Peer review report 1 on “Complications after Pancreaticoduodenectomy are Associated with higher Amounts of Intra- and Postoperative Fluid Therapy: A single Centre Retrospective Cohort Study”

Peer review report 1 on “Complications after Pancreaticoduodenectomy are Associated with higher Amounts of Intra- and Postoperative Fluid Therapy: A single Centre Retrospective Cohort Study”

Annals of Medicine and Surgery 13 Supplement 1 (2017) S105 Contents lists available at ScienceDirect Annals of Medicine and Surgery journal homepage...

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Annals of Medicine and Surgery 13 Supplement 1 (2017) S105

Contents lists available at ScienceDirect

Annals of Medicine and Surgery journal homepage: www.annalsjournal.com

Peer Review Report

Peer review report 1 on “Complications after Pancreaticoduodenectomy are Associated with higher Amounts of Intra- and Postoperative Fluid Therapy: A single Centre Retrospective Cohort Study”

[H1]Original Submission [H2]Recommendation Minor Revision.

[H2]Comments to the author This is a very nice retrospective analysis of a high number of pancreatic head resections. This study shows, that fluid administration can be linked to the incidence of complications. This study does add new information to the available literature and should therefore be published.

DOI of published article: http://dx.doi.org/10.1016/j.amsu.2017.02.042. http://dx.doi.org/10.1016/j.amsu.2017.03.002 2049-0801

However, there are a few things that need correction and clarification before publishing: On page 6 the authors talk about “borderline significant” results. There is only significance or not, and borderline significant is not a scientific analysis. The author could say, that there is a trend towards significance, however, this p-value, unfortunately, does not prove significance. Therefore this description should be deleted. On page 14, table 2, there are two different abbrecviations of red blood cell products. Please use only one - or describe the difference in the legend. One last question about tables 3 and 4: Please add the distribution of ASA status into both tables. Is there a correlation between sicker patients and complications? Anonymous reviewer.