4886819 Dihydropyridine derivatives and pharmaceutical composition thereof

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New Patents

4886807

4886812

NOVEL PYRIMIDOPYRIMIDINE DERIVATIVE, PROCESS FOR PRODUCING IT AND PHARMACEUTICAL COMPOSITION

TETRAHYDRO BENZTHIAZOLES, THE PREPARATION THEREOF AND THEIR USE AS INTERMEDIATE PRODUCTS OR AS PHARMACEUTICALS

Norihiko Kitamura, Akimoto Ohnishi, Katoh, Japan assigned to Nippon Zoki Pharmaceutical Co Ltd

Gerhart Griss, Claus Schneider, Rudolf Hurnaus, Walter Kobinger, Ludwig Pichler, Rudolf Bauer, Joachim Mierau, Dieter Hinzen, Gunter Schingnitz, late of Biberach, Federal Republic Of Germany assigned to Dr Karl Thomae GmbH

Pyrimidopyrimidine derivatives having the general formula See Patent for Chemical Structure (I) wherein RI is an alkyl group; R2 is an alkyl or phenyl group; R3 is a hydrogen atom, an alkyl or lower alkylamino group; and R4 is a hydrogen atom, an alkyl, halogenated lower alkyl, phenyl, amino or lower alkylamino group; and pharmaceutically acceptable salts thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

4886810 QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF USE Jun-ichi Matsumoto, Teruyuki Miyamoto, Hiroshi Egawa, Shinichi Nakamura, Ikoma, Japan assigned to Dainippon Pharmaceutical Co Ltd The present invention relates to quinoline derivatives of the formula See Patent for Chemical Structure (I) wherein Z is an amino group or a halogen atom, R is See Patent for Chemical Structure (A) or R5R6N(CH2)nR4R3N (B) in which R I is a hydrogen atom, a lower alkyl or haloalkyl group, R2 is a hydrogen atom or a lower alkyl group, R3 is a lower alkyl or haloalkyl group, R4 is a hydrogen atom or a lower alkyl group, R5 and R6 are the same or different and each represents a hydrogen atom or a lower alkyl group, or R5 and R6, together with the nitrogen atom to which they are attached, form a heterocyclic ring, and n is 0 or 1, with the proviso that when Z is an amino group, R is (B); and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents.

This invention relates to new tetrahydrobenzthiazoles of general formula See Patent for Chemical Structure (I) wherein R I represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms, R2 represents a hydrogen atom or an alkyl group, R3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms, R4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R3 and R4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R1 or R3 or both groups RI and R3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

4886819 DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF Atsuyuki Ashimori, Taizo Ono, Yoshihisa Inoue, Chikara Fukaya, Kazumasa Yokoyama, Kyoto, Japan assigned to The Green Cross Corporation Dihydropyridine derivatives of the formula See Patent for Chemical Structure (I) wherein RI,