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Sclerotherapy With 5% Ethanolamine Oleate in Oral Benign Vascular Lesions
ORAL AND MAXILLOFACIAL PATHOLOGY e222 Abstracts This study defined the impact of oral mucositis (OM) on outcomes in patients with multiple myeloma (MM) after autologous transplant who were receiving low-level laser therapy (LLLT). Methods: A total of 79 patients with MM were evaluated retrospectively. We examined the relationship between the worst OM grade and clinical outcomes. Results: Of 79 patients, 55 experienced OM grade 0-1, 16 OM grade 2, 7 grade 3, and 1 grade 4. Patients with OM grade 0-2 had statistically fewer days of oral pain compared with those with grade 3-4 (0.88 and 6.25 days, respectively). The worst OM grade was also significantly associated with days of narcotic therapy and length of LLLT. Severe OM was associated with worse clinical outcomes. Conclusion: In this transplantation setting, severe OM was not as common as previously reported in literature, probably due to LLLT. Controlled randomized trials should be performed to confirm the real benefit of LLLT.
PE-458 - RETROSPECTIVE ANALYSIS OF THE ORAL MUCOSA AND JAW LESIONS IN A SERVICE REFERRAL FOR ORAL PATHOLOGY. LAIZ FERNANDES MENDES NUNES, CAMILA DE NAZARÉ ALVES DE OLIVEIRA, ELITON BOTELHO DOS SANTOS, RICARDO SANTIAGO GOMEZ, RICARDO ALVES MESQUITA. FACULDADE DE ODONTOLOGIAeUFMG. This study describes the frequency of the oral lesions diagnosed in a service referral in oral pathology. Study Design: Charts of patients admitted for diagnosis in the Oral Pathology Clinic, School of Dentistry, Universidade Federal de Minas Gerais, Brazil, were evaluated. A total of 7295 records were analyzed for the following variables: age, gender, race, and diagnosis. The period was from 1990 to 2011. Results: Women (61.96%) and Caucasians (32.83%) predominated. Oral lesions were more prevalent in the fourth and fifth decades. Inflammatory fibrous hyperplasia (IFH) was the most frequent lesion (11.00%), followed by candidiasis (5.85%), mucocele (3.59%), and leukoplakia (2.76%). Conclusion: IFH was the most common oral lesion in this sample of the Brazilian population. CNPq #309209/20102; 472045/2011-3, FAPEMIG.
PE-459 - RETROSPECTIVE CLINICOPATHOLOGICAL ANALYSIS OF 172 CASES OF MINOR ORAL SALIVARY GLAND TUMORS IN A BRAZILIAN POPULATION. ALINE CORREA ABRAHAO, JULIANA DE NORONHA SANTOS NETTO, FÁBIO RAMÔA PIRES, MÁRCIA GRILLO CABRAL. FEDERAL UNIVERSITY OF RIO DE JANEIRO. Oral minor salivary gland tumors are uncommon lesions. This study determined the distribution and demographic features of oral minor salivary gland tumors (OMSGTs) in a Rio de Janeiro population. Methods: Clinicopathological features of 172 cases of OMSGTs diagnosed between 1942 and 2012 were taken from the files of two oral pathology services and reviewed. Results: Eighty-eight tumors were benign and 84 were malignant. Mean patient age was 51 years, and most of the patients were females. The palate was the most common location (56.4%). Pleomorphic adenoma (PA) (44%), mucoepidermoid carcinoma (MEC) (13%), and polymorphous low-grade adenocarcinoma (PLGA) (13%) were the most frequent neoplasms. Conclusion: The present data confirm PA, MEC, and PLGA as the most common OMSGTs. Epidemiological data of OMSGTs in specific populations can be of great interest for a better understanding of its biology and clinicopathological features.
