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4385062 1-((-2-Mercaptocycloalkyl) carbonyl)-l-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents
ii
New Patents 4385062
1-((-2MERCAPTOCYCLOALKYL) CARBONYL)-L-PROLINE DERIVATIVES, T H E PROCESS FOR THEIR MANUFACTURE, THE INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR USE AS ANTI-HYPERTENSIVE AGENTS Romeo Ciabatti; Giovanna Padova assigned to Gruppo Lepetit S p A
(CR'2)n R~ ' - ' ~ RI I HS
C--N II O
acceptable salts and in vivo hydrolyzable esters thereof, are active against Grampositive and Gram-negative bacteria which makes them useful as therapeutic and prophylactic agents against bacterial infections in animals, including man and poultry. A process for the preparation and pharmaceutical compositions comprising the penicillin, are also described.
4385059 THIAZOLE COMPOSITIONS Richard Franklin assigned to John Wyeth and Brother Limited
AOOR 2
1( ( 2 - M e r c a p t o c y c l o a l k y l ) c a r b o n y l ) - L proline derivatives of the formula wherein R, R1, and R2, each independently, represent hydrogen or a (C1-C4)alkyl radical, n represents the integer 1,2, 3, 4, or 5, and, in each of the n (CR'2) groups, R' represents hydrogen or (CI-C4)alkyl, are described as well as the process for their manufacture, the intermediates for their synthesis and their use as antihypertensive agents.
The invention concerns compounds of formula (I) or salts thereof, wherein R represents hydrogen which possess antiinflammatory activity and have low toxicity. Methods for preparing the compounds and pharmaceutical compositions are also disclosed.
4385057 DIPHENYLBUTYLPIPERAZINECARBOXAMIDES IN PHARMACEUTICAL COMPOSITIONS AND METHODS Anders K K Bjork; Knut Olsson; Aina Abramo; Erik Christensson assigned to AB Ferrosan
4385060 PENICILLINS John Clayton; Marti Cole assigned to Beecham Group Limited
.,x
)--4
IIt",
S CH3 ~-CH3
s•CH--CO--NH-• ~0 0
~
0~t-- N
R5 R6
~'CO.OH
,'/CH3
6 beta-(2-(2'-methylphenoxycarbonyl)-2thien-3'-ylacetamide) penicillanic acid of formula (I1): (ll) and pharmaceutically
Compounds having the general formula as herein defined and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions containing said compounds. Methods of treatment of humans and animals by such compounds and compositions.
New Patents 4385062
1-((-2MERCAPTOCYCLOALKYL) CARBONYL)-L-PROLINE DERIVATIVES, T H E PROCESS FOR THEIR MANUFACTURE, THE INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR USE AS ANTI-HYPERTENSIVE AGENTS Romeo Ciabatti; Giovanna Padova assigned to Gruppo Lepetit S p A
(CR'2)n R~ ' - ' ~ RI I HS
C--N II O
acceptable salts and in vivo hydrolyzable esters thereof, are active against Grampositive and Gram-negative bacteria which makes them useful as therapeutic and prophylactic agents against bacterial infections in animals, including man and poultry. A process for the preparation and pharmaceutical compositions comprising the penicillin, are also described.
4385059 THIAZOLE COMPOSITIONS Richard Franklin assigned to John Wyeth and Brother Limited
AOOR 2
1( ( 2 - M e r c a p t o c y c l o a l k y l ) c a r b o n y l ) - L proline derivatives of the formula wherein R, R1, and R2, each independently, represent hydrogen or a (C1-C4)alkyl radical, n represents the integer 1,2, 3, 4, or 5, and, in each of the n (CR'2) groups, R' represents hydrogen or (CI-C4)alkyl, are described as well as the process for their manufacture, the intermediates for their synthesis and their use as antihypertensive agents.
The invention concerns compounds of formula (I) or salts thereof, wherein R represents hydrogen which possess antiinflammatory activity and have low toxicity. Methods for preparing the compounds and pharmaceutical compositions are also disclosed.
4385057 DIPHENYLBUTYLPIPERAZINECARBOXAMIDES IN PHARMACEUTICAL COMPOSITIONS AND METHODS Anders K K Bjork; Knut Olsson; Aina Abramo; Erik Christensson assigned to AB Ferrosan
4385060 PENICILLINS John Clayton; Marti Cole assigned to Beecham Group Limited
.,x
)--4
IIt",
S CH3 ~-CH3
s•CH--CO--NH-• ~0 0
~
0~t-- N
R5 R6
~'CO.OH
,'/CH3
6 beta-(2-(2'-methylphenoxycarbonyl)-2thien-3'-ylacetamide) penicillanic acid of formula (I1): (ll) and pharmaceutically
Compounds having the general formula as herein defined and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions containing said compounds. Methods of treatment of humans and animals by such compounds and compositions.