- Email: [email protected]
Subject index to volume 2
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PATHOLOGY
Subject index to volume 2 I
A
[
Acini, salivary gland, normal, 128 Acinic cell carcinoma, salivary, 131,134-5 Actinomycosis, 243 Adenocarcinomas breast, fine needle aspiration false negatives, 140-1 false positives, 141-2 gynaecological, 95, 99 lung, fine needle aspiration, 146 salivary, 130 Adenofibromatous lesions of vagina, 99 Adenoid cystic carcinoma, salivary, 130, 133-4 Adenolymphoma, salivary, 131-2 Adenomas, see also Fibroadenoma breast (lactational), 142 fete ovarii, 95 salivary gland, 130 thyroid, 16-17, 27 Adhesion molecules, cell, 101-10 pathological processes and, 104-7 structures/functions, 101-4 in vasculitis, 262 kidney, 74 Adnexal ovarian (Wolffian) turnouts, 97 AIDS, see H1V infection and AIDS Allergic fungal sinusitis, 244-5 Ameloblastoma, 91 2 Anal carcinoma, 32-7 Anaplastic tumours, see Undifferentiated and anaplastic turnouts Angiocentric immunoproliferative nasal lesions, 249-52 Angioendotheliomas, 65-72 Angiogenesis, adhesion molecules and, 105-6 Angiosarcorna vs. retiform haemangioendotheliorna, 70 Animal models of systemic vasculitis, 261-2 Antibodies in autoimmune disease, see Autoantibodies in immunocytochemistry generation, 38 recently developed, 40-1
B-cell EBV infection and its consequences, 170, 251 lymphocytosis, 183-4 B-cell lymphoma, nasal/midfacial tissues, 250, 251 Bacterial infections adhesion molecules in, 104 nasal/paranasal granulomas due to, 239-42 Basal cell adenoma, salivary, 130 Basal cell carcinoma, skin, 6 Bcl-2
Hodgkin's disease and, 159 immunocytochemical detection, 41-2 Biopsy bone marrow in multiple myeloma, 223 breast, 138-45 fine needle, see Fine needle techniques intrathoracic lesion. 146-52 salivary gland, 127-37 vasculitis, 258 Blastomycosis, nasal, 246 Bleeding disorders, inherited, 106 Blistering diseases, 106 Bone, multiple myeloma affecting, 229 30 Bone marrow in multiple myeloma biopsy, 223 effects of tumour, 229-30 B o r r e l i a b u r g d o r f e r i , adhesion molecules and, 104 Botryoid odontogenic cyst, 89-90 Bowel, inflammatory disease, NO and, 118, see also ~pecific regions Brain NO and NO synthase in, 114 tumours, 175-80 Breast cancer, see Malignancy fine needle aspiration, 138-45 Buccal cyst, mandibular infected, 91 Bullae, 106
I
see also specific a n t i g e n s
Antigens in immunocytochemistry, unmasking, 38-9 Anus, carcinoma, 32-7 Apocrine carcinoma of skin, 6-7 Argentaffin carcinoids, cutaneous, 5 Arterial fibrornuscular dysplasia, 82 Askanazy cell, see Hiirthle cell Aspergilloma, paranasal, 243-4 Aspergillosis of nasal region, 243-5 Aspiration, fine needle, see Fine needle techniques Asthma and NO, 119 Astroblastoma, 178 Astrocytic turnouts, 176-7 Astrocytoma, 176, 177 Atheroembolism, cholesterol, 79 Atherosclerosis and NO production, 115-16 Autoantibodies in vasculitis, 249, 260-2, 263, see also specific
C
Cadherins, 102 in ernbryogenesis, 104 in malignancy, 106, 107, 108 in muscle development/function, 104 Calcifying odontogenic cyst, 92-3 Cancer, see Malignancy Carcinoids, see also Neuroendocrine tumours cutaneous, 5-6 ovarian, 216-19 Carcinoma acinic cell, 131, 134~5 adenoid cystic, 130, 133-4 anaplastic, 20, 29 breast, fine needle aspiration false negatives, 140-1 false positives, 141-2 choroid plexus, 178 colorectal, 108 duodenal, 13
antigens
of kidney, 73-4 Autoimmune (Hashimoto's) thyroiditis, 24, 25 Automation in immunocytochemistry, 41
Current Diagnostic Pathology (1995) 2, 267-273 9 1995 Pearson Professional Ltd
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267
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268 CURRENT DIAGNOSTIC PATHOLOGY epidermoid, s e e Epidermoid carcinoma follicular, s e e Follicular carcinoma gastric, s e e Stomach immunocytochemistry, 44 large cell, 147 lung, fine needle aspiration, 146-7 medlastinal metastases, fine needle aspiration, 151-2 medullary, 19 mesonephric, 95, 98-9, 99 muco-epidermoid, 131,134 nasopharyngeal, 169-70 neuroendocrine, 11, 13 odontogenic, 91, 92 ovarian chorionic, 205 clear cell, differential diagnosis, 200, 203 embryonal, s e e Embryonal carcinoma ovarian teratoma harbouring, 211,212 papillary, 17-19 poorly-differentiated, see Poorly-differentiated carcinoma salivary, 130, 131 skin, 3-5, 6-7 basal cell, 6 Merkel cell, 2-5 small cell, s e e Small cell carcinoma squamous cell, s e e Squamous cell carcinoma thyroid, 17-21, 26-7, 27-9, 29, 30 undifferentiated, 20, 29 uterine mesonephric, 98-9 Cardiovascular system, NO synthase activity, 115, s e e a l s o Heart CD antigens (in general) multiple myeloma, 226 nodular paragranuloma, 160 CD44 (and isoforms), 102 as hyaluronate receptor, 103 in inflammation, 105 malignancy and, 106-7 normal expression, 104 Cell adhesion molecules, s e e Adhesion Cell cycle in Hodgkin's disease, 158 Cell differentiation antigens, s e e CD Central nervous system NO and NO synthase in, 114 tumours, 175-80 Cervix, mesonephric (Wolffian) tumours, 98-9 Chemodectoma, 179 Chemotherapy embryonal carcinoma of ovary, 204 multiple myeloma, 232 teratoma (immature) of ovary, 209 yolk sac tumour of ovary, 203 Chest, fine needle aspiration biopsy of lesions in, s e e Fine needle techniques Children, haemangioendothelioma, 66, 69, 70, s e e a l s o e n t r i e s u n d e r Juvenile Cholesteatoma, maxillary antrum, 237 Cholesterol atheroembolism, 79 Cholesterol granuloma, maxillary antrum, 237 Choriocarcinoma, ovarian, 205 Chorionic gonadotrophin, human, dysgerminomas and serum levels of, 199, 200 Choroid plexus tumours, 178 Ctu'omoblastomycosis, nasal/paranasal, 246 Chromosomal abnormalities, s e e Cytogenetics Churg-Strauss syndrome vs. Wegener's granulomatosis, histological distinction, 249 Clear cell carcinoma, ovarian, differential diagnosis, 200, 203 Clear cell turnouts (unspecified types), thyroid, 27 Clotting, s e e Coagulation Coagulation inherited disorders, 106 in vasculitis pathogenesis, 263 Coccidioidomycosis, 246 Colitis, ulcerative, NO and, 118 Colorectal carcinoma and E-selectin, 108 Columnar cell carcinoma of thyroid, 19-20 Combined variable immunodeficiency, 190 Congenital defects in adhesion molecules, 106 C o n i d i o b o l u s c o r o n a t u s infection, 246 Cost-efficiency analysis in fine needle aspiration of breast, 142-3
C u n n i n g h a m e l l a b e r t h a l l e t i a e infection, 246 Cutaneous disorders, s e e Skin Cutting needle biopsy, breast, 138-9 Cyst(s)/cystic lesions jaw, 86-93 mediastinal, 149 ovary, 210-11,211 rete ovarii, 95 salivary gland, 128 Cystadenoma, papillary, 131-2 Cystic carcinoma, adenoid, salivary, 130, 133--4 Cystic teratoma, mature, 210-11 Cytogenetics lymphoproliferative disorders, 158, 183 multiple myeloma, 226 Cytokines in Hodgkin's disease, production, 158 in vasculitis pathogenesis, 262-3 Cytomegalovirus, immunocytochemistry, 43 Cytopathology, s e e s p e c i f i c c o n d i t i o n s Cytoplasmic neutrophil autoantibodies, s e e Neutrophil autoantibodies Cytotoxic drugs, s e e Chemotherapy; Immunosuppressive drugs
D
I
Dabska's malignant endovascular papillary angioendotheliomas, 70 Dentigerous cysts, 87-8 Dermoid cyst of ovary, 210-11 harbouring cancer, 211 Developmental cysts in jaws, 87-90 Diffuse Hodgkin's disease, 157-8 Double staining in immunocytochemistry, 40 Duct carcinoma, salivary, 131,135 Duodenal nenroendocrine tumours, 10, 12-13 Dysgerminoma, 199-200 Dysplasia, arterial fibromuscular, 82 E
