Aromatherapy & immunity: How the use of essential oil aids immune potentiality in four parts

AROMATHERAPY

Michael

Alexander

Products

of America,

Mobley

Road,

Y3556

IMMUNITY: HOW THE USE OF ESSENTIAL OIL AIDS IMMUNE POTENTIALITY IN FOUR PARTS

Essential HO72

Odessa

&

North

Florida

USA

PART I

- How ESSENTIAL OIL ODOURANTS AFFECT IMMUNE POTENTIALITY

MICHAEL

ALEXANDER

Optimal health and recovery from sickness - that is what the immune system evolved to do and works to achieve. Optimizing immune potentiality is essential to staying healthy or, should we become ill, recovery from illness. Is that not also one of the goals of the aromatherapist and at-home user of pure essential oils? Really, is it not the goal of everyone? It happens to be the most fortunate consequence of judicious aromatherapy use. The mechanisms by which aromatherapy treatments aid the immune system in staying well or recovery from illness are reviewed in a 4-part series starting here. 0 2001 Harcourt Publishers Ltd logical an

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of

neu-

chemical to

system

steroids,

specific

fimction

to the

neural

rather

are

overall

system.

the

areas

including that

course

activity

The

brain

of

which

occur

an

immune

appears

extent

what

immune

system.

in the

perceptions

is

This of

‘I‘he

mind

can

affect

computational

and

as well

as

be ftmneled

for

thence

to

the

immune

which

they

may

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system. for

to the

nervous

In

in

Part

use

Dethier,

a role

health

state

behdviour.

years

lion

Lectures

Doty,

I).

et

advances

our

raise

this

mood-

how

sus-

essential

threshold.

al.

Sarasota,

odourant

molecules,

immune

cells

system

input

Alexander,

M. (2000a)

matherapy To&y

neuropeptides,

hormones,

Alexander,

chemical

messengers,

Works:

placebo?

Is olfactory

aro-

Aromatheru,$y

16: 26-31.

synthetic

Hoiu Aromatherafiy

and egicaciow

pathwuys

l-37, B.C.,

Symposium:

on

XXI,

glutamatergic

Research

461-465.

20(4):

J.I?

et al.

against 3(3):

14-18,

human

Effects

of

system

in

Prophylactic

supervening

with

chronic

evaluation a placebo.

infec-

bronchi-

conducted

in

Phytotherafly

97-100.

A. et al. (1987)

putative

affects

dis-

Neurochemical

(1989) for

in patients

Research

a

of

and

April

cortex.

clinics

and

measurement in health

the rat cerebral

Gustavson,

M. (2000b)

pp.

imaging

E. et al. (1995)

tis. Statistical by

K., Wtight

FL.

linalol

tions

impulses,

(1999)

function

aromatherapy

generated

R.H.

Burnaby,

brain

AChemS

Ferley,

brain.

mil-

In Colbrow,

U.,

in

ease.

and

l(2):

Canada.

behav-

LO illness

well

hundred

Research,,

Fraser

by modifying

and

the

International

Linville’s

on O&tory

Simon

olfactory

stress

on

of

Nursing

of olfaction.

electrophysiological

correlations,

oils

Five

Allison

to real

discuss

T

breeze. Spring:

patients.

(1990)

susceptibility

we will

ed.,

Betts,

An evaluation

Palliative

VG.

Elisabetsky,

II

2d Diego

of essential

ed., Frank

the

intluencing

netcds.,

the

J. et al. (1995)

on the

directly

of

al.,

Quarlerly

of

defenses,

oil odourants

impulses

nervous

by

A.

67-73.

during

effect

Ray,

et

San

Aromatherapy

,Journal

instance,

including

to

or

immune

the

system,

to

illnesses

into

messages

response

iour

stimuli

on the immune

chemical

external

olfactory

physical

our

Sniffing

of cancer

plays

sickness-related

(1994)

the

with

in turn

Press,

being

to some

on

R.

Academic

brain

response.

know

going

input.

func-

hence

to

Ader,

olfac-

Doty

to changes

Del

implications

neuroendocrine

In

Corner,

cingulate 1997;

linked

olfactory

immune

other

are

an odourant’s

system,

produce

1999)

way,

parts

and

responding

et al.,

et al.,

In this

can

effects

and

Levy

cor-

1iypothalamus

The

ganglia

- see

of the

including

endocrine

(basal

input

and

other

and

48( 1):

19-22.

olfactory

and

key

activities

stresses,

located),

-

in

Behavior

Psychon,euroimmunology,

limbic

the primary

presented

and

immune

17.

Responsiveness

Physiological

the

in

nerves

1967),

other

receive

influences,

Pfaffman,

cortex

the

upward

into

otherm

is that

tional

ext,end

hypothalamus

is stimulated

receiving

immune

These

(which

with

as

directed

activity

50: 8 13-8

H.D.

(1991)

Neputa

of Pharmacy

stimuli

Besedovsky,

a

from

Journal

Physiology

work.

chemical

associated

as

of neurotrans-

connections

from

tory

and

an organized,

&

87-90.

patterns

the olfactory

(where

nuclei

act directly

or stimulators

from

forebrain

neuro-

peptides

and

Scott

by

state

revealed

Boiss.

olfactory

sleep.

neuro-

FL.

analgesic

P. et al. (1990)

to

neurotransmitters).

have

see

hence

psychological

by these

and

but

lends

and

‘(governed

The

do not

mission,

and

caesarea

in

hormone

in

(and

Odessa,

and Pharmacology

changes

changes

opioid

Badia,

accompanied

activity

by impulses

amines,

which

inhibitor5

In

are

and

by neuromodu-

neurotransmitters

sends

activity

nerve

influ-

experimental

immune

endocrine

chemically

of

is abundant indicates

levels,

hence

in O&action,

S. et al., (1998)Nepetalactone:

new

be

physiology,

Mechanisms

Spectmm,

Aydin,

about

state.

that

hypothalamus

common

and

evidence

corresponding

Whole

in various

can

oils in the hunzan

I&. I, Principal

endocrine

system

psychological

the

many

modified e.g.

exert

our

are

brain

immune

oJ essential

others,

information

up to the brain

ence

electrical

have

secretion

lators,

iI!ld

of the

regions

The

result

state

the systems

way,

Investigations

thought

communication,

transmitters,

this

transmitters),

speaking.

tcx

In

of

systems. system

are

in the immune

and

on

to

system

Conversely,

to act

that

to be restricted nervous

be active

LO

the immune

ways.

P, and

both

nervous

‘I‘here

messengers

the

rotransmitters

central

central

endorphins,

substance

influence

and

passed

CNS

hormones,

thought

as well.

realized

factors,

system.

and

corticotropin,

which

the

indi-

as a mechanism

chemical

the

A vast

between

Neurotransmitters, other

SYS-

commu-

messengers

including growth

of the body’s

two

in common.

the immune

and

and

and memory

communication

and

CNS

a lot of chemical

hardware

of

-

regulatory

nication

cate

The

human (homo

Androstenol, pheromone, sapiens)

mate

choice

performace.

Comparative Harris,

(2000)

R.J.

Database.

oj

10 1: 2 1 O-2 12. The

Aromatherujy

Essential

Consultants,

Oil

J.G.

and

Resource

(1997)

Mechanisms

crimination:

Shepherd,

G.M.

of olfactory

converging

common

Annual

dis-

across

phyla.

of Neuroscience

A. et al. (1991)

on cardiac

Effect

response

time

M.D.

Unconscious human

odour

W.R.

Nagai,

(1983)

to

17(3):

(1992)

in

odors.

S.C.

(1992)

effects

on creativity,

ceived

health.

Senses

Ambient

odor’s

mood,

Chemical

and

Senses

mood, to

C.

al.

(1992)

and

Archives 48(5):

i~euroimmunom~odulat~~n I,.M.,

et

al.

of human

Com$uter

(1997) olfaction.

Assisted

of func-

vividness mood:

Shibata,

Functional

l’ii;C

and

and

Schwartz, odour:

G.E. 1. Alteration

65:

of

Psidium

Journal

The

Plantu

J.W.

Pfaffman,

input

to

C.P the

158: H.

‘1,

eL al.

(1990)

exposed by

Recovery to high

stress

olt’actory InlPrnntionnl

CIJ Newo.5cience

5 1: 245-247.

H. et al. (1991) behavioral

effects

of

stimulation Jownul

Tmmunological of fragrance

of odours

Chemicai!

on

Senses

Sensory oils.

al.

