- Email: [email protected]
EMBRYONAL RHABDOMYOSARCOMA
ABSTRACTS
e22
an effort to allow for early detection of the primary tumor and initiation of the appropriate therapy.
€ IS SJOGREN’S SYNDROME ANOTHER POSSIBLE AUTOIMMUNE COMPLICATION OF CHIKUNGUNYA FEVER?. LUIZ ALCINO MONTEIRO GUEIROS, ALESSANDRA CARVALHO, JAIR e CARNEIRO LEAO, AYSA PINHEIRO, PAULA TOCHE and, ANGELA DUARTE Chikungunya (CHIK) fever is a tropical arbovirosis characterized by sudden fever, headache, rash, and severe arthralgia. The disease has been suggested to act as a trigger for several autoimmune disorders, especially rheumatoid arthritis. This abstract reports 2 cases of Sj€ ogren syndrome (SS) following CHIK infection. Both patients were female and presented with fever, arthralgia, rash, and arthritis during CHIK outbreak in Recife, Brazil. After several months, they developed severe sicca symptoms and 1 of them presented with parotid enlargement. Clinical salivary gland biopsy and serologic examination rendered the diagnosis of SS for both patients. No systemic features of SS were noted. New evidence has pointed to the development of autoimmune inflammatory musculoskeletal diseases following CHIK fever, such as rheumatoid arthritis, spondylitis, and systemic lupus as a sequel of the infection. Nevertheless, SS has rarely been associated with CHIK and this association should be better evaluated.
ORAL SQUAMOUS CELL CARCINOMA AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: 2 CASES IN PATIENTS WITH FANCONI ANEMIA. FERNANDA GON¸CALVES SALUM, KAREN CHERUBINI, LILIANE SOARES YURGEL and, MARIA ANTONIA ZANCANARO DE FIGUEIREDO Fanconi anemia (FA) is an autosomal recessive disorder with the following important features: (1) progressive bone marrow failure and (2) development of malignancies. We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue. After biopsy, the diagnosis of squamous cell carcinoma was confirmed. The patient received chemotherapy and radiotherapy but died 4 months later. In the second case, a 26-year-old patient presented with an irregular white plaque on the border of the tongue. After histopathologic diagnosis confirmation, the carcinoma was surgically resected and the patient is under follow-up evaluation. Patients with FA have a high risk for oral cancer and their systematic follow-up is essential.
EPSTEIN-BARR POSITIVE ULCERS OF THE ORAL CAVITY ASSOCIATED WITH IMMUNOSUPPRESSION IN A PATIENT WITH CANCER. VANESSA TONETTO MARQUES, ADRIANO TADEU MARANGONI, ANA RAPHAELA DEZAN CURVO, LEANDRO DORIGAN DE MACEDO and, LARA MARIA ALENCAR RAMOS INNOCENTINI A 24-year-old man with synovial sarcoma was hospitalized for neutropenic fever after chemotherapy, complaining of
OOOO January 2020 gingival pain for 1 day. No lymph node involvement was detected during neck palpation. Intraoral exam revealed a purple lesion involving the attached gingiva on the maxilla and mandible, of increased size and with a detachable overlying white plaque. There was rapid evolution to ulcerated lesions, causing an inability to feed. We performed an incisional biopsy and referred the patient for anatomopathologic examination, polymerase chain reaction (PCR), and culture for fungi and bacteria, a prescription of chlorhexidine 0.12%, and empiric fluconazole and acyclovir. PCR was positive for Epstein-Barr virus (EBV) with 1095 copies, so the patient was maintained on acyclovir for 15 days. The patient had significant improvement in pain and the oral lesions regressed after this period. This case demonstrated that EBV commonly occurs in immunosuppressed patients and underscores the importance of dentists in the diagnosis and control of oral complications in the multiprofessional hospital team.
