Mini-Oral Abstracts rapid in all groups (T50: 1.7 ± 0.7 vs. 1.2 ± 0.6 vs. 1.4 ± 5.0 min; water vs. fat vs. whey). Conclusion: In post-RYGB patients, consumption of whey protein, but not fat, prior to a meal attenuated post-prandial hyperglycaemia and slowed glucose absorption. These effects are not attributed to changes in PE, and are mediated solely through increased secretion of insulin and incretin hormones. Findings suggest that whey protein prior to a meal in RYGB patients may reduce long-term adverse effects of post-prandial hyperglycaemia. http://dx.doi.org/10.1016/j.orcp.2012.08.124 M122 This abstract has been withdrawn.
61 difference between the two diets. There was no significant change in expression of MAFbx/Atrogin-1. Conclusion: A 12 week HP diet compared to SP diet has more favourable outcomes on blood biochemical factors in sedentary overweight/obese women. PIK3CA may play an important role in maintaining lean muscle mass during moderate energy-restricted weight loss when consuming increased dietary protein and may influence the down-regulation of MuRF-1. http://dx.doi.org/10.1016/j.orcp.2012.08.126 M124 Is change in waist circumference associated with change in well-being during a health program? R. Freak-Poli 1,2,∗ , A. Peeters 1,2
http://dx.doi.org/10.1016/j.orcp.2012.08.125 M123 Skeletal Muscle Protein Synthesis and Degradation Following Energy Restricted Weight Loss C.M. McIver 1,∗ , P.M. Clifton 1,2 1 Commonwealth
Scientific and Industrial Research Organisation (CSIRO) Food and Nutritional Sciences, Adelaide, Australia 2 Baker IDI Heart and Diabetes Research Institute, Adelaide, Australia Aim: Excess body fat is a major risk factor for metabolic syndrome, cardiovascular disease and T2DM. During weight loss, the main treatment strategy for obesity, loss of lean muscle mass is frequently reported. In this study we aimed to determine the expression of genes involved in muscle protein synthesis and degradation following a moderate energy restricted weight loss dietary intervention in overweight/obese women. Method: Fourteen females (mean age 52 yrs, mean BMI 33 kg/m2 ) were randomised to a highprotein (HP) or standard-protein (SP), 12 week energy restricted diet. Body composition and blood lipid profiles were assessed. At baseline, week 2 and week 12 a skeletal muscle biopsy was collected for qRT-PCR analysis. Results: Both diets resulted in a mean weight loss of 7.54 (±2.73, HP) and 6.46 (±4.76, SP) kg, although there was no statistical difference between the diets. However, the HP diet had more favourable outcomes on blood biochemistry. PIK3CA showed significant differential gene expression between the two diets at both week 2 (P = 0.05) and week 12 (P = 0.01). MuRF1 was significantly down-regulated by weight loss, with no significant
1 Department of Epidemiology & Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, School of Public Health and Preventive Medicine, Monash University, Melbourne Australia 2 BakerIDI Heart and Diabetes Institute, Melbourne, Australia
Aim: To evaluate whether change in well-being is associated with change in waist circumference amongst participants in a four-month, pedometer, workplace health program. Method: 762 Adults employed in primarily sedentary occupations and voluntarily enrolled in a program aimed at increasing physical activity were recruited from ten Australian worksites in 2008. Data included independently measured waist circumference and self-administered WHO-Five Well-being Index (WHO-5) at baseline, four-months and twelve-month collection. Change and associations were assessed by multivariable linear and logistic regression analyses. Self-reported physical activity, average step count and other behavioural, anthropometric and biomedical measurements were controlled for in multivariable analyses. Results: Waist circumference (−1.6 cm, p = 0.002; 8.2% more meeting recommended guidelines, p < 0.001) and well-being (3.5 units, p < 0.001; 6.2% more with ‘positive’ scores, p < 0.001) improved immediately after completion of the health program. Baseline waist circumference was not associated with immediate change in well-being (p > 0.05). Eight-months after the completion of the program, the changes in waist circumference were not sustained, however, changes were in a beneficial direction (−0.5 cm, p = 0.1; 3.8%, p = 0.1). The changes in well-being were sustained at
