubstituted alkyl, aryl, alkylaryl or heterocyclic radicals and R' is a metal cation, an organic base or an organic radical, wherein the corresponding amino ester is reacted with a dialkoxytetrahydrofuran or a derivative thereof. Certain compounds comprised among those corresponding to the above formula, particularly the DL, D and L-alpha(N-pyrrolyl)-phenylacetic acids and certain esters thereof. Therapeutical compositions containing such compounds as active ingredient and therapeutical applications of said compounds.
4563479 SYNERGISTIC RADIATION PROTECTIVE PHARMACEUTICAL COMPOSITIONS Laszlo Benko Gyorgy Feuer, Budapest, Hungary assigned to Chinoin Gyogyszer es Vegyeszeti Termekek Gyar RT The invention is directed to a synergistic radiation protective pharmaceutical composition comprising 50 to 350 parts by weight of aminoalkyl-thiol-derivatives of the general formula II See Patent for Chemical Structure (II)
v
4563443
4563477
ACETYLSALICYLIC ACID THIOESTERS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PROCESS FOR THE PREPARATION OF ALPHA-(NPYRROLYL)-DERIVATIVE ACIDS, THE SALTS AND ESTERS THEREOF; ALPHA-(NPYRROLYL)-PHENYLACETIC ACIDS, THE ESTERS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTICAL APPLICATIONS THEREOF
Marino Gobetti, Guido Vandoni, Milan, Italy assigned to Edmond Pharma S r 1 Acetylsalicylic acid thioesters having antipyretic activity and useful for the symptomatic treatment of influenza of formula: See Patent for Chemical Structure wherein n is zero or 1, R1 is hydrogen, methyl or carboxy and R2 is hydrogen or an acetamido group; a process for their preparation by reacting a functional derivative of acetylsalicylic acid with the suitable thiol; and pharmaceutical compositions containing them as active ingredient.
4563453 THIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Ikuo Ueda, Masayuki Kato, Yosiharu Kasai, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Co Ltd New thiazine derivatives of the formula: See Patent for Chemical Structure wherein R 1 is hydrogen or acyl, R2 is hydrogen or lower alkyl, R3 is hydrogen, hydroxy, halogen, lower alkyl or lower alkoxy, Z is taken together with the adjacent carbon atoms to form an unsaturated heterocyclic ring which may be substituted with phenyl, halogen, acyl or lower alkyl, and the heavy solid line means single or double bond, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same. These derivatives and salts thereof are useful as antiinflammatory, analgesic and antirheumatic agents.
Francisco S Maldonado, PlaLuis , Jose L F Puentes, Jose M F Sousa-Faro, Le Spaia assigned to Antibioticos S A A process for the preparation of alpha-(Npyrrolyl)-derivative acids, the salts and esters thereof, of the formula See Patent for Chemical Structure in which R, R1, R2, R3 and R4 are hydrogen atoms or substituted or unsubstituted alkyl, aryl, alkylaryl or heterocyclic radicals and R' is a metal cation, an organic base or an organic radical, wherein the corresponding amino ester is reacted with a dialkoxytetrahydrofuran or a derivative thereof. Certain compounds comprised among those corresponding to the above formula, particularly the DL, D and L-alpha(N-pyrrolyl)-phenylacetic acids and certain esters thereof. Therapeutical compositions containing such compounds as active ingredient and therapeutical applications of said compounds.
4563479 SYNERGISTIC RADIATION PROTECTIVE PHARMACEUTICAL COMPOSITIONS Laszlo Benko Gyorgy Feuer, Budapest, Hungary assigned to Chinoin Gyogyszer es Vegyeszeti Termekek Gyar RT The invention is directed to a synergistic radiation protective pharmaceutical composition comprising 50 to 350 parts by weight of aminoalkyl-thiol-derivatives of the general formula II See Patent for Chemical Structure (II)