CENTRAL HEMANGIOMA OF THE ANTERIOR MANDIBLE WITH AGGRESSIVE CLINICAL APPEARANCE. MATEUS DUTRA SANTANA, GUSTAVO BARROSO MELLO ALVES, BRUNO COSTA FERREIRA, LEONEL PORTO DE CARVALHO, ALEXANDRE MAURITY DE PAULA AFONSO, BRUNO AUGUSTO BENEVENUTO DE e ANDRADE and, MARIO JOSE ROMANACH Central hemangioma (CH) of the jaws is a rare benign vascular neoplasm of variable radiographic appearance. A 32-yearold man was referred for evaluation of an ulcerated mass on the anterior mandible causing facial asymmetry for the last 6 months. The patient reported progressive growth and bleeding episodes. Intraoral examination revealed an erythematous and necrotic swelling in the lower anterior gingiva. Computerized tomography revealed a well-defined multilocular hypodense lesion involving the mandibular symphysis, containing hyperdense foci, with expansion and destruction of the buccal cortical bone, and teeth displacement and mobility. High blood content was detected during aspiration and surgical enucleation was performed after tumor embolization. Microscopically, large arterial blood vessels of variable sizes were observed, some of them containing intravascular concentric calcifications, confirming the diagnosis of CH. During a follow-up period of 6 months, the patient had no recurrence. CH of the jaws may show an aggressive clinical appearance, mimicking malignancy.
EMBRYONAL RHABDOMYOSARCOMA. JOSE FRANCISCO TORRES ANGUIANO, ISRAEL VIVANCO PEREZ, OSMAR ADAN CARCAMO IDIAQUEZ, DIEGO ACEVEDO CANTORAN, CARLOS MANUEL ROA ENCARNACION, ADOLFO NAVARRO ZARATE and, NANCY TRUJILLO GARCIA A 7-month-old female infant was sent to the clinic diagnosed by the oncology unit with embryonal rhabdomyosarcoma. The disease was detected at the time of her birth. She showed an increase in volume in the nasolabial region that was treated as a hemangioma without response to treatment. Diagnosis was established through a Tru-Cut (MeritMedical, South Jordan, UT) biopsy and it was confirmed with immunohistochemistry. The treatment was established with chemotherapy, then, she was sent to our clinical unit for assessment and surgical treatment. The contrasted tomography suggested tumor of the nasogenian
OOOO Volume 129, Number 1
ABSTRACTS
e23
region. Tumor resection was done. The results of the pathology report were, "Pleomorphic and poorly differentiated embryonal rhabdomyosarcoma, 4 cm in its largest diameter, necrosis and infiltration of surrounding soft tissue. Surgical limits in contact with tumor in various locations and osseous surgical limits without tumorous lesions." The patient continues to remain in stable condition and she is still receiving chemotherapy.
VARIABLE EXPRESSIVITY AND NOVEL PTEN GENE MUTATIONS IN COWDEN SYNDROME. RENATO ASSIS MACHADO, LIVIA MARIS RIBEIRO PARANAIBA, BRENO AMARAL ROCHA, GERALDO DE OLIVEIRA SILVA JUNIOR, THAYS TEIXEIRA DE SOUZA, FABIO RAMOA PIRES and, RICARDO DELLA COLETTA Cowden syndrome (CS) is a PTEN gene associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and 1 family with several individuals affected by CS. The isolated case showed typical features including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity and was caused by a novel nonsense mutation (c.940 G>T) in the PTEN gene. In the family, the proband showed erythema nodosum, duodenal ulcer, intestinal polyps, cervical lipoma, renal cysts, and glaucoma, whereas her family revealed multiple members with intestinal polyps and a sister with breast cancer diagnosed at early age. An intronic mutation was found (c.1026+32 T>G) in this family, with in silico analysis revealing the creation of a new donor splice site. This study confirms the involvement of the PTEN gene in CS and reinforces the variable clinical expressivity of disease.
NONCHARACTERIZED ODONTOGENIC LESION ENCOMPASSED BY PRIMORDIAL ODONTOGENIC TUMOR AND ADENOMATOID ODONTOGENIC HAMARTOMA. L.A.E.C. RAMIRO FRANKLIN BERNAL FARO, FRANKLIN BERNAL, VANIA ARIAS MENDEZ and, VANIA ARIAS-M. F We are reporting a clinical case of the complex histology of an oral sample from an 8-year-old girl. The histology analysis shares characteristics of a primordial odontogenic tumor (POT) and adenomatoid odontogenic hamartoma (AOH). The clinical evaluation reveals a left submandibular soreness and the presence of 1 cm in diameter radiolucent image in the region of the mandibular third molar with expanded and thin cortical bone. After enucleation, we obtained a white soft mass, showing on histology an ameloblastic epithelium and a stellate reticulum enveloping hypercellular myxoid connective tissue. On another field, the cells morphologically resembled odontoblasts; nevertheless the duct-like structures were absent. Some odontogenic tumors are lesions that are difficult to diagnose because of their histologic complexity and, in many of these cases, they are considered as unclassifiable hybrid or collision tumors. In summary, this rare and interesting case report should be characterized by a consensus of oral pathology experts.
ORAL PSEUDOLYMPHOMA: A DIAGNOS TIC CHALLENGE. TULIO MORANDIN BARROS DE OLIVEIRA, FERRISSE, ANALU LAIS DE BARROS PINTO GRIFONI,
HEITOR
ALBERGONI DA SILVEIRA, ANA THAIS BAGATINI, ANDREIA BUFALINO and, JORGE ESQUICHE LEON Pseudolymphoma (PL) is a benign reactive lymphoproliferative disease secondary to known or unknown stimuli mimicking a lymphomatous-appearing picture with potential misdiagnosis of overt lymphoma. A 64-year-old white man was referred for evaluation of ulceration on the left side of the buccal mucosa with 1 week of duration. The medical history revealed Alzheimer disease treated with donepezil and vildagliptin. Regional lymphadenopathy was absent and computerized tomography (CT) scans did not show alterations. An incisional biopsy was performed and microscopic analysis showed foci of angiocentric and perivascular lymphoid infiltrate containing atypical cells surrounded by fibrous stroma. Immunohistochemical analysis revealed positivity for CD3, CD4, CD25, and FOXP3. There was weak positivity for CD10 and BCL2. Almost all atypical cells were Ki-67 positive. Epstein-Barr virus-encoded RNA 1 and 2 (EBER1, EBER2) was negative. Complete blood counts and serology for herpes simplex virus 1 and 2 (HSV1, HSV2), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) were noncontributory. Four weeks after biopsy, the lesion disappeared, without treatment or modification or discontinuation of medications. A diagnosis of idiopathic PL was made.
DESMOPLASTIC AMELOBLASTOMA IN THE MAXILLA: A CASE REPORT. ANA CAROLINA LEMOS PIMENTEL, ANDREA LYRA, ALENA PEIXOTO MEDRADO, MIGUEL GUSTAVO SETUBAL, LIVIA PRATES SOARES ZERBINATI, JEAN NUNES DOS ^ SANTOS and, ANTONIO MARCIO TEIXEIRA MARCHIONNI Desmoplastic ameloblastoma is a rare variant with unknown biologic behavior. The purpose of this work is to report a case of a male patient, 17 years old, for whom the incisional biopsy was conclusive for desmoplastic ameloblastoma. Computed tomography and prototype were part of the surgical planning. Partial maxillectomy with a 0.5-cm margin was performed, involving 2.1 through 1.6 tooth, the border of the nasal cavity, and less them 3 mm below the infraorbital foramen. The maxillary structure was reconstructed with a 2.0 titanium system screen, to minimize communication between the mouth and maxillary sinus while maintaining the maxillary projection and the space to be reconstructed later. The tumor was send for histopathologic exam. The patient had a 1-year follow-up without recurrence, using a partial removable denture, to enable him to return to his daily routine.
THE USE OF PHOTOBIOMODULATION IN ORAL LESIONS IN A PATIENT WITH STEVENS-JOHNSON SYNDROME. HELENA DE CAMPOS ZINET, LETICIA RODRIGUES DE OLIVEIRA, AMANDA KIMURA LUCCHESI REIS, ISADORA DOURADO CARDOSO ALVES, MARCELO IVANDER ANDRADE WANDERLEY, MARIA PAULA SIQUEIRA DE MELO PERES and, JULIANA BERTOLDI FRANCO Stevens-Johnson syndrome (SJS) is a delayed-type hypersensitivity reaction that typically involves the skin and the mucous membranes with high morbidity and mortality rates. Photobiomodulation therapy (PBMT) stands out as an alternative treatment for SJS since it improves tissue repair and helps pain control. A female patient, 28 years of age, developed SJS after
e22
an effort to allow for early detection of the primary tumor and initiation of the appropriate therapy.
