5008243 Pharmaceutical composition containing a glycoprotein

5008243 Pharmaceutical composition containing a glycoprotein

New Patents 5008243 PHARMACEUTICAL COMPOSITION CONTAINING GLYCOPROTEIN A Masanori Ikuzawa, Yoshiharu Oguchi, Kenichi Matsunaga, Noriyuki Toyoda, Ta...

99KB Sizes 2 Downloads 53 Views

New Patents

5008243 PHARMACEUTICAL COMPOSITION CONTAINING GLYCOPROTEIN

A

Masanori Ikuzawa, Yoshiharu Oguchi, Kenichi Matsunaga, Noriyuki Toyoda, Takao Furusho, Takayoshi Fujii, Chikao Yoshikumi, Tokyo, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar,, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

ix

positions. The peptides are represented by formulae (1) to (16): See Patent fir Chemical Structure PS The novel peptides are useful for the therapy of diseases where a decrease in the activity of the immune system is desirable.

5008255 METHOD FOR ENHANCING SOLUBILITY OF TRIMETHOPRIM WITH SODIUM SULFACETAMIDE, AND SYNERGISTIC PHARMACEUTICAL COMPOSITIONS DERIVED THEREFROM John Edwards, Wesley W Han, Yusu Ali assigned to Alcon Laboratories Inc A method of preparing aqueous pharmaceutical compositions containing a synergistic combination of trimethoprim and sodium sulfa&amide is described. The method results in a significant improvement in the aqueous solubility of trimethoprim due to a favorable interaction between the trimethoprim and sodium sulfacetamide which is dependent on a mildly acidic PH.

5008256 5008246 NOVEL PEPTIDES SUPPRESSING THE FUNCTION OF THE IMMUNE SYSTEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Istvan Schon, Olga Nyeki, Lajos Kisfaludy, Laszlo Denes, Gyorgy Hajos, Laszlo Szporny, Budapest, Hungary assigned to Richter Gedeon Vegyeszeti Gyar R T The invention relates to novel peptides and their acid addition salts, suppressing the function of the immune system, pharmaceutical compositions containing these peptides as well as to a process for preparing these peptides and com-

SALTS OF RANITIDINE AND COMPLEXES OF BISMUTH WITH CARBOXYLIC ACIDS, AND PHARMACEUTICAL COMPOSITIONS THEREOF John W Clitherow, Sawbridgeworth, United Kingdom assigned to Glaxo Group Limited The invention relates to salts formed between ranitidine and a complex of bismuth with a carboxylic acid, and solvates of such salts. Examples of suitable carboxylic acids are citric acid, tartaric acid and agaricic acid. The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity aswith ranitidine together with sociated antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties.