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291 PERIPHERALLY LOCATED RENAL MASSES CARRY A HIGHER RISK OF HISTOLOGICALLY PROVEN BENIGN DISEASE WHEN COMPARED WITH CENTRAL MASSES
CA9 MRNA IS HIGHLY DETECTABLE IN THE SERUM OF PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA
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/L*)HQJ*=KDR$*HQWLO3HUUHW$3DXO6*HQLQ&*LJDQWH0 7RVWDLQ- 1 CHU of Saint-Etienne, Jean-Monnet University, Dept. of Urology, Saint-Etienne, France, 2CHU of Saint-Etienne, Jean-Monnet University, Dept. of Pathology, Saint-Etienne, France, 3CHU of Saint-Etienne, Jean-Monnet University, Immunology Laboratory, Saint-Etienne, France Introduction & Objectives: 5HFHQWVWXGLHVKDYHGHPRQVWUDWHGWKDWWKHFLUFXODWLQJ WXPRXUGHULYHG '1$ RU 51$ SURYLGHV QHZ ZD\V IRU GLDJQRVLV RU SURJQRVLV RI FDQFHU &$ LV IRXQG WR EH RQH RI WKH PRVW SRZHUIXO PROHFXODU PDUNHUV IRU FRQYHQWLRQDO RU FOHDU FHOO UHQDO FHOO FDQFHU FF5&& :H K\SRWKHVL]H WKDW &$ P51$H[SUHVVLRQLQVHUXPPLJKWEHDQHZPHWKRGIRUWKHPROHFXODUGLDJQRVLVRU IROORZXSRIFF5&& Material & Methods: 6HUXP VDPSOHV ZHUH FROOHFWHG IURP SDWLHQWV ZLWK D FF5&&VHUXPVDPSOHVIURPQRUPDOVXEMHFWVZHUHXVHGDVFRQWUROVVHUXP VDPSOHVZHUHWDNHQRQHZHHNDIWHUVXUJHU\VHUXPVDPSOHVZHUHDOVRREWDLQHG GXULQJIROORZXSDIWHUVXUJHU\$IWHUWKHH[WUDFWLRQRI51$ZHSHUIRUPHG573&5 WRPHDVXUH&$ H[SUHVVLRQ Results: &$ H[SUHVVLRQ ZDV GHWHFWHG LQ RI FF5&&V E\ RQH VWHS573&5DQGLQ RIFF5&&VE\TXDQWLWDWLYH3&5&$ P51$ H[SUHVVLRQ ZDV DEVHQW LQ WKH FRQWURO VHUXPV RI QRUPDO VXEMHFWV S 4XDQWLWDWLYH3&5LQGLFDWHGWKDWWKH&$ P51$OHYHOZDVUHODWHGZLWKWKHWXPRXU VL]HRUWXPRXUVWDJH)XUWKHUPRUH&$ P51$OHYHOZDVVLJQLᚏFDQWO\UHGXFHGLQ SDWLHQWVRQHZHHNDIWHUVXUJHU\$PRQJWKHVHUXPVDPSOHVIURPDORFDOL]HG GLVHDVHGXULQJIROORZXSZHUHIRXQGWREH&$ P51$SRVLWLYHLQSDWLHQWVZLWK DSRVWRSHUDWLYHPHWDVWDVLV Conclusions: 7KLV LV WKH ᚏUVW VWXG\ RI &$ P51$ H[SUHVVLRQ LQ WKH VHUXP RI FDQFHU SDWLHQWV :H IRXQG WKDW &$ P51$ LV KLJKO\ GHWHFWDEOH LQ WKH VHUXP RI SDWLHQWVZLWKDFF5&&7KHGHWHFWLRQRI&$ P51$LQVHUXPPD\SURYLGHDQHZ ZD\IRUPROHFXODUGLDJQRVLVRUVXUYHLOODQFHRIFF5&&2WKHUVWXGLHVDUHQHFHVVDU\ WRFRQᚏUPRXUUHVXOWVDQGWRLQYHVWLJDWHLWVYDOXHLQWKHHYDOXDWLRQRIHᚑFDF\RI DGMXYDQWWUHDWPHQW
ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR IS ASSOCIATED WITH CIGARETTE SMOKE, POOR PROGNOSIS AND CANCER CELL INVASION IN RENAL CELL CARCINOMA
290
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Introduction & Objectives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ᚏFDQFHZKLOHDOVRLGHQWLI\LQJDVVRFLDWLRQZLWKVPRNLQJKLVWRU\)XUWKHUPRUH ZHHOXFLGDWHWKHUROHRI$K5E\UHJXODWLQJWKHH[SUHVVLRQXVLQJLWVOLJDQGRUVL51$ IRU$K5LQYLWUR Material & Methods: $WRWDORISDWLHQWVZKRZHUHKLVWRORJLFDOO\YHULᚏHGWRKDYH 5&&ZHUHLQFOXGHGLQWKHVWXG\7KHPHGLDQDJHZDV\HDUV WR DQGWKH PHGLDQIROORZXSZDVPRQWKV WR 7KH$K5H[SUHVVLRQZDVLQYHVWLJDWHG E\ LPPXQRKLVWRFKHPLVWU\ DQG LWV DVVRFLDWLRQV ZLWK WKH FOLQLFRSDWKRORJLFDO SDUDPHWHUV DQG SURJQRVLV ZHUH DQDO\]HG 3DWLHQWV ZKR VPRNHG GDLO\ IRU PRUH WKDQ RQH \HDU ZHUH GHᚏQHG DV KDYLQJ D SRVLWLYH VPRNLQJ KLVWRU\ 7R GHWHUPLQH ZKHWKHUWKH$K5SDWKZD\DQGLQYDVLRQDFWLYLW\FDQEHDFWLYDWHGLQD5&&FHOOOLQH 2 ZH H[DPLQHG WKH H[SUHVVLRQ RI &<3V DQG 003V IROORZLQJ H[SRVXUH WR WHWUDFKORURGLEHQ]RSGLR[LQ 7&'' DOLJDQGRI$K5)XUWKHUPRUHZH H[DPLQHGWKHHᚎHFWRIGRZQUHJXODWLRQRI$K5LQ2E\WUDQVIHFWLRQRIVL51$ IRU$K5 Results: 7KH$K5H[SUHVVLRQZDVVLJQLᚏFDQWO\DVVRFLDWHGZLWKWKHVPRNLQJKLVWRU\ S JHQGHU S KLVWRORJLFDOJUDGH S DQGKLVWRORJ\ S $ PXOWLYDULDWH DQDO\VLV UHYHDOHG WKH WXPRU JUDGH S YDVFXODU LQYDVLRQ S DQG $K5 S EXW QRW WKH VPRNLQJ KLVWRU\ WR EH LQGHSHQGHQW SURJQRVWLF IDFWRUV IRU WKH GLVHDVHVSHFLᚏF VXUYLYDO 7KH \HDU GLVHDVHVSHFLᚏF VXUYLYDOUDWHVZHUH LQWKHORZ$K5JURXSDQG LQWKHKLJK$K5JURXS S 7&'' WUHDWPHQW XSUHJXODWHG WKH H[SUHVVLRQ OHYHOV RI $K5 &<3$ &<3% 003DQG003DQGFHOOVWUDQVIHFWHGZLWKVL51$IRU$K5 VKRZHG GHFUHDVHGH[SUHVVLRQRI$K5&<3$&<3%003003DQG003 Conclusions: $K5 ZDV H[SUHVVHG LQ 5&& DQG LW VKRZHG D SRVLWLYH FRUUHODWLRQ ZLWKWKHVPRNLQJKLVWRU\WKXVVXJJHVWLQJWKDWFLJDUHWWHVPRNHPD\EHDVVRFLDWHG ZLWKWKHFDUFLQRJHQHVLVRI5&&SUREDEO\GXHWRWKHDFWLYDWLRQRI$K52XUUHVXOWV
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0DVRQ5-$EGROHOO05HQGRQ5$ 1 Dalhousie University and Queen Elizabeth 2 Health Sciences Centre, Dept. of Urology, Halifax, Canada, 2Dalhousie University and Queen Elizabeth 2 Health Sciences Centre, Dept. of Radiology, Halifax, Canada Introduction & Objectives: 7KHULVHLQLQFLGHQWDOO\GHWHFWHGVPDOOUHQDOPDVVHV KDV EHHQ DFFRPSDQLHG E\ DQ LQFUHDVH LQ WKH SURSRUWLRQ RI OHVLRQV LQGHQWLᚏHG DV EHQLJQ SRVWRSHUDWLYHO\ %HFDXVH RI WKLV XURORJLVWV DUH LQ QHHG RI PRUH SUH