(1969)

psychic

effect

of

lavender

and

geranium.

ll(5):

eval-

Chemical

‘l’he

neuro-

Bulgarian

rose,

Eolia Medica

307-317. et al. (1999)

J.S.

,/ou7-iaZ Yamada,

Behavioral

oil from

Brown

Lipfiia

67:

and

Dember,

15:

W.N. on

stress.

oJNursing et

l(1): al.

and

of chamomile AC’I‘H rat

under

and 1244-1246.

and

21-30.

(1996)

inhalation

19(Y):

Pe~fiwtwr

care. International

on

tomized

(1990) vigilance

Aromatherapy

in palliative

plasma

oj

15-18.

S. (1995)

I(.

Biological

,Joumzal 127-133.

fragrances and

effects

albu (Mill.)

chemotypes.

of

Wilkinson,

pres-

165-173.

Effects

essential

et

massage

fragranre.

and

of

Flavorist

evidence.

1592-1594.

in mice

133:

in

16: 198.

performance

hypothala-

electrophysiological

Attention, behavior

S. et al. (1991)

Warm,

(1967)

oj

258-261.

adaptive

function.

Effects

and

37:

(Roxb.)

303.

N.E.

Medicu

cell sta-

,Journal

et al. (1961)

Ethno$harmncoloyy

133-135.

sure

of

offers

oil.

inhibitory

Indian,

H. (1989)

mental

Mast

deodoru

oil.

cat. Science

of essential

pentylenetetra-

seizures.

Cedrus

and

Vale, T.G.,

guyanensis

against

with

Shibata,

of

leaf essen-

qf

(1988)

of

wood

lipoxygenasc

J.M.

Tasev,

a pre-

deodora

Biology

affective

Senses

197-199.

2 1:

Journal

549-556. T.S.

oil

Olfactory

2: 174-180.

British

F.A. et al. (1997)

Science

Sprague,

Takeuchi,

stim-

fluency,

mus:

states.

Tomography

19(4):

of olfactory

associated

63:

wood

14(2):

J.M.G.

on

zole-induced

Effects

d epressive

on

Senses

Williams,

effects

study.

odors.

of

Lond.

Sugano,

prolonged

immunomodulatory

et al. (199913)

and

activity

the

fragrance

and

Scott,

tions

Functional

after

and

Psych,ology

immune

and

68-72.

U.A.

bilising

Ex;berimental

con-

20( 10):

of

liminary

Health

(1995)

Evaluation

imagery

protection

on

Chemical

ulation

tial

al.

Shinde, of

(1994)

Chemical

The

Performance,

et

of odors

Preliminary

70: 333-339.

uation

during

T,

CedvuA

Flauour

brain

A.

(1993)

fragrance

the

of

fatigue.

effects

human

health

citrus

and

Medicul

305-308. Komori,

on

activity

oj’

59.

et al. (1999a)

studies

by EEGs-odors

et

imaging

and

intermittent

U.A.

,Journul

15 l-l

on

effects

drowsiness.

S.C.

ErwironmerLtal

Shinde,

57:

16:

198.

per-

expo-

Intwwtional

Effects

Effects

M. et al. (1992)

Santos,

Knasko,

mice.

Senses,

Reducing

17( 1):

27-35.

MRI

(II).

stress

Roberts,

347-361.

Knasko,

(I).

of

359-364.

human

Chemical

Effects

Chemical

FragranceJournal

the

Topograof

in

Neuroscience

(1991)

humans

Sense.5 16:

Nasel,

Psychology

maps

al.

H. et al. (1991)

trolling

conditioning

al.

Ed

administration. 281-284.

Fitotera$ia

of drowsiness

al.

Biological

EEG

response

Brain

latency.

inhalation.

phical

Lorig,

on

sleep

in a reac-

Senses 16: 183. et

suljects.

Klemm,

I.evy,

odours

mental

20:

7: 221-231.

sure

et

ofodours

patterns

task. Chemical

Kirk-Smith,

of

Y.

Nakagawa,

Kikuchi,

by odor 46(3):

on humans

595-631.

tion

EEG

Psychobiology

183.

evidence

principles

Review

human

Miyake,

France.

Hildebrand,

for

Journal

Psychology

level

Effect oil vapour in

restriction

Pharmaceutical

ovariecstress. Bulletin

of