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226: Thyroid stimulating hormone and components of metabolic syndrome among outpatient cardiovascular patients in Georgia
Journal of Clinical Lipidology, Vol 2, No 5S, October 2008
statistical significance after controlling for age, BMI, total cholesterol, and creatinine (p=NS). The prevalence of MS increased gradually among groups according to the sex-specific UA quartiles. A multivariate linear regression analysis revealed that SUA level was not an independent variable affecting hfPWV or baPWV both in women and men. This suggests that higher SUA level is independently associated with MS particularly in women, but not with arterial stiffness in Korean subjects.
with euthyroid men (p-values <0.05). Hyperthyroid women had lower LDL-C, TCH and BMI compared with their euthyroid counterparts (p-values <0.05). TSH were correlated with waist circumference among males (r=0.24) and TG concentrations among females (r=0.15). Conclusion: Thyroid dysfunction was present among more than 40% of participants. Hyperthyroid participants had a better metabolic profile in this population than euthyroid participants. Further studies are needed to identify mechanisms behind this observation.
Funding: none Funding: This study was supported by an award from the NIH (T37¨CMD001449) 226 THYROID STIMULATING HORMONE AND COMPONENTS OF METABOLIC SYNDROME AMONG OUTPATIENT CARDIOVASCULAR PATIENTS IN GEORGIA N. Dolidze1, B. Gelaye2, D. Enquobahrie2,3, G. Chapidze1, M. A. Williams2. 1Emergency Cardiology Center, Tbilisi, Georgia, 2University of Washington, Seattle, WA, USA, 3Harvard University, Boston, MA, USA Objective: Thyroid dysfunction and metabolic syndrome (MetS) are associated with increased morbidity and mortality from cardiovascular (CV) diseases. MetS components and thyroid stimulating hormone (TSH) relationships were studied among CV patients. Methods: Male (N=112) and female (N=169) participants were recruited from an outpatient-clinic in Batumi, Georgia. MetS was defined using the Adult Treatment Panel III (ATP III) criteria as the presence of $3 of the following: (1) elevated blood pressure, (2) abdominal obesity, (3) reduced HDL-cholesterol (HDL-C), (4) elevated triglyceride (TG), and 5) elevated fasting glucose (FG). TSH was measured using an ELISA. Results: Females had higher TSH compared with males (mean TSH: 1.31 and 0.95 mg/dl, respectively). 38% of participants were hyperthyroid (46% males and 33% females) and 4% were hypothyroid (3% males and 4% females). Among males, MetS was less common among hyperthyroids compared with euthyroids (53% vs. 69%). Hyperthyroid men had lower LDL-C, total cholesterol (TCH) and FG compared
227 CARDIO-METABOLIC COMPLICATIONS OF SUBCLINICAL HYPOTHYROIDISM IN WOMEN WITH METABOLIC SYNDROME V. Romanov, O. Mitchenko, I. Chulaevskaya, A. Logvinenko. Institution of Cardiology, Department of Dyslipidemia, Kiev, Ukraine Objective: A subclinical hypothyroidism(SH) is the independent factor of cardiovascular diseases for women over 50 years. Methods: 52 women with metabolic syndrom (MS) are surveyed 2 gr.: 1 gr. – 30 pts with MS and SH (thyrotropin (TSH) =8,2± 2,7 IU /ml, FT4 = 2,8±0,1 ng/ml); 2 gr. – 22 pts with MS (ÒSH = 2,1± 0,4 IU/ml, FT4 = 1,9±0,1 ng/ml). Were determined: waist circumference (WC), body mass index (BMI), levels of TSH, free T4, glucose, insulin, leptin and lipids. Results: patients of 1 gr. had authentically large displays of abdominal obesity (WC=102,1±3,4 sm) in comparison with 2 gr. (WC=88,2±2,4 sm) though BMI in both groups did not differ (31,1±1,5 and 33,1±1,5 kg/m2 accordingly).In 1-st group the greatest displays of hyperleptinemia (34,4±4,7) ng/ml were marked, that considerably exceeded norm and can testify to occurrence resistance to leptin. In both groups it were marked normative of glucose and HOMA-index, whereas increased of the cholesterol level (5,4±0,2d mmol/l), hypertriglyceridemia (2,8±0,2) mmol/l and decrease HDL cholesterol (1,0±0,1) mmol/l were marked only in 1-st group.The women of 1 gr. had increase the left ventricular mass index =
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statistical significance after controlling for age, BMI, total cholesterol, and creatinine (p=NS). The prevalence of MS increased gradually among groups according to the sex-specific UA quartiles. A multivariate linear regression analysis revealed that SUA level was not an independent variable affecting hfPWV or baPWV both in women and men. This suggests that higher SUA level is independently associated with MS particularly in women, but not with arterial stiffness in Korean subjects.
with euthyroid men (p-values <0.05). Hyperthyroid women had lower LDL-C, TCH and BMI compared with their euthyroid counterparts (p-values <0.05). TSH were correlated with waist circumference among males (r=0.24) and TG concentrations among females (r=0.15). Conclusion: Thyroid dysfunction was present among more than 40% of participants. Hyperthyroid participants had a better metabolic profile in this population than euthyroid participants. Further studies are needed to identify mechanisms behind this observation.
Funding: none Funding: This study was supported by an award from the NIH (T37¨CMD001449) 226 THYROID STIMULATING HORMONE AND COMPONENTS OF METABOLIC SYNDROME AMONG OUTPATIENT CARDIOVASCULAR PATIENTS IN GEORGIA N. Dolidze1, B. Gelaye2, D. Enquobahrie2,3, G. Chapidze1, M. A. Williams2. 1Emergency Cardiology Center, Tbilisi, Georgia, 2University of Washington, Seattle, WA, USA, 3Harvard University, Boston, MA, USA Objective: Thyroid dysfunction and metabolic syndrome (MetS) are associated with increased morbidity and mortality from cardiovascular (CV) diseases. MetS components and thyroid stimulating hormone (TSH) relationships were studied among CV patients. Methods: Male (N=112) and female (N=169) participants were recruited from an outpatient-clinic in Batumi, Georgia. MetS was defined using the Adult Treatment Panel III (ATP III) criteria as the presence of $3 of the following: (1) elevated blood pressure, (2) abdominal obesity, (3) reduced HDL-cholesterol (HDL-C), (4) elevated triglyceride (TG), and 5) elevated fasting glucose (FG). TSH was measured using an ELISA. Results: Females had higher TSH compared with males (mean TSH: 1.31 and 0.95 mg/dl, respectively). 38% of participants were hyperthyroid (46% males and 33% females) and 4% were hypothyroid (3% males and 4% females). Among males, MetS was less common among hyperthyroids compared with euthyroids (53% vs. 69%). Hyperthyroid men had lower LDL-C, total cholesterol (TCH) and FG compared
227 CARDIO-METABOLIC COMPLICATIONS OF SUBCLINICAL HYPOTHYROIDISM IN WOMEN WITH METABOLIC SYNDROME V. Romanov, O. Mitchenko, I. Chulaevskaya, A. Logvinenko. Institution of Cardiology, Department of Dyslipidemia, Kiev, Ukraine Objective: A subclinical hypothyroidism(SH) is the independent factor of cardiovascular diseases for women over 50 years. Methods: 52 women with metabolic syndrom (MS) are surveyed 2 gr.: 1 gr. – 30 pts with MS and SH (thyrotropin (TSH) =8,2± 2,7 IU /ml, FT4 = 2,8±0,1 ng/ml); 2 gr. – 22 pts with MS (ÒSH = 2,1± 0,4 IU/ml, FT4 = 1,9±0,1 ng/ml). Were determined: waist circumference (WC), body mass index (BMI), levels of TSH, free T4, glucose, insulin, leptin and lipids. Results: patients of 1 gr. had authentically large displays of abdominal obesity (WC=102,1±3,4 sm) in comparison with 2 gr. (WC=88,2±2,4 sm) though BMI in both groups did not differ (31,1±1,5 and 33,1±1,5 kg/m2 accordingly).In 1-st group the greatest displays of hyperleptinemia (34,4±4,7) ng/ml were marked, that considerably exceeded norm and can testify to occurrence resistance to leptin. In both groups it were marked normative of glucose and HOMA-index, whereas increased of the cholesterol level (5,4±0,2d mmol/l), hypertriglyceridemia (2,8±0,2) mmol/l and decrease HDL cholesterol (1,0±0,1) mmol/l were marked only in 1-st group.The women of 1 gr. had increase the left ventricular mass index =
S105