RSHUDWLYHSUHGLFWRUVRISDWKRORJ\WRDLGLQGHFLVLRQPDNLQJEHIRUHHPEDUNLQJXSRQ QHSKURQVSDULQJ VXUJHU\ ZLWK LWV LQKHUHQW FRPSOLFDWLRQV +HUH ZH UHSRUW RQ WKH RGGV RI D EHQLJQ GLDJQRVLV IRU SHULSKHUDOO\ ORFDWHG UHQDO PDVVHV FRPSDUHG WR WKRVHORFDWHGFHQWUDOO\ZLWKLQWKHNLGQH\ Material & Methods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esults: 7KHSURSRUWLRQRIKLVWRORJLFDOO\FRQᚏUPHGEHQLJQGLVHDVHLQWKLVVHULHV ZDV7KHSURSRUWLRQRIEHQLJQGLVHDVHE\ORFDWLRQZDV DQG IRU FHQWUDO DQG SHULSKHUDO PDVVHV UHVSHFWLYHO\ 7KH HᚎHFW RI ORFDWLRQ ZDV IRXQG WR KDYHDVLJQLᚏFDQWSURJQRVWLFYDOXH S ZLWKDQDGMXVWHGRGGVUDWLRRI &, IRUWKHRGGVRIDEHQLJQGLDJQRVLVLQSHULSKHUDOFRPSDUHG WRFHQWUDOWXPRXUV7XPRUVL]HDQGSDWLHQWVH[ZHUHQRWVLJQLᚏFDQWSUHGLFWRUVRI EHQLJQSDWKRORJ\ S DQG UHVSHFWLYHO\ Conclusions: 3HULSKHUDOO\ ORFDWHG UHQDO PDVVHV ZHUH IRXQG WR EH WKUHH DQG D KDOI WLPHV PRUH OLNHO\ WR EH EHQLJQ WKDQ FHQWUDOO\ ORFDWHG UHQDO PDVVHV 7KLV LQIRUPDWLRQPD\EHXWLOL]HGZKHQVHOHFWLQJVWUDWHJLHVIRUWKHPDQDJHPHQWRIUHQDO PDVVHVSUHVXPHGWREH5&&
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,VKLGD0 0LNDPL6 .RVDND7 .RQR+ .LNXFKL( 1DJDWD+ 0L\DMLPD$1DNDJDZD.0XNDL02NDGD<2\D0 1 Keio University, School of Medicine, Dept. of Urology, Tokyo, Japan, 2Keio University Hospital, Dept. of Diagnostic Pathology, Tokyo, Japan, 3Keio University, School of Medicine, Dept. of Pathology, Tokyo, Japan
Eur Urol Suppl 2010;9(2):118
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0DUV]DOHN0:HKUEHUJHU&5DXFKHQZDOG00DGHUVEDFKHU6 Sozialmedizinisches Zentrum Ost, Dept. of Urology and Andrology, Vienna, Austria Introduction & Objectives: 7RDQDO\]HWKHRYHUDOOVXUYLYDORIUHQDOFHOOFDUFLQRPD SDWLHQWV WUHDWHG ZLWKLQ WKH SDVW \UV LQ RXU FRXQWU\ ZLWK SDUWLFXODU UHIHUHQFH UHJDUGLQJWXPRXUVWDJHDQGVH[ Material & Methods: $OO FDVHV RI UHQDO FHOO FDUFLQRPD GLDJQRVHG LQ $XVWULD EHWZHHQ DQGZHUHUHJLVWHUHGLQWKH$XVWULDQ&DQFHU5HJLVWU\ $&5 2YHUDOOVXUYLYDOLQWKHVHFDVHVZDVFDOFXODWHGXVLQJWKH.DSODQ0HLHUPHWKRGDQG &R[SURSRUWLRQDOKD]DUGVPRGHOVZHUHDGMXVWHGIRUWXPRXUVWDJH 710V\VWHP DQGVH[ Results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onclusions: 7KLV QDWLRQZLGH DQDO\VLV SURYLGHV HVWLPDWHV IRU WKH ORQJWHUP VXUYLYDORISDWLHQWVZLWKUHQDOFHOOFDQFHU2YHUDOOVXUYLYDOZDVVWURQJO\FRUUHODWHG WR WXPRXU VWDJH ZRPHQ KDG D ORQJHU RYHUDOO VXUYLYDO IRU S7S7 WXPRXUV \HDURYHUDOOVXUYLYDOLQUHQDOFHOOFDUFLQRPDSDWLHQWVGHFUHDVHVVLJQLᚏFDQWO\ZLWK DGYDQFLQJWXPRXUVWDJHQRGDOGLVHDVHDQGGLVWDQWPHWDVWDVLV+RZHYHURYHUDOO VXUYLYDOLVLQIDYRXURIIHPDOHSDWLHQWVWKURXJKRXW77DQG7GLVHDVHVWDJHV