€ IS SJOGREN’S SYNDROME ANOTHER POSSIBLE AUTOIMMUNE COMPLICATION OF CHIKUNGUNYA FEVER?. LUIZ ALCINO MONTEIRO GUEIROS, ALESSANDRA CARVALHO, JAIR e CARNEIRO LEAO, AYSA PINHEIRO, PAULA TOCHE and, ANGELA DUARTE Chikungunya (CHIK) fever is a tropical arbovirosis characterized by sudden fever, headache, rash, and severe arthralgia. The disease has been suggested to act as a trigger for several autoimmune disorders, especially rheumatoid arthritis. This abstract reports 2 cases of Sj€ ogren syndrome (SS) following CHIK infection. Both patients were female and presented with fever, arthralgia, rash, and arthritis during CHIK outbreak in Recife, Brazil. After several months, they developed severe sicca symptoms and 1 of them presented with parotid enlargement. Clinical salivary gland biopsy and serologic examination rendered the diagnosis of SS for both patients. No systemic features of SS were noted. New evidence has pointed to the development of autoimmune inflammatory musculoskeletal diseases following CHIK fever, such as rheumatoid arthritis, spondylitis, and systemic lupus as a sequel of the infection. Nevertheless, SS has rarely been associated with CHIK and this association should be better evaluated.
ORAL SQUAMOUS CELL CARCINOMA AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: 2 CASES IN PATIENTS WITH FANCONI ANEMIA. FERNANDA GON¸CALVES SALUM, KAREN CHERUBINI, LILIANE SOARES YURGEL and, MARIA ANTONIA ZANCANARO DE FIGUEIREDO Fanconi anemia (FA) is an autosomal recessive disorder with the following important features: (1) progressive bone marrow failure and (2) development of malignancies. We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue. After biopsy, the diagnosis of squamous cell carcinoma was confirmed. The patient received chemotherapy and radiotherapy but died 4 months later. In the second case, a 26-year-old patient presented with an irregular white plaque on the border of the tongue. After histopathologic diagnosis confirmation, the carcinoma was surgically resected and the patient is under follow-up evaluation. Patients with FA have a high risk for oral cancer and their systematic follow-up is essential.
EPSTEIN-BARR POSITIVE ULCERS OF THE ORAL CAVITY ASSOCIATED WITH IMMUNOSUPPRESSION IN A PATIENT WITH CANCER. VANESSA TONETTO MARQUES, ADRIANO TADEU MARANGONI, ANA RAPHAELA DEZAN CURVO, LEANDRO DORIGAN DE MACEDO and, LARA MARIA ALENCAR RAMOS INNOCENTINI A 24-year-old man with synovial sarcoma was hospitalized for neutropenic fever after chemotherapy, complaining of
OOOO January 2020 gingival pain for 1 day. No lymph node involvement was detected during neck palpation. Intraoral exam revealed a purple lesion involving the attached gingiva on the maxilla and mandible, of increased size and with a detachable overlying white plaque. There was rapid evolution to ulcerated lesions, causing an inability to feed. We performed an incisional biopsy and referred the patient for anatomopathologic examination, polymerase chain reaction (PCR), and culture for fungi and bacteria, a prescription of chlorhexidine 0.12%, and empiric fluconazole and acyclovir. PCR was positive for Epstein-Barr virus (EBV) with 1095 copies, so the patient was maintained on acyclovir for 15 days. The patient had significant improvement in pain and the oral lesions regressed after this period. This case demonstrated that EBV commonly occurs in immunosuppressed patients and underscores the importance of dentists in the diagnosis and control of oral complications in the multiprofessional hospital team.
