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260 The abdominal CT radiation does not modify seminal parameters
260
The abdominal CT radiation does not modify seminal parameters Eur Urol Suppl 2014;13;e260
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Ciudin A. 1 , Diaconu M.G.1 , Corral J.M.1 , Constantin V. 2 , Carap A. 2 , Alvarez-Vijande R.1 , Ballesca J.L. 3 , Alcaraz A. 1 1 Hospital
Clínic de Barcelona, Dept. of Urology, Barcelona, Spain, 2 Hospital Sf. Pantelimon Bucharest, Dept. of Surgery and Urology,
Bucharest, Romania, 3 Hospital Clínic de Barcelona, Dept. of Fertility, Barcelona, Spain INTRODUCTION & OBJECTIVES: There is a known relation between radiation and spermatogenesis as low doses of radiation can produce temporary maturation arrest and higher doses can produce definitive azoospermia. Furthermore, the CT scan is increasingly used for the diagnosis and monitoring of abdominal and pelvic diseases and is associated with a fair amount of radiation. Our objective was to determine if there is any modification in the seminal parameters of patients undergoing abdominal CT. MATERIAL & METHODS: Prospective study. The including criteria were: males, between 20 and 50 years of age undergoing programmed abdominal CT, normal semen analysis previous to the CT. Exclusion criteria: radiological explorations in the previous 6 months, patients denial to participate in the study. All patients underwent a standard semen analysis before undergoing the abdominal CT. All CTs had been indicated for other medical reasons as part of diagnostic or follow-up explorations. All CT were performed on the same machine with the same characteristics and the same estimated radiation dose. The CT investigated area reached the scrotum in all patients. Two semen analyses were performed at 1 and 3 months after the CT. In all patients blood analysis with FSH, LH, inhibin B, testosterone and SHBG were performed before and also 1 and 3 months after the abdominal CT. The Student t test and the Bland-Altman analysis were used for comparing the results. RESULTS: The study was offered to 60 patients. A total of 43 patients complied with the required criteria and agreed to participate were included. Two patients were lost to follow-up. Up to 41 patients finished the study and were included in the statistical analysis. Mean CT dose was 1400mGycm. All patients had baseline normal biochemical parameters. At 1 month a small decrease of total sperm count was seen but without statistical significance (Student t P=0.52). The Bland-Altman test showed a mean variation of 3.88% for total sperm count (-7millions (-3 to -14 millions) sperm over a total of 180millions (110 to 400 millions)) and a mean variation of 3.04% for A+B motility sperm (-2.5millions (-1 to -4millions) over a total of 82millions). No differences were encountered between baseline and three months parameters. Lower levels of inhibin B were registered at 1 month compared to baseline and 3 months with statistical significance (Student t P<0.05). The Bland-Altman analysis showed a mean variation of 23.91% (-55 (-20 to -80) over a total of 230 (160 - 320)) when comparing baseline with one month. No differences were encountered between baseline and three months parameters. FSH and also LH, testosterone and SHBG did not show differences between baseline and 1 or 3 months parameters. CONCLUSIONS: Standard abdominal CT produces a transitory decrease of inhibin B levels without affecting other sperm count or hormonal parameters.
The abdominal CT radiation does not modify seminal parameters Eur Urol Suppl 2014;13;e260
Print! Print!
Ciudin A. 1 , Diaconu M.G.1 , Corral J.M.1 , Constantin V. 2 , Carap A. 2 , Alvarez-Vijande R.1 , Ballesca J.L. 3 , Alcaraz A. 1 1 Hospital
Clínic de Barcelona, Dept. of Urology, Barcelona, Spain, 2 Hospital Sf. Pantelimon Bucharest, Dept. of Surgery and Urology,
Bucharest, Romania, 3 Hospital Clínic de Barcelona, Dept. of Fertility, Barcelona, Spain INTRODUCTION & OBJECTIVES: There is a known relation between radiation and spermatogenesis as low doses of radiation can produce temporary maturation arrest and higher doses can produce definitive azoospermia. Furthermore, the CT scan is increasingly used for the diagnosis and monitoring of abdominal and pelvic diseases and is associated with a fair amount of radiation. Our objective was to determine if there is any modification in the seminal parameters of patients undergoing abdominal CT. MATERIAL & METHODS: Prospective study. The including criteria were: males, between 20 and 50 years of age undergoing programmed abdominal CT, normal semen analysis previous to the CT. Exclusion criteria: radiological explorations in the previous 6 months, patients denial to participate in the study. All patients underwent a standard semen analysis before undergoing the abdominal CT. All CTs had been indicated for other medical reasons as part of diagnostic or follow-up explorations. All CT were performed on the same machine with the same characteristics and the same estimated radiation dose. The CT investigated area reached the scrotum in all patients. Two semen analyses were performed at 1 and 3 months after the CT. In all patients blood analysis with FSH, LH, inhibin B, testosterone and SHBG were performed before and also 1 and 3 months after the abdominal CT. The Student t test and the Bland-Altman analysis were used for comparing the results. RESULTS: The study was offered to 60 patients. A total of 43 patients complied with the required criteria and agreed to participate were included. Two patients were lost to follow-up. Up to 41 patients finished the study and were included in the statistical analysis. Mean CT dose was 1400mGycm. All patients had baseline normal biochemical parameters. At 1 month a small decrease of total sperm count was seen but without statistical significance (Student t P=0.52). The Bland-Altman test showed a mean variation of 3.88% for total sperm count (-7millions (-3 to -14 millions) sperm over a total of 180millions (110 to 400 millions)) and a mean variation of 3.04% for A+B motility sperm (-2.5millions (-1 to -4millions) over a total of 82millions). No differences were encountered between baseline and three months parameters. Lower levels of inhibin B were registered at 1 month compared to baseline and 3 months with statistical significance (Student t P<0.05). The Bland-Altman analysis showed a mean variation of 23.91% (-55 (-20 to -80) over a total of 230 (160 - 320)) when comparing baseline with one month. No differences were encountered between baseline and three months parameters. FSH and also LH, testosterone and SHBG did not show differences between baseline and 1 or 3 months parameters. CONCLUSIONS: Standard abdominal CT produces a transitory decrease of inhibin B levels without affecting other sperm count or hormonal parameters.