- Email: [email protected]
P161 NUTRITIONAL RISK FACTORS FOR BREAST CANCER: EXCESS BODY FAT AND SCARCE FUNCTIONAL NUTRIENT INTAKE
Nutrition and cancer 2 Results: The median follow-up was 12.5 months. We didn’t found any abdominal PRG site metastasis. Conclusion: In 270 pts with untreated HNCa and OesoCa, no abdominal wall metastasis occurred on PRG site. This result conduce us to advise this method instead of PEG in this population. References [1] I. Cruz, J-J. Mamel, P. Brady, M. Cass-garcia. Gastrointest Endosc 2005;62:708 11. [2] C. Joubert, M-P. Galais, E. Babin, K. Bouhier, T. Dao, M-A. Piquet. Nutrition Clinique et M´ etabolisme 2007; vol 21(suppl 2): S43 (abstract).
97 diet deficient in protective nutrients: e.g. phytoestrogens, fibre and n-3. Disclosure of Interest: All authors diclose any confict of interest.
P162 SURVEY ON NUTRITIONAL CARE IN PATIENTS WITH GRAFT-VERSUS-HOST DISEASE OF THE TRACTUS DIGESTIVUS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION IN THE NETHERLANDS B.S. van der Meij1 , N.J. Wierdsma1 , O.J. Visser2 , K. Duin1 , J.A.E. Langius1 . 1 Nutrition and Dietetics, 2 Hematology, VU University Medical Center, Amsterdam, Netherlands
Disclosure of Interest: None declared
P161 NUTRITIONAL RISK FACTORS FOR BREAST CANCER: EXCESS BODY FAT AND SCARCE FUNCTIONAL NUTRIENT INTAKE P. Amaral1 , R. Miguel1 , P. Ravasco1 , C. Cruz1 , I. Monteiro ˜o e Metabolismo, Grillo2 , M. Camilo1 . 1 Unidade Nutri¸ca Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 2 Radiotherapy Department, University Hospital of Santa Maria, Lisbon, Portugal Rationale: Obesity, excess body fat & adult weight gain, along with high saturated fat intake are acknowledged risk factors for breast cancer. Recent data suggested an inverse association between phytoestrogen intake & breast cancer incidence. This cross sectional study aimed to assess nutritional status, focusing on body fat, and to characterise the usual food intake in a cohort of breast cancer patients. Methods: During 2006, 71 consecutive women were evaluated: a SECA® floor scale+stadiometer was used to determine weight (kg)/height (m), BMI was calculated and categorized (WHO criteria); mid-arm circumference, triceps skinfold thickness & waist circumference were measured and used to calculate %body fat; food intake was estimated by a validated 1-year Food Frequency Questionnaire. Frequency analysis was used to evaluate prevalences; Mann Whitney U test assessed associations. Results: Mean age was 60±12 (36 90) yrs. Ductal invasive carcinoma was the most frequent (68%), p < 0.05. Most patients were in stage I (30%) or stage IIA (25%) of disease vs IIB (10%), IIIB (4%), IV (4%) or others (21%), p < 0.05. The majority of pts, 58 (82%) were overweight/obese, p < 0.001; 17 (24%) had a %body fat mass 30% & <35%, 46 (65%) had 35% of body fat vs only 8 (11%) with %body fat within normal range (p < 0.002). Moreover, 44 (62%) pts had a waist circumference higher then the maximum cut-off value of 88 cm and 43 (61%) pts had gained weight after diagnosis, p < 0.01. The dietary pattern indicated a low intake of vegetables and wholegrain cereals rich in complex carbohydrates (sources of fibre and phytoestrogens), and of fatty fish & nuts primary sources of n-3 PUFA’s. Conclusion: Our study firstly shows in the same cohort of breast cancer pts a vast prevalence & homogeneous pattern of overweight/obesity, excess body/abdominal fat & weight gain after diagnosis combined with a poor
Rationale: Graft-versus-Host Disease of the tractus digestivus (GvHD-TD) is seen in up to 30% of patients as a complication of allogeneic stem cell transplantation for haematological malignancies. Symptoms of GvHD-TD include diarrhoea (74%), abdominal cramps, nausea and vomiting. GvHD is frequently accompanied by malnutrition (43%). Studies on prevalence and quantification of malabsorption and vitamin deficiencies in GvHD-TD are lacking. The aim of this study was to investigate usual nutritional care for GvHD-TD patients in the Netherlands. Methods: We developed a standardized questionnaire on nutritional care and the use of diagnostic tests for malabsorption, for patients with GvHD-TD. Dutch experts, haematologists and dieticians, out of 10 specialized haematology transplantation centres were consulted. Results: Total response rate was 9 of 10 centres. A nutritional support protocol was present in 2 of the centres. In the chronic phase of GvHD-TD, enteral nutrition was advised in 8 of the 9 centres as a preferable nutritional therapy whereas in the acute stage enteral nutrition was advised in 5 centres. In acute GvHD fibres were omitted, or temporally no enteral nutrition was recommended in 2 centres. Vitamin supplementation as usual care was applied in 2 centres. Energetic needs was determined by Harris and Benedict formula in 8 centres, the other centre used indirect calorimetry on a regular base. Mean protein administration in all centres varied between 1 1.5 g/kg body weight. Qualitative or quantified stool analyses for malabsorption was performed in 2 centres. Conclusion: GvHD-TD requires intensive nutritional care. In the Netherlands, daily practice varies and no protocol concerning nutritional support has been implemented on a national level. This study has shown that it is necessary to develop nutritional guidelines for GvHD-TD patients and that more research is needed to support these. Disclosure of Interest: None declared
P163 A NOVEL APPROACH TO ASSESS BODY COMPOSITION CHANGE ASSOCIATED WITH PANCREATIC CANCER: USE OF DIAGNOSTIC CT SCANS B.H.L. Tan1 , L.A. Brown2 , K.C.H. Fearon1 , V.E. Baracos2 . 1 Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom; 2 Department of Oncology (Division of Palliative Care Medicine), University of Alberta, Edmonton, Canada Rationale: Nutritional depletion is common in patients with pancreatic cancer. CT imaging permits separation of
97 diet deficient in protective nutrients: e.g. phytoestrogens, fibre and n-3. Disclosure of Interest: All authors diclose any confict of interest.
