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Subject Index to Volume 66
SUBJECT INDEX TO VOLUME 66 Acoustic startle response prepulse inhibition of, 614 Acute psychological stress working memory-related activity in dorsolateral prefrontal cortex affected by, 25 Acute tryptophan depletion neural responses to emotional words in remitted major depressive disorder affected by, 441 Adcy8, 1123 Addiction stress and, 100 Adolescents anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in, e13 autism in, 316 bipolar disorder in corpus callosum aberrations in, 238 limbic aberrations in, 238 clozapine administration in, postpubertal emergence of brain structural pathology in schizophrenia prevented by, 1038 conduct disorder, decision making and executive function in, 162 psychosis in, gyral and sulcal cortical thinning associated with, 1047 Adverse rearing, 702 Affective disorders diffusion tensor imaging studies in, 814 retinoic acid receptor-␣ in, 832 Aggression borderline personality disorder and, 1107 Alcohol consumption alcohol dependence and, 795 cabergoline effects on, by affecting glial cell line-derived neurotrophic factor, 146 nicotine acetylcholine receptors and, 185 psychosocial adversity effects on, 102 serotonin transporter gene promoter polymorphism and, 102 varenicline effects on, in heavy-drinking smokers, 185 Alcohol dependence alcohol consumption and, 795 childhood risk factors for, 750 genetic risk for, 795 impulsivity and, 734 pro-opiomelanocortin gene variation and, 128 rapid eye movement sleep in, tumor necrosis factor-␣ antagonism effects on, 191 Alcoholism impulsivity and, 734 K-complexes affected by, 177 naltrexone for, 777 opioid receptors, 777 Amygdala enlargement of, in toddlers with autism, 942 glucocorticoid receptors in, 686 grief regulation and, 33 mineralocorticoid receptor overexpression in, corticosterone secretion and anxiety reduced by, 686 neuropeptide Y positive neuron density in, correlation with self-reported anxiety and depression in mesiotemporal lobe epilepsy patients, 433 perigenual anterior cingulate and, in bipolar disorder, 516 0006-3223/09/$36.00 doi:10.1016/S0006-3223(09)01315-8
protein phosphatase 2B blockade in, effect on anxiety- and depression-like behaviors in mice, 1139 reactivity to negative assessment of neutral faces, 847 responses to fearful faces in violent patients with schizophrenia, 570 stress effects on processing of biologically salient stimuli in, 649 thalamic and cortical inputs to, during juvenile–adult transition in mice, 964 Angelman syndrome, 349 Angry-impulsive personality dopamine transporter polymorphisms and, 717 Anhedonia nicotine withdrawal-induced, corticotropin-releasing factor receptor activation mediation of, 110 Anterior cingulate cortex autonomic arousal modulation by, 695 perigenual, 516 Anticipatory anxiety in posttraumatic stress disorder, 47 Antidepressants diazepam and, hippocampal dentate granule cell survival affected by, 5 erythropoietin’s actions as, 267 sleep deprivation and chronotherapy as, in bipolar disorder depression, 298 Anti-N-methyl-D-aspartate receptor encephalitis ovarian teratoma and, e13 Anxiety adverse rearing and, 702 anticipatory, in posttraumatic stress disorder patients, 47 neuropeptide Y positive neuron density in amygdala correlated with self-reports of, 433 protein phosphatase 2B blockade in amygdala effect on, 1139 serotonin transporter gene promoter polymorphisms and, 468 Anxiety disorders neurobiology of, 1072 serotonin-1A receptor in, 627 Appetitive behavior adverse rearing effects on, 702 At risk mental state, 1023 Attentional functioning dehydroepiandrosterone sulfate’s role in, 360 Attention-deficit/hyperactivity disorder BAIAP2 association with, 926 chromosome 6p and, 368 dehydroepiandrosterone sulfate’s role in attentional component of, 360 DRD4-7R as plasticity gene for, e5 electroencephalogram ⌽/ ratio and arousal in, 398 hyperactivity in, 972 hypo-arousal model of, 398 impulsivity in, 972 maternal smoking and, e5, 722 mu reactivity in, 376 phthalates exposure and, 958 prenatal smoking and, e5, 722 reading disabilities and, 368 SLIRTK1’s role in, 918 unpredictable sensory events in, neural reactivity to, 376 BIOL PSYCHIATRY 2009;66:1173–1181 © 2009 Society of Biological Psychiatry
1174 BIOL PSYCHIATRY 2009;66:1173–1181 Atypical antipsychotics cardiovascular risks, 1013 Autism/autism spectrum disorders A-C haplotype, 911 in adolescents, 316 atypical face vs. object processing and hemispheric asymmetries in infants at risk for, 950 brain volume in description of, 313, 316 magnetic resonance imaging of, 320 communication impairments in, 942 corpus callosum in, 316, 935 eagle-eyed visual acuity associated with, e19, e23 endophenotype, 978 ENGRAILED 2 as susceptibility gene for, 911 hemispheric asymmetries in, 950 hyperacuity associated with, e19, e21, e23 immune dysfunction in, 978 in infants, 950 lateralized response timing deficits in, 393 neuroligin and, 904, 906 object processing in, 950 perceptual enhancements in, e19 15q11-q13 region in, screening for genomic rearrangements and methylation abnormalities of, 349 striatal development in, 327 toddlers with, amygdala enlargement in, 942 visual acuity in, e19, e21, e23 Autonomic arousal anterior cingulate cortex modulation of, 695 during sleep in posttraumatic stress disorder, 41 Avoidance behavior Adcy8 and, 1123 BAIAP2 attention-deficit/hyperactivity disorder and, 926 Basal ganglia childhood adversity-induced dysfunction in, effect on reward processing, 206 Bcl-2 polymorphism gray matter volume in ventral striatum influenced by, 804 Benzodiazepines selective serotonin reuptake inhibitors and, hippocampal dentate granule cell survival affected by, 5 Bipolar disorder adolescents with corpus callosum aberrations in, 238 limbic aberrations in, 238 cingulate white matter neurons in, 486 depression serotonin-1A receptor binding in, positron emission tomography quantification of, 223 sleep deprivation and chronotherapy for, 298 emotional dysregulation in, 451 endophenotyes, 1123 gyrification changes in, 293 major depression and, differentiation between, 451 perigenual anterior cingulate and amygdala in, functional and structural connectivity between, 516 risk-aversion and risk-seeking behavior in, 840 Bone mineral density major depressive disorder and, 423 www.sobp.org/journal
Subject Index to Volume 66 Borderline personality disorder aggressive individuals with, 1107 dopamine transporter polymorphisms and, 717 emotional instability in, 854 five-factor model of personality and, 1131 negative social cues, psychological distancing to regulate responses to, 854 Brain methamphetamine-induced injuries, 118 reward function, corticotropin-releasing factor receptor activation mediation of nicotine withdrawal-induced deficits in, 110 trauma-induced injuries, 118 volume of, in autism description of, 313, 316 magnetic resonance imaging of, 320 Brain-derived neurotrophic factor cognitive enhancement in schizophrenia and, 549 depression-like behavior caused by, 84 neuroplasticity and, 549 obsessive-compulsive disorder therapeutic response associated with, 674 serotonin transporter receptors affected by, 477 serotonin-1A receptors unaffected by, 477 valine66methionine variant, in prefrontal gyrification in bipolar disorder, 293 ventral tegmental area, in cocaine craving, 137 Cabergoline alcohol drinking and seeking behaviors decreased by, through attenuation of glial cell line-derived neurotrophic factor, 146 Calpain methamphetamine-induced activation of, 118 Caspase methamphetamine-induced activation of, 118 Catecholamines depletion of, reward processing affected by, 201 Catechol-O-methyltransferase prepulse inhibition in schizophrenia affected by, 615 rs4818C/G polymorphism tolcapone and, effects on prepulse inhibition and working memory, 997 valine158methionine polymorphism affective psychopathology in childhood and, 231 reward processing affected by, 154 working memory networks modulated by, 540 Cerebellum early environmental deprivation effects on, in children, 1100 in schizophrenia, 1067 Cerebral cortex amygdala inputs, during juvenile–adult transition in mice, 964 in schizophrenia, 530, 578 thickness of in adolescents with first-episode early-onset psychosis, 1047 in autism, 320 Cerebral glucose metabolism serotonin modulation of, in depressed older adults, 259 Cerebrospinal fluid interleukin-6 levels, in suicide attempters, 287 neuropeptide Y levels, in posttraumatic stress disorder, 705
Subject Index to Volume 66 Child abuse cortisol reactivity affected by, 69 sexual, gray matter volume affected by, 542 Childhood maltreatment corticotropin-releasing hormone receptor gene and, interaction between, 681 cortisol response to stress in female youths exposed to, 62 hypothalamic-pituitary-adrenal axis dysregulation associated with, 62, 681 left basal ganglia dysfunction during reward anticipation secondary to, 206 stress reactivity and, 62 Children affective psychopathology in, genetic vulnerability to, 231 alcohol dependence risk factors, 750 amygdala enlargement in, with autism, 942 early deprivation in, effects on cerebellar volume and cognitive functioning, 1100 Chromosome 6p attention-deficit/hyperactivity disorder and, 368 Chromosome 15q11-q13 in autism spectrum disorders, screening for genomic rearrangements and methylation abnormalities of, 349 Chronotherapy sleep deprivation and, antidepressant response in bipolar disorder depression, 298 Cingulate cortex perigenual anterior, 516 white matter neurons of, in schizophrenia and bipolar disorder, 486 Citalopram cerebral glucose metabolism modulation by, in depressed older adults, 259 transcranial direct current-induced neuroplasticity affected by, 503 Clozapine in adolescents, postpubertal emergence of brain structural pathology in schizophrenia prevented by, 1038 Cocaine addiction to enhanced drug-related choice in, 169 thalamocortical dysfunctions in, 769 dopamine cell neuroadaptations after self-administration of, 801 ras-guanine nucleotide-releasing factor activation of extracellular signal-regulated kinase signaling in cocaine responses, 758 Cocaine craving ventral tegmental area brain-derived neurotrophic factor in incubation of, 137 Cognitive deficits in major depressive disorder, 879 Cognitive reappraisal of negative self-beliefs in social anxiety disorder, 1091 Cognitive-behavioral therapy schizophrenia treated with, dorsolateral prefrontal cortex activity as predictor of responsiveness to, 594 Conduct disorder early-onset, decision making and executive function in male adolescents with, 162 Copy number variations in schizophrenia, 1005
BIOL PSYCHIATRY 2009;66:1173–1181 1175 Corpus callosum aberrations of, in adolescents with bipolar disorder, 238 in autism, 316, 935 Cortical excitability in posttraumatic stress disorder, 54 serotonin transporter promoter polymorphism allelic variation as modulator of, 283 Corticosterone mineralocorticoid receptor overexpression in amygdala effects on secretion of, 686 Corticotropin-releasing factor gene expression, retinoic acid receptor-␣ in, 823 Corticotropin-releasing factor receptor in brain reward function deficits caused by nicotine withdrawal and stress-induced reinstatement of nicotineseeking, 110 childhood maltreatment and, hypothalamic-pituitary-adrenal axis reactivity affected by, 681 stress-induced redistribution of, in dorsal raphe nucleus, 76 Cortisol childhood maltreatment and abuse effects on, in adulthood, 62, 69 cognitive impairment in major depression and, 879 stress-related responses, in female youths exposed to childhood maltreatment, 62 C-reactive protein fatigue and, 871 as inflammatory markers in schizophrenia, 1013 D-cycloserine exposure-based therapy facilitated by using, 636 fear extinction using, 636 Decision making in early-onset conduct disorder, 162 Deep brain stimulation bithalamical, in Tourette syndrome, e15 subcallosal cingulate gyrus, for treatment-resistant depression, e11 Dehydroepiandrosterone stress tolerance and, 334 Dehydroepiandrosterone sulfate in attentional functioning, 360 stress tolerance and, 334 Depression. See also Major depressive disorder adverse rearing and, 702 bipolar serotonin-1A receptor binding in, positron emission tomography quantification of, 223 sleep deprivation and chronotherapy for, 298 brain-derived neurotrophic factor signaling effects as cause of, 84 cytokines in, 407 description of, 405 electroconvulsive therapy for, e11 epigenetics in, 812 gender and, 84 illness-induced, 407 inflammation-associated, subgenual cingulate activity changes caused by, 407 late-life, white matter abnormalities in, 245 neurogenesis in, 3 neuropeptide Y positive neuron density in amygdala correlated with self-reports of, 433 www.sobp.org/journal
1176 BIOL PSYCHIATRY 2009;66:1173–1181 older adults with, serotonin modulation of cerebral glucose metabolism in, 259 protein phosphatase 2B blockade in amygdala effect on, 1139 QK1 gene expression in suicide victims with, 824 reward function in, 199 reward processing in, catecholamine depletion effects on, 201 serotonin transporter gene promoter polymorphisms and, 468 sickness-induced, 407 subcallosal cingulate gyrus-deep brain stimulation for, in treatment-resistant depression, e11 in temporal lobe epilepsy, 433 transcranial magnetic stimulation for, 509 Depressive-like behavior vesicular glutamate transporter 1 expression and, 275 Diazepam fluoxetine and, hippocampal dentate granule cell survival affected by, 5 Diffusion tensor imaging in affective disorders, 814 Direct brain stimulation during stereotactic limbic surgery, autonomic responses to, 693 Discrimination learning in first-episode schizophrenia, 586 Dissociation dehydroepiandrosterone and dehydroepiandrosterone sulfate effects on, 334 DNA copy number variations in schizophrenia, 1005 Dopamine cell neuroadaptations, after cocaine self-administration, 801 reward processing affected by genetic variability in, 154 smoking-induced release of, in major depressive disorder, 898 Dopamine D1 histone activation inhibited by, 603 inactivation of, L-DOPA-induced dyskinesia inhibited by, 603 Dopamine transporter polymorphisms borderline personality disorder and, 717 Dopaminergic transmission bithalamical deep brain stimulation effects on, in Tourette syndrome, e15 Dorsal raphe nucleus corticotropin-releasing factor receptor subtypes in, stressinduced redistribution of, 76 Dorsolateral prefrontal cortex schizophrenia responsiveness to cognitive-behavioral therapy predicted by activity of, 594 working memory-related activity in, acute psychological stress effects on, 25 DRD4-7R attention-deficit/hyperactivity disorder and, e5 Drug dependence pro-opiomelanocortin gene variation and, 128 DTNBP1, 990 Dyskinesia, L-DOPA-induced dopamine D1 inactivation effects on, 603 in Parkinson disease, ⌬JunD striatal overexpression effects on, 554 www.sobp.org/journal
Subject Index to Volume 66 Dyslexia brain-based measures of processing deficits associated with, 341 Elderly schizophrenia in, neuropathology of cortical changes associated with, 578 Electroconvulsive seizures erythropoietin induction by, 267 Electroconvulsive therapy treatment-resistant depression treated with, e11 Electroencephalogram ⌽/ ratio, arousal in attention-deficit/hyperactivity disorder correlated with, 398 Emotional abuse childhood, cortisol reactivity affected by, 69 Emotional faces amygdala responses to, in violent patients with schizophrenia, 570 Emotional instability in borderline personality disorder, 854 Endocannabinoids signaling, genetic variation in, 9 Endophenotyes bipolar disorder, 1123 description of, 988 ENGRAILED 2, 911 Envy oxytocin effects on, 864 Epigenetics in depression, 812, 824 in suicide, 812, 824 Episodic memory in schizophrenia, 1031 Erythropoietin antidepressant-like efficacy of, 267 electroconvulsive seizure induction of, 267 E-selectin as inflammatory markers in schizophrenia, 1013 Ethanol neurodegeneration induced by, plasmin-mediated degradation of laminin ␥-1, 785 Executive function in early-onset conduct disorder, 162 Exposure-based therapy D-cycloserine with, for fear extinction, 636 Extinction fear memory, ␥-aminobutyric acid-A receptor insertion in amygdala impairment of, 665 Extracellular signal-regulated kinase signaling in striatum, Ras-guanine nucleotide-releasing factor activation of, 758 Facial expressions amygdala reactivity to, 847 Fatigue C-reactive protein and, 871 Fatty acid amide hydrolase, 9 Fear extinction D-cycloserine facilitation of, 636 Fear memory ␥-aminobutyric acid-A receptor insertion in amygdala effects on extinction of, 665
Subject Index to Volume 66
BIOL PSYCHIATRY 2009;66:1173–1181 1177
Fearful faces amygdala responses to, in violent patients with schizophrenia, 570 Five-factor model of personality borderline personality disorder and, 1131 Fluoxetine diazepam and, hippocampal dentate granule cell survival affected by, 5 Forebrain vesicular glutamate transporter 1 in, 275 Freud-2/CC2D1B serotonin-1A receptor expression repressed by, 214 Functional magnetic resonance imaging voxel-based morphometry and, for studying affective psychopathology in childhood, 231