OOOO February 2014 PE-460 - RISK OF NONSYNDROMIC CLEFT LIP AND PALATE IN RELATIVES OF WOMEN WITH BREAST CANCER. DANIELLA REIS BARBOSA MARTELLI, ALEXANDRE RESENDE VIEIRA, ALINE TAVARES FONSECA, RICARDO DELLA COLETTA, LÍVIA MARIS PARANAÍBA, PRISCILA MIRANDA SOARES, HERCÍLIO MARTELLI JÚNIOR. STATE UNIVERSTY OF MONTES CLAROS - MINAS GERAISeBRASIL. Nonsyndromic cleft lip and/or cleft palate (NSCL/P, OMIM119530) is the most common craniofacial birth defect. Epidemiological studies have assessed the relationship between cancer and NSCL/P. This study determined the frequency of NSCL/P in families of women with breast cancer (BC). Five hundred thirty-eight women (246 with BC and 292 without BC) were evaluated. Women from both groups completed a questionnaire concerning their family history of NSCL/P in first-degree relatives. We used chi-square and Fisher’s exact tests to determine statistically significant differences between both groups of women (a ¼ 0.05). From the 246 women with BC, two had a positive history of NSCL/P; in the control group, two women had a history of NSCL/P (chi-square with 1 degree of freedom, p ¼ 0.86; Fisher’s test, p ¼ 0.37). Thus the frequency of NSCL/P was not significantly increased in the first-degree relatives of women with BC. Acknowledgment: FAPEMIG.
PE-461 - SCHWARTZ-JAMPEL SYNDROME: CASE REPORT. DANIEL MIRANDA DE PAULA, ANNE MARIA GUIMARÃES LESSA, TAIANE DE OLIVEIRA GONZAGA SANTOS, VIVIANE ALMEIDA SARMENTO, PATRÍCIA LEITE RIBEIRO LAMBERTI, LILIANE ELZE FALCÃO KUSTERER, ANTÔNIO FERNANDO PEREIRA FALCÃO. UNIVERSIDADE FEDERAL DA BAHIA. Schwartz-Jampel syndrome is an autosomal recessive disorder characterized by short stature, skeletal dysplasias, myotonia, short palpebral fissures, hypertelorism, blepharospasms, micrognathia, retrognathia, palate atresia, facial muscle hypertrophy, growth retardation and delayed bone maturation, inclusion, and dental crowding. The types are defined by age at symptom onset as either classically diagnosed in childhood or the severe neonatal form. The diagnosis is based on clinical, dysmorphic, or electromyographic aspects. A literature review and clinical case report highlight clinical features related to dentistry. Young woman, 18, complained that she needed extractions and braces. According to the mother’s report she was diagnosed at age 3 years. Extraoral physical examination revealed short stature, maxillary micrognathia, pursed lips, and restricted facial movements. Intraoral examination and radiographs found crowding. The patient was referred to the surgeon and orthodontist to perform extractions and braces. She is currently being monitored orthodontically.
PE-462 - SCLEROTHERAPY WITH 5% ETHANOLAMINE OLEATE IN ORAL BENIGN VASCULAR LESIONS. MICHEL CAMPOS RIBEIRO, SORAYA DE MATTOS CAMARGO GROSSMANN, MARCIO BRUNO FIGUEIREDO DO AMARAL, RICARDO ALVES DE MESQUITA. FACULDADE DE ODONTOLOGIA DA UFMG. Oral benign vascular lesions (BVLs) such as hemangiomas, malformations, and varicose veins have different treatments.
OOOO Volume 117, Number 2 Oleate monoethanolamine offers effective and safe treatment. This study shows the results of treatment of BVLs with sclerotherapy using 5% ethanolamine oleate. The records of patients treated at School of Dentistry of UFMG for BVL were reviewed retrospectively, noting resolution, postoperative complications, and degree of satisfaction with treatment. The sample consisted of 15 patients (19 BVLs), 7 (46.7%) men and 8 (53.3%) women, with a mean age of 62.3 years. Resolution of lesions was observed an average of 14 days after initiation of treatment. There were no reported postoperative complications, and patients’ level of satisfaction was above 8 on a visual analog scale. Our results suggest that sclerotherapy with 5% ethanolamine oleate can be an effective treatment for BVL. CNPq #309209/2010-2; 472045/2011-3, FAPEMIG.