293
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/L*)HQJ*=KDR$*HQWLO3HUUHW$3DXO6*HQLQ&*LJDQWH0 7RVWDLQ- 1 CHU of Saint-Etienne, Jean-Monnet University, Dept. of Urology, Saint-Etienne, France, 2CHU of Saint-Etienne, Jean-Monnet University, Dept. of Pathology, Saint-Etienne, France, 3CHU of Saint-Etienne, Jean-Monnet University, Immunology Laboratory, Saint-Etienne, France Introduction & Objectives: 5HFHQWVWXGLHVKDYHGHPRQVWUDWHGWKDWWKHFLUFXODWLQJ WXPRXUGHULYHG '1$ RU 51$ SURYLGHV QHZ ZD\V IRU GLDJQRVLV RU SURJQRVLV RI FDQFHU &$ LV IRXQG WR EH RQH RI WKH PRVW SRZHUIXO PROHFXODU PDUNHUV IRU FRQYHQWLRQDO RU FOHDU FHOO UHQDO FHOO FDQFHU FF5&& :H K\SRWKHVL]H WKDW &$ P51$H[SUHVVLRQLQVHUXPPLJKWEHDQHZPHWKRGIRUWKHPROHFXODUGLDJQRVLVRU IROORZXSRIFF5&& Material & Methods: 6HUXP VDPSOHV ZHUH FROOHFWHG IURP SDWLHQWV ZLWK D FF5&&VHUXPVDPSOHVIURPQRUPDOVXEMHFWVZHUHXVHGDVFRQWUROVVHUXP VDPSOHVZHUHWDNHQRQHZHHNDIWHUVXUJHU\VHUXPVDPSOHVZHUHDOVRREWDLQHG GXULQJIROORZXSDIWHUVXUJHU\$IWHUWKHH[WUDFWLRQRI51$ZHSHUIRUPHG573&5 WRPHDVXUH&$ H[SUHVVLRQ Results: &$ H[SUHVVLRQ ZDV GHWHFWHG LQ RI FF5&&V E\ RQH VWHS573&5DQGLQ RIFF5&&VE\TXDQWLWDWLYH3&5&$ P51$ H[SUHVVLRQ ZDV DEVHQW LQ WKH FRQWURO VHUXPV RI QRUPDO VXEMHFWV S 4XDQWLWDWLYH3&5LQGLFDWHGWKDWWKH&$ P51$OHYHOZDVUHODWHGZLWKWKHWXPRXU VL]HRUWXPRXUVWDJH)XUWKHUPRUH&$ P51$OHYHOZDVVLJQLᚏFDQWO\UHGXFHGLQ SDWLHQWVRQHZHHNDIWHUVXUJHU\$PRQJWKHVHUXPVDPSOHVIURPDORFDOL]HG GLVHDVHGXULQJIROORZXSZHUHIRXQGWREH&$ P51$SRVLWLYHLQSDWLHQWVZLWK DSRVWRSHUDWLYHPHWDVWDVLV Conclusions: 7KLV LV WKH ᚏUVW VWXG\ RI &$ P51$ H[SUHVVLRQ LQ WKH VHUXP RI FDQFHU SDWLHQWV :H IRXQG WKDW &$ P51$ LV KLJKO\ GHWHFWDEOH LQ WKH VHUXP RI SDWLHQWVZLWKDFF5&&7KHGHWHFWLRQRI&$ P51$LQVHUXPPD\SURYLGHDQHZ ZD\IRUPROHFXODUGLDJQRVLVRUVXUYHLOODQFHRIFF5&&2WKHUVWXGLHVDUHQHFHVVDU\ WRFRQᚏUPRXUUHVXOWVDQGWRLQYHVWLJDWHLWVYDOXHLQWKHHYDOXDWLRQRIHᚑFDF\RI DGMXYDQWWUHDWPHQW
ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR IS ASSOCIATED WITH CIGARETTE SMOKE, POOR PROGNOSIS AND CANCER CELL INVASION IN RENAL CELL CARCINOMA