CENTRAL HEMANGIOMA OF THE ANTERIOR MANDIBLE WITH AGGRESSIVE CLINICAL APPEARANCE. MATEUS DUTRA SANTANA, GUSTAVO BARROSO MELLO ALVES, BRUNO COSTA FERREIRA, LEONEL PORTO DE CARVALHO, ALEXANDRE MAURITY DE PAULA AFONSO, BRUNO AUGUSTO BENEVENUTO DE e ANDRADE and, MARIO JOSE ROMANACH Central hemangioma (CH) of the jaws is a rare benign vascular neoplasm of variable radiographic appearance. A 32-yearold man was referred for evaluation of an ulcerated mass on the anterior mandible causing facial asymmetry for the last 6 months. The patient reported progressive growth and bleeding episodes. Intraoral examination revealed an erythematous and necrotic swelling in the lower anterior gingiva. Computerized tomography revealed a well-defined multilocular hypodense lesion involving the mandibular symphysis, containing hyperdense foci, with expansion and destruction of the buccal cortical bone, and teeth displacement and mobility. High blood content was detected during aspiration and surgical enucleation was performed after tumor embolization. Microscopically, large arterial blood vessels of variable sizes were observed, some of them containing intravascular concentric calcifications, confirming the diagnosis of CH. During a follow-up period of 6 months, the patient had no recurrence. CH of the jaws may show an aggressive clinical appearance, mimicking malignancy.
EMBRYONAL RHABDOMYOSARCOMA. JOSE FRANCISCO TORRES ANGUIANO, ISRAEL VIVANCO PEREZ, OSMAR ADAN CARCAMO IDIAQUEZ, DIEGO ACEVEDO CANTORAN, CARLOS MANUEL ROA ENCARNACION, ADOLFO NAVARRO ZARATE and, NANCY TRUJILLO GARCIA A 7-month-old female infant was sent to the clinic diagnosed by the oncology unit with embryonal rhabdomyosarcoma. The disease was detected at the time of her birth. She showed an increase in volume in the nasolabial region that was treated as a hemangioma without response to treatment. Diagnosis was established through a Tru-Cut (MeritMedical, South Jordan, UT) biopsy and it was confirmed with immunohistochemistry. The treatment was established with chemotherapy, then, she was sent to our clinical unit for assessment and surgical treatment. The contrasted tomography suggested tumor of the nasogenian
OOOO Volume 129, Number 1
ABSTRACTS
e23
region. Tumor resection was done. The results of the pathology report were, "Pleomorphic and poorly differentiated embryonal rhabdomyosarcoma, 4 cm in its largest diameter, necrosis and infiltration of surrounding soft tissue. Surgical limits in contact with tumor in various locations and osseous surgical limits without tumorous lesions." The patient continues to remain in stable condition and she is still receiving chemotherapy.
VARIABLE EXPRESSIVITY AND NOVEL PTEN GENE MUTATIONS IN COWDEN SYNDROME. RENATO ASSIS MACHADO, LIVIA MARIS RIBEIRO PARANAIBA, BRENO AMARAL ROCHA, GERALDO DE OLIVEIRA SILVA JUNIOR, THAYS TEIXEIRA DE SOUZA, FABIO RAMOA PIRES and, RICARDO DELLA COLETTA Cowden syndrome (CS) is a PTEN gene associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and 1 family with several individuals affected by CS. The isolated case showed typical features including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity and was caused by a novel nonsense mutation (c.940 G>T) in the PTEN gene. In the family, the proband showed erythema nodosum, duodenal ulcer, intestinal polyps, cervical lipoma, renal cysts, and glaucoma, whereas her family revealed multiple members with intestinal polyps and a sister with breast cancer diagnosed at early age. An intronic mutation was found (c.1026+32 T>G) in this family, with in silico analysis revealing the creation of a new donor splice site. This study confirms the involvement of the PTEN gene in CS and reinforces the variable clinical expressivity of disease.
NONCHARACTERIZED ODONTOGENIC LESION ENCOMPASSED BY PRIMORDIAL ODONTOGENIC TUMOR AND ADENOMATOID ODONTOGENIC HAMARTOMA. L.A.E.C. RAMIRO FRANKLIN BERNAL FARO, FRANKLIN BERNAL, VANIA ARIAS MENDEZ and, VANIA ARIAS-M. F We are reporting a clinical case of the complex histology of an oral sample from an 8-year-old girl. The histology analysis shares characteristics of a primordial odontogenic tumor (POT) and adenomatoid odontogenic hamartoma (AOH). The clinical evaluation reveals a left submandibular soreness and the presence of 1 cm in diameter radiolucent image in the region of the mandibular third molar with expanded and thin cortical bone. After enucleation, we obtained a white soft mass, showing on histology an ameloblastic epithelium and a stellate reticulum enveloping hypercellular myxoid connective tissue. On another field, the cells morphologically resembled odontoblasts; nevertheless the duct-like structures were absent. Some odontogenic tumors are lesions that are difficult to diagnose because of their histologic complexity and, in many of these cases, they are considered as unclassifiable hybrid or collision tumors. In summary, this rare and interesting case report should be characterized by a consensus of oral pathology experts.