E-cadherin, 102 in malignancy, 106, 107, 108 normal expression, 104 E-selectin, 103 inflammation and, 105 in malignancy, 108 Ectopic thyroid, 151 Ehlers-Danlos syndrome, 83, 84 Electron microscopy, carcinoma of skin (Merkel cell), 4-5 Embolism of atheromatous plaque, cholesterol, 79 cardiac myxoma, 80-1 Embryogenesis, adhesion molecules in, 1034 Embryonal carcinoma mediastinal, 151 ovarian, 203--4 differential diagnosis, 200, 203, 204 Embryonal tumours (in general), CNS, 179-80 Endocrine tumours, 2-31 gastroduodenal, 10-14 skin, 2-9 thyroid, 15-22, 26-30 Endodermal sinus tumour, s e e Yolk sac tumour Endometrioid-like yolk sac tumour, 202, 203 Endothelium/endothelial cell hyperplasia, intravascular, 67 in vasculitis, 262-3 of kidney, autoantibodies, 74 Endotoxin shock and NO production, 117 Endovascular papillary angioendotheliomas, Dabska's malignant, 70 Entomophthorosis, 245-6 Ependymal tumours intracranial, 178 ovarian, 219 Ependymoblastoma, 180 Ependymomas, 178, 219
SUBJECT INDEX TO VOLUME 2 269 Epidermoid carcinoma lung, 147 mediastinum, 151 Epithelial cell, EBV infection, 168-70 Epithelial cell tumours, see also Neuroepithelial tumours a n d specific types
EBV infection and, 169-70 salivary, 130-5 thyroid, classification, 15, 16 Epithelioid cell-rich Hodgkin' s disease, 155, 157 Epithelioid haemangioendothelioma, 69-70 Epithelimn, odontogenic, see Odontogenic epithelium Epstein-Barr vires infection, 163-74, 251 epithelial neoplasia, 169-70 immunocytochemistry, 43 infectious mononucleosis (IM) in, 165-6, 184 lymphoproliferative disease, 158, 165 9, 190, 251 Ergotism, chronic, 82 Esthesioneuroblastoma, 179 European Association for Haematopathology, abstracts presented at V1 lth meeting of, 46-59
[
F
Fat necrosis of breast diagnosed as cancer, 141-2 Female genital tract tumours, see Gynaecological tumours Fibrillary astrocytoma, 176 Fibroadenoma of breast diagnosed as cancer, 141 Fibrohistiocytic diffuse Hodgkin's disease, 157 Fibromuscular dysplasia, arterial, 82 Fine needle techniques (aspirates/biopsy), 127-52 breast, 138-45 intrathoracic lesion, 146-52 complications, 146 technique, 146 salivary gland, 127-37 thyroid, 23-31 Flow cytometry in lymphoproliferative disorders, 181 2 Follicular adenoma of thyroid, 16 17, 27 Follicular carcinoma of thyroid, 17 mixed medullary and, 19 Follicular centre cell lymphomas, 187-8 Follicular cysts in jaws, 87 8 Fungal refections, nasal/paranasal, 242 7
G Gammopathy, monoclonal, of uncertain significance (MGUS), 224, 230, 231 Gangliocytic paraganglioma, duodenal, I3 Gangliogliomas, 179 Garmer's duct turnouts, 97 Gastric problems, see Stomach Gastrin-producing tumours, 12 Gastrointestinal tract, NO activity, l 18, see also specific r e g i o n s Gemhistiocytic astrocytoma, 176 Genital tract tumours, see Gynaecological tumours Germ cell tumours, 199-221 immunocytochemistry, 44 mediastinal, 150-1 ovaries, 199-221 Giant cell astrocytoma, subependymal, 177 Giant cell gliohlastoma, 177 Glandular fever (infectious mononucleosis; IM), 165-6, 184 Glandular odontogenic cyst, 89-90 Glandular yolk sac tumour, 201-2 Glial-neuronal tumours, mixed, 179 Glioblastoma, 176-7 Glioma, 176-80 Gliomatosis cerebral, 179 peritoneal, 209 Glomeruli in vasculitis, 74-6 Goitre, multinodular, 24-5 Gonadotrophin, human chorionic, dysgerminomas and sermn levels of, 199, 200 Goodpasture's disease, 75, 76
]
Grading gliomas, 180 Hodgkin' s disease, 155-6 Granuloma(s) nasal/paranasal, 237 pregnancy, 237 renal vasculitis and, 74 Granulomatosis lymphomatoid, 250 pulmonary, 251 Wegener's, s e e Wegener's granulomatosis Granulosa cell tumours, juvenile, 204 Gynaecological tumours germ cell, 199-221 mesonephric/Wolffian, 94-100
Y Haemangioendotheliomas, 65-72 Haemangioma, juvenile cellular, 66 Haematopathology, abstracts presented at Vllth meeting of European Association for, 46-59 Haematopoiesis in multiple myeloma, failure, 230 Hamartoma, pulmonary, fine needle aspiration, 148 Hashimoto's thyroiditis, 24, 25 Head and neck carcinoma, EBV-associated, 169-70 Healing, wound, adhesion molecules and, 105-6 Heart, see also Cardiovascular system embolized myxoma, 80-1 NO activity, 117-18 H e l i c o b a c t e r p y l o r i , 184-5 Henoch-Schoenlein nephritis, 75-6 Hepatoid yolk sac turnout, 201,203 Histogenesis of thyroid tumours, 20 1 Histopathology, see specific c o n d i t i o n s Histoplasmosis, 246-7 HIV infection and AIDS aspergillosis in, 244 lymphomas in Hodgkin's, 158 non-Hodgkin's, 167. 251 nasal/paranasal intections in, 242, 244, 247 syphilis and, increased incidence, 242 Hodgkin's ceils, 152 gcnotype, 158 Hodgkin's disease, 153-62, 168, 189 90 cytokine production in, 158 EBV infection and, 158, 168, 19(/ historical background, 152 mediastinal, 151 types, 152 8 Hormone-producing tumours, duodenal, 12-13 Hiirthle (Askanazy) cell change benign (in thyroiditis), 25-6 neoplastic, 26, 27 Hyalinizing trabecular adenoma of thyroid, 17.27 Hyaluronate receptors, 103 inflammation and, 105 malignancy and, 106-7 normal expression, ! 04 Hyperplasia intravascular endothelial, 67 lymphoid, 184, 190 cutaneous, 186 Hypertension pregnancy-induced, NO production and, 116 17 pulmonary, see Pulmonary hypertension Hypertensive vascular disease as pseudovasculitis syndrome, 79
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Immunocytochemistry, see hnmunohistochemistry/immunocytochemistry lmmunodeficiency (disorder) adhesion molecule defect causing, 106 combined variable, 190 syndrome of acquired, see HIV infection and AIDS lmmunodiagnostic techniques (in general/unspecified), clonal lymphoproliferative disorders detected via, 181-94
270 CURRENT DIAGNOSTIC PATHOLOGY Immunofluorescence studies lymphoproliferative disorders, 181-2 vasculitis, 259 Immunogenetic studies, Hodgkin's disease, 158-9 Immunoglobulin(s), cytoplasmic, detection, 182 Immunoglobulin-like superfamily, t01 inflammation and, 105 malignancy and, 106 Immunohistochemistry/immunocytochemistry, 38-45 carcinoma of skin (Merkel cell), 4 nodular paragranuloma, 160 yolk sac tumours of ovary, 202-3 Immunopathogenesis, vasculitis, 258-9, 260-3 Immunophenotyping, plasma cell, 226 Immunoproliferative nasal lesions, angiocentric, 249-52 Immunosuppressive drugs, vasculitis, 2 6 3 4 In situ hybridization in EBV-associated disease, 165 immunocytochemistry and, combined, 40 Infants, haemangioendotheliomas, 66, 69 Infections, see also specific diseases and specific (types of) pathogens
adhesion molecules in, 104 AIDS-related opportunistic, 244, 247 immunocytochemistry, 43 lymphoid, distinction from neoplasia, 184--6 nasal/paranasal granulomas due to, 239--47 Inflammation, see also specific inflammatory conditions adhesion molecules and, 104-5 lymphoid, 184 mediastinal, 149, 151 mediators, in vasculitis pathogenesis, 262-3 Inflammatory bowel disease, NO and, 118 Inflammatory nasal lesions, 237-47 Inflammatory odontogenic cyst, 90-1 Insular carcinoid, ovarian, 216-17 Insular carcinoma, thyroid, 19-20, 27 Integrins, 102-3 angiogenesis and, 106 inflammation and, 105 Intensive care, 1-20 Inteffollicular Hodgkin's disease diffuse, 158 nodular sclerosing, 156-7 Interstitial tissues of kidney in vasculitis, 77 Intestine, inflammatory disease, NO and, 118, see also specific regions
Intracranial tumours, 175-80
Jaw cysts/cystic lesions, 86-93 Juvenile granulosa cell turnouts, 204 Juvenile haemangioendothelioma, benign (juvenile haemangioma), 66