PE-463 - SCROFULA: A PUBLIC HEALTH PROBLEM. ANNA TEREZA OLIVEIRA GÓES SIQUEIRA CAMPOS LIMA, JOÃO DE JESUS VIANA PINHEIRO, ANDRÉ LUIS RIBEIRO RIBEIRO, SERGIO DE MELO ALVES JUNIOR. UNIVERSIDADE FEDERAL DO PARÁ. Tuberculosis (TB) is a contagious infectious disease, common in developing countries, where the health strategies are low and weak. Therefore special care is needed on the part of health professionals and the population because there is no predictable way to eradicate TB. Usually its manifestation is pulmonary, but in a few cases it can be extrapulmonary, as in skeletal, urogenital, and lymph node tuberculosis. Brazilian young woman, 18, came to the CESUPA’s pathology department complaining of pain and swelling of the left submandibular cervical region. The standard submandibular incision was used to excise the enlarged lymph node and specimens were sent for histological evaluation and culture. Tissue cultures were positive for Mycobacterium tuberculosis. Final histological results revealed necrotizing, granulomatous, and multinucleated giant cells. The diagnosis was based on the lymph node histological culture, permitting appropriate treatment.
PE-464 - SEVERE SECONDARY HYPERPARATHYROIDISM AND PANORAMIC RADIOGRAPHY PARAMETERS. JOÃO CÉSAR GUIMARÃES HENRIQUES, REINHILDE JACOBS, RAFAELA RANGEL ROSA, SÉRGIO VITORINO CARDOSO, CAIO VINÍCIUS BARDI MATAI, JULIO CEZAR DE MELO CASTILHO. UNIVERSIDADE FEDERAL DE UBERLÂNDIA. This study evaluated the effects of renal osteodystrophy (RO) using panoramic radiography parameters. Materials and Methods: Qualitative (mandibular cortical index/trabecular bone pattern) and quantitative (mental index/calcification and resorption foci) parameters were applied from panoramic radiographs of chronic kidney disease (CKD) patients and controls. Results: Qualitative parameters demonstrated significant differences compared to the control group. The mean mental index was lower in patients with CKD, but the difference was not significant. Parathyroid hormone levels correlated with mental index, mandibular cortical index, and trabecular bone pattern. The mental index, mandibular cortical index, and trabecular bone pattern are good parameters for evaluating the effects of renal osteodystrophy. Conclusion: Renal osteodystrophy presented sufficient characteristics that could be identified by panoramic radiographic parameters.
ABSTRACTS Abstracts e223 PE-465 - SHOULD PERICORONAL FOLLICLES ASSOCIATED WITH MANDIBULAR THIRD MOLARS ROUTINELY BE SENT FOR HISTOPATHOLOGICAL ANALYSIS? A PROSPECTIVE STUDY AND SYSTEMATIC REVIEW OF THE LITERATURE. THALES SALLES ANGELIM VIANA, GALYLÉIA MENESES CAVALCANTE, PAULO GOBERLÂNIO BARROS SILVA, ROBERTA BARROSO CAVALCANTE, ALEXANDRE SIMÕES NOGUEIRA, KARUZA MARIA ALVES PEREIRA, FÁBIO WILDSON GURGEL COSTA. UNIVERSIDADE FEDERAL DO CEARÁ. Pathological changes associated with third molar follicles have been used to justify prophylactic tooth removal. This study investigated the pathological alterations related to mandibular third molar dental follicles. A prospective study was conducted with 120 patients. Patients were divided into two groups: G1 (presence of lesion) and G2 (absence of lesion). A systematic review of the literature was also performed. A total of 113 surgical specimens were analyzed. G1 was the most prevalent finding (p ¼ 0.0004). Lesions were found in patients between ages 20 and 25 years (p < 0.004). The most prevalent histological diagnosis was paradental cyst (47.7%; p < 0.0001). The systematic review of the literature showed that the majority of cases occur in patients under age 25 years and are mainly dentigerous cysts (p < 0.05). According to this study, prophylactic removal of mandibular third molars is suggested, in addition to routinely sending pericoronal follicles for histopathological analysis.