62 eight-months post program (3.4 units, p < 0.001; 2.5%, p = 0.1). Baseline waist circumference was not associated with long-term change in wellbeing (p > 0.05). However, an improvement in waist circumference of 1 cm during the program was associated with a 0.25 units long-term improvement in well-being (p = 0.05). Conclusion: Baseline waist circumference was not associated with immediate or long-term change in well-being. However, immediate improvements in waist circumference appear to explain some of the long-term improvement in well-being associated with participation in the health program. http://dx.doi.org/10.1016/j.orcp.2012.08.127 M125 Can counter-advertising reduce parent’s susceptibility to nutrition content claims and sports celebrity endorsements on energy-dense, nutrient poor foods? Experimental research H. Dixon 1 , M. Scully 1,∗ , B. Kelly 2 , K. Chapman 3 , R. Donovan 4 , J. Martin 5 , L. Baur 6 , D. Crawford 7 , S. Maloney 1 , M. Wakefield 1 1 Centre for Behavioural Research in Cancer, Cancer
Council Victoria, Melbourne, Australia 2 Human Nutrition Unit, School of Molecular Bioscience, University of Sydney, Australia 3 Cancer Council New South Wales, Australia 4 Centre for Behavioural Research in Cancer Control, Faculty of Health Sciences, Curtin University, Perth, Australia 5 Obesity Policy Coalition, Melbourne, Australia 6 Discipline of Paediatrics & Child Health, University of Sydney, Australia 7 Centre for Physical Activity and Nutrition Research, Deakin University, Melbourne, Australia Aim: To test parent’s responses to counteradvertisements designed to correct misleading front-of-pack food promotions and empower consumers to more critically and accurately evaluate advertised foods. Method: 1269 Parents of children aged 5—12 years, who were the main grocery buyer for their household, participated in this web-based experiment. A between-subjects design was used with parents randomly shown a front-of pack promotion (nutrition content claim or sports celebrity endorsement) and an advertisement (counter-ad targeting their front-of-pack promotion or a nonfood related control ad). Parents were initially shown their assigned advertisement and required to complete a series of ratings assessing their reactions to that ad. They were then shown a pair of
Mini-Oral Abstracts food packages — an energy-dense and nutrient-poor (EDNP) product featuring their assigned front-ofpack promotion and a healthier product from the same product category. Parents were required to choose which product they would prefer to buy, which product they thought was healthier, and then complete ratings of the EDNP product. Results: Compared to parents who saw a control advertisement, parents who saw a counteradvertisement: perceived EDNP products featuring front-of-pack promotions to be less healthy; expressed a lower likelihood of buying such products; and were more likely to read the nutrition information panel on EDNP products before making their choices. Conclusion: Counter-advertising may be an effective strategy for minimising the negative influence of unhealthy food marketing and supporting healthier food choices among parents. Funding: This study was funded by the Bupa Health Foundation & Cancer Council Victoria. http://dx.doi.org/10.1016/j.orcp.2012.08.128 M126 The ‘Endgame’ for sugar sweetened beverages G. Sundborn 1,∗ , R. Jackson 1 , S. Merriman 2 , P. Metcalf 1
Thornley 1 , T.
1 Division
of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand 2 Department of Biochemistry, School of Medical Sciences, University of Otago, Dunedin, New Zealand Aim: This paper reviews the rationale to act specifically on SBs and on the evidence relating SBs to health identifying current initiatives aimed at reducing SB consumption both internationally and in New Zealand. Method: An in depth literature review was undertaken to gather international and New Zealand specific information that look specifically at the relationship between SBs and unhealthy weight, and initiatives that have been undertaken to address consumption of SBs. Results: Sugar-sweetened beverages (SBs) contribute to higher BMI, the obesity epidemic and many chronic illnesses, while providing no necessary nutrients. Consumption of SBs should therefore be minimised especially in children and youth. This paper proposes an ‘End Game’ to the consumption of SBs and offers recommendations on practical solutions to achieve a gradual reduction and eventual elimination of SBs from the New Zealand diet.