P162 SURVEY ON NUTRITIONAL CARE IN PATIENTS WITH GRAFT-VERSUS-HOST DISEASE OF THE TRACTUS DIGESTIVUS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION IN THE NETHERLANDS B.S. van der Meij1 , N.J. Wierdsma1 , O.J. Visser2 , K. Duin1 , J.A.E. Langius1 . 1 Nutrition and Dietetics, 2 Hematology, VU University Medical Center, Amsterdam, Netherlands
Disclosure of Interest: None declared
P161 NUTRITIONAL RISK FACTORS FOR BREAST CANCER: EXCESS BODY FAT AND SCARCE FUNCTIONAL NUTRIENT INTAKE P. Amaral1 , R. Miguel1 , P. Ravasco1 , C. Cruz1 , I. Monteiro ˜o e Metabolismo, Grillo2 , M. Camilo1 . 1 Unidade Nutri¸ca Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 2 Radiotherapy Department, University Hospital of Santa Maria, Lisbon, Portugal Rationale: Obesity, excess body fat & adult weight gain, along with high saturated fat intake are acknowledged risk factors for breast cancer. Recent data suggested an inverse association between phytoestrogen intake & breast cancer incidence. This cross sectional study aimed to assess nutritional status, focusing on body fat, and to characterise the usual food intake in a cohort of breast cancer patients. Methods: During 2006, 71 consecutive women were evaluated: a SECA® floor scale+stadiometer was used to determine weight (kg)/height (m), BMI was calculated and categorized (WHO criteria); mid-arm circumference, triceps skinfold thickness & waist circumference were measured and used to calculate %body fat; food intake was estimated by a validated 1-year Food Frequency Questionnaire. Frequency analysis was used to evaluate prevalences; Mann Whitney U test assessed associations. Results: Mean age was 60±12 (36 90) yrs. Ductal invasive carcinoma was the most frequent (68%), p < 0.05. Most patients were in stage I (30%) or stage IIA (25%) of disease vs IIB (10%), IIIB (4%), IV (4%) or others (21%), p < 0.05. The majority of pts, 58 (82%) were overweight/obese, p < 0.001; 17 (24%) had a %body fat mass 30% & <35%, 46 (65%) had 35% of body fat vs only 8 (11%) with %body fat within normal range (p < 0.002). Moreover, 44 (62%) pts had a waist circumference higher then the maximum cut-off value of 88 cm and 43 (61%) pts had gained weight after diagnosis, p < 0.01. The dietary pattern indicated a low intake of vegetables and wholegrain cereals rich in complex carbohydrates (sources of fibre and phytoestrogens), and of fatty fish & nuts primary sources of n-3 PUFA’s. Conclusion: Our study firstly shows in the same cohort of breast cancer pts a vast prevalence & homogeneous pattern of overweight/obesity, excess body/abdominal fat & weight gain after diagnosis combined with a poor
Rationale: Graft-versus-Host Disease of the tractus digestivus (GvHD-TD) is seen in up to 30% of patients as a complication of allogeneic stem cell transplantation for haematological malignancies. Symptoms of GvHD-TD include diarrhoea (74%), abdominal cramps, nausea and vomiting. GvHD is frequently accompanied by malnutrition (43%). Studies on prevalence and quantification of malabsorption and vitamin deficiencies in GvHD-TD are lacking. The aim of this study was to investigate usual nutritional care for GvHD-TD patients in the Netherlands. Methods: We developed a standardized questionnaire on nutritional care and the use of diagnostic tests for malabsorption, for patients with GvHD-TD. Dutch experts, haematologists and dieticians, out of 10 specialized haematology transplantation centres were consulted. Results: Total response rate was 9 of 10 centres. A nutritional support protocol was present in 2 of the centres. In the chronic phase of GvHD-TD, enteral nutrition was advised in 8 of the 9 centres as a preferable nutritional therapy whereas in the acute stage enteral nutrition was advised in 5 centres. In acute GvHD fibres were omitted, or temporally no enteral nutrition was recommended in 2 centres. Vitamin supplementation as usual care was applied in 2 centres. Energetic needs was determined by Harris and Benedict formula in 8 centres, the other centre used indirect calorimetry on a regular base. Mean protein administration in all centres varied between 1 1.5 g/kg body weight. Qualitative or quantified stool analyses for malabsorption was performed in 2 centres. Conclusion: GvHD-TD requires intensive nutritional care. In the Netherlands, daily practice varies and no protocol concerning nutritional support has been implemented on a national level. This study has shown that it is necessary to develop nutritional guidelines for GvHD-TD patients and that more research is needed to support these. Disclosure of Interest: None declared
P163 A NOVEL APPROACH TO ASSESS BODY COMPOSITION CHANGE ASSOCIATED WITH PANCREATIC CANCER: USE OF DIAGNOSTIC CT SCANS B.H.L. Tan1 , L.A. Brown2 , K.C.H. Fearon1 , V.E. Baracos2 . 1 Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom; 2 Department of Oncology (Division of Palliative Care Medicine), University of Alberta, Edmonton, Canada Rationale: Nutritional depletion is common in patients with pancreatic cancer. CT imaging permits separation of