ORAL PSEUDOLYMPHOMA: A DIAGNOS TIC CHALLENGE. TULIO MORANDIN BARROS DE OLIVEIRA, FERRISSE, ANALU LAIS DE BARROS PINTO GRIFONI,
HEITOR
ALBERGONI DA SILVEIRA, ANA THAIS BAGATINI, ANDREIA BUFALINO and, JORGE ESQUICHE LEON Pseudolymphoma (PL) is a benign reactive lymphoproliferative disease secondary to known or unknown stimuli mimicking a lymphomatous-appearing picture with potential misdiagnosis of overt lymphoma. A 64-year-old white man was referred for evaluation of ulceration on the left side of the buccal mucosa with 1 week of duration. The medical history revealed Alzheimer disease treated with donepezil and vildagliptin. Regional lymphadenopathy was absent and computerized tomography (CT) scans did not show alterations. An incisional biopsy was performed and microscopic analysis showed foci of angiocentric and perivascular lymphoid infiltrate containing atypical cells surrounded by fibrous stroma. Immunohistochemical analysis revealed positivity for CD3, CD4, CD25, and FOXP3. There was weak positivity for CD10 and BCL2. Almost all atypical cells were Ki-67 positive. Epstein-Barr virus-encoded RNA 1 and 2 (EBER1, EBER2) was negative. Complete blood counts and serology for herpes simplex virus 1 and 2 (HSV1, HSV2), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) were noncontributory. Four weeks after biopsy, the lesion disappeared, without treatment or modification or discontinuation of medications. A diagnosis of idiopathic PL was made.
DESMOPLASTIC AMELOBLASTOMA IN THE MAXILLA: A CASE REPORT. ANA CAROLINA LEMOS PIMENTEL, ANDREA LYRA, ALENA PEIXOTO MEDRADO, MIGUEL GUSTAVO SETUBAL, LIVIA PRATES SOARES ZERBINATI, JEAN NUNES DOS ^ SANTOS and, ANTONIO MARCIO TEIXEIRA MARCHIONNI Desmoplastic ameloblastoma is a rare variant with unknown biologic behavior. The purpose of this work is to report a case of a male patient, 17 years old, for whom the incisional biopsy was conclusive for desmoplastic ameloblastoma. Computed tomography and prototype were part of the surgical planning. Partial maxillectomy with a 0.5-cm margin was performed, involving 2.1 through 1.6 tooth, the border of the nasal cavity, and less them 3 mm below the infraorbital foramen. The maxillary structure was reconstructed with a 2.0 titanium system screen, to minimize communication between the mouth and maxillary sinus while maintaining the maxillary projection and the space to be reconstructed later. The tumor was send for histopathologic exam. The patient had a 1-year follow-up without recurrence, using a partial removable denture, to enable him to return to his daily routine.
THE USE OF PHOTOBIOMODULATION IN ORAL LESIONS IN A PATIENT WITH STEVENS-JOHNSON SYNDROME. HELENA DE CAMPOS ZINET, LETICIA RODRIGUES DE OLIVEIRA, AMANDA KIMURA LUCCHESI REIS, ISADORA DOURADO CARDOSO ALVES, MARCELO IVANDER ANDRADE WANDERLEY, MARIA PAULA SIQUEIRA DE MELO PERES and, JULIANA BERTOLDI FRANCO Stevens-Johnson syndrome (SJS) is a delayed-type hypersensitivity reaction that typically involves the skin and the mucous membranes with high morbidity and mortality rates. Photobiomodulation therapy (PBMT) stands out as an alternative treatment for SJS since it improves tissue repair and helps pain control. A female patient, 28 years of age, developed SJS after