PE-466 - SPLUNC2A EXPRESSION IN PATIENTS HAVING AUTOLOGOUS BONE MARROW TRANSPLANTATION. LARA MARIA ALENCAR RAMOS, WILFREDO ALEJANDRO GONZÁLEZ-ARRIAGADA, ANDRÉIA APARECIDA DA SILVA, MARIA ELVIRA PIZZIGATTI CORREA, LYNNE BINGLE, PABLO AGUSTIN VARGAS, MARCIO AJUDARTE LOPES. PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS, UNICAMP, SÃO PAULO, BRAZIL. This study analyzed SPLUNC2A expression in patients who underwent high-dose chemotherapy for autologous hematopoietic stem cell transplantation (AHSCT). Materials and Methods: A study was performed with 14 AHPCT patients (mean age 45 years). Unstimulated saliva was collected for 5 min before the transplant, as well as 7 (D+7) and 21 (D+21) after. SPLUNC2A expression was analyzed by Western blotting. Data were analyzed statistically (ANOVA, T test, p < 0.05). Results: Densitometry of protein bands showed a higher level of SPLUN2A after transplant, measuring 0.54 0.22 compared to 0.44 0.35 before the transplant (p ¼ 0.58). In addition, salivary flow rate decreased after AHSCT, measuring 0.40 0.33 compared with 0.47 0.31 before the AHSCT (p ¼ 0.55). Conclusion: The present study, despite the small sample, describes recent findings showing that patients who undergo AHSCT may have changes in SPLUNC2A expression and in salivary flow rate.
PE-467 - IMMUNE CELLS IN DIFFERENT CLINICAL PRESENTATIONS OF DENTURE STOMATITIS. KAREN HENRIETTE PINKE, PATRÍCIA FREITAS-FARIA, THAÍS HELENA GASPAROTO, ALINE CARVALHO BATISTA, TAIANE PRISCILA GARDIZANI, VANESSA SOARES LARA. BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO.
PE-458 - RETROSPECTIVE ANALYSIS OF THE ORAL MUCOSA AND JAW LESIONS IN A SERVICE REFERRAL FOR ORAL PATHOLOGY. LAIZ FERNANDES MENDES NUNES, CAMILA DE NAZARÉ ALVES DE OLIVEIRA, ELITON BOTELHO DOS SANTOS, RICARDO SANTIAGO GOMEZ, RICARDO ALVES MESQUITA. FACULDADE DE ODONTOLOGIAeUFMG. This study describes the frequency of the oral lesions diagnosed in a service referral in oral pathology. Study Design: Charts of patients admitted for diagnosis in the Oral Pathology Clinic, School of Dentistry, Universidade Federal de Minas Gerais, Brazil, were evaluated. A total of 7295 records were analyzed for the following variables: age, gender, race, and diagnosis. The period was from 1990 to 2011. Results: Women (61.96%) and Caucasians (32.83%) predominated. Oral lesions were more prevalent in the fourth and fifth decades. Inflammatory fibrous hyperplasia (IFH) was the most frequent lesion (11.00%), followed by candidiasis (5.85%), mucocele (3.59%), and leukoplakia (2.76%). Conclusion: IFH was the most common oral lesion in this sample of the Brazilian population. CNPq #309209/20102; 472045/2011-3, FAPEMIG.
PE-459 - RETROSPECTIVE CLINICOPATHOLOGICAL ANALYSIS OF 172 CASES OF MINOR ORAL SALIVARY GLAND TUMORS IN A BRAZILIAN POPULATION. ALINE CORREA ABRAHAO, JULIANA DE NORONHA SANTOS NETTO, FÁBIO RAMÔA PIRES, MÁRCIA GRILLO CABRAL. FEDERAL UNIVERSITY OF RIO DE JANEIRO. Oral minor salivary gland tumors are uncommon lesions. This study determined the distribution and demographic features of oral minor salivary gland tumors (OMSGTs) in a Rio de Janeiro population. Methods: Clinicopathological features of 172 cases of OMSGTs diagnosed between 1942 and 2012 were taken from the files of two oral pathology services and reviewed. Results: Eighty-eight tumors were benign and 84 were malignant. Mean patient age was 51 years, and most of the patients were females. The palate was the most common location (56.4%). Pleomorphic adenoma (PA) (44%), mucoepidermoid carcinoma (MEC) (13%), and polymorphous low-grade adenocarcinoma (PLGA) (13%) were the most frequent neoplasms. Conclusion: The present data confirm PA, MEC, and PLGA as the most common OMSGTs. Epidemiological data of OMSGTs in specific populations can be of great interest for a better understanding of its biology and clinicopathological features.
OOOO February 2014 PE-460 - RISK OF NONSYNDROMIC CLEFT LIP AND PALATE IN RELATIVES OF WOMEN WITH BREAST CANCER. DANIELLA REIS BARBOSA MARTELLI, ALEXANDRE RESENDE VIEIRA, ALINE TAVARES FONSECA, RICARDO DELLA COLETTA, LÍVIA MARIS PARANAÍBA, PRISCILA MIRANDA SOARES, HERCÍLIO MARTELLI JÚNIOR. STATE UNIVERSTY OF MONTES CLAROS - MINAS GERAISeBRASIL. Nonsyndromic cleft lip and/or cleft palate (NSCL/P, OMIM119530) is the most common craniofacial birth defect. Epidemiological studies have assessed the relationship between cancer and NSCL/P. This study determined the frequency of NSCL/P in families of women with breast cancer (BC). Five hundred thirty-eight women (246 with BC and 292 without BC) were evaluated. Women from both groups completed a questionnaire concerning their family history of NSCL/P in first-degree relatives. We used chi-square and Fisher’s exact tests to determine statistically significant differences between both groups of women (a ¼ 0.05). From the 246 women with BC, two had a positive history of NSCL/P; in the control group, two women had a history of NSCL/P (chi-square with 1 degree of freedom, p ¼ 0.86; Fisher’s test, p ¼ 0.37). Thus the frequency of NSCL/P was not significantly increased in the first-degree relatives of women with BC. Acknowledgment: FAPEMIG.
PE-461 - SCHWARTZ-JAMPEL SYNDROME: CASE REPORT. DANIEL MIRANDA DE PAULA, ANNE MARIA GUIMARÃES LESSA, TAIANE DE OLIVEIRA GONZAGA SANTOS, VIVIANE ALMEIDA SARMENTO, PATRÍCIA LEITE RIBEIRO LAMBERTI, LILIANE ELZE FALCÃO KUSTERER, ANTÔNIO FERNANDO PEREIRA FALCÃO. UNIVERSIDADE FEDERAL DA BAHIA. Schwartz-Jampel syndrome is an autosomal recessive disorder characterized by short stature, skeletal dysplasias, myotonia, short palpebral fissures, hypertelorism, blepharospasms, micrognathia, retrognathia, palate atresia, facial muscle hypertrophy, growth retardation and delayed bone maturation, inclusion, and dental crowding. The types are defined by age at symptom onset as either classically diagnosed in childhood or the severe neonatal form. The diagnosis is based on clinical, dysmorphic, or electromyographic aspects. A literature review and clinical case report highlight clinical features related to dentistry. Young woman, 18, complained that she needed extractions and braces. According to the mother’s report she was diagnosed at age 3 years. Extraoral physical examination revealed short stature, maxillary micrognathia, pursed lips, and restricted facial movements. Intraoral examination and radiographs found crowding. The patient was referred to the surgeon and orthodontist to perform extractions and braces. She is currently being monitored orthodontically.
PE-462 - SCLEROTHERAPY WITH 5% ETHANOLAMINE OLEATE IN ORAL BENIGN VASCULAR LESIONS. MICHEL CAMPOS RIBEIRO, SORAYA DE MATTOS CAMARGO GROSSMANN, MARCIO BRUNO FIGUEIREDO DO AMARAL, RICARDO ALVES DE MESQUITA. FACULDADE DE ODONTOLOGIA DA UFMG. Oral benign vascular lesions (BVLs) such as hemangiomas, malformations, and varicose veins have different treatments.
OOOO Volume 117, Number 2 Oleate monoethanolamine offers effective and safe treatment. This study shows the results of treatment of BVLs with sclerotherapy using 5% ethanolamine oleate. The records of patients treated at School of Dentistry of UFMG for BVL were reviewed retrospectively, noting resolution, postoperative complications, and degree of satisfaction with treatment. The sample consisted of 15 patients (19 BVLs), 7 (46.7%) men and 8 (53.3%) women, with a mean age of 62.3 years. Resolution of lesions was observed an average of 14 days after initiation of treatment. There were no reported postoperative complications, and patients’ level of satisfaction was above 8 on a visual analog scale. Our results suggest that sclerotherapy with 5% ethanolamine oleate can be an effective treatment for BVL. CNPq #309209/2010-2; 472045/2011-3, FAPEMIG.
PE-463 - SCROFULA: A PUBLIC HEALTH PROBLEM. ANNA TEREZA OLIVEIRA GÓES SIQUEIRA CAMPOS LIMA, JOÃO DE JESUS VIANA PINHEIRO, ANDRÉ LUIS RIBEIRO RIBEIRO, SERGIO DE MELO ALVES JUNIOR. UNIVERSIDADE FEDERAL DO PARÁ. Tuberculosis (TB) is a contagious infectious disease, common in developing countries, where the health strategies are low and weak. Therefore special care is needed on the part of health professionals and the population because there is no predictable way to eradicate TB. Usually its manifestation is pulmonary, but in a few cases it can be extrapulmonary, as in skeletal, urogenital, and lymph node tuberculosis. Brazilian young woman, 18, came to the CESUPA’s pathology department complaining of pain and swelling of the left submandibular cervical region. The standard submandibular incision was used to excise the enlarged lymph node and specimens were sent for histological evaluation and culture. Tissue cultures were positive for Mycobacterium tuberculosis. Final histological results revealed necrotizing, granulomatous, and multinucleated giant cells. The diagnosis was based on the lymph node histological culture, permitting appropriate treatment.
PE-464 - SEVERE SECONDARY HYPERPARATHYROIDISM AND PANORAMIC RADIOGRAPHY PARAMETERS. JOÃO CÉSAR GUIMARÃES HENRIQUES, REINHILDE JACOBS, RAFAELA RANGEL ROSA, SÉRGIO VITORINO CARDOSO, CAIO VINÍCIUS BARDI MATAI, JULIO CEZAR DE MELO CASTILHO. UNIVERSIDADE FEDERAL DE UBERLÂNDIA. This study evaluated the effects of renal osteodystrophy (RO) using panoramic radiography parameters. Materials and Methods: Qualitative (mandibular cortical index/trabecular bone pattern) and quantitative (mental index/calcification and resorption foci) parameters were applied from panoramic radiographs of chronic kidney disease (CKD) patients and controls. Results: Qualitative parameters demonstrated significant differences compared to the control group. The mean mental index was lower in patients with CKD, but the difference was not significant. Parathyroid hormone levels correlated with mental index, mandibular cortical index, and trabecular bone pattern. The mental index, mandibular cortical index, and trabecular bone pattern are good parameters for evaluating the effects of renal osteodystrophy. Conclusion: Renal osteodystrophy presented sufficient characteristics that could be identified by panoramic radiographic parameters.