Kaposiform haemangioendothelioma of infancy/childhood, 69 Kaposi's sarcoma, haemangioendotheliomas simulating, 68, 69 Keratinization, anal carcinoma, 34, 36, 37 Keratinizing squamous cell carcinoma, anal carcinoma regarded as, 37 Keratocyst, odontogenic, 88-9 Kidney, vasculitis, 73-7 Klebsiella rhinoscleroma, 239-40 Kveim-Siltzbach test, 239
I
L
L-selecfin, 103 inflammation and, 105 malignancy and, 106 Lactation-relatedbenign lesions diagnosed as breast cancer, 142 Large cell carcinoma of lung, 147 Large cell lymphoma, ovarian, differential diagnosis, 200 Leprosy, 240-2 Leucocyte adhesion deficiency, 106
]
Leukaemia lymphoblastic, acute, 186-7 lymphocytic, chronic, 183-4 plasma cell, 230 Light chain restriction in lymphoproliferative disorders, 181-2 Light microscopy, see specific conditions Lobular carcinoma of breast, fine needle aspiration, false negatives, 141 Lukes and Butler classification of Hodgkin's disease, 152 Lung cancer, see Malignancy fine needle aspiration of lesions, 147-9 lymphomatoid granulomatosis, 251 NO production and, 118-19 vasculature, see Pulmonary hypertension Lyme disease, adhesion molecules in, 104 Lymph nodes mediastinal, inflammation, 151 polymorphous haemangioendothelioma of, 71 Lymphoblastic leukaemia, acute, 186-7 Lymphocyte(s) B- and T-, see B-cell; T-cell clonal populations, in lymphoproliferative disorders, detection and significance, 181-94 Lymphocyte-depleted Hodgkin's disease, 155 Lymphocyte-predominant/rich Hodgkin's disease, 155, 157, 189-90 questioning existence, 160 Lymphocytic leukaemia, chronic, 183-4 Lymphoepithelial lesions, salivary, benign, 129-30 Lymphohistiocyte-predominant Hodgkin's disease, 155 Lymphoma, 165-9, 184-6, 187-8, 249-52, see also Adenolymphoma angiocentric, 249-52 EBV-associated, 158, 165-9, 190, 251 gastric, 184q5 Hodgkin's, see Hodgkin's disease immunodeficiency and acquired, see HIV infection and AIDS combined variable, 190 mediastinal, 151 ovarian large cell, differential diagnosis, 200 salivary, 135~5 thyroid, 29 Lymphomatoid granulomatosis, see Granulomatosis Lymphomatoid papulosis, 186 Lymphoproliferative disorders (in general), 165-9, 181-94, 249-52 in Epstein-Baxr virus infection, 158, 165-9, 190, 251 monoclonality, detection and significance, 181-94 nasal, 249-52
M-cadherin, normal expression, 104 M-protein monitoring of patients with, 231 myelomas not secreting, 230-1 Malignancy/cancer (and potential/intermediate malignancy) adhesion molecules and, 106-7, 107-8 anal, 32-7 breast (metastases of), 152 breast (primary tumour), fine needle aspiration false negatives, 140-1 false positives, 141-2 EBV-associated, 158, 165-70, 190, 251 endocrine, 10-13, 16-21 gastric, see Stomach in-anunocytochemistry, 44 lung, 146-7 metastases, 151-2 mediastinal, fine needle aspiration, 150-1, 151, 152-3 nasal/midfacial tissues, 249-52 nasopharyngeal, 169-70 ovarian, 199-205, 208-9, 211-12, 214-20 rete ovarii, 95, 98-9, 99 salivary gland, 130, 131 secondary, see Metastases skin, 10-13 teratomas harbouring, 151, 211-12 thyroid, 16-21, 26-7, 27-30
SUBJECT INDEX TO VOLUME 2 271 transformation to, jaw cyst, 91-3 vascuIar, 69-71 MALTomas/MALT-type lymphomas gastric, 184--6 nasal/midfacial tissue, 250 Mandibular infected buccal cyst, 91 Masson's vegetant intravascular haemangioendothelioma, 67 Maxillary antrum cholesteatoma, 237 cholesterol granuloma, 237 Mediastinum, 60-3, 14%52 self-assessment questions, 60-3 space-occupying lesions, fine needle aspiration, 14%52 Medullary carcinoma, thyroid, 19 Medulloblastoma, 179 Medulloepithelioma, 180 Mercuric chloride, vasculitis model employing, 261-2 Merkel cell carcinoma (skin), 2-5 Mesodermal mixed ovarian tumours, 209 Mesonephric tumours of female genital tract, 94-100 Metastases, turnout CD44 and, 106-7 site lung, fine needle aspiration, 148 mediastinum, fine needle aspiration, 15l-2 thyroid, 29 N-Methyl-D-aspartate receptors and NO synthase, 114 Microscopy electron, carcinoma of skin (Merkel cell), 4-5 light, see specific c o n d i t i o n s Microwave pretreatment, antigen unmasking via, 38-9 Mikulicz cells, 240 Mikulicz disease, 129-30 Mixed cellularity Hodgkin's disease, 155, 157, 190 Mixed tumours CNS, 178, 179 ovarian germ cell, 205 mesodermal, 209 salivary gland, 130 thyroid carcinoma, 19 Models, experimental, systemic vasculitis, 261 2 Monoclonal gammopathy of uncertain significance (MGUS), 224, 230, 231 Monodermal teratoma, 214-21 Mononucleosis, infectious (IM), 165-6, 184 Motility, receptor for hyaluronate-mediated, 103 Mucinous carcinoids, ovarian, 218-19 Muco-epidermoid carcinoma, salivary, 131, 134 Muco-epidermoid odontogenic cyst, 90 Mucormycosis, 245 Mucosa-associated lymphoid tissue lymphomas, s e e MALTomas Miillerian tumours vs. Wolffian turnouts, 94, 95 Multinodular goitre, 24-5 Multiple myeloma, see Myeloma, multiple Muscle development and function, cadherins in, 104 Mutations in lymphoproliferative disorders, 183 M y c o b a c t e r i a spp leprae, 240-2 t u b e r c u l o s i s , see Tuberculoma; Tuberculosis Mycotic infections, nasal/paranasal, 242-7 Myeloma, multiple (plasma cell myeloma), 188-9, 222-35 classification, 227 diagnosis, 188-9, 223-5 epidemiology, 222 manifestations, 188-9, 223 pathogenesis, 222-3 prognostic factors, 227-8 staging, 228-9 treatment, 189, 231-3 variants, 230-1 Myeloperoxidase vasculitis model employing immunization with, 261 in vasculitis pathogenesis, 261 Myiasis, 237, 241-2 in leprosy, 241-2 nasal, 237, 241-2 Myospherulosis, 237-8 Myxoma, cardiac embolized, 80-1 Myxopapillary ependymoma, 178
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N
N-cadherin, normal expression, 104 NADPH-diaphorase activity, staining for, 113-14, 115 Nasal uleerative/necrotizing diseases, 236-55 Nasopharyngeal carcinoma, 169-70 Necrotizing nasal/paranasal diseases, 236-55 Neoplasms, see Malignancy; Tumours Nephritis, Henoch-Schoenlein, 75-6 Nervous system central, NO and NO synthase in, 114 development/function, cadherins in, 104 Neurilemmoma, mediastinal tumours, 152 Neuroblastoma, 180 olfactory, 179 Neuroectodennal turnouts ovarian, 219-20 primitive, see Primitive neuroectodermal tumours Neuroendocrine turnouts, gastroduodenal, 10-14, see also Carcinoids Neuroepithelial tumours, 175-80 Neurofibromatosis, 82 Neurogenic mediastinal tumours, 152 Neuronal-glial tumours, mixed, 179 Neutrophil autoantibodies (ANCA) in vasculitis, 73-4, 249, 2602, 263 kidney, 73-4 Nitric oxide, 111-21 actions, 112-13 production, 111-21 in vasculitis pathogenesis, 263 Nitric oxide synthase, 111-21 detection and localization, 113-14 isoforms, 111-12 in pathology, 114-19, 263 NMDA receptors and NO synthase, 114 Nocardiosis, 243 Nodular goitre, 24-5 Nodular paragranuloma, 159-60 Nodular sclerosing Hodgkin's disease, 154 7, 190 early lesions preceding, 156-7 subtypes, 155-7 Nose, ulcerative/necrotizing diseases, 236-55
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o
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Odontogenic epithelium, 86-92 cysts arising from residues of, 87-93 malignant transformation, 91-3 general characteristics, 86-7 Olfactory neuroblastoma, 179 Oligodendroglioma, 178 Oncocytoma, salivary, 131, 132 Oncogenes, lymphomas and Hodgkin's, 159 non-Hodgkin's, 167 Open biopsy, breast, 138-9 Osteoclast-activating factors, myeloma-produced, 229 Osteosclerotic multiple mycloma, 231 Ovaries germ cell tumours, 199-221 mesonephric (Wolffian) tumours, 95-7
[
P
l
P-selectin, 103 inflammation and, 105 malignancy and, 106 p53 gene, lymphoproliferative disorders and, 159, 183 immunocytochemical detection, 41 Papillary angioendotheliomas, Dabska's malignant endovascular, 70 Papillary carcinoma breast, fine needle aspiration, false negatives, 141 thyroid, 17-19, 27-8 Papillary cystadenoma, 131-2
272 CURRENT DIAGNOSTIC PATHOLOGY Retiform Wolffian differentiation, uterine stromal tumours with, 97-8, 98 Rhinomucormycosis, 245 Rhinoscleroma, 239-40 Rhinosporidiosis, 242-3 Rye classification of Hodgkin' s disease, 152
Papilloma breast, fine needle aspiration, diagnosed as cancer, 142 choroid plexus, 178 Paradental cyst, 90-1 Paraganglioma, 179 gangliocytic, duodenal, 13 Paragranuloma, nodular, 159-60 Paranasal sinuses, ulcerative/necrotizing diseases, 236-55 Pemphigoid, bullous, 106 Pemphigus, 106 Periodontal cyst, 89 Peritoneal gliomatosis, 209 Phospholipids, autoantibodies, vaso-occlusive disease and, 81-2 Phycomycosis, 245-6 Pilocytic astrocytoma, 177 Pityriasis lichenoides, 186 Plasma cell(s), in myeloma diagnosis histotopography, 224-5 immunologic characterization, 225 immunophenotyping, 226 labelling index, 225 qualitative abnormalities, 224 quantity, 223-4 Plasma cell leukaemia, 230 Plasma cell myeloma, see Myeloma Plasmacytoma, salivary, 136 Plasmacytosis, reactive vs., neoplastic, 225 Platelets and vasculitis, 263 Pleomorphic adenoma, salivary, 130 Pleomorphic xanthoastrocytoma, 177 Polyarteritis aetiopathogenesis, 259-63 historical aspects, 257-8 treatment, 263-4 Polyembryoma, 204-5 Polymerase chain reaction lymphoblastic leukaemia, 186-7 lymphomas Hodgkin's, 159 non-Hodgkin's, 182-3, 187 T-ceU receptor gene rearrangements, 182-3 Polymorphous haemangioendothelioma of lymph nodes, 71 Polyposis, nasal, 237 Polyvesicular-vitellineyolk sac tumour, 201 Poorly-differentiated carcinoma duodenum, 13 gastric, 11 thyroid, 19-20, 27 Pre-eclampsia, NO production and, 116-17 Pregnancy benign breast lesions diagnosed as cancer, 142 granuloma, 237 hypertension induced by, NO production and, 116-17 Primitive neuroectodermal tumours CNS, 179 ovarian, 219 Primordial cyst in jaw, 88-9 Prostatic lesions, immunocytochemistry, 44 Proteinase 3 and vasculitis, 261 Protoplasmic astrocytoma, 176 Protozoal infections, adhesion molecules in, 104 Pseudoangiosarcoma, 67 Pseudovasculitis syndromes, 78-85 Pulmonary hypertension NO inhalation in, 119 as pseudovasculitis syndrome, 79 Pulmonary tissues, see Lung
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R
R-cadherin, normal expression, 104 Radicular cyst, 90 Reed-Sternberg cells, see Sternberg-Reed cells Renal vasculitis, 73-7 Respiratory tract, see Lung; Pulmonary hypertension Rete ovarii, proliferative and neoplastic lesions, 95-7 Retiform haemangioend0thelioma, 70 Retiform Sertoli-Leydig cell tumour, 95, 96-7
[
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s
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Salivary duct, carcinoma originating from, 131, 135 Salivary gland, 127-37, see a l s o entries under Sialaspirates, 127-37 disorders, 128-36 neoplastic, 130--6 normal, 128 Sarcoidosis, nasal, 239 Sarcoma Hodgkin' s, 157-8 Kaposi's, haemangioendotheliomas simulating, 68, 69 salivary, 136 Schwannoma (neurilemmoma), mediastinal tumours, 152 Scleroma, 239-40 Sebaceous ovarian tumours, 220 Selectins, 103 inflammation and, 105 malignancy and, 106, 108 Seminoma, mediastinal, 151 Sertoli-Leydig cell tumour, retiform, 95, 96-7 Shock, endotoxic, NO production and, 117 Sialadenitis, 129 Sialometaplasia, 238-9 Sialo-odontogenic cyst, 90 Sicca syndrome, 129-30 Sinuses, paranasal, ulcerative/necrotizing diseases, 236-55 Sinusitis in AIDS/HIV disease, 247 allergic fungal, 244-5 Sjtgren's syndrome, salivary gland lesions benign, 129-30 malignant, 136 Skin blistering diseases, 106 endocrine tumours, 2-9 lymphocyte populations, clonal, 186 Small cell carcinoma lung, 147-8 mediastinal metastases, 151-2 skin, 2-5 Small vessel disease in hypertension as pseudovasculitis syndrome, 79 Smouldering multiple myeloma, 230 Somatostatin-producing tumours, 12-13 Spindle cell haemangioendothelioma, 68 Spongioblastoma, 178-9 Squamous cell carcinoma keratinizing, anal carcinoma regarded as, 37 ovarian teratoma harbouring, 211,212 Staging, multiple myeloma, 228-9 Staining in immunocytochemistry, see also s p e c i f i c stains automated, 41 double, 40 Sternberg-Reed cells, 152, 190 genotype, 158 Stomach carcinoma, 11 E-cadherin and, 108 lymphoma, 184-6 neuroendocrine tumours, 10-12, 13 Stromal tumours, uterine, with retiform Wolffian differentiation, 97-8, 98 Struma ovarii, 214-16 Strumal carcinoids, ovarian, 217-18 Subependymal giant cell astrocytoma, 177 Subependymoma, 178 Syncytiotrophoblastic cells in dysgerminoma, 200 Syphilis, nasal involvement, 242 Systemic vasculitis, see Vasculitis
SUBJECT INDEX TO VOLUME 2 273 T
T-cadherin, normal expression, 104 T-cell(s) lymphocytosis, 184 vasculitis and the role of, 262, 263 T-cell lymphoma cutaneous, 186 EBV and, 167-8, 251 nasal/midfacial tissues, 250, 251 T-cell receptor genes antibodies detecting products of, 182 rearrangements, detection, 182-3 Teratoma, 208-21 malignant/immature, 151,208-9 undifferentiated, see Embryonal carcinoma mature cystic, see Dermoid cyst with secondary tumour, 151,212 solid, 210 mediastinal, 150-1 monodermal, 214-21 ovarian, 208-21 Thorax, fine needle aspiration biopsy of lesions in, see Fine needle techniques Thymomas, 149-50 Thyroid, 15-31 ectopic, 151 fine needle aspiration, 23-31 lesions neoplastic, 15-22, 26-30 non-neoplastic, 24-6 normal cytology, 24 Thyroiditis, 25-6 Toxic granuloma of nasal tissues, 237 Trabecular adenoma of thyroid, hyalinizing, 17, 27 Trabecular carcinoids cutaneous, 5-6 ovarian, 217 Transitional cell tumours of Wolffian areas, 99 100 Translocations in lymphoproliferative disorders, 183 Transplantation, lymphoproliferative disease fbllowing, 166-7, 190 T r e p o n e m a p a l l i d u m , 242 Triplet diagnostic method in fine needle aspiration of breast, 139, 142-3 Tuberculoma, puhnonary, fine needle aspiration, 148 Tuberculosis, nasal, 239 Tubular carcinoma of breast, fine needle aspiration, false negatives, 140-1 Tubules, renal, in vasculitis, 76 Tumour(s), s e e also ,~pecific types adhesion molecules and, 106-7, 107 8 anal, 32-7 brain, 175-80 colorectal, 108 duodenal, 10, 12-13 endocrine, 2-31 gastric, see Stomach gynaecological, see Gynaecological tumours immunocytochemistry, 44 lung, fine needle aspiration, 146-7 malignant, see Malignancy mediastinal, fine needle aspiration, 150-1, 151, 152-3 salivary, 130-6 Tumour suppression genes, 107
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I
Ulcerative colitis, NO and, 118 Ulcerative nasal/paranasal diseases, 236-55 Undifferentiated and anaplastic tumours astrocytic, 176 ependymal, 178, 219 ovaries, 201,219 thyroid carcinoma, 20, 29 Uterine cervix, mesonephric (Wolffian) tumours, 98-9 Uterine corpus, mesonephric (Wolffian) tumours, 97-8
Vagina, mesonephric tmnours, 99 Vascular disease, 65-85 Vasculitis, 73-7, 256-65 conditions mimicking, 78-85 renal, 73-7 systemic, 256-65 aetiopathogenesis, 258-9, 260-3 histopathology, 259-60 historical overview, 256-9 nasal involvement, 247-9 treatment, 263-4 Vaso-occlusive disease of antiphospholipid syndrome, 81-2 VCAM-1 and vasculitis, 262 Viral infections adhesion molecules in, 104 immunocytochemistry, 43 yon Recklinghausen's disease, 82
I
w
1
Warthin's tumour, 131 2 Wegener's granulomatosis, 247-9 aetiopathogenesis, 259-63 p a s s i m clinical features, 247 9 historical aspects, 258 limited, 249 nasal involvement, 247-9 treatment, 263M Wolffian turnouts of female genital tract, 94-100 Womcn, genital tract tumours, see Gynaecological tumours Wound healing, adhesion molecules and, 105 6
I
x
J
Xanthoastrocytoma, pleomorphic, 177 X-linked polymorphism in lymphoproliferative disorders, 183
Y Yolk sac tumour (endodermal sinus tumour), ovarian, 201 3 differential diagnosis, 200, 203
Zollinger-Ellison syndrome, /0, 12 Zygomycosis, 245-6
J
PATHOLOGY
Subject index to volume 2 I
A
[
Acini, salivary gland, normal, 128 Acinic cell carcinoma, salivary, 131,134-5 Actinomycosis, 243 Adenocarcinomas breast, fine needle aspiration false negatives, 140-1 false positives, 141-2 gynaecological, 95, 99 lung, fine needle aspiration, 146 salivary, 130 Adenofibromatous lesions of vagina, 99 Adenoid cystic carcinoma, salivary, 130, 133-4 Adenolymphoma, salivary, 131-2 Adenomas, see also Fibroadenoma breast (lactational), 142 fete ovarii, 95 salivary gland, 130 thyroid, 16-17, 27 Adhesion molecules, cell, 101-10 pathological processes and, 104-7 structures/functions, 101-4 in vasculitis, 262 kidney, 74 Adnexal ovarian (Wolffian) turnouts, 97 AIDS, see H1V infection and AIDS Allergic fungal sinusitis, 244-5 Ameloblastoma, 91 2 Anal carcinoma, 32-7 Anaplastic tumours, see Undifferentiated and anaplastic turnouts Angiocentric immunoproliferative nasal lesions, 249-52 Angioendotheliomas, 65-72 Angiogenesis, adhesion molecules and, 105-6 Angiosarcorna vs. retiform haemangioendotheliorna, 70 Animal models of systemic vasculitis, 261-2 Antibodies in autoimmune disease, see Autoantibodies in immunocytochemistry generation, 38 recently developed, 40-1
B-cell EBV infection and its consequences, 170, 251 lymphocytosis, 183-4 B-cell lymphoma, nasal/midfacial tissues, 250, 251 Bacterial infections adhesion molecules in, 104 nasal/paranasal granulomas due to, 239-42 Basal cell adenoma, salivary, 130 Basal cell carcinoma, skin, 6 Bcl-2
Hodgkin's disease and, 159 immunocytochemical detection, 41-2 Biopsy bone marrow in multiple myeloma, 223 breast, 138-45 fine needle, see Fine needle techniques intrathoracic lesion. 146-52 salivary gland, 127-37 vasculitis, 258 Blastomycosis, nasal, 246 Bleeding disorders, inherited, 106 Blistering diseases, 106 Bone, multiple myeloma affecting, 229 30 Bone marrow in multiple myeloma biopsy, 223 effects of tumour, 229-30 B o r r e l i a b u r g d o r f e r i , adhesion molecules and, 104 Botryoid odontogenic cyst, 89-90 Bowel, inflammatory disease, NO and, 118, see also ~pecific regions Brain NO and NO synthase in, 114 tumours, 175-80 Breast cancer, see Malignancy fine needle aspiration, 138-45 Buccal cyst, mandibular infected, 91 Bullae, 106
I
see also specific a n t i g e n s
Antigens in immunocytochemistry, unmasking, 38-9 Anus, carcinoma, 32-7 Apocrine carcinoma of skin, 6-7 Argentaffin carcinoids, cutaneous, 5 Arterial fibrornuscular dysplasia, 82 Askanazy cell, see Hiirthle cell Aspergilloma, paranasal, 243-4 Aspergillosis of nasal region, 243-5 Aspiration, fine needle, see Fine needle techniques Asthma and NO, 119 Astroblastoma, 178 Astrocytic turnouts, 176-7 Astrocytoma, 176, 177 Atheroembolism, cholesterol, 79 Atherosclerosis and NO production, 115-16 Autoantibodies in vasculitis, 249, 260-2, 263, see also specific
C
Cadherins, 102 in ernbryogenesis, 104 in malignancy, 106, 107, 108 in muscle development/function, 104 Calcifying odontogenic cyst, 92-3 Cancer, see Malignancy Carcinoids, see also Neuroendocrine tumours cutaneous, 5-6 ovarian, 216-19 Carcinoma acinic cell, 131, 134~5 adenoid cystic, 130, 133-4 anaplastic, 20, 29 breast, fine needle aspiration false negatives, 140-1 false positives, 141-2 choroid plexus, 178 colorectal, 108 duodenal, 13
antigens
of kidney, 73-4 Autoimmune (Hashimoto's) thyroiditis, 24, 25 Automation in immunocytochemistry, 41
Current Diagnostic Pathology (1995) 2, 267-273 9 1995 Pearson Professional Ltd
.
267
1
268 CURRENT DIAGNOSTIC PATHOLOGY epidermoid, s e e Epidermoid carcinoma follicular, s e e Follicular carcinoma gastric, s e e Stomach immunocytochemistry, 44 large cell, 147 lung, fine needle aspiration, 146-7 medlastinal metastases, fine needle aspiration, 151-2 medullary, 19 mesonephric, 95, 98-9, 99 muco-epidermoid, 131,134 nasopharyngeal, 169-70 neuroendocrine, 11, 13 odontogenic, 91, 92 ovarian chorionic, 205 clear cell, differential diagnosis, 200, 203 embryonal, s e e Embryonal carcinoma ovarian teratoma harbouring, 211,212 papillary, 17-19 poorly-differentiated, see Poorly-differentiated carcinoma salivary, 130, 131 skin, 3-5, 6-7 basal cell, 6 Merkel cell, 2-5 small cell, s e e Small cell carcinoma squamous cell, s e e Squamous cell carcinoma thyroid, 17-21, 26-7, 27-9, 29, 30 undifferentiated, 20, 29 uterine mesonephric, 98-9 Cardiovascular system, NO synthase activity, 115, s e e a l s o Heart CD antigens (in general) multiple myeloma, 226 nodular paragranuloma, 160 CD44 (and isoforms), 102 as hyaluronate receptor, 103 in inflammation, 105 malignancy and, 106-7 normal expression, 104 Cell adhesion molecules, s e e Adhesion Cell cycle in Hodgkin's disease, 158 Cell differentiation antigens, s e e CD Central nervous system NO and NO synthase in, 114 tumours, 175-80 Cervix, mesonephric (Wolffian) tumours, 98-9 Chemodectoma, 179 Chemotherapy embryonal carcinoma of ovary, 204 multiple myeloma, 232 teratoma (immature) of ovary, 209 yolk sac tumour of ovary, 203 Chest, fine needle aspiration biopsy of lesions in, s e e Fine needle techniques Children, haemangioendothelioma, 66, 69, 70, s e e a l s o e n t r i e s u n d e r Juvenile Cholesteatoma, maxillary antrum, 237 Cholesterol atheroembolism, 79 Cholesterol granuloma, maxillary antrum, 237 Choriocarcinoma, ovarian, 205 Chorionic gonadotrophin, human, dysgerminomas and serum levels of, 199, 200 Choroid plexus tumours, 178 Ctu'omoblastomycosis, nasal/paranasal, 246 Chromosomal abnormalities, s e e Cytogenetics Churg-Strauss syndrome vs. Wegener's granulomatosis, histological distinction, 249 Clear cell carcinoma, ovarian, differential diagnosis, 200, 203 Clear cell turnouts (unspecified types), thyroid, 27 Clotting, s e e Coagulation Coagulation inherited disorders, 106 in vasculitis pathogenesis, 263 Coccidioidomycosis, 246 Colitis, ulcerative, NO and, 118 Colorectal carcinoma and E-selectin, 108 Columnar cell carcinoma of thyroid, 19-20 Combined variable immunodeficiency, 190 Congenital defects in adhesion molecules, 106 C o n i d i o b o l u s c o r o n a t u s infection, 246 Cost-efficiency analysis in fine needle aspiration of breast, 142-3
C u n n i n g h a m e l l a b e r t h a l l e t i a e infection, 246 Cutaneous disorders, s e e Skin Cutting needle biopsy, breast, 138-9 Cyst(s)/cystic lesions jaw, 86-93 mediastinal, 149 ovary, 210-11,211 rete ovarii, 95 salivary gland, 128 Cystadenoma, papillary, 131-2 Cystic carcinoma, adenoid, salivary, 130, 133--4 Cystic teratoma, mature, 210-11 Cytogenetics lymphoproliferative disorders, 158, 183 multiple myeloma, 226 Cytokines in Hodgkin's disease, production, 158 in vasculitis pathogenesis, 262-3 Cytomegalovirus, immunocytochemistry, 43 Cytopathology, s e e s p e c i f i c c o n d i t i o n s Cytoplasmic neutrophil autoantibodies, s e e Neutrophil autoantibodies Cytotoxic drugs, s e e Chemotherapy; Immunosuppressive drugs
D
I
Dabska's malignant endovascular papillary angioendotheliomas, 70 Dentigerous cysts, 87-8 Dermoid cyst of ovary, 210-11 harbouring cancer, 211 Developmental cysts in jaws, 87-90 Diffuse Hodgkin's disease, 157-8 Double staining in immunocytochemistry, 40 Duct carcinoma, salivary, 131,135 Duodenal nenroendocrine tumours, 10, 12-13 Dysgerminoma, 199-200 Dysplasia, arterial fibromuscular, 82 E
E-cadherin, 102 in malignancy, 106, 107, 108 normal expression, 104 E-selectin, 103 inflammation and, 105 in malignancy, 108 Ectopic thyroid, 151 Ehlers-Danlos syndrome, 83, 84 Electron microscopy, carcinoma of skin (Merkel cell), 4-5 Embolism of atheromatous plaque, cholesterol, 79 cardiac myxoma, 80-1 Embryogenesis, adhesion molecules in, 1034 Embryonal carcinoma mediastinal, 151 ovarian, 203--4 differential diagnosis, 200, 203, 204 Embryonal tumours (in general), CNS, 179-80 Endocrine tumours, 2-31 gastroduodenal, 10-14 skin, 2-9 thyroid, 15-22, 26-30 Endodermal sinus tumour, s e e Yolk sac tumour Endometrioid-like yolk sac tumour, 202, 203 Endothelium/endothelial cell hyperplasia, intravascular, 67 in vasculitis, 262-3 of kidney, autoantibodies, 74 Endotoxin shock and NO production, 117 Endovascular papillary angioendotheliomas, Dabska's malignant, 70 Entomophthorosis, 245-6 Ependymal tumours intracranial, 178 ovarian, 219 Ependymoblastoma, 180 Ependymomas, 178, 219
SUBJECT INDEX TO VOLUME 2 269 Epidermoid carcinoma lung, 147 mediastinum, 151 Epithelial cell, EBV infection, 168-70 Epithelial cell tumours, see also Neuroepithelial tumours a n d specific types
EBV infection and, 169-70 salivary, 130-5 thyroid, classification, 15, 16 Epithelioid cell-rich Hodgkin' s disease, 155, 157 Epithelioid haemangioendothelioma, 69-70 Epithelimn, odontogenic, see Odontogenic epithelium Epstein-Barr vires infection, 163-74, 251 epithelial neoplasia, 169-70 immunocytochemistry, 43 infectious mononucleosis (IM) in, 165-6, 184 lymphoproliferative disease, 158, 165 9, 190, 251 Ergotism, chronic, 82 Esthesioneuroblastoma, 179 European Association for Haematopathology, abstracts presented at V1 lth meeting of, 46-59
[
F
Fat necrosis of breast diagnosed as cancer, 141-2 Female genital tract tumours, see Gynaecological tumours Fibrillary astrocytoma, 176 Fibroadenoma of breast diagnosed as cancer, 141 Fibrohistiocytic diffuse Hodgkin's disease, 157 Fibromuscular dysplasia, arterial, 82 Fine needle techniques (aspirates/biopsy), 127-52 breast, 138-45 intrathoracic lesion, 146-52 complications, 146 technique, 146 salivary gland, 127-37 thyroid, 23-31 Flow cytometry in lymphoproliferative disorders, 181 2 Follicular adenoma of thyroid, 16 17, 27 Follicular carcinoma of thyroid, 17 mixed medullary and, 19 Follicular centre cell lymphomas, 187-8 Follicular cysts in jaws, 87 8 Fungal refections, nasal/paranasal, 242 7
G Gammopathy, monoclonal, of uncertain significance (MGUS), 224, 230, 231 Gangliocytic paraganglioma, duodenal, I3 Gangliogliomas, 179 Garmer's duct turnouts, 97 Gastric problems, see Stomach Gastrin-producing tumours, 12 Gastrointestinal tract, NO activity, l 18, see also specific r e g i o n s Gemhistiocytic astrocytoma, 176 Genital tract tumours, see Gynaecological tumours Germ cell tumours, 199-221 immunocytochemistry, 44 mediastinal, 150-1 ovaries, 199-221 Giant cell astrocytoma, subependymal, 177 Giant cell gliohlastoma, 177 Glandular fever (infectious mononucleosis; IM), 165-6, 184 Glandular odontogenic cyst, 89-90 Glandular yolk sac tumour, 201-2 Glial-neuronal tumours, mixed, 179 Glioblastoma, 176-7 Glioma, 176-80 Gliomatosis cerebral, 179 peritoneal, 209 Glomeruli in vasculitis, 74-6 Goitre, multinodular, 24-5 Gonadotrophin, human chorionic, dysgerminomas and sermn levels of, 199, 200 Goodpasture's disease, 75, 76
]
Grading gliomas, 180 Hodgkin' s disease, 155-6 Granuloma(s) nasal/paranasal, 237 pregnancy, 237 renal vasculitis and, 74 Granulomatosis lymphomatoid, 250 pulmonary, 251 Wegener's, s e e Wegener's granulomatosis Granulosa cell tumours, juvenile, 204 Gynaecological tumours germ cell, 199-221 mesonephric/Wolffian, 94-100
Y Haemangioendotheliomas, 65-72 Haemangioma, juvenile cellular, 66 Haematopathology, abstracts presented at Vllth meeting of European Association for, 46-59 Haematopoiesis in multiple myeloma, failure, 230 Hamartoma, pulmonary, fine needle aspiration, 148 Hashimoto's thyroiditis, 24, 25 Head and neck carcinoma, EBV-associated, 169-70 Healing, wound, adhesion molecules and, 105-6 Heart, see also Cardiovascular system embolized myxoma, 80-1 NO activity, 117-18 H e l i c o b a c t e r p y l o r i , 184-5 Henoch-Schoenlein nephritis, 75-6 Hepatoid yolk sac turnout, 201,203 Histogenesis of thyroid tumours, 20 1 Histopathology, see specific c o n d i t i o n s Histoplasmosis, 246-7 HIV infection and AIDS aspergillosis in, 244 lymphomas in Hodgkin's, 158 non-Hodgkin's, 167. 251 nasal/paranasal intections in, 242, 244, 247 syphilis and, increased incidence, 242 Hodgkin's ceils, 152 gcnotype, 158 Hodgkin's disease, 153-62, 168, 189 90 cytokine production in, 158 EBV infection and, 158, 168, 19(/ historical background, 152 mediastinal, 151 types, 152 8 Hormone-producing tumours, duodenal, 12-13 Hiirthle (Askanazy) cell change benign (in thyroiditis), 25-6 neoplastic, 26, 27 Hyalinizing trabecular adenoma of thyroid, 17.27 Hyaluronate receptors, 103 inflammation and, 105 malignancy and, 106-7 normal expression, ! 04 Hyperplasia intravascular endothelial, 67 lymphoid, 184, 190 cutaneous, 186 Hypertension pregnancy-induced, NO production and, 116 17 pulmonary, see Pulmonary hypertension Hypertensive vascular disease as pseudovasculitis syndrome, 79
I
i
]
Immunocytochemistry, see hnmunohistochemistry/immunocytochemistry lmmunodeficiency (disorder) adhesion molecule defect causing, 106 combined variable, 190 syndrome of acquired, see HIV infection and AIDS lmmunodiagnostic techniques (in general/unspecified), clonal lymphoproliferative disorders detected via, 181-94
270 CURRENT DIAGNOSTIC PATHOLOGY Immunofluorescence studies lymphoproliferative disorders, 181-2 vasculitis, 259 Immunogenetic studies, Hodgkin's disease, 158-9 Immunoglobulin(s), cytoplasmic, detection, 182 Immunoglobulin-like superfamily, t01 inflammation and, 105 malignancy and, 106 Immunohistochemistry/immunocytochemistry, 38-45 carcinoma of skin (Merkel cell), 4 nodular paragranuloma, 160 yolk sac tumours of ovary, 202-3 Immunopathogenesis, vasculitis, 258-9, 260-3 Immunophenotyping, plasma cell, 226 Immunoproliferative nasal lesions, angiocentric, 249-52 Immunosuppressive drugs, vasculitis, 2 6 3 4 In situ hybridization in EBV-associated disease, 165 immunocytochemistry and, combined, 40 Infants, haemangioendotheliomas, 66, 69 Infections, see also specific diseases and specific (types of) pathogens
adhesion molecules in, 104 AIDS-related opportunistic, 244, 247 immunocytochemistry, 43 lymphoid, distinction from neoplasia, 184--6 nasal/paranasal granulomas due to, 239--47 Inflammation, see also specific inflammatory conditions adhesion molecules and, 104-5 lymphoid, 184 mediastinal, 149, 151 mediators, in vasculitis pathogenesis, 262-3 Inflammatory bowel disease, NO and, 118 Inflammatory nasal lesions, 237-47 Inflammatory odontogenic cyst, 90-1 Insular carcinoid, ovarian, 216-17 Insular carcinoma, thyroid, 19-20, 27 Integrins, 102-3 angiogenesis and, 106 inflammation and, 105 Intensive care, 1-20 Inteffollicular Hodgkin's disease diffuse, 158 nodular sclerosing, 156-7 Interstitial tissues of kidney in vasculitis, 77 Intestine, inflammatory disease, NO and, 118, see also specific regions
Intracranial tumours, 175-80
Jaw cysts/cystic lesions, 86-93 Juvenile granulosa cell turnouts, 204 Juvenile haemangioendothelioma, benign (juvenile haemangioma), 66
Kaposiform haemangioendothelioma of infancy/childhood, 69 Kaposi's sarcoma, haemangioendotheliomas simulating, 68, 69 Keratinization, anal carcinoma, 34, 36, 37 Keratinizing squamous cell carcinoma, anal carcinoma regarded as, 37 Keratocyst, odontogenic, 88-9 Kidney, vasculitis, 73-7 Klebsiella rhinoscleroma, 239-40 Kveim-Siltzbach test, 239
I
L
L-selecfin, 103 inflammation and, 105 malignancy and, 106 Lactation-relatedbenign lesions diagnosed as breast cancer, 142 Large cell carcinoma of lung, 147 Large cell lymphoma, ovarian, differential diagnosis, 200 Leprosy, 240-2 Leucocyte adhesion deficiency, 106
]
Leukaemia lymphoblastic, acute, 186-7 lymphocytic, chronic, 183-4 plasma cell, 230 Light chain restriction in lymphoproliferative disorders, 181-2 Light microscopy, see specific conditions Lobular carcinoma of breast, fine needle aspiration, false negatives, 141 Lukes and Butler classification of Hodgkin's disease, 152 Lung cancer, see Malignancy fine needle aspiration of lesions, 147-9 lymphomatoid granulomatosis, 251 NO production and, 118-19 vasculature, see Pulmonary hypertension Lyme disease, adhesion molecules in, 104 Lymph nodes mediastinal, inflammation, 151 polymorphous haemangioendothelioma of, 71 Lymphoblastic leukaemia, acute, 186-7 Lymphocyte(s) B- and T-, see B-cell; T-cell clonal populations, in lymphoproliferative disorders, detection and significance, 181-94 Lymphocyte-depleted Hodgkin's disease, 155 Lymphocyte-predominant/rich Hodgkin's disease, 155, 157, 189-90 questioning existence, 160 Lymphocytic leukaemia, chronic, 183-4 Lymphoepithelial lesions, salivary, benign, 129-30 Lymphohistiocyte-predominant Hodgkin's disease, 155 Lymphoma, 165-9, 184-6, 187-8, 249-52, see also Adenolymphoma angiocentric, 249-52 EBV-associated, 158, 165-9, 190, 251 gastric, 184q5 Hodgkin's, see Hodgkin's disease immunodeficiency and acquired, see HIV infection and AIDS combined variable, 190 mediastinal, 151 ovarian large cell, differential diagnosis, 200 salivary, 135~5 thyroid, 29 Lymphomatoid granulomatosis, see Granulomatosis Lymphomatoid papulosis, 186 Lymphoproliferative disorders (in general), 165-9, 181-94, 249-52 in Epstein-Baxr virus infection, 158, 165-9, 190, 251 monoclonality, detection and significance, 181-94 nasal, 249-52
M-cadherin, normal expression, 104 M-protein monitoring of patients with, 231 myelomas not secreting, 230-1 Malignancy/cancer (and potential/intermediate malignancy) adhesion molecules and, 106-7, 107-8 anal, 32-7 breast (metastases of), 152 breast (primary tumour), fine needle aspiration false negatives, 140-1 false positives, 141-2 EBV-associated, 158, 165-70, 190, 251 endocrine, 10-13, 16-21 gastric, see Stomach in-anunocytochemistry, 44 lung, 146-7 metastases, 151-2 mediastinal, fine needle aspiration, 150-1, 151, 152-3 nasal/midfacial tissues, 249-52 nasopharyngeal, 169-70 ovarian, 199-205, 208-9, 211-12, 214-20 rete ovarii, 95, 98-9, 99 salivary gland, 130, 131 secondary, see Metastases skin, 10-13 teratomas harbouring, 151, 211-12 thyroid, 16-21, 26-7, 27-30
SUBJECT INDEX TO VOLUME 2 271 transformation to, jaw cyst, 91-3 vascuIar, 69-71 MALTomas/MALT-type lymphomas gastric, 184--6 nasal/midfacial tissue, 250 Mandibular infected buccal cyst, 91 Masson's vegetant intravascular haemangioendothelioma, 67 Maxillary antrum cholesteatoma, 237 cholesterol granuloma, 237 Mediastinum, 60-3, 14%52 self-assessment questions, 60-3 space-occupying lesions, fine needle aspiration, 14%52 Medullary carcinoma, thyroid, 19 Medulloblastoma, 179 Medulloepithelioma, 180 Mercuric chloride, vasculitis model employing, 261-2 Merkel cell carcinoma (skin), 2-5 Mesodermal mixed ovarian tumours, 209 Mesonephric tumours of female genital tract, 94-100 Metastases, turnout CD44 and, 106-7 site lung, fine needle aspiration, 148 mediastinum, fine needle aspiration, 15l-2 thyroid, 29 N-Methyl-D-aspartate receptors and NO synthase, 114 Microscopy electron, carcinoma of skin (Merkel cell), 4-5 light, see specific c o n d i t i o n s Microwave pretreatment, antigen unmasking via, 38-9 Mikulicz cells, 240 Mikulicz disease, 129-30 Mixed cellularity Hodgkin's disease, 155, 157, 190 Mixed tumours CNS, 178, 179 ovarian germ cell, 205 mesodermal, 209 salivary gland, 130 thyroid carcinoma, 19 Models, experimental, systemic vasculitis, 261 2 Monoclonal gammopathy of uncertain significance (MGUS), 224, 230, 231 Monodermal teratoma, 214-21 Mononucleosis, infectious (IM), 165-6, 184 Motility, receptor for hyaluronate-mediated, 103 Mucinous carcinoids, ovarian, 218-19 Muco-epidermoid carcinoma, salivary, 131, 134 Muco-epidermoid odontogenic cyst, 90 Mucormycosis, 245 Mucosa-associated lymphoid tissue lymphomas, s e e MALTomas Miillerian tumours vs. Wolffian turnouts, 94, 95 Multinodular goitre, 24-5 Multiple myeloma, see Myeloma, multiple Muscle development and function, cadherins in, 104 Mutations in lymphoproliferative disorders, 183 M y c o b a c t e r i a spp leprae, 240-2 t u b e r c u l o s i s , see Tuberculoma; Tuberculosis Mycotic infections, nasal/paranasal, 242-7 Myeloma, multiple (plasma cell myeloma), 188-9, 222-35 classification, 227 diagnosis, 188-9, 223-5 epidemiology, 222 manifestations, 188-9, 223 pathogenesis, 222-3 prognostic factors, 227-8 staging, 228-9 treatment, 189, 231-3 variants, 230-1 Myeloperoxidase vasculitis model employing immunization with, 261 in vasculitis pathogenesis, 261 Myiasis, 237, 241-2 in leprosy, 241-2 nasal, 237, 241-2 Myospherulosis, 237-8 Myxoma, cardiac embolized, 80-1 Myxopapillary ependymoma, 178
I
N
N-cadherin, normal expression, 104 NADPH-diaphorase activity, staining for, 113-14, 115 Nasal uleerative/necrotizing diseases, 236-55 Nasopharyngeal carcinoma, 169-70 Necrotizing nasal/paranasal diseases, 236-55 Neoplasms, see Malignancy; Tumours Nephritis, Henoch-Schoenlein, 75-6 Nervous system central, NO and NO synthase in, 114 development/function, cadherins in, 104 Neurilemmoma, mediastinal tumours, 152 Neuroblastoma, 180 olfactory, 179 Neuroectodennal turnouts ovarian, 219-20 primitive, see Primitive neuroectodermal tumours Neuroendocrine turnouts, gastroduodenal, 10-14, see also Carcinoids Neuroepithelial tumours, 175-80 Neurofibromatosis, 82 Neurogenic mediastinal tumours, 152 Neuronal-glial tumours, mixed, 179 Neutrophil autoantibodies (ANCA) in vasculitis, 73-4, 249, 2602, 263 kidney, 73-4 Nitric oxide, 111-21 actions, 112-13 production, 111-21 in vasculitis pathogenesis, 263 Nitric oxide synthase, 111-21 detection and localization, 113-14 isoforms, 111-12 in pathology, 114-19, 263 NMDA receptors and NO synthase, 114 Nocardiosis, 243 Nodular goitre, 24-5 Nodular paragranuloma, 159-60 Nodular sclerosing Hodgkin's disease, 154 7, 190 early lesions preceding, 156-7 subtypes, 155-7 Nose, ulcerative/necrotizing diseases, 236-55
I
I
o
I
Odontogenic epithelium, 86-92 cysts arising from residues of, 87-93 malignant transformation, 91-3 general characteristics, 86-7 Olfactory neuroblastoma, 179 Oligodendroglioma, 178 Oncocytoma, salivary, 131, 132 Oncogenes, lymphomas and Hodgkin's, 159 non-Hodgkin's, 167 Open biopsy, breast, 138-9 Osteoclast-activating factors, myeloma-produced, 229 Osteosclerotic multiple mycloma, 231 Ovaries germ cell tumours, 199-221 mesonephric (Wolffian) tumours, 95-7
[
P
l
P-selectin, 103 inflammation and, 105 malignancy and, 106 p53 gene, lymphoproliferative disorders and, 159, 183 immunocytochemical detection, 41 Papillary angioendotheliomas, Dabska's malignant endovascular, 70 Papillary carcinoma breast, fine needle aspiration, false negatives, 141 thyroid, 17-19, 27-8 Papillary cystadenoma, 131-2
272 CURRENT DIAGNOSTIC PATHOLOGY Retiform Wolffian differentiation, uterine stromal tumours with, 97-8, 98 Rhinomucormycosis, 245 Rhinoscleroma, 239-40 Rhinosporidiosis, 242-3 Rye classification of Hodgkin' s disease, 152
Papilloma breast, fine needle aspiration, diagnosed as cancer, 142 choroid plexus, 178 Paradental cyst, 90-1 Paraganglioma, 179 gangliocytic, duodenal, 13 Paragranuloma, nodular, 159-60 Paranasal sinuses, ulcerative/necrotizing diseases, 236-55 Pemphigoid, bullous, 106 Pemphigus, 106 Periodontal cyst, 89 Peritoneal gliomatosis, 209 Phospholipids, autoantibodies, vaso-occlusive disease and, 81-2 Phycomycosis, 245-6 Pilocytic astrocytoma, 177 Pityriasis lichenoides, 186 Plasma cell(s), in myeloma diagnosis histotopography, 224-5 immunologic characterization, 225 immunophenotyping, 226 labelling index, 225 qualitative abnormalities, 224 quantity, 223-4 Plasma cell leukaemia, 230 Plasma cell myeloma, see Myeloma Plasmacytoma, salivary, 136 Plasmacytosis, reactive vs., neoplastic, 225 Platelets and vasculitis, 263 Pleomorphic adenoma, salivary, 130 Pleomorphic xanthoastrocytoma, 177 Polyarteritis aetiopathogenesis, 259-63 historical aspects, 257-8 treatment, 263-4 Polyembryoma, 204-5 Polymerase chain reaction lymphoblastic leukaemia, 186-7 lymphomas Hodgkin's, 159 non-Hodgkin's, 182-3, 187 T-ceU receptor gene rearrangements, 182-3 Polymorphous haemangioendothelioma of lymph nodes, 71 Polyposis, nasal, 237 Polyvesicular-vitellineyolk sac tumour, 201 Poorly-differentiated carcinoma duodenum, 13 gastric, 11 thyroid, 19-20, 27 Pre-eclampsia, NO production and, 116-17 Pregnancy benign breast lesions diagnosed as cancer, 142 granuloma, 237 hypertension induced by, NO production and, 116-17 Primitive neuroectodermal tumours CNS, 179 ovarian, 219 Primordial cyst in jaw, 88-9 Prostatic lesions, immunocytochemistry, 44 Proteinase 3 and vasculitis, 261 Protoplasmic astrocytoma, 176 Protozoal infections, adhesion molecules in, 104 Pseudoangiosarcoma, 67 Pseudovasculitis syndromes, 78-85 Pulmonary hypertension NO inhalation in, 119 as pseudovasculitis syndrome, 79 Pulmonary tissues, see Lung
I
R
R-cadherin, normal expression, 104 Radicular cyst, 90 Reed-Sternberg cells, see Sternberg-Reed cells Renal vasculitis, 73-7 Respiratory tract, see Lung; Pulmonary hypertension Rete ovarii, proliferative and neoplastic lesions, 95-7 Retiform haemangioend0thelioma, 70 Retiform Sertoli-Leydig cell tumour, 95, 96-7
[
I
s
]
Salivary duct, carcinoma originating from, 131, 135 Salivary gland, 127-37, see a l s o entries under Sialaspirates, 127-37 disorders, 128-36 neoplastic, 130--6 normal, 128 Sarcoidosis, nasal, 239 Sarcoma Hodgkin' s, 157-8 Kaposi's, haemangioendotheliomas simulating, 68, 69 salivary, 136 Schwannoma (neurilemmoma), mediastinal tumours, 152 Scleroma, 239-40 Sebaceous ovarian tumours, 220 Selectins, 103 inflammation and, 105 malignancy and, 106, 108 Seminoma, mediastinal, 151 Sertoli-Leydig cell tumour, retiform, 95, 96-7 Shock, endotoxic, NO production and, 117 Sialadenitis, 129 Sialometaplasia, 238-9 Sialo-odontogenic cyst, 90 Sicca syndrome, 129-30 Sinuses, paranasal, ulcerative/necrotizing diseases, 236-55 Sinusitis in AIDS/HIV disease, 247 allergic fungal, 244-5 Sjtgren's syndrome, salivary gland lesions benign, 129-30 malignant, 136 Skin blistering diseases, 106 endocrine tumours, 2-9 lymphocyte populations, clonal, 186 Small cell carcinoma lung, 147-8 mediastinal metastases, 151-2 skin, 2-5 Small vessel disease in hypertension as pseudovasculitis syndrome, 79 Smouldering multiple myeloma, 230 Somatostatin-producing tumours, 12-13 Spindle cell haemangioendothelioma, 68 Spongioblastoma, 178-9 Squamous cell carcinoma keratinizing, anal carcinoma regarded as, 37 ovarian teratoma harbouring, 211,212 Staging, multiple myeloma, 228-9 Staining in immunocytochemistry, see also s p e c i f i c stains automated, 41 double, 40 Sternberg-Reed cells, 152, 190 genotype, 158 Stomach carcinoma, 11 E-cadherin and, 108 lymphoma, 184-6 neuroendocrine tumours, 10-12, 13 Stromal tumours, uterine, with retiform Wolffian differentiation, 97-8, 98 Struma ovarii, 214-16 Strumal carcinoids, ovarian, 217-18 Subependymal giant cell astrocytoma, 177 Subependymoma, 178 Syncytiotrophoblastic cells in dysgerminoma, 200 Syphilis, nasal involvement, 242 Systemic vasculitis, see Vasculitis
SUBJECT INDEX TO VOLUME 2 273 T
T-cadherin, normal expression, 104 T-cell(s) lymphocytosis, 184 vasculitis and the role of, 262, 263 T-cell lymphoma cutaneous, 186 EBV and, 167-8, 251 nasal/midfacial tissues, 250, 251 T-cell receptor genes antibodies detecting products of, 182 rearrangements, detection, 182-3 Teratoma, 208-21 malignant/immature, 151,208-9 undifferentiated, see Embryonal carcinoma mature cystic, see Dermoid cyst with secondary tumour, 151,212 solid, 210 mediastinal, 150-1 monodermal, 214-21 ovarian, 208-21 Thorax, fine needle aspiration biopsy of lesions in, see Fine needle techniques Thymomas, 149-50 Thyroid, 15-31 ectopic, 151 fine needle aspiration, 23-31 lesions neoplastic, 15-22, 26-30 non-neoplastic, 24-6 normal cytology, 24 Thyroiditis, 25-6 Toxic granuloma of nasal tissues, 237 Trabecular adenoma of thyroid, hyalinizing, 17, 27 Trabecular carcinoids cutaneous, 5-6 ovarian, 217 Transitional cell tumours of Wolffian areas, 99 100 Translocations in lymphoproliferative disorders, 183 Transplantation, lymphoproliferative disease fbllowing, 166-7, 190 T r e p o n e m a p a l l i d u m , 242 Triplet diagnostic method in fine needle aspiration of breast, 139, 142-3 Tuberculoma, puhnonary, fine needle aspiration, 148 Tuberculosis, nasal, 239 Tubular carcinoma of breast, fine needle aspiration, false negatives, 140-1 Tubules, renal, in vasculitis, 76 Tumour(s), s e e also ,~pecific types adhesion molecules and, 106-7, 107 8 anal, 32-7 brain, 175-80 colorectal, 108 duodenal, 10, 12-13 endocrine, 2-31 gastric, see Stomach gynaecological, see Gynaecological tumours immunocytochemistry, 44 lung, fine needle aspiration, 146-7 malignant, see Malignancy mediastinal, fine needle aspiration, 150-1, 151, 152-3 salivary, 130-6 Tumour suppression genes, 107
I [
u
I
Ulcerative colitis, NO and, 118 Ulcerative nasal/paranasal diseases, 236-55 Undifferentiated and anaplastic tumours astrocytic, 176 ependymal, 178, 219 ovaries, 201,219 thyroid carcinoma, 20, 29 Uterine cervix, mesonephric (Wolffian) tumours, 98-9 Uterine corpus, mesonephric (Wolffian) tumours, 97-8
Vagina, mesonephric tmnours, 99 Vascular disease, 65-85 Vasculitis, 73-7, 256-65 conditions mimicking, 78-85 renal, 73-7 systemic, 256-65 aetiopathogenesis, 258-9, 260-3 histopathology, 259-60 historical overview, 256-9 nasal involvement, 247-9 treatment, 263-4 Vaso-occlusive disease of antiphospholipid syndrome, 81-2 VCAM-1 and vasculitis, 262 Viral infections adhesion molecules in, 104 immunocytochemistry, 43 yon Recklinghausen's disease, 82
I
w
1
Warthin's tumour, 131 2 Wegener's granulomatosis, 247-9 aetiopathogenesis, 259-63 p a s s i m clinical features, 247 9 historical aspects, 258 limited, 249 nasal involvement, 247-9 treatment, 263M Wolffian turnouts of female genital tract, 94-100 Womcn, genital tract tumours, see Gynaecological tumours Wound healing, adhesion molecules and, 105 6
I
x
J
Xanthoastrocytoma, pleomorphic, 177 X-linked polymorphism in lymphoproliferative disorders, 183
Y Yolk sac tumour (endodermal sinus tumour), ovarian, 201 3 differential diagnosis, 200, 203
Zollinger-Ellison syndrome, /0, 12 Zygomycosis, 245-6
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