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Effect of MER-29 (Triparanol) on serum cholesterol, cholesterol esters and liver enzymes
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DISclL:~IoN
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a.+~+l 1+~+.~+++" ~++ t}++++ r+,+++ +\+++~i+ |++i,++t+l+~++u+ :++++1 l+_~++++i+~+ /+F:l.~++~l:+-kS+ l~+~+I 3. P,++++.+{+'. E ++;.++ A+:i:,+++. 1¢ W l+++ t+i+.ri+ t++++,.P++,+ "+',2+ .% . I+ot~,-r+ +'~I+ +| I . a,i~+1 l.l~+Ik<'t. ."-2 +'W." i't) Ie++ri'ht'+b+,++'r'-'m]a f~ti+| tti<+,~iilliv :Ivid: I.++l}~ l+:i+llt >i+;+ly+ { "i+++~+I+'~+i * m
I0.
~++++~71. P..++'+.+-
I. IgI+;t+m+ T . 1¢.. l~,ari;va+ +F+.+ l++~++~;5!i++~+ +M 1"2 +++,d P+'d+,p, di+ F I++: }l+'d+w++,+,+~ +}+ }+I+Ji+'i +Jilt| tl~,.+~i"+ i-]~++++++,.~+~+r,+l+Q+ ~II:l{.'~+. +~+ ++h++~i+-+i+'r+,l >+v~l|t,+++4+~ in+ IBld++,r F+,d. l%,+e :.~::~+.~.J. 1939. 5 I+3"~-+~, ~. +++ a++,l I:+-ivdu+a~++ M : B d , + ++tPi*tI
ItI++
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ii:lt++!l.
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,'+:4tS~
i t { . | I n l m t , I+.. l.~r:ullt,w, t t I£., Znmv~ff. It.. Kuku~hiln:,~2 1"++ 1~.. am'l {lMl~t.gt~,r. T t'++: ' f l u " h)'t~clmtt..~l,,r~++mie eff+~-~ t { l t t t - - l { ~ l |+ t!aS++l tl,~fl¢~nd+'r~ W a n d
{'II,)b:miaI~, ..k+ V . :
liUNKIN AXD RFSRIX T h e ehol0.slerol h)weri))g effect of 1 - [p.t(¢i - d i e l h y l a m i n o e l h y o x y ) .. l,htmyl{ - I - (p- ~oiy} ). 2- (l) " ehl,~ro phenyl){ etha,ml in hypertensive re:u,. .1. (*!in. I n v e s l . &S','1013. i90,1.'* 14. tt,~lla))der, W., C|ml):),)ia)). A. V. a n d Wi{kins, R. W. : Effecls of ~n initlbitor of cholesterol biosynthesi.% ~ril)ar:mol (MEtl+2~B. in suhjcr~s wit h ~md wit hOtl{ eor(~lltiEV aI'I~.~D" di.~ea~se. CiV(:tllIlliml ~0:71a-714, 19/'19. 15. th~liis)er, L, 1£.. K a n t e r , S. I,.. Pmvel{, P. B, a n d I i e n H e h , V. L.: T h e (,fleet of aMrenergie Moi-king :*ge,,l.~ (indudi))g eh{,)rl)romaziim) on s e r n m iil)id levels of plitienls ,a'id~ d i s o n h , r.- ,)f fa~ me~M~oJism, a. C h r o n i e l)i~ease.~ 6: 3, 1957. 16. J,mes, R. J.. Reiss, (), 1(.. B a i l e r , E. I,. and C o h e n , L . : Effec! of :~ t~ndn ex. tract ,)¢~ | n r n o v e r t a l e ,)f serun) ('holester,)I Pr, le. S-oe Exi*'r. Biol. Med. 54;:.142~441;. 1957~ }7. d~mes, il..), a n d ( ; o l d e m M. V. : l)i(,~ary fa~ a))d eh,)lf,s)ero| m e l l f | . d i s m il* n o r m a | stti)jeels. CirmllaIi,m 18:403, 19~;S. IS. Kin.~eli. L. W., P a r t r i d g e , J., l~oli~)R, l.,- Mnrge)h S. ~,l)d Mirimels. (L,: l)ie(ury modifivati~)~) (g s e r u m eho]eslerol az~d p h o s p h o l i p i d },.vels, J.
Clin. Emh~erinot. and ~Irl.,~b. ,g:il{~.)~lla, t952, 19. Lewis. tL : l';lt'ect {ff eer~uin ,tielury (,ils on bi|e41vid seero~)~l~ l*rv,{ s ( ' r t l { | t ¢[mleslor~)}. l.:~ll¢,et t:1(1!10.-l(~)2. |95S~ ~(}. l,isn~t, P., ( t u k s . W. :lnd Muy,,r. d. t{.: h t | d b i t i ( m cd" r h o h . s l o r ~ syn|h~*i>, using .\IER.2{L (:irmd:~lhm ~0:'/30. 1.q59. 21. Rebinding. |f, W., lti¢:m(,, N. ;ira| ('¢dLe)~. s v r u m lipids i~) w , m e m A.M.A. Are|}. ht~. Med. lf*O:7:$9..7{a. I957. ~2, 8 a u t h u . | ), |L :uM M,,-kerjm,. S. : Sl ~di~,e: t hesi.- ill l)~qp|m)~is..Mvtnt,,)Ii~m 4:F/tl 8:m, 1958. 2;% N:mme{. tL s n d Sl(q~mr, A : Ilr, l~uqbm ~f tlm |eWd *)f ~erunl el)~:L,,yter,)i il~ malt }Lv ~w~m~)'ei~) ('ircUl~di,m ;.Y I~A|, 2.I. Slei)ter. A.. l:h)krt. M. ~m,l { ~ a k k , ' - . I
~¢')rn~:i- by -ra{ ue,~myei~) ('ireuia , i . . ~,):;'rl ;;'a, )t,5:~. ~5. T - L i : m . I.. m),i T~um, N : Ttw ,4;iva,W ]i,~ler~J <){ paiivtd~ wit{, e~,r,~mur) ather,,~e)er-~i, Am. J Med ;ze L~.*..*' 133o1:{7. 1 9 > .
TH~: Cu.~ Hca.,~-¢: T h a n k you, Dr. ]~u~ki,. Dr. Halperin, will .YOUeominuc t he discussion ,,f elhfi(,nl a,. l'~'et',
(Tril)lli'ailol)
CJiolcstciot
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( .'\)-;. ( ) t i'efi':lin fi-f,lll 7 1 i y l i l g i h l i l i l i i ~ t i l l . i > t i l i g , h l ' i , l t k i l i g ( l l , w t i t . ~ I h ,it,,,. g l ' f l ] ) t i i c l l t : l l l l l di,~i:iptinliry ttliPi'lf~l'~, htl,~ Jl<,Pll 7t i n i t l h l i i i i l £ ill I ill' ¢'XI l+l'lli~ '. It" ] ) r . I3loch {'Jill : i l l l l l i t I h i i b |lP htls ]PIil'ltt'(l ,~tJlllfithil!~, I t l i ] l i k ~.Vl' ~ttl /';iI1 ~;i/ili' l h : l l we. } } ~ v ( ' ll('ell Ill~e..
c h o l e s t e r o l syttl tiesi.~. :\tlPrtl!)t~ t(t l)t'e~'¢'llt clt~t|c.
W~. ~tudi~-d v~-ry ii~14~..~iv,.ly 17 : ~ l u i t p : , l i , . t ~ ~,,,'vr t5 v , - . v - . i :t~,' i , ' , , , , f , - . ~',, ~-C'I'¢'11 1t1¢~tt1|1~. W ~ - h ~ l v l , llitt ii.-ln~t~,d l.-vtl:ll).- :In ,.tt~.li~l Iillltlt~t'l" W | l l i tlltt| It, it h:~,t 7i1¢,h illl¢¢li~Jvl, > t l l t i y . ,~,t]{t,>-2f, w:,.- il>,.~i ~t,tlt-r;lll;l" ill ;i l l i l - : l T t , t>i' 7D|) fliT. it:ltls', ]+,~;i:~l I tiri-~- ~'~,tok.~. "t'w,,Iv<~ l~lt i¢-lil ~ W¢'I'I, hy l,'rl ~'li,
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{viqf,i, ,l+~li~, ;tl li+;l+t I,.t.}llli~t~i++~ w|l+¢.ti i~++
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612
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tet~deney for s e r u m l a c t i c d e h y d r o g e i i a s e a e l i v i t i e s to fail f~llowllJg ~ I E H . ~ ) . I hi." sa one r e a a o n w h y we d i d p y r u v a l e tilaltJl'Iflilliio{iolt~, b~te.uu~e o l i r [,icmliemicat eol-lsli| i l i n l s advisx~t its { h a ~ l l ! ! d e r (':t:+l'tIt ilt f:iI'iillfli~t:ltlttite~, folh~wi ng l i c a t i o n ¢d i h e h e p a t i c a r t e r y , W i t h isehemia of t h e liver, l li,- rise Ill tiif:Iitti~ l i l l l y Ill,ill;ill;,d l l n ill iSJt t h e a c t i v i t y of lael-ie d e h y } J r o g e n a ; ~ * . While: no eonsisiei~t { -] l l:l l : e,tl , Si(tl* tqcT(~f,lD f,~-(~i~f} l , i l e o m l t t , r ~ : - d j 71 w a ~
wer+.~ diflk;ult, t o ovalltlail~. Tvco of o~/r p l i l i e n i s w i l h p o s i l i v e ) . t a s l e r e:-gereis, te.-l~ sl:io,a~:d i l l t l ) r o V l : i l f i ' l l l j~ {lie lesi ",ift.r~, 7,~11;,I1..........o~tlh¢~rapv.. T h e rlq-ord of olin is . h t i w i i ill l i ~~{
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liUNKIN AXD RFSRIX T h e ehol0.slerol h)weri))g effect of 1 - [p.t(¢i - d i e l h y l a m i n o e l h y o x y ) .. l,htmyl{ - I - (p- ~oiy} ). 2- (l) " ehl,~ro phenyl){ etha,ml in hypertensive re:u,. .1. (*!in. I n v e s l . &S','1013. i90,1.'* 14. tt,~lla))der, W., C|ml):),)ia)). A. V. a n d Wi{kins, R. W. : Effecls of ~n initlbitor of cholesterol biosynthesi.% ~ril)ar:mol (MEtl+2~B. in suhjcr~s wit h ~md wit hOtl{ eor(~lltiEV aI'I~.~D" di.~ea~se. CiV(:tllIlliml ~0:71a-714, 19/'19. 15. th~liis)er, L, 1£.. K a n t e r , S. I,.. Pmvel{, P. B, a n d I i e n H e h , V. L.: T h e (,fleet of aMrenergie Moi-king :*ge,,l.~ (indudi))g eh{,)rl)romaziim) on s e r n m iil)id levels of plitienls ,a'id~ d i s o n h , r.- ,)f fa~ me~M~oJism, a. C h r o n i e l)i~ease.~ 6: 3, 1957. 16. J,mes, R. J.. Reiss, (), 1(.. B a i l e r , E. I,. and C o h e n , L . : Effec! of :~ t~ndn ex. tract ,)¢~ | n r n o v e r t a l e ,)f serun) ('holester,)I Pr, le. S-oe Exi*'r. Biol. Med. 54;:.142~441;. 1957~ }7. d~mes, il..), a n d ( ; o l d e m M. V. : l)i(,~ary fa~ a))d eh,)lf,s)ero| m e l l f | . d i s m il* n o r m a | stti)jeels. CirmllaIi,m 18:403, 19~;S. IS. Kin.~eli. L. W., P a r t r i d g e , J., l~oli~)R, l.,- Mnrge)h S. ~,l)d Mirimels. (L,: l)ie(ury modifivati~)~) (g s e r u m eho]eslerol az~d p h o s p h o l i p i d },.vels, J.
Clin. Emh~erinot. and ~Irl.,~b. ,g:il{~.)~lla, t952, 19. Lewis. tL : l';lt'ect {ff eer~uin ,tielury (,ils on bi|e41vid seero~)~l~ l*rv,{ s ( ' r t l { | t ¢[mleslor~)}. l.:~ll¢,et t:1(1!10.-l(~)2. |95S~ ~(}. l,isn~t, P., ( t u k s . W. :lnd Muy,,r. d. t{.: h t | d b i t i ( m cd" r h o h . s l o r ~ syn|h~*i>, using .\IER.2{L (:irmd:~lhm ~0:'/30. 1.q59. 21. Rebinding. |f, W., lti¢:m(,, N. ;ira| ('¢dLe)~. s v r u m lipids i~) w , m e m A.M.A. Are|}. ht~. Med. lf*O:7:$9..7{a. I957. ~2, 8 a u t h u . | ), |L :uM M,,-kerjm,. S. : Sl ~di~,e: t hesi.- ill l)~qp|m)~is..Mvtnt,,)Ii~m 4:F/tl 8:m, 1958. 2;% N:mme{. tL s n d Sl(q~mr, A : Ilr, l~uqbm ~f tlm |eWd *)f ~erunl el)~:L,,yter,)i il~ malt }Lv ~w~m~)'ei~) ('ircUl~di,m ;.Y I~A|, 2.I. Slei)ter. A.. l:h)krt. M. ~m,l { ~ a k k , ' - . I
~¢')rn~:i- by -ra{ ue,~myei~) ('ireuia , i . . ~,):;'rl ;;'a, )t,5:~. ~5. T - L i : m . I.. m),i T~um, N : Ttw ,4;iva,W ]i,~ler~J <){ paiivtd~ wit{, e~,r,~mur) ather,,~e)er-~i, Am. J Med ;ze L~.*..*' 133o1:{7. 1 9 > .
TH~: Cu.~ Hca.,~-¢: T h a n k you, Dr. ]~u~ki,. Dr. Halperin, will .YOUeominuc t he discussion ,,f elhfi(,nl a,. l'~'et',