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Increased sensitivity to oxidative stress in a creosote-adapted population of mummichog (Fundulus heteroclitus)
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Abstracts / Marine Environmental Research 50 (2000) 61±81
Increased sensitivity to oxidative stress in a creosote-adapted population of mummichog (Fundulus heteroclitus) J.N. Meyer, E.D. MacLean, R.T. Di Giulio Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
Abstract With increasing frequency, aquatic organisms inhabit regions where biochemical adaptations to contaminants are essential for survival. The resultant selection for individuals better adapted to a polluted environment may result in a population better able to survive certain stressors, but less ®t in terms of other stressors. Research with F1 ospring of the mummichog Fundulus heteroclitus collected from a highly creosote-contaminated site on the Elizabeth River has explored the nature of the resistance demonstrated by this population, as well as some of the costs associated with it. F1 larvae and juveniles from the Elizabeth River were more able to survive exposure to contaminated sediments from the Elizabeth River, either in the presence or absence of UV light, than were F1 ospring of control site (York River) Fundulus. On the other hand, the Elizabeth River F1 population was more susceptible to phototoxicity as mediated by pure anthracene or ¯uoranthene, indicating a possible cost of adaptation. Furthermore, preliminary studies suggest that Elizabeth River Fundulus are more sensitive to another source of oxidative stress, H2O2. Ongoing studies are exploring the biochemical and genetic bases of these dierences. PII: S0141-1136(00)00158-6
Interactive eects of CB 126 and benzo[a]pyrene on biotransformation enzymes, metabolites in bile and DNA adducts in the dab (Limanda limanda) A. van Schanke a, J.M. Everaarts a, J.P. Boon a, F.J. van Schooten b, M. van den Berg c a
Department of Marine Biogeochemistry and Toxicology, Netherlands Institute for Sea Research, PO Box 59, 1790 AB Den Burg Texel, The Netherlands b Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands c Research Institute of Toxicology, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
Abstracts / Marine Environmental Research 50 (2000) 61±81
Increased sensitivity to oxidative stress in a creosote-adapted population of mummichog (Fundulus heteroclitus) J.N. Meyer, E.D. MacLean, R.T. Di Giulio Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
Abstract With increasing frequency, aquatic organisms inhabit regions where biochemical adaptations to contaminants are essential for survival. The resultant selection for individuals better adapted to a polluted environment may result in a population better able to survive certain stressors, but less ®t in terms of other stressors. Research with F1 ospring of the mummichog Fundulus heteroclitus collected from a highly creosote-contaminated site on the Elizabeth River has explored the nature of the resistance demonstrated by this population, as well as some of the costs associated with it. F1 larvae and juveniles from the Elizabeth River were more able to survive exposure to contaminated sediments from the Elizabeth River, either in the presence or absence of UV light, than were F1 ospring of control site (York River) Fundulus. On the other hand, the Elizabeth River F1 population was more susceptible to phototoxicity as mediated by pure anthracene or ¯uoranthene, indicating a possible cost of adaptation. Furthermore, preliminary studies suggest that Elizabeth River Fundulus are more sensitive to another source of oxidative stress, H2O2. Ongoing studies are exploring the biochemical and genetic bases of these dierences. PII: S0141-1136(00)00158-6
Interactive eects of CB 126 and benzo[a]pyrene on biotransformation enzymes, metabolites in bile and DNA adducts in the dab (Limanda limanda) A. van Schanke a, J.M. Everaarts a, J.P. Boon a, F.J. van Schooten b, M. van den Berg c a
Department of Marine Biogeochemistry and Toxicology, Netherlands Institute for Sea Research, PO Box 59, 1790 AB Den Burg Texel, The Netherlands b Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands c Research Institute of Toxicology, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands