288 ASSESSMENT OF MORTALITY FOR NON CANCER-RELATED MORTALITY IN PATIENTS WITH HISTOLOGICALLY PROVEN SMALL RENAL MASSES MANAGED NON-SURGICALLY

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Poster Session 18 RENAL TUMOURS: DIAGNOSIS AND IMAGING 1 Sunday, 18 April, 12.15-13.45, Barcelona Room

286

EXTERNAL VALIDATION OF A NOMOGRAM PREDICTING DISEASE-SPECIFIC SURVIVAL OF PATIENTS WITH PAPILLARY RENAL CELL CARCINOMA

+XWWHUHU*&&KURPHFNL7)=LJHXQHU50DQQZHLOHU6.ODWWH7.DPSHO .HWWQHU.3XPPHU.5HP]L0 1 Medical University Graz, Dept. of Urology, Graz, Austria, 2Medical University Graz, Institute of Pathology, Graz, Austria, 3Medical University Vienna, Dept. of Urology, Vienna, Austria Introduction & Objectives: 3URJQRVWLFLQGLFDWRUVRISDSLOODU\UHQDOFHOOFDUFLQRPD 35&&  DUH QRW ZHOO GHᚏQHG 5HFHQWO\ D QRPRJUDP SUHGLFWLQJ FDQFHUVSHFLᚏF VXUYLYDO&66 LQSDWLHQWVDᚎHFWHGE\35&&KDVEHHQGHYHORSHG.ODWWHHWDO(XU 8URO6XSSO 2XULQWHQWLRQZDVWRH[WHUQDOO\YDOLGDWHWKLVQRPRJUDP Material & Methods: $IWHULQVWLWXWLRQDOUHYLHZERDUGDSSURYDOGDWDZHUHUHWULHYHG IURPWKH5&&GDWDEDVHRIRXULQVWLWXWLRQ$OO5&&VSHFLPHQVRULJLQDOO\FODVVLᚏHGDV 35&&XQGHUZHQWDV\VWHPDWLFSDWKRORJLFDOUHHYDOXDWLRQDFFRUGLQJWRVWULFWFULWHULD E\ RQH SDWKRORJLVW 60  ZKR ZDV EOLQGHG WR SDWLHQWVಬ RXWFRPHV 7KH WXPRXUV ZHUHHYDOXDWHGZLWKUHVSHFWWRS7FODVVLᚏFDWLRQ710 O\PSKQRGHVWDWXV )XKUPDQ JUDGH ,,9  WXPRXU VL]H VXEW\SH RI 35&& W\SH  RU   DQG WXPRXU QHFURVLVDEVHQWSUHVHQWLQืRULQ!RIWKHWXPRXUDUHDUHVSHFWLYHO\  'LVHDVHVSHFLᚏFVXUYLYDOGDWDZHUHUHWULHYHGIURPRXUGDWDEDVH7KHQRPRJUDP SUHGLFWLQJ\HDU&66SUREDELOLWLHVFRQVLVWVRIWKHIROORZLQJSDUDPHWHUVLQFLGHQWDO RUV\PSWRPDWLFSUHVHQWDWLRQS7FODVVLᚏFDWLRQ0VWDWXV0RU0 DWSUHVHQWDWLRQ YDVFXODU LQYDVLRQ DQG VHPLTXDQWLWDWLYH DVVHVVPHQW RI QHFURVLV DV GHVFULEHG DERYH&DQFHUVSHFLᚏFVXUYLYDOSUREDELOLWLHVZHUHFDOFXODWHGZLWKWKHQRPRJUDP IRUPXOD GHULYHG IURP WKH GHYHORSPHQW FRKRUW 7KH QRPRJUDPSUHGLFWHG VXUYLYDO SUREDELOLWLHV DQG DFWXDO &66 ZHUH FRPSDUHG PRUHRYHU SUHGLFWLYH DFFXUDFLHV ZHUHGHᚏQHGXVLQJWKHSUHGLFWHGSUREDELOLW\YDOLGDWLRQPHWKRG Results: 7KH H[WHUQDO YDOLGDWLRQ FRKRUW FRQVLVWHG RI  SDWLHQWV  IHPDOHV PDOHV XQGHUJRLQJVXUJHU\IRU35&&IURPWR0HDQDJHZDV \HDUV UDQJH      WXPRXUV ZHUH 35&& W\SH  DQG    ZHUH W\SH7KHS7FODVVLᚏFDWLRQVZHUHS7DLQ S7ELQ S7LQ  S7DLQ DQGS7ELQ FDVHVUHVSHFWLYHO\)XKUPDQ JUDGH,ZDVSUHVHQWLQ JUDGH,,LQ DQGJUDGH,,,LQ  WXPRXUVUHVSHFWLYHO\6HYHQ SDWLHQWVSUHVHQWHGZLWKQRGHSRVLWLYHGLVHDVH DQGVL[ ZLWKGLVWDQWPHWDVWDVHV0HGLDQWXPRXUVL]HZDVFPPHDQ UDQJH 9DVFXODULQYDVLRQZDVREGHUYHGLQ DEVHQFHRIQHFURVLV LQ    SUHVHQFH RI QHFURVLV ื LQ    DQG QHFURVLV ! LQ    WXPRXUV UHVSHFWLYHO\ 0HGLDQ IROORZXS ZDV  PRQWKV PHDQ  UDQJH   ,Q PXOWLYDULDWH DQDO\VHV 7VWDJH 1VWDJH 0VWDJH DV ZHOO DV YDVFXODULQYDVLRQZHUHVWDWLVWLFDOO\VLJQLᚏFDQWDOOS &DQFHUUHODWHGPRUWDOLW\ RFFXUUHGLQ SDWLHQWV0HGLDQWLPHIURPVXUJHU\WRGHDWKIURPFDQFHUZDV PRQWKVPHDQUDQJH 7KHSUHGLFWLYHDFFXUDF\RIWKHQRPRJUDPLQ WKHH[WHUQDOYDOLGDWLRQFRKRUWZDV Conclusions: :HZHUHDEOHWRYDOLGDWHWKHQRPRJUDPSUHGLFWLQJGLVHDVHVSHFLᚏF VXUYLYDO RI SDWLHQWV ZLWK 35&& ZLWK D SUHGLFWLYH DFFXUDF\ RI  7KXV WKLV QRPRJUDPFRXOGEHUHFRPPHQGHGIRUIROORZXSVWUDWLᚏFDWLRQ

287

PRETREATMENT NEUTROPHIL-TO-LYMPHOCYTE RATIO IS AN INDEPENDENT PREDICTOR OF METASTASIS IN PATIENTS WITH NON-METASTATIC RENAL CELL CARCINOMA

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288

ASSESSMENT OF MORTALITY FOR NON CANCERRELATED MORTALITY IN PATIENTS WITH HISTOLOGICALLY PROVEN SMALL RENAL MASSES MANAGED NON-SURGICALLY

-HOGUHV&/XJKH]]DQL*%XG¦XV//LEHUPDQ'6XQ06KDULDW6) 3HUURWWH3*UDHIHQ00RQWRUVL).DUDNLHZLF]3, 1 Cancer Prognostics and Health Outcomes Unit, Dept. of Urology, Montreal, Canada, 2Vita-Salute San Raffaele, Dept. of Urology, Milan, Italy, 3Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany, 4University of Montreal Health Center, Dept. of Urology, Montreal, Canada, 5University of Montreal Health Center, Cancer Prognostics and Health Outcomes Unit, Montreal, Canada Introduction & Objectives: 7KH 1DWLRQDO &RPSUHKHQVLYH &DQFHU 1HWZRUN JXLGHOLQHV VXJJHVW WKH XVH RI QRQVXUJLFDO PDQDJHPHQW 160  IRU VPDOO UHQDO PDVVHV LQ SDWLHQWV ZLWK PXOWLSOH FRPRUELGLWLHV DQG LQ WKRVH ZLWK OLPLWHG OLIH H[SHFWDQF\:HH[DPLQHGWKHUDWHVRIQRQFDQFHUUHODWHGPRUWDOLW\1&50 LQWKLV FDWHJRU\RISDWLHQWV Material & Methods: :LWKLQ WKH 6XUYHLOODQFH (SLGHPLRORJ\ DQG (QG 5HVXOWV GDWDEDVHZHLGHQWLᚏHG160SDWLHQWVIRU7DUHQDOFHOOFDUFLQRPDEHWZHHQ DQG1&50UDWHVZHUHDVVHVVHGZLWKWKH.DSODQ0HLHUDQGOLIHWDEOH PHWKRGV/RJUDQNWHVWVZHUHXVHGIRULQWHUJURXSFRPSDULVRQV Results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ᚏHGPDOLJQDQFLHV  Conclusions: 2OGHUSDWLHQWVDUHPRUHOLNHO\WRGLHRI1&50WKDQWKHLU\RXQJHU FRXQWHUSDUWV 6LPLODUO\ PDOHV DQG $IULFDQ $PHULFDQV DUH PRUH SURQH WR GLH RI 1&50 WKDQ WKHLU IHPDOH DQG &DXFDVLDQ FRXQWHUSDUWV 7KH UDWH RI 1&50 UDWHV KDYHGHFUHDVHGLQ160SDWLHQWVIRUVPDOOUHQDOPDVVHVLQUHQDOFHOOFDUFLQRPD 7KLV LPSOLHV WKDW LQGLFDWLRQ IRU 160 LQ WKHVH SDWLHQWV PD\ KDYH EHFRPH OHVV VHOHFWLYH7KHUHIRUH160PD\UHTXLUHDUHDSSUDLVDO

Eur Urol Suppl 2010;9(2):117