ABSTRACTS Abstracts e223 PE-465 - SHOULD PERICORONAL FOLLICLES ASSOCIATED WITH MANDIBULAR THIRD MOLARS ROUTINELY BE SENT FOR HISTOPATHOLOGICAL ANALYSIS? A PROSPECTIVE STUDY AND SYSTEMATIC REVIEW OF THE LITERATURE. THALES SALLES ANGELIM VIANA, GALYLÉIA MENESES CAVALCANTE, PAULO GOBERLÂNIO BARROS SILVA, ROBERTA BARROSO CAVALCANTE, ALEXANDRE SIMÕES NOGUEIRA, KARUZA MARIA ALVES PEREIRA, FÁBIO WILDSON GURGEL COSTA. UNIVERSIDADE FEDERAL DO CEARÁ. Pathological changes associated with third molar follicles have been used to justify prophylactic tooth removal. This study investigated the pathological alterations related to mandibular third molar dental follicles. A prospective study was conducted with 120 patients. Patients were divided into two groups: G1 (presence of lesion) and G2 (absence of lesion). A systematic review of the literature was also performed. A total of 113 surgical specimens were analyzed. G1 was the most prevalent finding (p ¼ 0.0004). Lesions were found in patients between ages 20 and 25 years (p < 0.004). The most prevalent histological diagnosis was paradental cyst (47.7%; p < 0.0001). The systematic review of the literature showed that the majority of cases occur in patients under age 25 years and are mainly dentigerous cysts (p < 0.05). According to this study, prophylactic removal of mandibular third molars is suggested, in addition to routinely sending pericoronal follicles for histopathological analysis.
PE-466 - SPLUNC2A EXPRESSION IN PATIENTS HAVING AUTOLOGOUS BONE MARROW TRANSPLANTATION. LARA MARIA ALENCAR RAMOS, WILFREDO ALEJANDRO GONZÁLEZ-ARRIAGADA, ANDRÉIA APARECIDA DA SILVA, MARIA ELVIRA PIZZIGATTI CORREA, LYNNE BINGLE, PABLO AGUSTIN VARGAS, MARCIO AJUDARTE LOPES. PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS, UNICAMP, SÃO PAULO, BRAZIL. This study analyzed SPLUNC2A expression in patients who underwent high-dose chemotherapy for autologous hematopoietic stem cell transplantation (AHSCT). Materials and Methods: A study was performed with 14 AHPCT patients (mean age 45 years). Unstimulated saliva was collected for 5 min before the transplant, as well as 7 (D+7) and 21 (D+21) after. SPLUNC2A expression was analyzed by Western blotting. Data were analyzed statistically (ANOVA, T test, p < 0.05). Results: Densitometry of protein bands showed a higher level of SPLUN2A after transplant, measuring 0.54 0.22 compared to 0.44 0.35 before the transplant (p ¼ 0.58). In addition, salivary flow rate decreased after AHSCT, measuring 0.40 0.33 compared with 0.47 0.31 before the AHSCT (p ¼ 0.55). Conclusion: The present study, despite the small sample, describes recent findings showing that patients who undergo AHSCT may have changes in SPLUNC2A expression and in salivary flow rate.
PE-467 - IMMUNE CELLS IN DIFFERENT CLINICAL PRESENTATIONS OF DENTURE STOMATITIS. KAREN HENRIETTE PINKE, PATRÍCIA FREITAS-FARIA, THAÍS HELENA GASPAROTO, ALINE CARVALHO BATISTA, TAIANE PRISCILA GARDIZANI, VANESSA SOARES LARA. BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO.