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2002 Analysis on behavior of chimeric mice between tenascin knock-out and normal mice
S236
20. Behavior
2001 Department
COLLATERAL PROJECTIONS OF THE MIDLINE THALAMIC NEURONS TO BOTH THE NUCLEUS ACCUMBENS AND THE MEDIAL PREFRONTAL CORTEX IN THE RAT of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan
Kazuyoshi Otake, Yasuhisa Nakamura The midline thalamic nuclei have been known to send projection fibers to the nucleus accumbens (NAc) and the infralimbic area (IL) of the medial prefrontal cortex. We sought to determine whether or not midline thalamic neurons projecting to the NAc issue axon collaterals to the IL in chloral hydrate-anesthetized Sprague-Dawley rats. Retrograde double-labeling study revealed that a subset of midline/intralaminar thalamic neurons, principally in the paraventricular thalamic nucleus, send projection fibers to both the NAc and the IL via axon collaterals. Dually projecting neurons identified in the present study may represent a potential link between the limbic striatum and the viscera-limbic associated cortex, thus suggesting that non-discriminative information relayed to the prefrontal cortex might exert an influence through the same neurons on the nucleus accumbens implicated in affective behavior.
2002
ANALYSIS ON BEHAVIOR OF CHIMERIC MICE BETWEEN OUT AND NORMAL MICE Div. Exp. Anim. Res., RIKEN, 3-l-l Koyadai, Tsukuba, Ibaraki 305, Japan
TENASCIN
KNOCK-
ATSUSHI YOSHIKI, MORIAKI KUSAKABE TNKO is a tenascin knockout mouse strain with behavioral abnormality, such as circling, head tossing and drowning. In order to elucidate the effect of cellular and extracellular environments in the brain tissue on the behavioral abnormality of TNKO, we have generated aggregation chimeras between TNKO and C3H/HeN. We have measured behavioral characteristics of TNKO, C3H and chimeras by a small animal track analysis system. In the open field, TNKO showed significantly more turns and longer duration of back walk than C3H did. In the swimming pool, TNKO mice went into a panic immediately after falling on the water and drowned, or swam in a small circle with abnormal posture. The behavioral pattern of each chimeric mouse in the open field and swimming pool varied from an abnormal TNKO-type pattern to a normal C3H-type. These results indicate that the intermingling pattern of cells in the brain from TNKO and C3H might affect the behavioral characters of chimeric mice.
20. Behavior
2001 Department
COLLATERAL PROJECTIONS OF THE MIDLINE THALAMIC NEURONS TO BOTH THE NUCLEUS ACCUMBENS AND THE MEDIAL PREFRONTAL CORTEX IN THE RAT of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan
Kazuyoshi Otake, Yasuhisa Nakamura The midline thalamic nuclei have been known to send projection fibers to the nucleus accumbens (NAc) and the infralimbic area (IL) of the medial prefrontal cortex. We sought to determine whether or not midline thalamic neurons projecting to the NAc issue axon collaterals to the IL in chloral hydrate-anesthetized Sprague-Dawley rats. Retrograde double-labeling study revealed that a subset of midline/intralaminar thalamic neurons, principally in the paraventricular thalamic nucleus, send projection fibers to both the NAc and the IL via axon collaterals. Dually projecting neurons identified in the present study may represent a potential link between the limbic striatum and the viscera-limbic associated cortex, thus suggesting that non-discriminative information relayed to the prefrontal cortex might exert an influence through the same neurons on the nucleus accumbens implicated in affective behavior.
2002
ANALYSIS ON BEHAVIOR OF CHIMERIC MICE BETWEEN OUT AND NORMAL MICE Div. Exp. Anim. Res., RIKEN, 3-l-l Koyadai, Tsukuba, Ibaraki 305, Japan
TENASCIN
KNOCK-
ATSUSHI YOSHIKI, MORIAKI KUSAKABE TNKO is a tenascin knockout mouse strain with behavioral abnormality, such as circling, head tossing and drowning. In order to elucidate the effect of cellular and extracellular environments in the brain tissue on the behavioral abnormality of TNKO, we have generated aggregation chimeras between TNKO and C3H/HeN. We have measured behavioral characteristics of TNKO, C3H and chimeras by a small animal track analysis system. In the open field, TNKO showed significantly more turns and longer duration of back walk than C3H did. In the swimming pool, TNKO mice went into a panic immediately after falling on the water and drowned, or swam in a small circle with abnormal posture. The behavioral pattern of each chimeric mouse in the open field and swimming pool varied from an abnormal TNKO-type pattern to a normal C3H-type. These results indicate that the intermingling pattern of cells in the brain from TNKO and C3H might affect the behavioral characters of chimeric mice.