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Introduction & Objectives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ᚏFDQFHZKLOHDOVRLGHQWLI\LQJDVVRFLDWLRQZLWKVPRNLQJKLVWRU\)XUWKHUPRUH ZHHOXFLGDWHWKHUROHRI$K5E\UHJXODWLQJWKHH[SUHVVLRQXVLQJLWVOLJDQGRUVL51$ IRU$K5LQYLWUR Material & Methods: $WRWDORISDWLHQWVZKRZHUHKLVWRORJLFDOO\YHULᚏHGWRKDYH 5&&ZHUHLQFOXGHGLQWKHVWXG\7KHPHGLDQDJHZDV\HDUV WR DQGWKH PHGLDQIROORZXSZDVPRQWKV WR 7KH$K5H[SUHVVLRQZDVLQYHVWLJDWHG E\ LPPXQRKLVWRFKHPLVWU\ DQG LWV DVVRFLDWLRQV ZLWK WKH FOLQLFRSDWKRORJLFDO SDUDPHWHUV DQG SURJQRVLV ZHUH DQDO\]HG 3DWLHQWV ZKR VPRNHG GDLO\ IRU PRUH WKDQ RQH \HDU ZHUH GHᚏQHG DV KDYLQJ D SRVLWLYH VPRNLQJ KLVWRU\ 7R GHWHUPLQH ZKHWKHUWKH$K5SDWKZD\DQGLQYDVLRQDFWLYLW\FDQEHDFWLYDWHGLQD5&&FHOOOLQH 2 ZH H[DPLQHG WKH H[SUHVVLRQ RI &<3V DQG 003V IROORZLQJ H[SRVXUH WR WHWUDFKORURGLEHQ]RSGLR[LQ 7&'' DOLJDQGRI$K5)XUWKHUPRUHZH H[DPLQHGWKHHᚎHFWRIGRZQUHJXODWLRQRI$K5LQ2E\WUDQVIHFWLRQRIVL51$ IRU$K5 Results: 7KH$K5H[SUHVVLRQZDVVLJQLᚏFDQWO\DVVRFLDWHGZLWKWKHVPRNLQJKLVWRU\ S JHQGHU S KLVWRORJLFDOJUDGH S DQGKLVWRORJ\ S $ PXOWLYDULDWH DQDO\VLV UHYHDOHG WKH WXPRU JUDGH S YDVFXODU LQYDVLRQ S DQG $K5 S EXW QRW WKH VPRNLQJ KLVWRU\ WR EH LQGHSHQGHQW SURJQRVWLF IDFWRUV IRU WKH GLVHDVHVSHFLᚏF VXUYLYDO 7KH \HDU GLVHDVHVSHFLᚏF VXUYLYDOUDWHVZHUH LQWKHORZ$K5JURXSDQG LQWKHKLJK$K5JURXS S 7&'' WUHDWPHQW XSUHJXODWHG WKH H[SUHVVLRQ OHYHOV RI $K5 &<3$ &<3% 003DQG003DQGFHOOVWUDQVIHFWHGZLWKVL51$IRU$K5 VKRZHG GHFUHDVHGH[SUHVVLRQRI$K5&<3$&<3%003003DQG003 Conclusions: $K5 ZDV H[SUHVVHG LQ 5&& DQG LW VKRZHG D SRVLWLYH FRUUHODWLRQ ZLWKWKHVPRNLQJKLVWRU\WKXVVXJJHVWLQJWKDWFLJDUHWWHVPRNHPD\EHDVVRFLDWHG ZLWKWKHFDUFLQRJHQHVLVRI5&&SUREDEO\GXHWRWKHDFWLYDWLRQRI$K52XUUHVXOWV
PERIPHERALLY LOCATED RENAL MASSES CARRY A HIGHER RISK OF HISTOLOGICALLY PROVEN BENIGN DISEASE WHEN COMPARED WITH CENTRAL MASSES
0DVRQ5-$EGROHOO05HQGRQ5$ 1 Dalhousie University and Queen Elizabeth 2 Health Sciences Centre, Dept. of Urology, Halifax, Canada, 2Dalhousie University and Queen Elizabeth 2 Health Sciences Centre, Dept. of Radiology, Halifax, Canada Introduction & Objectives: 7KHULVHLQLQFLGHQWDOO\GHWHFWHGVPDOOUHQDOPDVVHV KDV EHHQ DFFRPSDQLHG E\ DQ LQFUHDVH LQ WKH SURSRUWLRQ RI OHVLRQV LQGHQWLᚏHG DV EHQLJQ SRVWRSHUDWLYHO\ %HFDXVH RI WKLV XURORJLVWV DUH LQ QHHG RI PRUH SUH RSHUDWLYHSUHGLFWRUVRISDWKRORJ\WRDLGLQGHFLVLRQPDNLQJEHIRUHHPEDUNLQJXSRQ QHSKURQVSDULQJ VXUJHU\ ZLWK LWV LQKHUHQW FRPSOLFDWLRQV +HUH ZH UHSRUW RQ WKH RGGV RI D EHQLJQ GLDJQRVLV IRU SHULSKHUDOO\ ORFDWHG UHQDO PDVVHV FRPSDUHG WR WKRVHORFDWHGFHQWUDOO\ZLWKLQWKHNLGQH\ Material & Methods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esults: 7KHSURSRUWLRQRIKLVWRORJLFDOO\FRQᚏUPHGEHQLJQGLVHDVHLQWKLVVHULHV ZDV7KHSURSRUWLRQRIEHQLJQGLVHDVHE\ORFDWLRQZDV DQG IRU FHQWUDO DQG SHULSKHUDO PDVVHV UHVSHFWLYHO\ 7KH HᚎHFW RI ORFDWLRQ ZDV IRXQG WR KDYHDVLJQLᚏFDQWSURJQRVWLFYDOXH S ZLWKDQDGMXVWHGRGGVUDWLRRI &, IRUWKHRGGVRIDEHQLJQGLDJQRVLVLQSHULSKHUDOFRPSDUHG WRFHQWUDOWXPRXUV7XPRUVL]HDQGSDWLHQWVH[ZHUHQRWVLJQLᚏFDQWSUHGLFWRUVRI EHQLJQSDWKRORJ\ S DQG UHVSHFWLYHO\ Conclusions: 3HULSKHUDOO\ ORFDWHG UHQDO PDVVHV ZHUH IRXQG WR EH WKUHH DQG D KDOI WLPHV PRUH OLNHO\ WR EH EHQLJQ WKDQ FHQWUDOO\ ORFDWHG UHQDO PDVVHV 7KLV LQIRUPDWLRQPD\EHXWLOL]HGZKHQVHOHFWLQJVWUDWHJLHVIRUWKHPDQDJHPHQWRIUHQDO PDVVHVSUHVXPHGWREH5&&
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Eur Urol Suppl 2010;9(2):118
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0DUV]DOHN0:HKUEHUJHU&5DXFKHQZDOG00DGHUVEDFKHU6 Sozialmedizinisches Zentrum Ost, Dept. of Urology and Andrology, Vienna, Austria Introduction & Objectives: 7RDQDO\]HWKHRYHUDOOVXUYLYDORIUHQDOFHOOFDUFLQRPD SDWLHQWV WUHDWHG ZLWKLQ WKH SDVW \UV LQ RXU FRXQWU\ ZLWK SDUWLFXODU UHIHUHQFH UHJDUGLQJWXPRXUVWDJHDQGVH[ Material & Methods: $OO FDVHV RI UHQDO FHOO FDUFLQRPD GLDJQRVHG LQ $XVWULD EHWZHHQ DQGZHUHUHJLVWHUHGLQWKH$XVWULDQ&DQFHU5HJLVWU\ $&5 2YHUDOOVXUYLYDOLQWKHVHFDVHVZDVFDOFXODWHGXVLQJWKH.DSODQ0HLHUPHWKRGDQG &R[SURSRUWLRQDOKD]DUGVPRGHOVZHUHDGMXVWHGIRUWXPRXUVWDJH 710V\VWHP DQGVH[ Results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onclusions: 7KLV QDWLRQZLGH DQDO\VLV SURYLGHV HVWLPDWHV IRU WKH ORQJWHUP VXUYLYDORISDWLHQWVZLWKUHQDOFHOOFDQFHU2YHUDOOVXUYLYDOZDVVWURQJO\FRUUHODWHG WR WXPRXU VWDJH ZRPHQ KDG D ORQJHU RYHUDOO VXUYLYDO IRU S7S7 WXPRXUV \HDURYHUDOOVXUYLYDOLQUHQDOFHOOFDUFLQRPDSDWLHQWVGHFUHDVHVVLJQLᚏFDQWO\ZLWK DGYDQFLQJWXPRXUVWDJHQRGDOGLVHDVHDQGGLVWDQWPHWDVWDVLV+RZHYHURYHUDOO VXUYLYDOLVLQIDYRXURIIHPDOHSDWLHQWVWKURXJKRXW77DQG7GLVHDVHVWDJHV
293
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