Guanfacine prefrontal cortex affected by, 307 Gyral thickness in adolescents with first episode early-onset psychosis, 1047
␥-aminobutyric acid in posttraumatic stress disorder, 54 ␥-aminobutyric acid-A receptor amygdala insertion of, effects on extinction of fear memory, 665 Gambling catechol-O-methyltransferase valine158methionine polymorphism effects on neurophysiological responses to monetary gains and losses, 154 Iowa Gambling Task, 743 risk-related studies, 743 Gating serotonin-2A receptor polymorphisms and, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Gender depression and, 84 Gene expression patterns in posttraumatic stress disorder, 708 Generalized anxiety disorder metabolic syndrome and, 91 unpredictable averse stimuli in, anxiety responses to, 47 Generalized social anxiety disorder uncinate fasciculus in, white matter abnormality in, 691 Glial cell line– derived neurotrophic factor cabergoline effects on, in alcohol drinking and seeking patients, 146 ventral tegmental area, in cocaine craving, 137 Gloating oxytocin effects on, 864 Glucocorticoid receptors in amygdala, 686 Glucose metabolism cerebral, serotonin modulation of, 259 Glutamate dysregulation of, in schizophrenia, 530, 533 gray matter volume and, 533 Glycogen synthase kinase-3 blocked inhibitory serine-phosphorylation of, 494 Gray matter volume Bcl-2 polymorphism influences on, in ventral striatum, 804 childhood sexual abuse effects on, 542 in elderly schizophrenia patients, 578 glutamatergic dysfunction and, 533 Grief neural mechanisms of regulation, 33
Illness-induced depression, 407 Immune dysfunction in autism, 978 Implicit association test, 522 Impulsive aggression in borderline personality disorder, 1107 Impulsivity alcohol dependence and, 734 in attention-deficit/hyperactivity disorder, 972 preclinical and clinical research of, 714 Inflammation markers of, in schizophrenia, 1013 mood deterioration induced by, subgenual cingulate activity changes caused by, 407 sickness behaviors caused by, 415 Intercellular adhesion molecule-1 as inflammatory markers in schizophrenia, 1013 Interleukin-6 cerebrospinal fluid levels of, in suicide attempters, 287 Iowa Gambling Task, 743
Hippocampus dentate granule cells, diazepam and fluoxetine effects on, 5 Histone 3 dopamine D1 inactivation effects on activation of, 603 Hyperacuity in autism, e19, e21, e23 Hypo-arousal model of attention-deficit/hyperactivity disorder, 398 Hypothalamic-pituitary-adrenal axis childhood maltreatment effects on, 62, 681 dysfunction of, in posttraumatic stress disorder, 708
K-complexes alcoholism effects on, 177 Ketamine suicidality measures treated with, 522 Laminin ␥-1 plasmin-mediated degradation of, in ethanol-induced neurodegeneration, 785 Late life depression white matter abnormalities in, 245 L-DOPA-induced dyskinesia dopamine D1 inactivation effects on, 603 in Parkinson disease, ⌬JunD striatal overexpression effects on, 554 Learning procedural, 393 Light therapy retinal effects of, in seasonal affective disorder patients, 253 Limbic surgery, stereotactic autonomic responses to direct brain stimulation during, 693 Limbic system aberrations of, in adolescents with bipolar disorder, 238 Magnetic resonance imaging brain volume and cortical thickness in autism studied using, 320 www.sobp.org/journal
1178 BIOL PSYCHIATRY 2009;66:1173–1181 neuroanatomic biomarker for psychosis elucidated using, 1055 Major depressive disorder. See also Depression bipolar disorder and, differentiation between, 451 bone mineral density risks and, 423 cognitive impairment in, 879 metabolic syndrome and, 91 osteoporosis risks and, 423 QK1 gene expression in suicide victims with, 824 remitted, acute tryptophan depletion effects on neural responses to emotional words in, 441 rewards processing of, catecholamine depletion effects on, 201 psychotherapy effects on neural responses to, 886 smoking-induced dopamine release in, 898 suicide victims with, QK1 gene expression in, 824 transcranial magnetic stimulation for, 509 Maternal smoking attention-deficit/hyperactivity disorder and, e5, 722 monoamine oxidase A activity reductions associated with, 722 Metabolic syndrome generalized anxiety disorder and, 91 Metacognition in schizophrenia, 1031 Methamphetamine brain injuries caused by, 118 calpain and caspase activation caused by, 118 Methodology importance of, e1 timing-related improvements in, e3 Mineralocorticoid receptor amygdala overexpression of, corticosterone secretion and anxiety reduced by, 686 Monetary gains and losses catechol-O-methyltransferase valine158methionine polymorphism effects on neurophysiological responses to, 154 reward circuitry responsivity to, in posttraumatic stress disorder, 1083 Monoamine oxidase A in pregnant smokers, 728 Mood inflammation-associated deterioration of, subgenual cingulate activity changes caused by, 407 Mu reactivity in attention-deficit/hyperactivity disorder, 376 Naltrexone, 777 Negative self-beliefs in social anxiety disorder, 1091 Neuregulin-1 prepulse inhibition in schizophrenia affected by, 615 Neurogenesis in depression, 3 diazepam and fluoxetine effects on, 5 glycogen synthase kinase-3 inhibitory control blockade effects on, 494 Neurokinin-1 receptor binding of, in panic disorder, 94 Neuroligin autism and, 904, 906 Neuroligin 4, 906 www.sobp.org/journal
Subject Index to Volume 66 Neuropeptide Y cerebrospinal fluid, in posttraumatic stress disorder, 705 positive neuron density in amygdala correlated with selfreports of anxiety and depression, 433 Neuroplasticity brain-derived neurotrophic factor’s role in, 549 serotonin effects on, 503 Nicotine acetylcholine receptors alcohol consumption and, 185 Nicotine withdrawal brain reward function deficits caused by, corticotropinreleasing factor receptor activation mediation of, 110 NOX2 oxidative stress caused by, 384 Obsessive-compulsive disorder brain-derived neurotrophic factor haplotype associated with therapeutic response in, 674 serotonin transporter effects on treatment response to sertraline for, 1115 SLIRTK1’s role in, 918 Opioid receptors alcoholism and, 777 Orbital frontal cortex in impulsive aggression regulation, 1107 Orbitomedial prefrontal cortex, 451 Osteoporosis major depressive disorder and, 423 Ovarian teratoma anti-N-methyl-D-aspartate receptor encephalitis associated with, e13 Oxidative stress NOX2-derived, 384 Oxytocin envy and schadenfreude increased with, 864 Panic disorder neurokinin-1 receptor binding reductions in patients with, 94 Parkinson disease L-DOPA-induced dyskinesia in, ⌬JunD striatal overexpression effects on, 554 Paternal transmission of complex phenotypes, 1061 Perigenual anterior cingulate amygdala and, in bipolar disorder, 516 Phenotypes paternal transmission of, in inbred mice, 1061 Phosphorylation SLITRK1, 918 Phthalates attention-deficit/hyperactivity disorder and, 958 Plasmin laminin ␥-1 degradation mediated by, 785 Positron emission tomography [18F]SPA-RQ, neurokinin-1 receptor binding in panic disorder studied using, 94 serotonin-1A receptor binding in bipolar depression quantified using, 223 Posttraumatic stress disorder anxious reactivity in, 47 cerebrospinal fluid neuropeptide Y concentrations in, 705 cortical excitability dysfunctions in, 54 emotion regulation in, functional magnetic resonance imaging study of, 656
Subject Index to Volume 66 fear extinction in, 1075 ␥-aminobutyric acid-A-ergic function in, 54 gene expression patterns associated with, 708 hypothalamic-pituitary-adrenal axis dysfunction in, 708 monetary gains and losses in, reward circuitry responsivity to, 1083 neurobiology of, 1072 neuropeptide Y concentrations in, 705 selective serotonin reuptake inhibitors for, 17 serotonin effects on, 17 sleep in, autonomic activation during, 41 unpredictable averse stimuli in, anxiety increases during anticipation of, 47 Prader-Willi syndrome, 349 Prefrontal cortex dorsolateral acute psychological stress effects on working memoryrelated activity in, 25 schizophrenia responsiveness to cognitive-behavioral therapy predicted by activity of, 594 warning signs, guanfacine effects on, 307 grief regulation and, 33 guanfacine potentiation of, 307 orbitomedial, 451 Prefrontal gyrification index in bipolar disorder, 293 Pregnancy smoking during, reduced monoamine oxidase A activity in, 728 Prenatal smoking attention-deficit/hyperactivity disorder and, e5, 722 Prepulse inhibition of acoustic startle response, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Preschool neurophysiology in, behavioral prediction of reading ability improved by, 341 Procedural learning, 393 Pro-opiomelanocortin gene substance dependence vulnerability associated with variation in, 128 Protein phosphatase 2B blockade in amygdala, effect on anxiety- and depressionlike behaviors in mice, 1139 Psychopathy schizophrenia and, 570 Psychosis in adolescents, gyral and sulcal cortical thinning associated with, 1047 cognitive status used to predict, 1023 neuroanatomic biomarker for, magnetic resonance imagingbased, 1055 prodromal symptoms of, glutamate dysfunction in patients with, 533 white matter integrity in subjects at high risk for, 562 Psychotherapy neural responses to rewards in major depression affected by, 886 QK1 in suicide victims with major depressive disorder, 824
BIOL PSYCHIATRY 2009;66:1173–1181 1179 Rapid eye movement sleep in alcohol dependence, tumor necrosis factor-␣ antagonism effects on, 191 Ras-guanine nucleotide-releasing factor extracellular signal-regulated kinase signaling in striatum activated by, 758 Reading ability behavioral prediction of, neurophysiology in preschool effects on, 341 Reading disabilities attention-deficit/hyperactivity disorder and, 368 Resilience functional magnetic resonance imaging study of deliberate emotion regulation in, 656 Retina light therapy effects on, in seasonal affective disorder patients, 253 Retinoic acid receptor-␣ in corticotropin-releasing factor gene expression, 823 Reward catechol-O-methyltransferase valine158methionine polymorphism effects on, 154 Reward anticipation ventral striatal activation during, 734 Reward processing basal ganglia dysfunctions, childhood adversity effects on, 206 catecholamine depletion effects on, 201 Rewarding stimuli adverse rearing effects on, 702 Risk-seeking behavior in bipolar disorder, 840 Rule-reversals in first-episode schizophrenia, 586 Schadenfreude oxytocin effects on, 864 Schizophrenia amygdala responses to fearful faces in violent patients with, 570 brain-derived neurotrophic factor and, 549 cerebellar tracts in, microstructural organization of, 1067 cingulate white matter neurons in, 486 clozapine administration in adolescents, postpubertal emergence of brain structural pathology prevented by, 1038 cognition in description of, 1031 enhancement of, brain-derived neurotrophic factor as biomarker of, 549 cognitive-behavioral therapy in, dorsolateral prefrontal cortex activity as predictor of responsiveness to, 594 cortical development in, 530 DNA copy number variation in, 1005 DTNBP1 as candidate gene for, 990 elderly persons with, neuropathology of cortical changes in, 578 first-episode, discrimination learning, reversal, and setshifting in, 586 glutamatergic dysregulation in, 530 inflammatory markers in, 1013 intradimensional/extradimensional task assessments, 586 metacognition in, 1031 www.sobp.org/journal
1180 BIOL PSYCHIATRY 2009;66:1173–1181 phenotypes, 990 prepulse inhibition in, serotonin-2A receptor modulation of, 615 prodromal symptoms of, glutamate dysfunction in patients with, 533 psychopathy and, 570 white matter microstructural disruptions in, 562 Seasonal affective disorder light therapy effects on the retina of patients with, 253 Selective serotonin reuptake inhibitors diazepam and, hippocampal dentate granule cell survival affected by, 5 posttraumatic stress disorder treated with, 17 venlafaxine versus, comprehensive analysis of remission with, e7, e9 Self-beliefs, negative in social anxiety disorder, 1091 Sensorimotor gating serotonin-2A receptor polymorphisms and, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Serotonin cerebral glucose metabolism modulation by, in depressed older adults, 259 posttraumatic stress disorder symptoms affected by, 17 transcranial direct current-induced neuroplasticity affected by, 503 Serotonin transporter brain-derived neurotrophic factor genetic variation and, 477 treatment response to sertraline in obsessive-compulsive disorder predicted by, 1115 Serotonin transporter promoter polymorphism alcohol intake and, 102 cortical excitability modulated by allelic variation in, 283 genotyping of, 468 LL genotype, 102 Serotonin-1A receptor in anxiety disorders, 627 in bipolar depression, positron emission tomography quantification of, 223 brain-derived neurotrophic factor genetic variation effects on, 477 Freud-2/CC2D1B repressor of expression of, 214 Serotonin-2A receptor polymorphisms sensorimotor gating and, 614 Sertraline obsessive-compulsive disorder treated with, serotonin transporter as predictor of response to, 1115 Set-shifting in first-episode schizophrenia, 586 Sexual abuse, childhood gray matter volume affected by, 542 Sexual violence functional magnetic resonance imaging study of deliberate emotion regulation in, 656 Sickness behaviors associated with, neural origins of, 415 depression caused by, 407 Sleep alcoholism effects on, 177 K-complexes in, alcoholism effects on, 177 in posttraumatic stress disorder, 41 www.sobp.org/journal
Subject Index to Volume 66 Sleep deprivation chronotherapy and, antidepressant response in bipolar disorder depression, 298 SLITRK1, 918 Smoking attention-deficit/hyperactivity disorder and, e5, 722 dopamine release induced by, in major depressive disorder, 898 monoamine oxidase A activity affected by, 728 Social anxiety disorder cognitive reappraisal of negative self-beliefs in, 1091 Spermidine/spermine N1-acetyltransferase promoter variants in suicide completers, 460 Stereotactic limbic surgery autonomic responses to direct brain stimulation during, 693 Stress acute psychological, working memory-related activity in dorsolateral prefrontal cortex affected by, 25 addiction and, 100 amygdala processing of biologically salient stimuli affected by, 649 corticotropin-releasing factor receptor subtypes in dorsal raphe nucleus redistributed by, 76 cortisol response to, in female youths exposed to childhood maltreatment, 62 dehydroepiandrosterone and dehydroepiandrosterone sulfate effects on tolerance to, 334 depression-like behavior induced by, gender-related differences in impact of brain-derived neurotrophic signaling on, 84 oxidative, NOX2-derived, 384 vesicular glutamate transporter 1 in forebrain as biological mediator of increased vulnerability to, 275 Stress reactivity childhood maltreatment and, 62 Striatum in autism, 327 extracellular signal-regulated kinase signaling in, Rasguanine nucleotide-releasing factor activation of, 758 ⌬JunD overexpression in, L-DOPA-induced dyskinesia in Parkinson disease reset by, 554 ventral activation during reward anticipation, 734 Bcl-2 polymorphism influences on gray matter volume in, 804 hyperactivity and impulsive in attention-deficit/hyperactivity disorder affected by, 972 Subcallosal cingulate gyrus-deep brain stimulation treatment-resistant depression treated with, e11 Subgenual cingulate inflammation-induced alterations in, 407 Substance dependence pro-opiomelanocortin gene variation and, 128 Suicidality implicit association test used to assess, 522 ketamine effects on measures of, in treatment-resistant depression, 522 Suicide epigenetics in, 812 QK1 gene expression in victims of, with major depressive disorder, 824
Subject Index to Volume 66 spermidine/spermine N1-acetyltransferase promoter variants in, 460 Suicide attempters interleukin-6 levels in cerebrospinal fluid of, 287 Temporal lobe epilepsy self-reported anxiety and depression in, density of neuropeptide Y positive neurons in amygdala correlated with, 433 Thalamocortical dysrhythmia in cocaine addiction, 769 Thalamus amygdala inputs, during juvenile–adult transition in mice, 964 Tolcapone catechol-O-methyltransferase rs4818C/G polymorphism and, effects on prepulse inhibition and working memory, 997 Tourette syndrome bithalamical deep brain stimulation in, e15 SLIRTK1’s role in, 918 Transcranial magnetic stimulation antidepressant response of, associated with more lateral and anterior prefrontal coil location, 509 Tryptophan acute depletion of, neural responses to emotional words in remitted major depressive disorder affected by, 441 Tumor necrosis factor-␣ rapid eye movement sleep in alcohol dependence normalized by antagonism of, 191 Uncinate fasciculus white matter abnormality in, in generalized social anxiety disorder, 691 Varenicline alcohol self-administration reduced using, 185 Vascular cell adhesion molecule-1 as inflammatory markers in schizophrenia, 1013
BIOL PSYCHIATRY 2009;66:1173–1181 1181 Venlafaxine selective serotonin reuptake inhibitors versus, comprehensive analysis of remission with, e7, e9 Ventral striatum activation during reward anticipation, 734 Bcl-2 polymorphism influences on gray matter volume in, 804 hyperactivity and impulsive in attention-deficit/hyperactivity disorder affected by, 972 Ventral tegmental area glial cell line– derived neurotrophic factor cabergoline effects on, in alcohol drinking and seeking patients, 146 in cocaine craving, 137 Vesicular glutamate transporter 1 depressive-like behavior susceptibilities secondary to decreased expression of, 275 Visual acuity in autism, e19, e21, e23 Voxel-based morphometry functional magnetic resonance imaging and, for studying affective psychopathology in childhood, 231 White matter abnormalities of in late life depression, 245 in uncinate fasciculus in generalized social anxiety disorder, 691 cingulate neurons, in schizophrenia and bipolar disorder, 486 in psychosis, 562 in schizophrenia, 486, 562 Working memory catechol-O-methyltransferase valine158methionine polymorphism modulation of, 540 in dorsolateral prefrontal cortex, acute psychological stress effects on, 25 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997
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protein phosphatase 2B blockade in, effect on anxiety- and depression-like behaviors in mice, 1139 reactivity to negative assessment of neutral faces, 847 responses to fearful faces in violent patients with schizophrenia, 570 stress effects on processing of biologically salient stimuli in, 649 thalamic and cortical inputs to, during juvenile–adult transition in mice, 964 Angelman syndrome, 349 Angry-impulsive personality dopamine transporter polymorphisms and, 717 Anhedonia nicotine withdrawal-induced, corticotropin-releasing factor receptor activation mediation of, 110 Anterior cingulate cortex autonomic arousal modulation by, 695 perigenual, 516 Anticipatory anxiety in posttraumatic stress disorder, 47 Antidepressants diazepam and, hippocampal dentate granule cell survival affected by, 5 erythropoietin’s actions as, 267 sleep deprivation and chronotherapy as, in bipolar disorder depression, 298 Anti-N-methyl-D-aspartate receptor encephalitis ovarian teratoma and, e13 Anxiety adverse rearing and, 702 anticipatory, in posttraumatic stress disorder patients, 47 neuropeptide Y positive neuron density in amygdala correlated with self-reports of, 433 protein phosphatase 2B blockade in amygdala effect on, 1139 serotonin transporter gene promoter polymorphisms and, 468 Anxiety disorders neurobiology of, 1072 serotonin-1A receptor in, 627 Appetitive behavior adverse rearing effects on, 702 At risk mental state, 1023 Attentional functioning dehydroepiandrosterone sulfate’s role in, 360 Attention-deficit/hyperactivity disorder BAIAP2 association with, 926 chromosome 6p and, 368 dehydroepiandrosterone sulfate’s role in attentional component of, 360 DRD4-7R as plasticity gene for, e5 electroencephalogram ⌽/ ratio and arousal in, 398 hyperactivity in, 972 hypo-arousal model of, 398 impulsivity in, 972 maternal smoking and, e5, 722 mu reactivity in, 376 phthalates exposure and, 958 prenatal smoking and, e5, 722 reading disabilities and, 368 SLIRTK1’s role in, 918 unpredictable sensory events in, neural reactivity to, 376 BIOL PSYCHIATRY 2009;66:1173–1181 © 2009 Society of Biological Psychiatry
1174 BIOL PSYCHIATRY 2009;66:1173–1181 Atypical antipsychotics cardiovascular risks, 1013 Autism/autism spectrum disorders A-C haplotype, 911 in adolescents, 316 atypical face vs. object processing and hemispheric asymmetries in infants at risk for, 950 brain volume in description of, 313, 316 magnetic resonance imaging of, 320 communication impairments in, 942 corpus callosum in, 316, 935 eagle-eyed visual acuity associated with, e19, e23 endophenotype, 978 ENGRAILED 2 as susceptibility gene for, 911 hemispheric asymmetries in, 950 hyperacuity associated with, e19, e21, e23 immune dysfunction in, 978 in infants, 950 lateralized response timing deficits in, 393 neuroligin and, 904, 906 object processing in, 950 perceptual enhancements in, e19 15q11-q13 region in, screening for genomic rearrangements and methylation abnormalities of, 349 striatal development in, 327 toddlers with, amygdala enlargement in, 942 visual acuity in, e19, e21, e23 Autonomic arousal anterior cingulate cortex modulation of, 695 during sleep in posttraumatic stress disorder, 41 Avoidance behavior Adcy8 and, 1123 BAIAP2 attention-deficit/hyperactivity disorder and, 926 Basal ganglia childhood adversity-induced dysfunction in, effect on reward processing, 206 Bcl-2 polymorphism gray matter volume in ventral striatum influenced by, 804 Benzodiazepines selective serotonin reuptake inhibitors and, hippocampal dentate granule cell survival affected by, 5 Bipolar disorder adolescents with corpus callosum aberrations in, 238 limbic aberrations in, 238 cingulate white matter neurons in, 486 depression serotonin-1A receptor binding in, positron emission tomography quantification of, 223 sleep deprivation and chronotherapy for, 298 emotional dysregulation in, 451 endophenotyes, 1123 gyrification changes in, 293 major depression and, differentiation between, 451 perigenual anterior cingulate and amygdala in, functional and structural connectivity between, 516 risk-aversion and risk-seeking behavior in, 840 Bone mineral density major depressive disorder and, 423 www.sobp.org/journal
Subject Index to Volume 66 Borderline personality disorder aggressive individuals with, 1107 dopamine transporter polymorphisms and, 717 emotional instability in, 854 five-factor model of personality and, 1131 negative social cues, psychological distancing to regulate responses to, 854 Brain methamphetamine-induced injuries, 118 reward function, corticotropin-releasing factor receptor activation mediation of nicotine withdrawal-induced deficits in, 110 trauma-induced injuries, 118 volume of, in autism description of, 313, 316 magnetic resonance imaging of, 320 Brain-derived neurotrophic factor cognitive enhancement in schizophrenia and, 549 depression-like behavior caused by, 84 neuroplasticity and, 549 obsessive-compulsive disorder therapeutic response associated with, 674 serotonin transporter receptors affected by, 477 serotonin-1A receptors unaffected by, 477 valine66methionine variant, in prefrontal gyrification in bipolar disorder, 293 ventral tegmental area, in cocaine craving, 137 Cabergoline alcohol drinking and seeking behaviors decreased by, through attenuation of glial cell line-derived neurotrophic factor, 146 Calpain methamphetamine-induced activation of, 118 Caspase methamphetamine-induced activation of, 118 Catecholamines depletion of, reward processing affected by, 201 Catechol-O-methyltransferase prepulse inhibition in schizophrenia affected by, 615 rs4818C/G polymorphism tolcapone and, effects on prepulse inhibition and working memory, 997 valine158methionine polymorphism affective psychopathology in childhood and, 231 reward processing affected by, 154 working memory networks modulated by, 540 Cerebellum early environmental deprivation effects on, in children, 1100 in schizophrenia, 1067 Cerebral cortex amygdala inputs, during juvenile–adult transition in mice, 964 in schizophrenia, 530, 578 thickness of in adolescents with first-episode early-onset psychosis, 1047 in autism, 320 Cerebral glucose metabolism serotonin modulation of, in depressed older adults, 259 Cerebrospinal fluid interleukin-6 levels, in suicide attempters, 287 neuropeptide Y levels, in posttraumatic stress disorder, 705
Subject Index to Volume 66 Child abuse cortisol reactivity affected by, 69 sexual, gray matter volume affected by, 542 Childhood maltreatment corticotropin-releasing hormone receptor gene and, interaction between, 681 cortisol response to stress in female youths exposed to, 62 hypothalamic-pituitary-adrenal axis dysregulation associated with, 62, 681 left basal ganglia dysfunction during reward anticipation secondary to, 206 stress reactivity and, 62 Children affective psychopathology in, genetic vulnerability to, 231 alcohol dependence risk factors, 750 amygdala enlargement in, with autism, 942 early deprivation in, effects on cerebellar volume and cognitive functioning, 1100 Chromosome 6p attention-deficit/hyperactivity disorder and, 368 Chromosome 15q11-q13 in autism spectrum disorders, screening for genomic rearrangements and methylation abnormalities of, 349 Chronotherapy sleep deprivation and, antidepressant response in bipolar disorder depression, 298 Cingulate cortex perigenual anterior, 516 white matter neurons of, in schizophrenia and bipolar disorder, 486 Citalopram cerebral glucose metabolism modulation by, in depressed older adults, 259 transcranial direct current-induced neuroplasticity affected by, 503 Clozapine in adolescents, postpubertal emergence of brain structural pathology in schizophrenia prevented by, 1038 Cocaine addiction to enhanced drug-related choice in, 169 thalamocortical dysfunctions in, 769 dopamine cell neuroadaptations after self-administration of, 801 ras-guanine nucleotide-releasing factor activation of extracellular signal-regulated kinase signaling in cocaine responses, 758 Cocaine craving ventral tegmental area brain-derived neurotrophic factor in incubation of, 137 Cognitive deficits in major depressive disorder, 879 Cognitive reappraisal of negative self-beliefs in social anxiety disorder, 1091 Cognitive-behavioral therapy schizophrenia treated with, dorsolateral prefrontal cortex activity as predictor of responsiveness to, 594 Conduct disorder early-onset, decision making and executive function in male adolescents with, 162 Copy number variations in schizophrenia, 1005
BIOL PSYCHIATRY 2009;66:1173–1181 1175 Corpus callosum aberrations of, in adolescents with bipolar disorder, 238 in autism, 316, 935 Cortical excitability in posttraumatic stress disorder, 54 serotonin transporter promoter polymorphism allelic variation as modulator of, 283 Corticosterone mineralocorticoid receptor overexpression in amygdala effects on secretion of, 686 Corticotropin-releasing factor gene expression, retinoic acid receptor-␣ in, 823 Corticotropin-releasing factor receptor in brain reward function deficits caused by nicotine withdrawal and stress-induced reinstatement of nicotineseeking, 110 childhood maltreatment and, hypothalamic-pituitary-adrenal axis reactivity affected by, 681 stress-induced redistribution of, in dorsal raphe nucleus, 76 Cortisol childhood maltreatment and abuse effects on, in adulthood, 62, 69 cognitive impairment in major depression and, 879 stress-related responses, in female youths exposed to childhood maltreatment, 62 C-reactive protein fatigue and, 871 as inflammatory markers in schizophrenia, 1013 D-cycloserine exposure-based therapy facilitated by using, 636 fear extinction using, 636 Decision making in early-onset conduct disorder, 162 Deep brain stimulation bithalamical, in Tourette syndrome, e15 subcallosal cingulate gyrus, for treatment-resistant depression, e11 Dehydroepiandrosterone stress tolerance and, 334 Dehydroepiandrosterone sulfate in attentional functioning, 360 stress tolerance and, 334 Depression. See also Major depressive disorder adverse rearing and, 702 bipolar serotonin-1A receptor binding in, positron emission tomography quantification of, 223 sleep deprivation and chronotherapy for, 298 brain-derived neurotrophic factor signaling effects as cause of, 84 cytokines in, 407 description of, 405 electroconvulsive therapy for, e11 epigenetics in, 812 gender and, 84 illness-induced, 407 inflammation-associated, subgenual cingulate activity changes caused by, 407 late-life, white matter abnormalities in, 245 neurogenesis in, 3 neuropeptide Y positive neuron density in amygdala correlated with self-reports of, 433 www.sobp.org/journal
1176 BIOL PSYCHIATRY 2009;66:1173–1181 older adults with, serotonin modulation of cerebral glucose metabolism in, 259 protein phosphatase 2B blockade in amygdala effect on, 1139 QK1 gene expression in suicide victims with, 824 reward function in, 199 reward processing in, catecholamine depletion effects on, 201 serotonin transporter gene promoter polymorphisms and, 468 sickness-induced, 407 subcallosal cingulate gyrus-deep brain stimulation for, in treatment-resistant depression, e11 in temporal lobe epilepsy, 433 transcranial magnetic stimulation for, 509 Depressive-like behavior vesicular glutamate transporter 1 expression and, 275 Diazepam fluoxetine and, hippocampal dentate granule cell survival affected by, 5 Diffusion tensor imaging in affective disorders, 814 Direct brain stimulation during stereotactic limbic surgery, autonomic responses to, 693 Discrimination learning in first-episode schizophrenia, 586 Dissociation dehydroepiandrosterone and dehydroepiandrosterone sulfate effects on, 334 DNA copy number variations in schizophrenia, 1005 Dopamine cell neuroadaptations, after cocaine self-administration, 801 reward processing affected by genetic variability in, 154 smoking-induced release of, in major depressive disorder, 898 Dopamine D1 histone activation inhibited by, 603 inactivation of, L-DOPA-induced dyskinesia inhibited by, 603 Dopamine transporter polymorphisms borderline personality disorder and, 717 Dopaminergic transmission bithalamical deep brain stimulation effects on, in Tourette syndrome, e15 Dorsal raphe nucleus corticotropin-releasing factor receptor subtypes in, stressinduced redistribution of, 76 Dorsolateral prefrontal cortex schizophrenia responsiveness to cognitive-behavioral therapy predicted by activity of, 594 working memory-related activity in, acute psychological stress effects on, 25 DRD4-7R attention-deficit/hyperactivity disorder and, e5 Drug dependence pro-opiomelanocortin gene variation and, 128 DTNBP1, 990 Dyskinesia, L-DOPA-induced dopamine D1 inactivation effects on, 603 in Parkinson disease, ⌬JunD striatal overexpression effects on, 554 www.sobp.org/journal
Subject Index to Volume 66 Dyslexia brain-based measures of processing deficits associated with, 341 Elderly schizophrenia in, neuropathology of cortical changes associated with, 578 Electroconvulsive seizures erythropoietin induction by, 267 Electroconvulsive therapy treatment-resistant depression treated with, e11 Electroencephalogram ⌽/ ratio, arousal in attention-deficit/hyperactivity disorder correlated with, 398 Emotional abuse childhood, cortisol reactivity affected by, 69 Emotional faces amygdala responses to, in violent patients with schizophrenia, 570 Emotional instability in borderline personality disorder, 854 Endocannabinoids signaling, genetic variation in, 9 Endophenotyes bipolar disorder, 1123 description of, 988 ENGRAILED 2, 911 Envy oxytocin effects on, 864 Epigenetics in depression, 812, 824 in suicide, 812, 824 Episodic memory in schizophrenia, 1031 Erythropoietin antidepressant-like efficacy of, 267 electroconvulsive seizure induction of, 267 E-selectin as inflammatory markers in schizophrenia, 1013 Ethanol neurodegeneration induced by, plasmin-mediated degradation of laminin ␥-1, 785 Executive function in early-onset conduct disorder, 162 Exposure-based therapy D-cycloserine with, for fear extinction, 636 Extinction fear memory, ␥-aminobutyric acid-A receptor insertion in amygdala impairment of, 665 Extracellular signal-regulated kinase signaling in striatum, Ras-guanine nucleotide-releasing factor activation of, 758 Facial expressions amygdala reactivity to, 847 Fatigue C-reactive protein and, 871 Fatty acid amide hydrolase, 9 Fear extinction D-cycloserine facilitation of, 636 Fear memory ␥-aminobutyric acid-A receptor insertion in amygdala effects on extinction of, 665
Subject Index to Volume 66
BIOL PSYCHIATRY 2009;66:1173–1181 1177
Fearful faces amygdala responses to, in violent patients with schizophrenia, 570 Five-factor model of personality borderline personality disorder and, 1131 Fluoxetine diazepam and, hippocampal dentate granule cell survival affected by, 5 Forebrain vesicular glutamate transporter 1 in, 275 Freud-2/CC2D1B serotonin-1A receptor expression repressed by, 214 Functional magnetic resonance imaging voxel-based morphometry and, for studying affective psychopathology in childhood, 231
Guanfacine prefrontal cortex affected by, 307 Gyral thickness in adolescents with first episode early-onset psychosis, 1047
␥-aminobutyric acid in posttraumatic stress disorder, 54 ␥-aminobutyric acid-A receptor amygdala insertion of, effects on extinction of fear memory, 665 Gambling catechol-O-methyltransferase valine158methionine polymorphism effects on neurophysiological responses to monetary gains and losses, 154 Iowa Gambling Task, 743 risk-related studies, 743 Gating serotonin-2A receptor polymorphisms and, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Gender depression and, 84 Gene expression patterns in posttraumatic stress disorder, 708 Generalized anxiety disorder metabolic syndrome and, 91 unpredictable averse stimuli in, anxiety responses to, 47 Generalized social anxiety disorder uncinate fasciculus in, white matter abnormality in, 691 Glial cell line– derived neurotrophic factor cabergoline effects on, in alcohol drinking and seeking patients, 146 ventral tegmental area, in cocaine craving, 137 Gloating oxytocin effects on, 864 Glucocorticoid receptors in amygdala, 686 Glucose metabolism cerebral, serotonin modulation of, 259 Glutamate dysregulation of, in schizophrenia, 530, 533 gray matter volume and, 533 Glycogen synthase kinase-3 blocked inhibitory serine-phosphorylation of, 494 Gray matter volume Bcl-2 polymorphism influences on, in ventral striatum, 804 childhood sexual abuse effects on, 542 in elderly schizophrenia patients, 578 glutamatergic dysfunction and, 533 Grief neural mechanisms of regulation, 33
Illness-induced depression, 407 Immune dysfunction in autism, 978 Implicit association test, 522 Impulsive aggression in borderline personality disorder, 1107 Impulsivity alcohol dependence and, 734 in attention-deficit/hyperactivity disorder, 972 preclinical and clinical research of, 714 Inflammation markers of, in schizophrenia, 1013 mood deterioration induced by, subgenual cingulate activity changes caused by, 407 sickness behaviors caused by, 415 Intercellular adhesion molecule-1 as inflammatory markers in schizophrenia, 1013 Interleukin-6 cerebrospinal fluid levels of, in suicide attempters, 287 Iowa Gambling Task, 743
Hippocampus dentate granule cells, diazepam and fluoxetine effects on, 5 Histone 3 dopamine D1 inactivation effects on activation of, 603 Hyperacuity in autism, e19, e21, e23 Hypo-arousal model of attention-deficit/hyperactivity disorder, 398 Hypothalamic-pituitary-adrenal axis childhood maltreatment effects on, 62, 681 dysfunction of, in posttraumatic stress disorder, 708
K-complexes alcoholism effects on, 177 Ketamine suicidality measures treated with, 522 Laminin ␥-1 plasmin-mediated degradation of, in ethanol-induced neurodegeneration, 785 Late life depression white matter abnormalities in, 245 L-DOPA-induced dyskinesia dopamine D1 inactivation effects on, 603 in Parkinson disease, ⌬JunD striatal overexpression effects on, 554 Learning procedural, 393 Light therapy retinal effects of, in seasonal affective disorder patients, 253 Limbic surgery, stereotactic autonomic responses to direct brain stimulation during, 693 Limbic system aberrations of, in adolescents with bipolar disorder, 238 Magnetic resonance imaging brain volume and cortical thickness in autism studied using, 320 www.sobp.org/journal
1178 BIOL PSYCHIATRY 2009;66:1173–1181 neuroanatomic biomarker for psychosis elucidated using, 1055 Major depressive disorder. See also Depression bipolar disorder and, differentiation between, 451 bone mineral density risks and, 423 cognitive impairment in, 879 metabolic syndrome and, 91 osteoporosis risks and, 423 QK1 gene expression in suicide victims with, 824 remitted, acute tryptophan depletion effects on neural responses to emotional words in, 441 rewards processing of, catecholamine depletion effects on, 201 psychotherapy effects on neural responses to, 886 smoking-induced dopamine release in, 898 suicide victims with, QK1 gene expression in, 824 transcranial magnetic stimulation for, 509 Maternal smoking attention-deficit/hyperactivity disorder and, e5, 722 monoamine oxidase A activity reductions associated with, 722 Metabolic syndrome generalized anxiety disorder and, 91 Metacognition in schizophrenia, 1031 Methamphetamine brain injuries caused by, 118 calpain and caspase activation caused by, 118 Methodology importance of, e1 timing-related improvements in, e3 Mineralocorticoid receptor amygdala overexpression of, corticosterone secretion and anxiety reduced by, 686 Monetary gains and losses catechol-O-methyltransferase valine158methionine polymorphism effects on neurophysiological responses to, 154 reward circuitry responsivity to, in posttraumatic stress disorder, 1083 Monoamine oxidase A in pregnant smokers, 728 Mood inflammation-associated deterioration of, subgenual cingulate activity changes caused by, 407 Mu reactivity in attention-deficit/hyperactivity disorder, 376 Naltrexone, 777 Negative self-beliefs in social anxiety disorder, 1091 Neuregulin-1 prepulse inhibition in schizophrenia affected by, 615 Neurogenesis in depression, 3 diazepam and fluoxetine effects on, 5 glycogen synthase kinase-3 inhibitory control blockade effects on, 494 Neurokinin-1 receptor binding of, in panic disorder, 94 Neuroligin autism and, 904, 906 Neuroligin 4, 906 www.sobp.org/journal
Subject Index to Volume 66 Neuropeptide Y cerebrospinal fluid, in posttraumatic stress disorder, 705 positive neuron density in amygdala correlated with selfreports of anxiety and depression, 433 Neuroplasticity brain-derived neurotrophic factor’s role in, 549 serotonin effects on, 503 Nicotine acetylcholine receptors alcohol consumption and, 185 Nicotine withdrawal brain reward function deficits caused by, corticotropinreleasing factor receptor activation mediation of, 110 NOX2 oxidative stress caused by, 384 Obsessive-compulsive disorder brain-derived neurotrophic factor haplotype associated with therapeutic response in, 674 serotonin transporter effects on treatment response to sertraline for, 1115 SLIRTK1’s role in, 918 Opioid receptors alcoholism and, 777 Orbital frontal cortex in impulsive aggression regulation, 1107 Orbitomedial prefrontal cortex, 451 Osteoporosis major depressive disorder and, 423 Ovarian teratoma anti-N-methyl-D-aspartate receptor encephalitis associated with, e13 Oxidative stress NOX2-derived, 384 Oxytocin envy and schadenfreude increased with, 864 Panic disorder neurokinin-1 receptor binding reductions in patients with, 94 Parkinson disease L-DOPA-induced dyskinesia in, ⌬JunD striatal overexpression effects on, 554 Paternal transmission of complex phenotypes, 1061 Perigenual anterior cingulate amygdala and, in bipolar disorder, 516 Phenotypes paternal transmission of, in inbred mice, 1061 Phosphorylation SLITRK1, 918 Phthalates attention-deficit/hyperactivity disorder and, 958 Plasmin laminin ␥-1 degradation mediated by, 785 Positron emission tomography [18F]SPA-RQ, neurokinin-1 receptor binding in panic disorder studied using, 94 serotonin-1A receptor binding in bipolar depression quantified using, 223 Posttraumatic stress disorder anxious reactivity in, 47 cerebrospinal fluid neuropeptide Y concentrations in, 705 cortical excitability dysfunctions in, 54 emotion regulation in, functional magnetic resonance imaging study of, 656
Subject Index to Volume 66 fear extinction in, 1075 ␥-aminobutyric acid-A-ergic function in, 54 gene expression patterns associated with, 708 hypothalamic-pituitary-adrenal axis dysfunction in, 708 monetary gains and losses in, reward circuitry responsivity to, 1083 neurobiology of, 1072 neuropeptide Y concentrations in, 705 selective serotonin reuptake inhibitors for, 17 serotonin effects on, 17 sleep in, autonomic activation during, 41 unpredictable averse stimuli in, anxiety increases during anticipation of, 47 Prader-Willi syndrome, 349 Prefrontal cortex dorsolateral acute psychological stress effects on working memoryrelated activity in, 25 schizophrenia responsiveness to cognitive-behavioral therapy predicted by activity of, 594 warning signs, guanfacine effects on, 307 grief regulation and, 33 guanfacine potentiation of, 307 orbitomedial, 451 Prefrontal gyrification index in bipolar disorder, 293 Pregnancy smoking during, reduced monoamine oxidase A activity in, 728 Prenatal smoking attention-deficit/hyperactivity disorder and, e5, 722 Prepulse inhibition of acoustic startle response, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Preschool neurophysiology in, behavioral prediction of reading ability improved by, 341 Procedural learning, 393 Pro-opiomelanocortin gene substance dependence vulnerability associated with variation in, 128 Protein phosphatase 2B blockade in amygdala, effect on anxiety- and depressionlike behaviors in mice, 1139 Psychopathy schizophrenia and, 570 Psychosis in adolescents, gyral and sulcal cortical thinning associated with, 1047 cognitive status used to predict, 1023 neuroanatomic biomarker for, magnetic resonance imagingbased, 1055 prodromal symptoms of, glutamate dysfunction in patients with, 533 white matter integrity in subjects at high risk for, 562 Psychotherapy neural responses to rewards in major depression affected by, 886 QK1 in suicide victims with major depressive disorder, 824
BIOL PSYCHIATRY 2009;66:1173–1181 1179 Rapid eye movement sleep in alcohol dependence, tumor necrosis factor-␣ antagonism effects on, 191 Ras-guanine nucleotide-releasing factor extracellular signal-regulated kinase signaling in striatum activated by, 758 Reading ability behavioral prediction of, neurophysiology in preschool effects on, 341 Reading disabilities attention-deficit/hyperactivity disorder and, 368 Resilience functional magnetic resonance imaging study of deliberate emotion regulation in, 656 Retina light therapy effects on, in seasonal affective disorder patients, 253 Retinoic acid receptor-␣ in corticotropin-releasing factor gene expression, 823 Reward catechol-O-methyltransferase valine158methionine polymorphism effects on, 154 Reward anticipation ventral striatal activation during, 734 Reward processing basal ganglia dysfunctions, childhood adversity effects on, 206 catecholamine depletion effects on, 201 Rewarding stimuli adverse rearing effects on, 702 Risk-seeking behavior in bipolar disorder, 840 Rule-reversals in first-episode schizophrenia, 586 Schadenfreude oxytocin effects on, 864 Schizophrenia amygdala responses to fearful faces in violent patients with, 570 brain-derived neurotrophic factor and, 549 cerebellar tracts in, microstructural organization of, 1067 cingulate white matter neurons in, 486 clozapine administration in adolescents, postpubertal emergence of brain structural pathology prevented by, 1038 cognition in description of, 1031 enhancement of, brain-derived neurotrophic factor as biomarker of, 549 cognitive-behavioral therapy in, dorsolateral prefrontal cortex activity as predictor of responsiveness to, 594 cortical development in, 530 DNA copy number variation in, 1005 DTNBP1 as candidate gene for, 990 elderly persons with, neuropathology of cortical changes in, 578 first-episode, discrimination learning, reversal, and setshifting in, 586 glutamatergic dysregulation in, 530 inflammatory markers in, 1013 intradimensional/extradimensional task assessments, 586 metacognition in, 1031 www.sobp.org/journal
1180 BIOL PSYCHIATRY 2009;66:1173–1181 phenotypes, 990 prepulse inhibition in, serotonin-2A receptor modulation of, 615 prodromal symptoms of, glutamate dysfunction in patients with, 533 psychopathy and, 570 white matter microstructural disruptions in, 562 Seasonal affective disorder light therapy effects on the retina of patients with, 253 Selective serotonin reuptake inhibitors diazepam and, hippocampal dentate granule cell survival affected by, 5 posttraumatic stress disorder treated with, 17 venlafaxine versus, comprehensive analysis of remission with, e7, e9 Self-beliefs, negative in social anxiety disorder, 1091 Sensorimotor gating serotonin-2A receptor polymorphisms and, 614 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997 Serotonin cerebral glucose metabolism modulation by, in depressed older adults, 259 posttraumatic stress disorder symptoms affected by, 17 transcranial direct current-induced neuroplasticity affected by, 503 Serotonin transporter brain-derived neurotrophic factor genetic variation and, 477 treatment response to sertraline in obsessive-compulsive disorder predicted by, 1115 Serotonin transporter promoter polymorphism alcohol intake and, 102 cortical excitability modulated by allelic variation in, 283 genotyping of, 468 LL genotype, 102 Serotonin-1A receptor in anxiety disorders, 627 in bipolar depression, positron emission tomography quantification of, 223 brain-derived neurotrophic factor genetic variation effects on, 477 Freud-2/CC2D1B repressor of expression of, 214 Serotonin-2A receptor polymorphisms sensorimotor gating and, 614 Sertraline obsessive-compulsive disorder treated with, serotonin transporter as predictor of response to, 1115 Set-shifting in first-episode schizophrenia, 586 Sexual abuse, childhood gray matter volume affected by, 542 Sexual violence functional magnetic resonance imaging study of deliberate emotion regulation in, 656 Sickness behaviors associated with, neural origins of, 415 depression caused by, 407 Sleep alcoholism effects on, 177 K-complexes in, alcoholism effects on, 177 in posttraumatic stress disorder, 41 www.sobp.org/journal
Subject Index to Volume 66 Sleep deprivation chronotherapy and, antidepressant response in bipolar disorder depression, 298 SLITRK1, 918 Smoking attention-deficit/hyperactivity disorder and, e5, 722 dopamine release induced by, in major depressive disorder, 898 monoamine oxidase A activity affected by, 728 Social anxiety disorder cognitive reappraisal of negative self-beliefs in, 1091 Spermidine/spermine N1-acetyltransferase promoter variants in suicide completers, 460 Stereotactic limbic surgery autonomic responses to direct brain stimulation during, 693 Stress acute psychological, working memory-related activity in dorsolateral prefrontal cortex affected by, 25 addiction and, 100 amygdala processing of biologically salient stimuli affected by, 649 corticotropin-releasing factor receptor subtypes in dorsal raphe nucleus redistributed by, 76 cortisol response to, in female youths exposed to childhood maltreatment, 62 dehydroepiandrosterone and dehydroepiandrosterone sulfate effects on tolerance to, 334 depression-like behavior induced by, gender-related differences in impact of brain-derived neurotrophic signaling on, 84 oxidative, NOX2-derived, 384 vesicular glutamate transporter 1 in forebrain as biological mediator of increased vulnerability to, 275 Stress reactivity childhood maltreatment and, 62 Striatum in autism, 327 extracellular signal-regulated kinase signaling in, Rasguanine nucleotide-releasing factor activation of, 758 ⌬JunD overexpression in, L-DOPA-induced dyskinesia in Parkinson disease reset by, 554 ventral activation during reward anticipation, 734 Bcl-2 polymorphism influences on gray matter volume in, 804 hyperactivity and impulsive in attention-deficit/hyperactivity disorder affected by, 972 Subcallosal cingulate gyrus-deep brain stimulation treatment-resistant depression treated with, e11 Subgenual cingulate inflammation-induced alterations in, 407 Substance dependence pro-opiomelanocortin gene variation and, 128 Suicidality implicit association test used to assess, 522 ketamine effects on measures of, in treatment-resistant depression, 522 Suicide epigenetics in, 812 QK1 gene expression in victims of, with major depressive disorder, 824
Subject Index to Volume 66 spermidine/spermine N1-acetyltransferase promoter variants in, 460 Suicide attempters interleukin-6 levels in cerebrospinal fluid of, 287 Temporal lobe epilepsy self-reported anxiety and depression in, density of neuropeptide Y positive neurons in amygdala correlated with, 433 Thalamocortical dysrhythmia in cocaine addiction, 769 Thalamus amygdala inputs, during juvenile–adult transition in mice, 964 Tolcapone catechol-O-methyltransferase rs4818C/G polymorphism and, effects on prepulse inhibition and working memory, 997 Tourette syndrome bithalamical deep brain stimulation in, e15 SLIRTK1’s role in, 918 Transcranial magnetic stimulation antidepressant response of, associated with more lateral and anterior prefrontal coil location, 509 Tryptophan acute depletion of, neural responses to emotional words in remitted major depressive disorder affected by, 441 Tumor necrosis factor-␣ rapid eye movement sleep in alcohol dependence normalized by antagonism of, 191 Uncinate fasciculus white matter abnormality in, in generalized social anxiety disorder, 691 Varenicline alcohol self-administration reduced using, 185 Vascular cell adhesion molecule-1 as inflammatory markers in schizophrenia, 1013
BIOL PSYCHIATRY 2009;66:1173–1181 1181 Venlafaxine selective serotonin reuptake inhibitors versus, comprehensive analysis of remission with, e7, e9 Ventral striatum activation during reward anticipation, 734 Bcl-2 polymorphism influences on gray matter volume in, 804 hyperactivity and impulsive in attention-deficit/hyperactivity disorder affected by, 972 Ventral tegmental area glial cell line– derived neurotrophic factor cabergoline effects on, in alcohol drinking and seeking patients, 146 in cocaine craving, 137 Vesicular glutamate transporter 1 depressive-like behavior susceptibilities secondary to decreased expression of, 275 Visual acuity in autism, e19, e21, e23 Voxel-based morphometry functional magnetic resonance imaging and, for studying affective psychopathology in childhood, 231 White matter abnormalities of in late life depression, 245 in uncinate fasciculus in generalized social anxiety disorder, 691 cingulate neurons, in schizophrenia and bipolar disorder, 486 in psychosis, 562 in schizophrenia, 486, 562 Working memory catechol-O-methyltransferase valine158methionine polymorphism modulation of, 540 in dorsolateral prefrontal cortex, acute psychological stress effects on, 25 tolcapone and catechol-O-methyltransferase rs4818C/G polymorphism effects on, 997
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